Sarah Gabriel

Early precursor T cells establish and propagate T cell exhaustion in chronic infection

Daniel T Utzschneider, Sarah S Gabriel, David Chisanga, Renee Gloury, Patrick M Gubser, Ajithkumar Vasanthakumar, Wei Shi, Axel Kallies

Journal article  |  2020  |  Nature Immunology

MCL-1 is essential for survival but dispensable for metabolic fitness of FOXP3( )regulatory T cells

Charis E Teh, Alissa K Robbins, Darren C Henstridge, Grant Dewson, Sarah T Diepstraten, Gemma Kelly, Mark A Febbraio, Sarah S Gabriel, Lorraine A O'Reilly, Andreas Strasser, Daniel HD Gray

Journal article  |  2020  |  Cell Death and Differentiation

FOXP3+ regulatory T (Treg) cells are essential for maintaining immunological tolerance. Given their importance in immune-related d..

IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis

Michael Sze Yuan Low, Erica J Brodie, Pasquale L Fedele, Yang Liao, George Grigoriadis, Andreas Strasser, Axel Kallies, Simon N Willis, Julie Tellier, Wei Shi, Sarah Gabriel, Kristy O'Donnell, Catherine Pitt, Stephen L Nutt, David Tarlinton

Journal article  |  2019  |  Cell Reports

The transcription factor interferon regulatory factor 4 (IRF4) is critical for the development, maintenance, and function of plasm..

Tissue-resident memory T cells keep cancer dormant

Sarah Sharon Gabriel, Axel Kallies

Journal article  |  2019  |  Cell Research

Transcription Factor IRF4 Promotes CD8( ) T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection

Kevin Man, Sarah S Gabriel, Yang Liao, Renee Gloury, Simon Preston, Darren C Henstridge, Marc Pellegrini, Dietmar Zehn, Friederike Berberich-Siebelt, Mark A Febbraio, Wei Shi, Axel Kallies

Journal article  |  2017  |  Immunity

Bone marrow transplantation improves proximal tubule dysfunction in a mouse model of Dent disease.

Sarah S Gabriel, Hendrica Belge, Alkaly Gassama, Huguette Debaix, Alessandro Luciani, Thomas Fehr, Olivier Devuyst

Journal article  |  2017  |  Kidney International

Dent disease is a rare X-linked tubulopathy caused by mutations in the endosomal chloride-proton exchanger (ClC-5) resulting in de..

Sugars and fat - A healthy way to generate functional regulatory T cells

Sarah Sharon Gabriel, Axel Kallies

Journal article  |  2016  |  European Journal of Immunology

Glucose- and glutamine-fueled stabilization of C-Myc is required for T-cell proliferation and malignant transformation

SS Gabriel, A Kallies

Journal article  |  2016  |  Cell Death Discovery

Distinctive Expression of Bcl-2 Factors in Regulatory T Cells Determines a Pharmacological Target to Induce Immunological Tolerance.

Sarah Sharon Gabriel, Nina Bon, Jin Chen, Thomas Wekerle, Andrew Bushell, Thomas Fehr, Pietro Ernesto Cippà

Journal article  |  2016  |  Frontiers in Immunology

Distinctive molecular characteristics of functionally diverse lymphocyte populations may represent novel pharmacological targets f..

Bcl-2 inhibition to overcome memory cell barriers in transplantation.

PE Cippà, SS Gabriel, AK Kraus, J Chen, T Wekerle, A Guimezanes, RP Wüthrich, T Fehr

Journal article  |  2014  |  American Journal of Transplantation

Memory T cells (Tm) represent a major barrier for immunosuppression and tolerance induction after solid organ transplantation. Tak..