Alex Garnham

Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis

Margaret A Potts, Shinsuke Mizutani, Alexandra L Garnham, Connie SN Li Wai Suen, Andrew J Kueh, Lin Tai, Martin Pal, Andreas Strasser, Marco J Herold

Journal article  |  2023  |  CELL DEATH AND DIFFERENTIATION

Many lymphoid malignancies arise from deregulated c-MYC expression in cooperation with additional genetic lesions. While many of t..

A necroptosis-independent function of RIPK3 promotes immune dysfunction and prevents control of chronic LCMV infection

Simon P Preston, Cody C Allison, Jan Schaefer, William Clow, Stefanie M Bader, Sophie Collard, Wasan O Forsyth, Michelle P Clark, Alexandra L Garnham, Connie SN Li-Wai-Suen, Thanushi Peiris, Jack Teale, Liana Mackiewicz, Sophia Davidson, Marcel Doerflinger, Marc Pellegrini

Journal article  |  2023  |  CELL DEATH & DISEASE

Necroptosis is a lytic and inflammatory form of cell death that is highly constrained to mitigate detrimental collateral tissue da..

MLKL deficiency protects against low-grade, sterile inflammation in aged mice

Emma C Tovey C Crutchfield, Sarah E Garnish, Jessica Day, Holly Anderton, Shene Chiou, Anne Hempel, Cathrine Hall, Komal M Patel, Pradnya Gangatirkar, Katherine R Martin, Connie SN Li Wai Suen, Alexandra L Garnham, Andrew J Kueh, Ian P Wicks, John Silke, Ueli Nachbur, Andre L Samson, James M Murphy, Joanne M Hildebrand

Journal article  |  2023  |  CELL DEATH AND DIFFERENTIATION

MLKL and RIPK3 are the core signaling proteins of the inflammatory cell death pathway, necroptosis, which is a known mediator and ..

Stem cell plasticity, acetylation of H3K14, and de novo gene activation rely on KAT7.

Andrew J Kueh, Maria I Bergamasco, Anna Quaglieri, Belinda Phipson, Connie SN Li-Wai-Suen, Ingrid M Lönnstedt, Yifang Hu, Zhi-Ping Feng, Chris Woodruff, Rose E May, Stephen Wilcox, Alexandra L Garnham, Michael P Snyder, Gordon K Smyth, Terence P Speed, Tim Thomas, Anne K Voss

Journal article  |  2023  |  Cell Rep

In the conventional model of transcriptional activation, transcription factors bind to response elements and recruit co-factors, i..

Single-cell multiomics reveal the scale of multilayered adaptations enabling CLL relapse during venetoclax therapy

Rachel Thijssen, Luyi Tian, Mary Ann Anderson, Christoffer Flensburg, Andrew Jarratt, Alexandra L Garnham, Jafar S Jabbari, Hongke Peng, Thomas E Lew, Charis E Teh, Quentin Gouil, Angela Georgiou, Tania Tan, Tirta M Djajawi, Constantine S Tam, John F Seymour, Piers Blombery, Daniel HD Gray, Ian J Majewski, Matthew E Ritchie, et al.

Journal article  |  2022  |  BLOOD

Venetoclax (VEN) inhibits the prosurvival protein BCL2 to induce apoptosis and is a standard therapy for chronic lymphocytic leuke..

Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest

Johannes Wichmann, Catherine Pitt, Samantha Eccles, Alexandra L Garnham, Connie SN Li-Wai-Suen, Rose May, Elizabeth Allan, Stephen Wilcox, Marco J Herold, Gordon K Smyth, Brendon J Monahan, Tim Thomas, Anne K Voss

Journal article  |  2022  |  CELL DEATH & DISEASE

Histone acetylation is essential for initiating and maintaining a permissive chromatin conformation and gene transcription. Dysreg..

Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer

Sarah A Best, Patrick M Gubser, Shalini Sethumadhavan, Ariena Kersbergen, Yashira L Negron Abril, Joshua Goldford, Katherine Sellers, Waruni Abeysekera, Alexandra L Garnham, Jackson A McDonald, Clare E Weeden, Dovile Anderson, David Pirman, Thomas P Roddy, Darren J Creek, Axel Kallies, Gillian Kingsbury, Kate D Sutherland

Journal article  |  2022  |  CELL METABOLISM

The tumor microenvironment (TME) contains a rich source of nutrients that sustains cell growth and facilitate tumor development. G..

Molecular profiling reveals features of clinical immunity and immunosuppression in asymptomatic P. falciparum malaria

Stephanie Studniberg, Lisa J Ioannidis, Retno AS Utami, Leily Trianty, Yang Liao, Waruni Abeysekera, Connie SN Li-Wai-Suen, Halina M Pietrzak, Julie Healer, Agatha M Puspitasari, Dwi Apriyanti, Farah Coutrier, Jeanne R Poespoprodjo, Enny Kenangalem, Benediktus Andries, Pak Prayoga, Novita Sariyanti, Gordon K Smyth, Alan F Cowman, Ric N Price, et al.

Journal article  |  2022  |  MOLECULAR SYSTEMS BIOLOGY

Clinical immunity to P. falciparum malaria is non-sterilizing, with adults often experiencing asymptomatic infection. Historically..

Cytotoxicity-Related Gene Expression and Chromatin Accessibility Define a Subset of CD4( ) T Cells That Mark Progression to Type 1 Diabetes

Naiara G Bediaga, Alexandra L Garnham, Gaetano Naselli, Esther Bandala-Sanchez, Natalie L Stone, Joanna Cobb, Jessica E Harbison, John M Wentworth, Annette-G Ziegler, Jennifer J Couper, Gordon K Smyth, Leonard C Harrison

Journal article  |  2022  |  DIABETES

Type 1 diabetes in children is heralded by a preclinical phase defined by circulating autoantibodies to pancreatic islet antigens...

The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal

Yuqing Yang, Andrew J Kueh, Zoe L Grant, Waruni Abeysekera, Alexandra L Garnham, Stephen Wilcox, Craig D Hyland, Ladina Di Rago, Don Metcalf, Warren S Alexander, Leigh Coultas, Gordon K Smyth, Anne K Voss, Tim Thomas

Journal article  |  2022  |  BLOOD

The histone acetyltransferase HBO1 (MYST2, KAT7) is indispensable for postgastrulation development, histone H3 lysine 14 acetylati..