Jenny McKimm-Breschkin

COVID-19, Influenza and RSV: Surveillance-informed prevention and treatment - Meeting report from an isirv-WHO virtual conference

Jennifer L McKimm-Breschkin, Alan J Hay, Bin Cao, Rebecca J Cox, Jake Dunning, Ann C Moen, Daniel Olson, Andres Pizzorno, Frederick G Hayden

Journal article  |  2022  |  ANTIVIRAL RESEARCH

The International Society for Influenza and other Respiratory Virus Diseases (isirv) and the WHO held a joint virtual conference f..

Influenza polymerase inhibitor resistance: Assessment of the current state of the art-A report of the isirv Antiviral group

Michael G Ison, Frederick G Hayden, Alan J Hay, Larisa Gubareva, Elena A Govorkova, Emi Takashita, Jennifer L McKimm-Breschkin

Journal article  |  2021  |  ANTIVIRAL RESEARCH

It is more than 20 years since the neuraminidase inhibitors, oseltamivir and zanamivir were approved for the treatment and prevent..

Substitutions at H134 and in the 430-loop region in influenza B neuraminidases can confer reduced susceptibility to multiple neuraminidase inhibitors

Peter G Mohr, Janelle Williams, Masato Tashiro, Victor A Streltsov, Jennifer L McKimm-Breschkin

Journal article  |  2020  |  ANTIVIRAL RESEARCH

With the introduction of the influenza specific neuraminidase inhibitors (NAIs) in 1999, there were concerns about the emergence a..

A clinical trial lacking a control group.

Mike Bray, Jennifer McKimm-Breschkin

Journal article  |  2019  |  Int J Infect Dis

Passaging of an influenza A(H1N1)pdm09 virus in a difluoro sialic acid inhibitor selects for a novel, but unfit I106M neuraminidase mutant

Jennifer L McKimm-Breschkin, Susan Barrett, Charley McKenzie-Kludas, Julie McAuley, Victor A Streltsov, Stephen G Withers

Journal article  |  2019  |  ANTIVIRAL RESEARCH

An influenza A(H1N1)pdm09 and an influenza B virus were passaged in 3-fluoro(eq)-4-guanidino difluoro sialic acid (3Feq4Gu DFSA), ..

Structure of an Influenza A virus N9 neuraminidase with a tetrabrachion-domain stalk

Victor A Streltsov, Peter M Schmidt, Jennifer L McKimm-Breschkin

Journal article  |  2019  |  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS

The influenza neuraminidase (NA) is a homotetramer with head, stalk, transmembrane and cytoplasmic regions. The structure of the N..

Influenza Virus Neuraminidase Structure and Functions

Julie L McAuley, Brad P Gilbertson, Sanja Trifkovic, Lorena E Brown, Jennifer L McKimm-Breschkin

Journal article  |  2019  |  FRONTIERS IN MICROBIOLOGY

With the constant threat of emergence of a novel influenza virus pandemic, there must be continued evaluation of the molecular mec..

Identification of Indonesian Glade 2.1 highly pathogenic influenza A(H5N1) viruses with N294S and S246N neuraminidase substitutions which further reduce oseltamivir susceptibility

Jennifer L McKimm-Breschkin, Susan Barrett, Frank YK Wong, undefined Pudjiatmoko, Muhammad Azhar, Paul Selleck, Kelly R Davies, Nining Hartaningsih, James McGrane

Journal article  |  2018  |  ANTIVIRAL RESEARCH

We have tested the in vitro susceptibility to the neuraminidase (NA) inhibitors of 96 highly pathogenic clade 2.1 A(H5N1) viruses ..

Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8-and 9-Deoxygenated 2,3-Difluoro-N-acetylneuraminic Acid Derivatives

Jennifer L McKimm-Breschkin, Susan Barrett, Patricia A Pilling, Stefan Hader, Andrew G Watts, Victor A Streltsov

Journal article  |  2018  |  JOURNAL OF MEDICINAL CHEMISTRY

Competitive inhibitors of the influenza neuraminidase (NA) were discovered almost 20 years ago, with zanamivir and oseltamivir lic..

Mouse Saliva Inhibits Transit of Influenza Virus to the Lower Respiratory Tract by Efficiently Blocking Influenza Virus Neuraminidase Activity

Brad Gilbertson, Wy Ching Ng, Simon Crawford, Jenny L McKimm-Breschkin, Lorena E Brown

Journal article  |  2017  |  JOURNAL OF VIROLOGY

We previously identified a novel inhibitor of influenza virus in mouse saliva that halts the progression of susceptible viruses fr..