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Dr

Matthew Rutar

Senior Research Fellow In Neuroimmunology
Anatomy And Neuroscience
Innate immunity
Retinal degenerations
age-related macular degeneration (AMD)
science & technology
life sciences & biomedicine
ophthalmology
animals
macular degeneration
retina
Matthew Rutar's Profile Picture
Dr

Matthew Rutar

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Immunological processes of the eye
Matthew Rutar's Profile Picture
Dr

Matthew Rutar

 
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Matthew's  Short Profile
 

Dr Matthew Rutar is a Research Fellow based in the Department of Anatomy and Neuroscience. His main research interest is in exploring the immunological environment of the eye and brain, and particularly their role in orchestrating inflammation in ocular diseases such as age-related macular degeneration (AMD) – a disease that is a leading cause of blindness worldwide.

Matthew is well-versed in retinal cell biology and molecular biology techniques in unravelling the inflammatory factors at play in retinal pathology, and has recently branched into applications such as high-throughput sequencing and gene therapy. His current research will explore the role of innate immune signalling cascades in driving inflammation and leukocyte recruitment in retinal dystrophies such as AMD. Ultimately, his work aims to uncover innovative therapeutics that suppress inflammation, and improve patient outcomes.

Projects

Displaying the 3 most recent projects by Matthew Rutar.

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MACROPHAGES AS NOVEL TARGETS FOR AMELIORATING DELETERIOUS COMPLEMENT ACTIVATION IN RETINAL DEGENERATION

2019 - 2022
Active
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FANTOM6

2018 - 2025
Active
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Synthetic macrophages

2018 - 2021
Active

3

Projects

Project Types

2

Research Contracts

1

Research Grant

Scholarly Works

Displaying the 10 most recent scholarly works by Matthew Rutar.

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A method for gene knockdown in the retina using a lipid-based carrier

Joshua A Chu-Tan, Nilisha Fernando, Riemke Aggio-Bruce, Adrian Cioanca, Krisztina Valter, Nektaria Andronikou, Xavier deMollerat du Jeu, Matt Rutar, Jan Provis, Riccardo Natoli

Journal article  |  2020  |  Molecular Vision

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Targeting P2X7 receptors as a means for treating retinal disease

Erica L Fletcher, Anna Y Wang, Andrew I Jobling, Matthew V Rutar, Ursula Greferath, Ben Gu, Kirstan A Vessey

Journal article  |  2019  |  Drug Discovery Today

Age-related macular degeneration and glaucoma are the commonest causes of irreversible vision loss in industrialized countries. Th..

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An integrated analysis of myeloid cells identifies gaps in in vitro models of in vivo biology

Nadia Rajab, Paul Angel, Yidi Deng, Jennifer Gu, Vanta Jameson, Mariola Kurowska-Stolarska, Simon Milling, Simon Milling, Chris Pacheco, Matt Rutar, Andrew Laslett, Kim Anh Lê Cao, Jarny Choi, Christine Wells

Journal article  |  2019

Summary The Stemformatics myeloid atlas is an integrated transcriptome atlas of human macrophages and dendritic cells that systema..

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A novel protective role of the C-type lectin Mincle in modulating inflammation and lesion size a mouse model of choroidal neovascularization

Matt Rutar, Alice Brandli, Gene Venables, Erica L Fletcher, Christine Wells

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

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Investigation the role of active microRNA in the degenerating retina using Ago2 HITS-CLIP

Riccardo Carlo Natoli, Nilisha Fernando, Zhi-Ping Feng, Hardip Patel, Kate Hannan, Konstantin Panov, Nadine Hein, Matt Rutar, Joshua Aaron Chu-Tan

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

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Characterisation and application of primary cultured retinal mononuclear phagocytes

Riemke Aggio-Bruce, Nunzio Franco, Nilisha Fernando, Matt Rutar, Riccardo Carlo Natoli

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

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Designer macrophages: Pitfalls and opportunities for modelling macrophage phenotypes from pluripotent stem cells

Nadia Rajab, Matthew Rutar, Andrew L Laslett, Christine A Wells

Journal article  |  2018  |  Differentiation

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Photoreceptor Survival Is Regulated by GSTO1-1 in the Degenerating Retina

Nilisha Fernando, Yvette Wooff, Riemke Aggio-Bruce, Joshua A Chu-Tan, Haihan Jiao, Catherine Dietrich, Matt Rutar, Melissa Rooke, Deepthi Menon, Janis T Eells, Krisztina Valter, Philip G Board, Jan Provis, Riccardo Natoli

Journal article  |  2018  |  Investigative Opthalmology & Visual Science

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Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration

Haihan Jiao, Matt Rutar, Nilisha Fernando, Ted Yednock, Sethu Sankaranarayanan, Riemke Aggio-Bruce, Jan Provis, Riccardo Natoli

Journal article  |  2018  |  Molecular Neurodegeneration

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MicroRNA-124 Dysregulation is Associated With Retinal Inflammation and Photoreceptor Death in the Degenerating Retina

Joshua A Chu-Tan, Matt Rutar, Kartik Saxena, Riemke Aggio-Bruce, Rohan W Essex, Krisztina Valter, Haihan Jiao, Nilisha Fernando, Yvette Wooff, Michele C Madigan, Jan Provis, Riccardo Natoli

Journal article  |  2018  |  Investigative Opthalmology & Visual Science

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Scholarly Works

Keyword Analysis

Clinical Health (organs, Diseases and Abnormal Conditions)
Ophthalmology and Optometry
Neurosciences
Immunology
Expanding Knowledge
Public Health and Health Services
Clinical Sciences
Cognitive Sciences
Genetics
Human Pharmaceutical Products

Credentials

Positions

Positions

Senior Research Fellow In Neuroimmunology

Anatomy And Neuroscience

Education

Education

PhD in Biomedical Neuroscience

The Australian National University

Bachelor of Medical Science with Honours

The Australian National University

Links

Links