Matthew Rutar

A method for gene knockdown in the retina using a lipid-based carrier

Joshua A Chu-Tan, Nilisha Fernando, Riemke Aggio-Bruce, Adrian Cioanca, Krisztina Valter, Nektaria Andronikou, Xavier deMollerat du Jeu, Matt Rutar, Jan Provis, Riccardo Natoli

Journal article  |  2020  |  Molecular Vision

Targeting P2X7 receptors as a means for treating retinal disease

Erica L Fletcher, Anna Y Wang, Andrew I Jobling, Matthew V Rutar, Ursula Greferath, Ben Gu, Kirstan A Vessey

Journal article  |  2019  |  Drug Discovery Today

Age-related macular degeneration and glaucoma are the commonest causes of irreversible vision loss in industrialized countries. Th..

iMAC: An interactive atlas to explore phenotypic differences between in vivo, ex vivo and in vitro-derived myeloid cells in the Stemformatics platform

Nadia Rajab, Paul Angel, Mariola Kurowska-Stolarska, Simon Milling, Chris Pacheco, Matt Rutar, Jarny Choi, Christine Wells

Journal article  |  2019

Summary Macrophages isolated from different tissues have distinct niche roles that maintain tissue homeostasis, as well as providi..

A novel protective role of the C-type lectin Mincle in modulating inflammation and lesion size a mouse model of choroidal neovascularization

Matt Rutar, Alice Brandli, Gene Venables, Erica L Fletcher, Christine Wells

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Characterisation and application of primary cultured retinal mononuclear phagocytes

Riemke Aggio-Bruce, Nunzio Franco, Nilisha Fernando, Matt Rutar, Riccardo Carlo Natoli

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Designer macrophages: Pitfalls and opportunities for modelling macrophage phenotypes from pluripotent stem cells

Nadia Rajab, Matthew Rutar, Andrew L Laslett, Christine A Wells

Journal article  |  2018  |  Differentiation

Photoreceptor Survival Is Regulated by GSTO1-1 in the Degenerating Retina

Nilisha Fernando, Yvette Wooff, Riemke Aggio-Bruce, Joshua A Chu-Tan, Haihan Jiao, Catherine Dietrich, Matt Rutar, Melissa Rooke, Deepthi Menon, Janis T Eells, Krisztina Valter, Philip G Board, Jan Provis, Riccardo Natoli

Journal article  |  2018  |  Investigative Opthalmology & Visual Science

Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration

Haihan Jiao, Matt Rutar, Nilisha Fernando, Ted Yednock, Sethu Sankaranarayanan, Riemke Aggio-Bruce, Jan Provis, Riccardo Natoli

Journal article  |  2018  |  Molecular Neurodegeneration

MicroRNA-124 Dysregulation is Associated With Retinal Inflammation and Photoreceptor Death in the Degenerating Retina

Joshua A Chu-Tan, Matt Rutar, Kartik Saxena, Riemke Aggio-Bruce, Rohan W Essex, Krisztina Valter, Haihan Jiao, Nilisha Fernando, Yvette Wooff, Michele C Madigan, Jan Provis, Riccardo Natoli

Journal article  |  2018  |  Investigative Opthalmology & Visual Science

Dynamic Interplay of Innate and Adaptive Immunity During Sterile Retinal Inflammation: Insights From the Transcriptome

Riccardo Natoli, Elizabeth Mason, Haihan Jiao, Aaron Chuah, Hardip Patel, Nilisha Fernando, Krisztina Valter, Christine A Wells, Jan Provis, Matt Rutar

Journal article  |  2018  |  Frontiers in Immunology

Obesity-induced metabolic disturbance drives complement activation by retinal microglia

Matt Rutar, Riccardo Natoli, Nilisha Fernando, Jan Provis

Conference Proceedings  |  2018  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

MicroRNA-124 is redistributed from neurons to glia to reduce inflammation and slow progressive retinal degeneration

Joshua Aaron Chu-Tan, Matt Rutar, Kartik Saxena, Riemke Aggio-Bruce, Rohan W Essex, Krisztina Valter, Haihan Jiao, Michele C Madigan, Jan Provis, Riccardo Natoli

Conference Proceedings  |  2018  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Obesity-induced metabolic disturbance drives oxidative stress and complement activation in the retinal environment

Riccardo Natoli, Nilisha Fernando, Tess Dahlenburg, Haihan Jiao, Riemke Aggio-Bruce, Nigel L Barnett, Juan Manuel Chao de la Barca, Guillaume Tcherkez, Pascal Reynier, Johnny Fang, Joshua A Chu-Tan, Krisztina Valter, Jan Provis, Matt Rutar

Journal article  |  2018  |  Molecular Vision

Dynamic interplay of innate and adaptive immunity during sterile retinal inflammation: Insights from the transcriptome

Riccardo Natoli, Elizabeth Mason, Haihan Jiao, Aaron Chuah, Hardip Patel, Nilisha Fernando, Krisztina Valter, Christine Wells, Jan Provis, Matt Rutar

Journal article  |  2018  |  Frontiers in Immunology

The pathogenesis of many retinal degenerations, such as age-related macular degeneration (AMD), is punctuated by an ill-defined ne..

Retinal monocyte-derived complement, not systemically derived complement contributes to the early onset of focal retinal degeneration

Haihan Jiao, Riccardo Natoli, Nilisha Fernando, Tanja Racic, Joshua Chu-Tan, Krisztina Valter, Matt Rutar, Jan Provis

Conference Proceedings  |  2017  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Retinal Macrophages Synthesize C3 and Activate Complement in AMD and in Models of Focal Retinal Degeneration

Riccardo Natoli, Nilisha Fernando, Haihan Jiao, Tanja Racic, Michele Madigan, Nigel L Barnett, Joshua A Chu-Tan, Krisztina Valter, Jan Provis, Matt Rutar

Journal article  |  2017  |  Investigative Opthalmology & Visual Science

Microglia- derived IL-1 beta promotes chemokine expression by Muller cells and RPE in focal retinal degeneration

Riccardo Natoli, Nilisha Fernando, Michele Madigan, Joshua A Chu-Tan, Krisztina Valter, Jan Provis, Matt Rutar

Journal article  |  2017  |  Molecular Neurodegeneration

The Role of Pyruvate in Protecting 661W Photoreceptor-Like Cells Against Light-Induced Cell Death

Riccardo Natoli, Matt Rutar, Yen-Zhen Lu, Joshua A Chu-Tan, Yuwei Chen, Kartik Saxena, Michele Madigan, Krisztina Valter, Jan M Provis

Journal article  |  2016  |  Current Eye Research

Chronic accumulations of complement-expressing microglia/macrophages accompany the progressive expansion of the retinal lesion in an animal model of atrophic AMD

Nilisha Fernando, Tanja Racic, Riccardo Natoli, Krisztina Valter, Jan Provis, Matt Rutar

Conference Proceedings  |  2016  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

The value of broad spectrum chemokine inhibitors in modulating microglia/macrophage-mediated inflammation in a model of atrophic AMD

Matt Rutar, Nilisha Fernando, Riccardo Natoli, Jan Provis, Krisztina Valter

Conference Proceedings  |  2016  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

A model of progressive photo-oxidative degeneration and inflammation in the pigmented C57BL/6J mouse retina

Riccardo Natoli, Haihan Jiao, Nigel L Barnett, Nilisha Fernando, Krisztina Valter, Jan M Provis, Matt Rutar

Journal article  |  2016  |  Experimental Eye Research

The broad-spectrum chemokine inhibitor NR58-3.14.3 modulates macrophage-mediated inflammation in the diseased retina

Nilisha Fernando, Riccardo Natoli, Krisztina Valter, Jan Provis, Matt Rutar

Journal article  |  2016  |  Journal of Neuroinflammation

Role of Chemokines in Shaping Macrophage Activity in AMD

Matt Rutar, Jan M Provis

Journal article  |  2016  |  Advances in experimental medicine and biology

Efficacy of 670 nm Light Therapy to Protect against Photoreceptor Cell Death Is Dependent on the Severity of Damage

Joshua A Chu-Tan, Matt Rutar, Kartik Saxena, Yunlu Wu, Lauren Howitt, Krisztina Valter, Jan Provis, Riccardo Natoli

Journal article  |  2016  |  International Journal of Photoenergy

Spatiotemporal Cadence of Macrophage Polarisation in a Model of Light-Induced Retinal Degeneration

Haihan Jiao, Riccardo Natoll, Krisztina Valter, Jan M Provis, Matt Rutar

Journal article  |  2015  |  PLOS ONE

Retinal microglia: Just bystander or target for therapy?

Marcus Karlstetter, Rebecca Scholz, Matt Rutar, Wai T Wong, Jan M Provis, Thomas Langmann

Journal article  |  2015  |  Progress in Retinal and Eye Research

Identification of miRNAs in a Model of Retinal Degenerations

Kartik Saxena, Matthew Viktor Rutar, Jan M Provis, Riccardo Carlo Natoli

Journal article  |  2015  |  Investigative Opthalmology & Visual Science

Chemokine-mediated inflammation in the degenerating retina is coordinated by Muller cells, activated microglia, and retinal pigment epithelium

Matt Rutar, Riccardo Natoli, RX Chia, Krisztina Valter, Jan M Provis

Journal article  |  2015  |  Journal of Neuroinflammation

670nm-A Stop Sign for Retinal Degenerations?

K Valter, R Albarracin, R Natoli, M Rutar, J Provis

Conference Proceedings  |  2015  |  Proceedings of the WALT Biennial Congress and NAALT Annual Conference

Synthesis and Propagation of Complement C3 by Microglia/Monocytes in the Aging Retina

Matt Rutar, Krisztina Valter, Riccardo Natoli, Jan M Provis

Journal article  |  2014  |  PLoS ONE

THE RAT LIGHT DAMAGE MODEL OF RETINAL DEGENERATION MIMICS NORMAL AGING OF THE SD RAT RETINA

Jan Provis, Riccardo Natoli, Kristina Valter, Matt Rutar

Conference Proceedings  |  2013  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

670 NM PHOTOBIOMODULATION AS A TREATMENT FOR AGE-RELATED MACULAR DEGENERATION

Riccardo Natoli, Matt Rutar, Rizalyn Albarracin, Krisztina Valter, Jan Provis

Conference Proceedings  |  2013  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

MICRORNAS ASSOCIATED WITH A MODEL OF RETINAL DEGENERATION

Kartik Saxena, Riccardo Natoli, Matt Rutar, Jan Provis

Conference Proceedings  |  2013  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

SYNTHESIS AND PROPAGATION OF CHEMOKINES AND THEIR REGULATORS IN AN ANIMAL MODEL OF ATROPHIC AMD

Matt Rutar, Kristie RX Chia, Riccardo Natoli, Jan Provis

Conference Proceedings  |  2013  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

670 nm light mitigates oxygen-induced degeneration in C57BL/6J mouse retina

Rizalyn Albarracin, Riccardo Natoli, Matthew Rutar, Krisztina Valter, Jan Provis

Journal article  |  2013  |  BMC Neuroscience

670nm Photobiomodulation as a Novel Protection against Retinopathy of Prematurity: Evidence from Oxygen Induced Retinopathy Models

Riccardo Natoli, Krisztina Valter, Marconi Barbosa, Jane Dahlstrom, Matt Rutar, Alison Kent, Jan Provis

Journal article  |  2013  |  PLoS ONE

Chemokine-mediated guidance of the inflammatory response by Muller cells, microglia, and RPE in an animal model of atrophic AMD

Matt Rutar, Rong Xian Chia, Riccardo Natoli, Jan Provis

Conference Proceedings  |  2013  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

ROLE OF CHEMOKINE IMMUNE RESPONSE PATHWAYS IN A LIGHT-INDUCED DEGENERATIVE MODEL OF ATROPHIC AMD

Matt Rutar, Kristie Chia, Riccardo Natoli, Jan Provis

Conference Proceedings  |  2012  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

670-nm light treatment reduces complement propagation following retinal degeneration

Matt Rutar, Riccardo Natoli, Rizalyn Albarracin, Krisztina Valter, Jan Provis

Journal article  |  2012  |  Journal of Neuroinflammation

Small interfering RNA-mediated suppression of Ccl2 in Muller cells attenuates microglial recruitment and photoreceptor death following retinal degeneration

Matt Rutar, Riccardo Natoli, Jan M Provis

Journal article  |  2012  |  Journal of Neuroinflammation

Complement Activation in Retinal Degeneration

Matt Rutar, Riccardo Natoli, Jan Provis, Krisztina Valter

Journal article  |  2012  |  Advances in Experimental Medicine and Biology

MECHANISM OF PROTECTION BY 670NM LIGHT PRETREATMENT: OBSERVATIONS FROM TWO ANIMAL MODELS OF RETINAL DEGENERATION

Rizalyn Albarracin, Riccardo Natoli, Krisztina Valter, Matt Rutar, Jan Provis

Conference Proceedings  |  2011  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

GUIDANCE OF COMPLEMENT ACTIVATION BY INFILTRATING MONOCYTES IN ANIMAL MODELS OF AGEING AND AGE-RELATED MACULAR DEGENERATION

Matt Rutar, Riccardo Natoli, Krisztina Valter, Jan Provis

Conference Proceedings  |  2011  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Analysis of Complement Expression in Light-Induced Retinal Degeneration: Synthesis and Deposition of C3 by Microglia/Macrophages Is Associated with Focal Photoreceptor Degeneration

Matt Rutar, Riccardo Natoli, Peter Kozulin, Krisztina Valter, Paul Gatenby, Jan M Provis

Journal article  |  2011  |  Investigative Opthalmology & Visual Science

Early Focal Expression of the Chemokine Ccl2 by Muller Cells during Exposure to Damage-Inducing Bright Continuous Light

Matt Rutar, Riccardo Natoli, Krisztina Valter, Jan M Provis

Journal article  |  2011  |  Investigative Opthalmology & Visual Science

Brief Exposure to Damaging Light Causes Focal Recruitment of Macrophages, and Long-Term Destabilization of Photoreceptors in the Albino Rat Retina

Matt Rutar, Jan M Provis, Krisztina Valter

Journal article  |  2010  |  Current Eye Research