Oliver Hofmann

A beta-accelerated neurodegeneration caused by Alzheimer's-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice

Leah K Cuddy, Dmitry Prokopenko, Eric P Cunningham, Ross Brimberry, Peter Song, Rory Kirchner, Brad A Chapman, Oliver Hofmann, Winston Hide, Daniele Procissi, Taleen Hanania, Steven C Leiser, Rudolph E Tanzi, Robert Vassar

Journal article  |  2020  |  Science Translational Medicine

Inotuzumab ozogamicin resistance associated with a novel CD22 truncating mutation in a case of B-acute lymphoblastic leukaemia

Georgina L Ryland, Allison Barraclough, Chun Yew Fong, Shaun Fleming, Ashish Bajel, Oliver Hofmann, David Westerman, Sean Grimmond, Piers Blombery

Journal article  |  2020  |  British Journal of Haematology

RAF1 rearrangements are common in pancreatic acinar cell carcinomas

Owen WJ Prall, Violeta Nastevski, Huiling Xu, Christopher RE McEvoy, Joep HA Vissers, David J Byrne, Elena Takano, Satwica Yerneni, Sarah Ellis, Thomas Green, Catherine A Mitchell, William K Murray, Clare L Scott, Sean M Grimmond, Oliver Hofmann, Anthony Papenfuss, Damien Kee, Andrew Fellowes, Ian S Brown, Gregory Miller, et al.

Journal article  |  2020  |  Modern Pathology

Identification of Novel Alzheimer's Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data.

Dmitry Prokopenko, Julian Hecker, Rory Kirchner, Brad A Chapman, Oliver Hoffman, Kristina Mullin, Winston Hide, Lars Bertram, Nan Laird, Dawn L DeMeo, Christoph Lange, Rudolph E Tanzi

Journal article  |  2020  |  Scientific Reports

With the advent of whole genome-sequencing (WGS) studies, family-based designs enable sex-specific analysis approaches that can be..

Pan-cancer analysis of whole genomes

Peter J Campbell, Gad Getz, Jan O Korbel, Joshua M Stuart, Jennifer L Jennings, Lincoln D Stein, Marc D Perry, Hardeep K Nahal-Bose, BF Francis Ouellette, Constance H Li, Esther Rheinbay, G Petur Nielsen, Dennis C Sgroi, Chin-Lee Wu, William C Faquin, Vikram Deshpande, Paul C Boutros, Alexander J Lazar, Katherine A Hoadley, David N Louis, et al.

Journal article  |  2020  |  Nature

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this v..

Arteria: An automation system for a sequencing core facility

Johan Dahlberg, Johan Hermansson, Steinar Sturlaugsson, Mariya Lysenkova, Patrik Smeds, Claes Ladenvall, Roman Valls Guimera, Florian Reisinger, Oliver Hofmann, Pontus Larsson

Journal article  |  2019  |  GigaScience

How can digital health be used to improve outcomes in pancreatic ductal adenocarcinoma (PDAC)? Examining the potential of the PURPLE translational pancreatic cancer platform

Belinda Lee, Julia Shapiro, Benjamin Thomson, Sumitra Ananda, Lara Lipton, Sue-Anne McLachlan, Rachel Wong, Prasad Cooray, Matthew Burge, Kate Clarke, Sharon Pattison, Mehrdad Nikfarjam, Niall Tebbutt, Marion Harris, Daniel Croagh, David Goldstein, Adnan Nagrial, Rob Zielinski, Amitesh Roy, Cheng Ean Chee, et al.

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

COPY-NUMBER SIGNATURES AND MUTATIONAL PROCESSES IN HIGH GRADE SEROUS OVARIAN CARCINOMA

Geoff Macintyre, Teodora E Goranova, Dilrini De Silva, Darren Ennis, Anna M Piskorz, Matthew Eldridge, Daoud Sie, Liz-Anne Lewsley, Aishah Hanif, Cheryl Wilson, Suzanne Dowson, Rosalind M Glasspool, Michelle Lockley, Elly Brockbank, Ana Montes, Axel Walther, Sudha Sundar, Richard Edmondson, Geoff D Hall, Andrew Clamp, et al.

Conference Proceedings  |  2019  |  CLINICAL CANCER RESEARCH

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Claire Vennin, Pauline Melenec, Romain Rouet, Max Nobis, Aurelie S Cazet, Kendelle J Murphy, David Herrmann, Daniel A Reed, Morghan C Lucas, Sean C Warren, Zehra Elgundi, Mark Pinese, Gabriella Kalna, Daniel Roden, Monisha Samuel, Anaiis Zaratzian, Shane T Grey, Andrew Da Silva, Wilfred Leung, Suresh Mathivanan, et al.

Journal article  |  2019  |  Nature Communications

Preparing Australia for genomic medicine: data, computing and digital health

David P Hansen, Marcel E Dinger, Oliver Hofmann, Natalie Thorne, Tiffany F Boughtwood

Journal article  |  2019  |  The Medical Journal of Australia