Rebecca Stewart

An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca2 signaling and motility in Toxoplasma gondii

Luning Yang, Alessandro D Uboldi, Simona Seizova, Mary-Louise Wilde, Michael J Coffey, Nicholas J Katris, Yoshiki Yamaryo-Botte, Martina Kocan, Ross AD Bathgate, Rebecca J Stewart, Malcolm J McConville, Philip E Thompson, Cyrille Y Botte, Christopher J Tonkin

Journal article  |  2019  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Protozoan parasites of the phylum Apicomplexa actively move through tissue to initiate and perpetuate infection. The regulation of..

Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2R gamma(null) Mouse Model of Malaria

Paul R Gilson, William Nguyen, William A Poole, Jose E Teixeira, Jennifer K Thompson, Kaiyuan Guo, Rebecca J Stewart, Trent D Ashton, Karen L White, Laura M Sanz, Francisco-Javier Gamo, Susan A Charman, Sergio Wittlin, James Duffy, Christopher J Tonkin, Wai-Hong Tham, Brendan S Crabb, Brian M Cooke, Christopher D Huston, Alan F Cowman, et al.

Journal article  |  2019  |  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A series of 4-amino 2-anilinoquinazolines optimized for activity against the most lethal malaria parasite of humans, Plasmodium fa..

Protein O-fucosyltransferase 2-mediated O-glycosylation of the adhesin MIC2 is dispensable for Toxoplasma gondii tachyzoite infection

Sachin Khurana, Michael J Coffey, Alan John, Alessandro D Uboldi, My-Hang Huynh, Rebecca J Stewart, Vern B Carruthers, Christopher J Tonkin, Ethan D Goddard-Borger, Nichollas E Scott

Journal article  |  2019  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Toxoplasma gondii is a ubiquitous, obligate intracellular eukaryotic parasite that causes congenital birth defects, disease in imm..

Protein kinase A negatively regulates Ca2 signalling in Toxoplasma gondii

Alessandro D Uboldi, Mary-Louise Wilde, Emi A McRae, Rebecca J Stewart, Laura F Dagley, Luning Yang, Nicholas J Katris, Sanduni Hapuarachchi, Michael J Coffey, Adele M Lehane, Cyrille Y Botte, Ross F Waller, Andrew Webb, Malcolm J McConville, Christopher J Tonkin

Journal article  |  2018  |  PLOS BIOLOGY

The phylum Apicomplexa comprises a group of obligate intracellular parasites that alternate between intracellular replicating stag..

A forward genetic screen identifies a negative regulator of rapid Ca2 -dependent cell egress (MS1) in the intracellular parasite Toxoplasma gondii

James M McCoy, Rebecca J Stewart, Alessandro D Uboldi, Dongdi Li, Jan Schroder, Nicollas E Scott, Anthony T Papenfuss, Adele M Lehane, Leonard J Foster, Christopher J Tonkin

Journal article  |  2017  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Toxoplasma gondii, like all apicomplexan parasites, uses Ca2+ signaling pathways to activate gliding motility to power tissue diss..

Analysis of Ca2 mediated signaling regulating Toxoplasma infectivity reveals complex relationships between key molecules

Rebecca J Stewart, Lachlan Whitehead, Brunda Nijagal, Brad E Sleebs, Guillaume Lessene, Malcolm J McConville, Kelly L Rogers, Christopher J Tonkin

Journal article  |  2017  |  CELLULAR MICROBIOLOGY

Host cell invasion, exit and parasite dissemination is critical to the pathogenesis of apicomplexan parasites such as Toxoplasma g..

Phosphorylation of SNAP is Required for Secretory Organelle Biogenesis in Toxoplasma gondii

Rebecca J Stewart, David JP Ferguson, Lachlan Whitehead, Clare H Bradin, Hong J Wu, Christopher J Tonkin

Journal article  |  2016  |  TRAFFIC

Upon infection, apicomplexan parasites quickly invade host cells and begin a replicative cycle rapidly increasing in number over a..

Characterisation of molecular regulation and intracellular signalling of the Toxoplasma gondii lytic cycle Rebecca J.

RJ Stewart

Thesis / Dissertation  |  2016

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

Michael J Coffey, Brad E Sleebs, Alessandro D Uboldi, Alexandra Garnham, Magdalena Franco, Nicole D Marino, Michael W Panas, David JP Ferguson, Marta Enciso, Matthew T O'Neill, Sash Lopaticki, Rebecca J Stewart, Grant Dewson, Gordon K Smyth, Brian J Smith, Seth L Masters, John C Boothroyd, Justin A Boddey, Christopher J Tonkin

Journal article  |  2015  |  ELIFE

Infection by Toxoplasma gondii leads to massive changes to the host cell. Here, we identify a novel host cell effector export path..

Disassembly activity of actin-depolymerizing factor (ADF) is associated with distinct cellular processes in apicomplexan parasites

Silvia Haase, Dennis Zimmermann, Maya A Olshina, Mark Wilkinson, Fabio Fisher, Yan Hong Tan, Rebecca J Stewart, Christopher J Tonkin, Wilson Wong, David R Kovar, Jake Baum

Journal article  |  2015  |  MOLECULAR BIOLOGY OF THE CELL

Proteins of the actin-depolymerizing factor (ADF)/cofilin family have been shown to be crucial for the motility and survival of ap..