Kevin John Selva

Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 variants via multiplex assay.

Ester Lopez, Ebene R Haycroft, Amy Adair, Francesca L Mordant, Matthew T O'Neill, Phillip Pymm, Samuel J Redmond, Wen Shi Lee, Nicholas A Gherardin, Adam K Wheatley, Jennifer A Juno, Kevin John Selva, Samantha K Davis, Samantha L Grimley, Leigh Harty, Damian Fj Purcell, Kanta Subbarao, Dale I Godfrey, Stephen J Kent, Wai-Hong Tham, et al.

Journal article  |  2021  |  JCI Insight

The SARS-CoV-2 Receptor Binding Domain (RBD) is both the principal target of neutralizing antibodies, and one of the most rapidly ..

Decay of Fc-dependent antibody functions after mild to moderate COVID-19

Wen Shi Lee, Kevin John Selva, Samantha K Davis, Bruce D Wines, Arnold Reynaldi, Robyn Esterbauer, Hannah G Kelly, Ebene R Haycroft, Hyon-Xhi Tan, Jennifer A Juno, Adam K Wheatley, P Mark Hogarth, Deborah Cromer, Miles P Davenport, Amy W Chung, Stephen J Kent

Journal article  |  2021  |  CELL REPORTS MEDICINE

The capacity of antibodies to engage with immune cells via the Fc region is important in preventing and controlling many infectiou..

Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial.

Keith J Chappell, Francesca L Mordant, Zheyi Li, Danushka K Wijesundara, Paula Ellenberg, Julia A Lackenby, Stacey TM Cheung, Naphak Modhiran, Michael S Avumegah, Christina L Henderson, Kym Hoger, Paul Griffin, Jillian Bennet, Luca Hensen, Wuji Zhang, Thi HO Nguyen, Sara Marrero-Hernandez, Kevin J Selva, Amy W Chung, Mai H Tran, et al.

Journal article  |  2021  |  Lancet Infect Dis

BACKGROUND: Given the scale of the ongoing COVID-19 pandemic, the development of vaccines based on different platforms is essentia..

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

Kevin J Selva, Carolien E van de Sandt, Melissa M Lemke, Christina Y Lee, Suzanne K Shoffner, Brendon Y Chua, Samantha K Davis, Thi HO Nguyen, Louise C Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, Francesca Mordant, David C Jackson, Katie L Flanagan, Jane Crowe, Shidan Tosif, Melanie R Neeland, Philip Sutton, Paul Licciardi, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-..

Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19

Adam K Wheatley, Jennifer A Juno, Jing J Wang, Kevin J Selva, Arnold Reynaldi, Hyon-Xhi Tan, Wen Shi Lee, Kathleen M Wragg, Hannah G Kelly, Robyn Esterbauer, Samantha K Davis, Helen E Kent, Francesca L Mordant, Timothy E Schlub, David L Gordon, David S Khoury, Kanta Subbarao, Deborah Cromer, Tom P Gordon, Amy W Chung, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

The durability of infection-induced SARS-CoV-2 immunity has major implications for reinfection and vaccine development. Here, we s..

Robust correlations across six SARS-CoV-2 serology assays detecting distinct antibody features

Louise C Rowntree, Brendon Y Chua, Suellen Nicholson, Marios Koutsakos, Luca Hensen, Celia Douros, Kevin Selva, Francesca L Mordant, Chinn Yi Wong, Jennifer R Habel, Wuji Zhang, Xiaoxiao Jia, Lily Allen, Denise L Doolan, David C Jackson, Adam K Wheatley, Stephen J Kent, Fatima Amanat, Florian Krammer, Kanta Subbarao, et al.

Journal article  |  2021  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Objectives: As the world transitions into a new era of the COVID-19 pandemic in which vaccines become available, there is an incre..

Decay of Fc-dependent antibody functions after mild to moderate COVID-19

Wen Shi Lee, Kevin John Selva, Samantha Davis, Bruce Wines, Arnold Reynaldi, Robyn Esterbauer, Hannah Kelly, Ebene Haycroft, Hyon-Xhi Tan, Jennifer Juno, Adam Wheatley, Mark Hogarth, Deborah Cromer, Miles Davenport, Amy Chung, Stephen Kent

Journal article  |  2020

The capacity of antibodies to engage with innate and adaptive immune cells via the Fc region is important in preventing and contro..

Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19

Shidan Tosif, Melanie R Neeland, Philip Sutton, Paul V Licciardi, Sohinee Sarkar, Kevin J Selva, Anh Ha Do Lien, Celeste Donato, Zheng Quan Toh, Rachel Higgins, Carolien Van de Sandt, Melissa M Lemke, Christina Y Lee, Suzanne K Shoffner, Katie L Flanagan, Kelly B Arnold, Francesca L Mordant, Kim Mulholland, Julie Bines, Kate Dohle, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

Compared to adults, children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly mild or asymptom..

Evolution of immunity to SARS-CoV-2

Adam Wheatley, Jennifer Juno, Jing Wang, Kevin Selva, Arnold Reynaldi, Hyon-Xhi Tan, Wen Shi Lee, Kathleen Wragg, Hannah Kelly, Robyn Esterbauer, Samantha Davis, Helen Kent, Francesca Mordant, Timothy Schlub, David Gordon, David Khoury, Kanta Subbarao, Deborah Cromer, Tom Gordon, Amy Chung, et al.

Journal article  |  2020

The durability of infection-induced SARS-CoV-2 immunity has major implications for public health mitigation and vaccine developmen..

Distinct systems serology features in children, elderly and COVID patients

Kevin Selva, Carolien van de Sandt, Melissa Lemke, Christina Lee, Suzanne Shoffner, Brendon Chua, Thi HO Nguyen, Louise Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, David Jackson, Katie Flanagan, Jane Crowe, Allen Cheng, Denise Doolan, Fatima Amanat, Florian Krammer, Keith Chappell, Naphak Modhiran, et al.

Journal article  |  2020

SARS-CoV-2, the pandemic coronavirus that causes COVID-19, has infected millions worldwide, causing unparalleled social and econom..