Michael Milevskiy

Activation of the Ion Channel TRPV4 Induces Epithelial to Mesenchymal Transition in Breast Cancer Cells.

Iman Azimi, Mélanie Robitaille, Kaela Armitage, Choon Leng So, Michael JG Milevskiy, Korinne Northwood, Huai Fang Lim, Erik W Thompson, Sarah J Roberts-Thomson, Gregory R Monteith

Journal article  |  2020  |  Int J Mol Sci

Epithelial to mesenchymal transition (EMT) in cancer is important in therapeutic resistance and invasiveness. Calcium signaling is..

Transient receptor potential cation channel subfamily V and breast cancer.

Choon Leng So, Michael JG Milevskiy, Gregory R Monteith

Journal article  |  2020  |  Lab Invest

Transient receptor potential cation channel subfamily V (TRPV) channels play important roles in a variety of cellular processes. O..

NCS-1 expression is higher in basal breast cancers and regulates calcium influx and cytotoxic responses to doxorubicin.

Alice HL Bong, Mélanie Robitaille, Michael JG Milevskiy, Sarah J Roberts-Thomson, Gregory R Monteith

Journal article  |  2020  |  Mol Oncol

Neuronal calcium sensor-1 (NCS-1) is a positive modulator of IP3 receptors and was recently associated with poorer survival in bre..

MicroRNA-196a is regulated by ER and is a prognostic biomarker in ER breast cancer.

Michael JG Milevskiy, Udai Gujral, Carolina Del Lama Marques, Andrew Stone, Korinne Northwood, Lez J Burke, Julia MW Gee, Kenneth Nephew, Susan Clark, Melissa A Brown

Journal article  |  2019  |  Br J Cancer

BACKGROUND: MicroRNAs are potent post-transcriptional regulators involved in all hallmarks of cancer. Mir-196a is transcribed from..

ORAI1 and ORAI3 in Breast Cancer Molecular Subtypes and the Identification of ORAI3 as a Hypoxia Sensitive Gene and a Regulator of Hypoxia Responses

Iman Azimi, Michael JG Milevskiy, Silke B Chalmers, Kunsala TDS Yapa, Melanie Robitaille, Christopher Henry, Gregory J Baillie, Erik W Thompson, Sarah J Roberts-Thomson, Gregory R Monteith

Journal article  |  2019  |  CANCERS

The remodeling of specific calcium-permeable ion channels is a feature of some breast cancer subtypes. ORAI1 is a protein that for..

An assessment of the potential role of intracellular Ca2 store regulators in breast cancer cells

AH Bong, SJ Roberts-Thomson, MJ Milevskiy, GR Monteith

Conference Proceedings  |  2019  |  CANCER RESEARCH

Abstract Background: Calcium (Ca2+) regulates many crucial cellular processes including cell survival, proliferatio..

Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

Nai Yang Fu, Bhupinder Pal, Yunshun Chen, Felicity C Jackling, Michael Milevskiy, Francois Vaillant, Bianca D Capaldo, Fusheng Guo, Kevin H Liu, Anne C Rios, Nicholas Lim, Andrew J Kueh, David M Virshup, Marco J Herold, Haley O Tucker, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2018  |  DEVELOPMENTAL CELL

Long-lived quiescent mammary stem cells (MaSCs) are presumed to coordinate the dramatic expansion of ductal epithelium that occurs..

MiR-29b-1-5p is altered in BRCA1 mutant tumours and is a biomarker in basal-like breast cancer.

Michael JG Milevskiy, Gurveen K Sandhu, Anna Wronski, Darren Korbie, Brooke L Brewster, Annette Shewan, Stacey L Edwards, Juliet D French, Melissa A Brown

Journal article  |  2018  |  Oncotarget

Depletion of BRCA1 protein in mouse mammary glands results in defects in lactational development and increased susceptibility to m..

TARGETING MYCN OVER-EXPRESSION WITH BRD4 INHIBITION IN THE PROLIFERATIVE C5 SUBTYPE OF HIGH GRADE SEROUS OVARIAN CANCER (HGSOC)

GY Ho, O Kondrashova, C Vandenberg, E Kyran, E Lieschke, V Heong, M Milevskiy, T Papenfuss, J Schroeder, J Weroha, M Dawson, D Bowtell, H Barker, M Wakefield, C Scott

Conference Proceedings  |  2018  |  INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids

Ewa M Michalak, Michael JG Milevskiy, Rachel M Joyce, Johanna F Dekkers, Paul R Jamieson, Bhupinder Pal, Caleb A Dawson, Yifang Hu, Stuart H Orkin, Warren S Alexander, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2018  |  PLOS BIOLOGY

Distinct transcriptional states are maintained through organization of chromatin, resulting from the sum of numerous repressive an..