Dale Garsed

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

Stefan C Dentro, Ignaty Leshchiner, Kerstin Haase, Maxime Tarabichi, Jeff Wintersinger, Amit G Deshwar, Kaixian Yu, Yulia Rubanova, Geoff Macintyre, Jonas Demeulemeester, Ignacio Vazquez-Garcia, Kortine Kleinheinz, Dimitri G Livitz, Salem Malikic, Nilgun Donmez, Subhajit Sengupta, Pavana Anur, Clemency Jolly, Marek Cmero, Daniel Rosebrock, et al.

Journal article  |  2021  |  CELL

Intra-tumor heterogeneity (ITH) is a mechanism of therapeutic resistance and therefore an important clinical challenge. However, t..

ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer

RE Miller, A Leary, CL Scott, V Serra, CJ Lord, D Bowtell, DK Chang, DW Garsed, J Jonkers, JA Ledermann, S Nik-Zainal, I Ray-Coquard, SP Shah, X Matias-Guiu, EM Swisher, LR Yates

Journal article  |  2020  |  Annals of Oncology

BACKGROUND: Homologous recombination repair deficiency (HRD) is a frequent feature of high-grade serous ovarian, fallopian tube an..

Menopausal hormone therapy prior to the diagnosis of ovarian cancer is associated with improved survival

Katharine K Brieger, Siri Peterson, Alice W Lee, Bhramar Mukherjee, Kelly M Bakulski, Aliya Alimujiang, Hoda Anton-Culver, Michael S Anglesio, Elisa Bandera, Andrew Berchuck, David DL Bowtell, Georgia Chenevix-Trench, Kathleen R Cho, Daniel W Cramer, Anna DeFazio, Jennifer A Doherty, Renee T Fortner, Dale W Garsed, Simon A Gayther, Aleksandra Gentry-Maharaj, et al.

Journal article  |  2020  |  GYNECOLOGIC ONCOLOGY

PURPOSE: Prior studies of menopausal hormone therapy (MHT) and ovarian cancer survival have been limited by lack of hormone regime..

Sex differences in oncogenic mutational processes

Constance H Li, Stephenie D Prokopec, Ren X Sun, Fouad Yousif, Nathaniel Schmitz, Paul C Boutros

Journal article  |  2020  |  NATURE COMMUNICATIONS

Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside t..

Molecular analysis of exceptional response in high-grade serous ovarian cancer.

Dale Garsed, Ahwan Pandey, Sian Fereday, Kathryn Alsop, Maartje Wouters, Flurina Saner, Catherine Kennedy, Celeste Pearce, Malcolm Pike, Susan Ramus, Martin Kobel, Anna deFazio, Ellen Goode, Brad Nelson, David Bowtell

Conference Proceedings  |  2020  |  CLINICAL CANCER RESEARCH

Pan-cancer analysis of whole genomes

Peter J Campbell, Gad Getz, Jan O Korbel, Joshua M Stuart, Jennifer L Jennings, Lincoln D Stein, Marc D Perry, Hardeep K Nahal-Bose, BF Francis Ouellette, Constance H Li, Esther Rheinbay, G Petur Nielsen, Dennis C Sgroi, Chin-Lee Wu, William C Faquin, Vikram Deshpande, Paul C Boutros, Alexander J Lazar, Katherine A Hoadley, David N Louis, et al.

Journal article  |  2020  |  NATURE

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this v..

Patterns of somatic structural variation in human cancer genomes

Yilong Li, Nicola D Roberts, Jeremiah A Wala, Ofer Shapira, Steven E Schumacher, Kiran Kumar, Ekta Khurana, Sebastian Waszak, Jan O Korbel, James E Haber, Marcin Imielinski, Joachim Weischenfeldt, Rameen Beroukhim, Peter J Campbell, Kadir C Akdemir, Eva G Alvarez, Adrian Baez-Ortega, Paul C Boutros, David DL Bowtell, Benedikt Brors, et al.

Journal article  |  2020  |  NATURE

A key mutational process in cancer is structural variation, in which rearrangements delete, amplify or reorder genomic segments th..

The evolutionary history of 2,658 cancers

Moritz Gerstung, Clemency Jolly, Ignaty Leshchiner, Stefan C Dentro, Santiago Gonzalez, Daniel Rosebrock, Thomas J Mitchell, Yulia Rubanova, Pavana Anur, Kaixian Yu, Maxime Tarabichi, Amit Deshwar, Jeff Wintersinger, Kortine Kleinheinz, Ignacio Vazquez-Garcia, Kerstin Haase, Lara Jerman, Subhajit Sengupta, Geoff Macintyre, Salem Malikic, et al.

Journal article  |  2020  |  NATURE

Cancer develops through a process of somatic evolution1,2. Sequencing data from a single biopsy represent a snapshot of this proce..

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Esther Rheinbay, Morten Muhlig Nielsen, Federico Abascal, Jeremiah A Wala, Ofer Shapira, Grace Tiao, Henrik Hornshoj, Julian M Hess, Randi Istrup Juul, Ziao Lin, Lars Feuerbach, Radhakrishnan Sabarinathan, Tobias Madsen, Jaegil Kim, Loris Mularoni, Shimin Shuai, Andres Lanzos, Carl Herrmann, Yosef E Maruvka, Ciyue Shen, et al.

Journal article  |  2020  |  NATURE

The discovery of drivers of cancer has traditionally focused on protein-coding genes1-4. Here we present analyses of driver point ..

Genomic footprints of activated telomere maintenance mechanisms in cancer.

Lina Sieverling, Chen Hong, Sandra D Koser, Philip Ginsbach, Kortine Kleinheinz, Barbara Hutter, Delia M Braun, Isidro Cortés-Ciriano, Ruibin Xi, Rolf Kabbe, Peter J Park, Roland Eils, Matthias Schlesner, undefined PCAWG-Structural Variation Working Group, Benedikt Brors, Karsten Rippe, David TW Jones, Lars Feuerbach, undefined PCAWG Consortium

Journal article  |  2020  |  Nat Commun

Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or ..