Ruidong Xiang

Genome-wide fine-mapping identifies pleiotropic and functional variants that predict many traits across global cattle populations.

Ruidong Xiang, Iona M MacLeod, Hans D Daetwyler, Gerben de Jong, Erin O'Connor, Chris Schrooten, Amanda J Chamberlain, Michael E Goddard

Journal article  |  2021  |  Nature Communications

The difficulty in finding causative mutations has hampered their use in genomic prediction. Here, we present a methodology to fine..

New loci and neuronal pathways for resilience to heat stress in animals

Evans Cheruiyot, Mekonnen Haile-Mariam, Benjamin Cocks, Iona MacLeod, Ruidong Xiang, Jennie Pryce

Journal article  |  2021

Climate change and resilience to warming climates have implications for humans, livestock, and wildlife. The genetic mechanisms th..

Expression quantitative trait loci in sheep liver and muscle contribute to variations in meat traits

Zehu Yuan, Bolormaa Sunduimijid, Ruidong Xiang, Ralph Behrendt, Matthew I Knight, Brett A Mason, Coralie M Reich, Claire Prowse-Wilkins, Christy J Vander Jagt, Amanda J Chamberlain, Iona M MacLeod, Fadi Li, Xiangpeng Yue, Hans D Daetwyler

Journal article  |  2021  |  Genetics Selection Evolution

BACKGROUND: Variants that regulate transcription, such as expression quantitative trait loci (eQTL), have shown enrichment in geno..

Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle

Jigme Dorji, Christy J Vander Jagt, Josie B Garner, Leah C Marett, Brett A Mason, Coralie M Reich, Ruidong Xiang, Emily L Clark, Benjamin G Cocks, Amanda J Chamberlain, Iona M MacLeod, Hans D Daetwyler

Journal article  |  2020  |  BMC Genomics

BACKGROUND: Mutations in the mitochondrial genome have been implicated in mitochondrial disease, often characterized by impaired c..

Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle

Jigme Dorji, Christy Vander Jagt, Josie Garner, Leah Marett, Brett Mason, Coralie Reich, Ruidong Xiang, Emily Clark, Benjamin Cocks, Amanda Chamberlain, Iona MacLeod, Hans Daetwyler

Journal article  |  2020

Background: Mutations in the mitochondrial genome have been implicated in mitochondrial disease, often characterized by impaired ..

Meta-analysis for milk fat and protein percentage using imputed sequence variant genotypes in 94,321 cattle from eight cattle breeds

Irene van den Berg, Ruidong Xiang, Janez Jenko, Hubert Pausch, Mekki Boussaha, Chris Schrooten, Thierry Tribout, Arne B Gjuvsland, Didier Boichard, Oyvind Nordbo, Marie-Pierre Sanchez, Mike E Goddard

Journal article  |  2020  |  Genetics Selection Evolution

Effect direction meta-analysis of GWAS identifies extreme, prevalent and shared pleiotropy in a large mammal

Ruidong Xiang, Irene van den Berg, Iona M MacLeod, Hans D Daetwyler, Michael E Goddard

Journal article  |  2020  |  Communications Biology

In genome-wide association studies (GWAS), variants showing consistent effect directions across populations are considered as true..

Transcriptomic analyses revealed common tailed and perirenal adipose differentially expressed genes in four Chinese indigenous sheep breeds

Zehu Yuan, Ruidong Xiang, Wanhong Li, Fadi Li, Xiangpeng Yue

Journal article  |  2019  |  Livestock Science

Analyses of inter-individual variations of sperm DNA methylation and their potential implications in cattle

Shuli Liu, Lingzhao Fang, Yang Zhou, Daniel JA Santos, Ruidong Xiang, Hans D Daetwyler, Amanda J Chamberlain, John B Cole, Cong-jun Li, Ying Yu, Li Ma, Shengli Zhang, George E Liu

Journal article  |  2019  |  BMC Genomics

BACKGROUND: DNA methylation has been shown to be involved in many biological processes, including X chromosome inactivation in fem..

Quantifying the contribution of sequence variants with regulatory and evolutionary significance to 34 bovine complex traits

Ruidong Xiang, Irene van den Berg, Iona M MacLeod, Benjamin J Hayes, Claire P Prowse-Wilkins, Min Wang, Sunduimijid Bolormaa, Zhiqian Liu, Simone J Rochfort, Coralie M Reich, Brett A Mason, Christy J Vander Jagt, Hans D Daetwyler, Mogens S Lund, Amanda J Chamberlain, Michael E Goddard

Journal article  |  2019  |  Proceedings of the National Academy of Sciences of USA