Charbel Darido

The Balance between Differentiation and Terminal Differentiation Maintains Oral Epithelial Homeostasis

Yuchen Bai, Jarryd Boath, Gabrielle R White, Uluvitike GIU Kariyawasam, Camile S Farah, Charbel Darido

Journal article  |  2021  |  CANCERS

The oral epithelium is one of the fastest repairing and continuously renewing tissues. Stem cell activation within the basal layer..

The functional GRHL3-filaggrin axis maintains a tumor differentiation potential and influences drug sensitivity

Yuchen Bai, Zixuan Zhao, Jarryd Boath, Bryce J van denderen, Charbel Darido

Journal article  |  2021  |  MOLECULAR THERAPY

Current therapies for treating heterogeneous cancers such as head and neck squamous cell carcinoma (HNSCC) are non-selective and a..

Bacterial Antigens Reduced the Inhibition Effect of Capsaicin on Cal 27 Oral Cancer Cell Proliferation

Rajdeep Chakraborty, Karen Vickery, Charbel Darido, Shoba Ranganathan, Honghua Hu

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oral cancer is a major global health problem with high incidence and low survival rates. The oral cavity contains biofilms as dent..

EHF is essential for epidermal and colonic epithelial homeostasis, and suppresses Apc-initiated colonic tumorigenesis

Camilla M Reehorst, Rebecca Nightingale, Ian Y Luk, Laura Jenkins, Frank Koentgen, David S Williams, Charbel Darido, Fiona Tan, Holly Anderton, Michael Chopin, Kael Schoffer, Moritz F Eissmann, Michael Buchert, Dmitri Mouradov, Oliver M Sieber, Matthias Ernst, Amardeep S Dhillon, John M Mariadason

Journal article  |  2021  |  DEVELOPMENT

Ets homologous factor (EHF) is a member of the epithelial-specific Ets (ESE) family of transcription factors. To investigate its r..

The functional GRHL3-FLG axis predicts targeted therapy response in head and neck cancer

Y Bai, Z Zhao, BJV Denderen, C Darido

Conference Proceedings  |  2021  |  ANNALS OF ONCOLOGY

The 4-NQO mouse model: An update on a well-established in vivo model of oral carcinogenesis

J Bouaoud, G De Souza, C Darido, A Tortereau, M Elkabets, C Bertolus, P Saintigny

Book Chapter  |  2021  |  Methods in Cell Biology

The early detection and management of oral premalignant lesions (OPMDs) improve their outcomes. Animal models that mimic histologi..

Treatments of Squamous Cell Cancer.

Charbel Darido

Journal article  |  2020  |  Cancers (Basel)

It is now clear that the most common solid cancer is squamous cell cancer (SCC) [...].

Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure

Marina R Carpinelli, Michael E de Vries, Alana Auden, Tariq Butt, Zihao Deng, Darren D Partridge, Lee B Miles, Smitha R Georgy, Jody J Haigh, Charbel Darido, Simone Brabletz, Thomas Brabletz, Marc P Stemmler, Sebastian Dworkin, Stephen M Jane

Journal article  |  2020  |  DISEASE MODELS & MECHANISMS

Cleft lip and palate are common birth defects resulting from failure of the facial processes to fuse during development. The mamma..

Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure.

Marina R Carpinelli, Michael E de Vries, Alana Auden, Tariq Butt, Zihao Deng, Darren D Partridge, Lee B Miles, Smitha R Georgy, Jody J Haigh, Charbel Darido, Simone Brabletz, Thomas Brabletz, Marc P Stemmler, Sebastian Dworkin, Stephen M Jane

Journal article  |  2020  |  Dis Model Mech

Cleft lip and palate are common birth defects resulting from failure of the facial processes to fuse during development. The mamma..

Targeted Therapy Against the Cell of Origin in Cutaneous Squamous Cell Carcinoma

Stephen J Goldie, Ginevra Chincarini, Charbel Darido

Journal article  |  2019  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Squamous cell carcinomas (SCC), including cutaneous SCCs, are by far the most frequent cancers in humans, accounting for 80% of al..