Matthew Rutar

Ocular Lymphatic and Glymphatic Systems: Implications for Retinal Health and Disease.

Nasir Uddin, Matt Rutar

Journal article  |  2022  |  Int J Mol Sci

Clearance of ocular fluid and metabolic waste is a critical function of the eye in health and disease. The eye has distinct fluid ..

Anti-inflammatory and neuroprotective properties of the corticosteroid fludrocortisone in retinal degeneration

Tanja Racic, Andrew Chang, Nilisha Fernando, Alice Brandli, Riccardo Natoli, Philip Penfold, Jan M Provis, Matt Rutar

Journal article  |  2021  |  EXPERIMENTAL EYE RESEARCH

The pathogenesis of outer retinal degenerations has been linked to the elevation of cytokines that orchestrate pro-inflammatory re..

Functional microRNA targetome undergoes degeneration-induced shift in the retina

Joshua A Chu-Tan, Adrian V Cioanca, Zhi-Ping Feng, Yvette Wooff, Ulrike Schumann, Riemke Aggio-Bruce, Hardip Patel, Matt Rutar, Katherine Hannan, Konstantin Panov, Jan Provis, Riccardo Natoli

Journal article  |  2021  |  MOLECULAR NEURODEGENERATION

BACKGROUND: MicroRNA (miRNA) play a significant role in the pathogenesis of complex neurodegenerative diseases including age-relat..

An integrated analysis of human myeloid cells identifies gaps in in vitro models of in vivo biology

Nadia Rajab, Paul W Angel, Yidi Deng, Jennifer Gu, Vanta Jameson, Mariola Kurowska-Stolarska, Simon Milling, Chris M Pacheco, Matt Rutar, Andrew L Laslett, Kim-Anh Le Cao, Jarny Choi, Christine A Wells

Journal article  |  2021  |  STEM CELL REPORTS

The Stemformatics myeloid atlas is an integrated transcriptome atlas of human macrophages and dendritic cells that systematically ..

Ablation of C3 modulates macrophage reactivity in the outer retina during photo-oxidative damage

Haihan Jiao, Jan M Provis, Riccardo Natoli, Matt Rutar

Journal article  |  2020  |  MOLECULAR VISION

PURPOSE: Dysregulation of the complement cascade contributes to a variety of retinal dystrophies, including age-related macular de..

A method for gene knockdown in the retina using a lipid-based carrier

Joshua A Chu-Tan, Nilisha Fernando, Riemke Aggio-Bruce, Adrian Cioanca, Krisztina Valter, Nektaria Andronikou, Xavier deMollerat du Jeu, Matt Rutar, Jan Provis, Riccardo Natoli

Journal article  |  2020  |  MOLECULAR VISION

PURPOSE: The use of small non-coding nucleic acids, such as siRNA and miRNA, has allowed for a deeper understanding of gene functi..

Animal and Human Models of Retinal Diseases

Erica L Fletcher, Alice Pebay, Matt V Rutar, Kiana Kakavand, Anna Y Wang, Kirstan A Vessey, Andrew I Jobling, Ursula Greferath

Book Chapter  |  2020

Targeting P2X7 receptors as a means for treating retinal disease

Erica L Fletcher, Anna Y Wang, Andrew I Jobling, Matthew V Rutar, Ursula Greferath, Ben Gu, Kirstan A Vessey

Journal article  |  2019  |  DRUG DISCOVERY TODAY

Age-related macular degeneration and glaucoma are the commonest causes of irreversible vision loss in industrialized countries. Th..

Investigation the role of active microRNA in the degenerating retina using Ago2 HITS-CLIP

Riccardo Carlo Natoli, Nilisha Fernando, Zhi-Ping Feng, Hardip Patel, Kate Hannan, Konstantin Panov, Nadine Hein, Matt Rutar, Joshua Aaron Chu-Tan

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

A novel protective role of the C-type lectin Mincle in modulating inflammation and lesion size a mouse model of choroidal neovascularization

Matt Rutar, Alice Brandli, Gene Venables, Erica L Fletcher, Christine Wells

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE