Alison Anderson

Human In Vitro Models of Epilepsy Using Embryonic and Induced Pluripotent Stem Cells

Muhammad Shahid Javaid, Tracie Tan, Naomi Dvir, Alison Anderson, Terence J. O'Brien, Patrick Kwan, Ana Antonic-Baker

Journal article  |  2022  |  CELLS

The challenges in making animal models of complex human epilepsy phenotypes with varied aetiology highlights the need to develop a..

An Integrated Multi-Omic Network Analysis Identifies Seizure-Associated Dysregulated Pathways in the GAERS Model of Absence Epilepsy

Anna Harutyunyan, Debbie Chong, Rui Li, Anup D Shah, Zahra Ali, Cheng Huang, Christopher K Barlow, Piero Perucca, Terence J O'Brien, Nigel C Jones, Ralf B Schittenhelm, Alison Anderson, Pablo M Casillas-Espinosa

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Absence epilepsy syndromes are part of the genetic generalized epilepsies, the pathogenesis of which remains poorly understood, al..

Network Preservation Analysis Reveals Dysregulated Synaptic Modules and Regulatory Hubs Shared Between Alzheimer's Disease and Temporal Lobe Epilepsy

Anna Harutyunyan, Nigel C Jones, Patrick Kwan, Alison Anderson

Journal article  |  2022  |  FRONTIERS IN GENETICS

Background: There is increased prevalence of epilepsy in patients with Alzheimer's disease (AD). Although shared pathological and ..

Potential role of regulatory DNA variants in modifying the risk of severe cutaneous reactions induced by aromatic anti-seizure medications

Kerry A Mullan, Alison Anderson, Yi-Wu Shi, Jia-Hong Ding, Ching-Ching Ng, Zhibin Chen, Larry Baum, Stacey Cherny, Slave Petrovski, Pak C Sham, Kheng-Seang Lim, Wei-Ping Liao, Patrick Kwan

Journal article  |  2022  |  EPILEPSIA

OBJECTIVE: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions. Antise..

Alpha-lipoic acid analogues in the regulation of redox balance in epilepsy: A molecular docking and simulation study

Muhammad Shahid Javaid, Ana Antonic-Baker, Eleni Pitsillou, Julia Liang, Chris French, Andrew Hung, Terence J O'Brien, Patrick Kwan, Tom C Karagiannis, Alison Anderson

Journal article  |  2022  |  JOURNAL OF MOLECULAR GRAPHICS & MODELLING

OBJECTIVE: Oxidative stress is one of the pathophysiological mechanisms implicated in drug-resistant epilepsy. Recurrent seizures ..

ggVolcanoR: A Shiny app for customizable visualization of differential expression datasets

Kerry A Mullan, Liesl M Bramberger, Prithvi Raj Munday, Gabriel Goncalves, Jerico Revote, Nicole A Mifsud, Patricia T Illing, Alison Anderson, Patrick Kwan, Anthony W Purcell, Chen Li

Journal article  |  2021  |  COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL

Volcano and other analytical plots (e.g., correlation plots, upset plots, and heatmaps) serve as important data visualization meth..

One step closer towards personalized epilepsy management

Zhibin Chen, Alison Anderson, Zongyuan Ge, Patrick Kwan

Journal article  |  2021  |  BRAIN

This scientific commentary refers to ‘Towards realizing the vision of precision medicine: AI based prediction of clinical drug res..

Sex Differences in the Risk of Cutaneous Adverse Drug Reactions Induced by Antiseizure Medications: A Systematic Review and Meta-analysis

Israa Alfares, Muhammad Shahid Javaid, Zhibin Chen, Alison Anderson, Ana Antonic-Baker, Patrick Kwan

Journal article  |  2021  |  CNS DRUGS

BACKGROUND: Cutaneous adverse drug reactions (cADRs) are one of the most common, severe, and life-threatening types of adverse rea..

Prenatal valproate exposure and adverse neurodevelopmental outcomes: Does sex matter?

Eliza Honybun, Rebecca Thwaites, Charles B Malpas, Genevieve Rayner, Alison Anderson, Janet Graham, Alison Hitchcock, Terence J O'Brien, Frank JE Vajda, Piero Perucca

Journal article  |  2021  |  EPILEPSIA

OBJECTIVE: Prenatal exposure to the antiepileptic drug (AED) valproic acid (VPA) is associated with an increased risk of impaired ..

New era of personalised epilepsy management

Zhibin Chen, Ben Rollo, Ana Antonic-Baker, Alison Anderson, Yuanlin Ma, Terence J O'Brien, Zongyuan Ge, Xuefeng Wang, Patrick Kwan

Journal article  |  2020  |  BMJ-BRITISH MEDICAL JOURNAL

The trial and error approach to epilepsy treatment has not changed for over a century but machine learning and patient derived ste..