Ashraful Haque

Memory CD4( ) T cells that co-express PD1 and CTLA4 have reduced response to activating stimuli facilitating HIV latency

Thomas A Rasmussen, Jennifer M Zerbato, Ajantha Rhodes, Carolin Tumpach, Ashanti Dantanarayana, James H McMahon, Jillian SY Lau, J Judy Chang, Celine Gubser, Wendy Brown, Rebecca Hoh, Melissa Krone, Rachel Pascoe, Chris Y Chiu, Michael Bramhall, Hyun Jae Lee, Ashraful Haque, Remi Fromentin, Nicolas Chomont, Jeffrey Milush, et al.

Journal article  |  2022  |  CELL REPORTS MEDICINE

Programmed cell death 1 (PD1) and cytotoxic T lymphocyte-associated protein 4 (CTLA4) suppress CD4+ T cell activation and may prom..

Publication speed: a balancing act between author urgency and editorial process

Jessica G Borger, Ashraful Haque

Journal article  |  2022  |  IMMUNOLOGY AND CELL BIOLOGY

An introduction to spatial transcriptomics for biomedical research

Cameron G Williams, Hyun Jae Lee, Takahiro Asatsuma, Roser Vento-Tormo, Ashraful Haque

Journal article  |  2022  |  GENOME MEDICINE

Single-cell transcriptomics (scRNA-seq) has become essential for biomedical research over the past decade, particularly in develop..

Similarly efficacious anti-malarial drugs SJ733 and pyronaridine differ in their ability to remove circulating parasites in mice

Arya SheelaNair, Aleksandra S Romanczuk, Rosemary A Aogo, Rohit Nemai Haldar, Lianne IM Lansink, Deborah Cromer, Yandira G Salinas, R Kiplin Guy, James S McCarthy, Miles P Davenport, Ashraful Haque, David S Khoury

Journal article  |  2022  |  MALARIA JOURNAL

BACKGROUND: Artemisinin-based combination therapy (ACT) has been a mainstay for malaria prevention and treatment. However, emergen..

A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity

Yannick O Alexandre, Dominik Schienstock, Hyun Jae Lee, Luke C Gandolfo, Cameron G Williams, Sapna Devi, Bhupinder Pal, Joanna R Groom, Wang Cao, Susan N Christo, Claire L Gordon, Graham Starkey, Rohit D'Costa, Laura K Mackay, Ashraful Haque, Burkhard Ludewig, Gabrielle T Belz, Scott N Mueller

Journal article  |  2022  |  SCIENCE IMMUNOLOGY

The spleen is a compartmentalized organ that serves as a blood filter and safeguard of systemic immune surveillance. Labyrinthine ..

Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection

Zhe Zhao, Huimeng Wang, Mai Shi, Tianyuan Zhu, Troi Pediongco, Xin Yi Lim, Bronwyn S Meehan, Adam G Nelson, David P Fairlie, Jeffrey YW Mak, Sidonia BG Eckle, Marcela de Lima Moreira, Carolin Tumpach, Michael Bramhall, Cameron G Williams, Hyun Jae Lee, Ashraful Haque, Maximilien Evrard, Jamie Rossjohn, James McCluskey, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Mucosal-associated Invariant T (MAIT) cells are recognized for their antibacterial functions. The protective capacity of MAIT cell..

Studying lymphocyte differentiation in the spleen via spatial transcriptomics

Cameron Gerard Williams, Jessica A Engel, Megan SF Soon, Evan Murray, Fei Chen, Ashraful Haque

Conference Proceedings  |  2021  |  JOURNAL OF IMMUNOLOGY

Abstract Immune cell positioning within secondary lymphoid tissues likely affects cell-cell interaction and subsequ..

Exposure to host inflammation in vivo induces rapid transcriptomic change and impaired maturation in malaria parasites

Lianne IM Lansink, Jessica A Engel, Hyun Jae Lee, Megan SF Soon, Cameron G Williams, Rosemary A Aogo, Deborah Cromer, Miles P Davenport, David S Khoury, Ashraful Haque

Conference Proceedings  |  2021  |  JOURNAL OF IMMUNOLOGY

Abstract We previously reported slowing of the Plasmodium life-cycle in acutely-infected wild-type but not immune-d..

Transcriptome dynamics of CD4( ) T cells during malaria maps gradual transit from effector to memory

Megan SF Soon, Hyun Jae Lee, Jessica A Engel, Jasmin Straube, Bryce S Thomas, Clara PS Pernold, Lachlan S Clarke, Pawat Laohamonthonkul, Rohit N Haldar, Cameron G Williams, Lianne IM Lansink, Marcela L Moreira, Michael Bramhall, Lambros T Koufariotis, Scott Wood, Xi Chen, Kylie R James, Tapio Lonnberg, Steven W Lane, Gabrielle T Belz, et al.

Journal article  |  2020  |  NATURE IMMUNOLOGY

The dynamics of CD4+ T cell memory development remain to be examined at genome scale. In malaria-endemic regions, antimalarial che..

Treatment of Swine Closed Head Injury with Perfluorocarbon NVX-428.

Francoise Arnaud, Ashraful Haque, Maj Erin Morris, Paula Moon-Massat, Charles Auker, Saha Biswajit, Brittany Hazzard, Lam Thuy Vi Tran Ho, Richard McCarron, Anke Scultetus

Journal article  |  2020  |  Med Sci (Basel)

Pre-hospital treatment of traumatic brain injury (TBI) with co-existing polytrauma is complicated by requirements for intravenous ..