Ashraful Haque

Transcriptome dynamics of CD4( ) T cells during malaria maps gradual transit from effector to memory

Megan SF Soon, Hyun Jae Lee, Jessica A Engel, Jasmin Straube, Bryce S Thomas, Clara PS Pernold, Lachlan S Clarke, Pawat Laohamonthonkul, Rohit N Haldar, Cameron G Williams, Lianne IM Lansink, Marcela L Moreira, Michael Bramhall, Lambros T Koufariotis, Scott Wood, Xi Chen, Kylie R James, Tapio Lonnberg, Steven W Lane, Gabrielle T Belz, et al.

Journal article  |  2020  |  Nature Immunology

The dynamics of CD4+ T cell memory development remain to be examined at genome scale. In malaria-endemic regions, antimalarial che..

The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

Susanna S Ng, Fabian De Labastida Rivera, Juming Yan, Dillon Corvino, Indrajit Das, Ping Zhang, Rachel Kuns, Shashi Bhushan Chauhan, Jiajie Hou, Xian-Yang Li, Teija CM Frame, Benjamin A McEnroe, Eilish Moore, Jinrui Na, Jessica A Engel, Megan SF Soon, Bhawana Singh, Andrew J Kueh, Marco J Herold, Marcela Montes de Oca, et al.

Journal article  |  2020  |  Nature Immunology

Single-cell transcriptomics of alloreactive CD4( ) T cells over time reveals divergent fates during gut graft-versus-host disease

Jessica A Engel, Hyun Jae Lee, Cameron G Williams, Rachel Kuns, Stuart Olver, Lianne IM Lansink, Megan SF Soon, Stacey B Andersen, Joseph E Powell, Valentine Svensson, Sarah A Teichmann, Geoffrey R Hill, Antiopi Varelias, Motoko Koyama, Ashraful Haque

Journal article  |  2020  |  JCI Insight

Acute gastrointestinal (GI) graft-versus-host disease (GVHD) is a primary determinant of mortality after allogeneic hematopoietic ..

Th2-like T-follicular helper cells promote functional antibody production during Plasmodium falciparum infection

Jo-Anne Chan, Fabian de Labastida Rivera, Jessica Loughland, Jessica Engel, Hyun Jae Lee, Arya SheelaNair, Bruce Wines, Fiona Amante, Lachlan Webb, Pamela Mukhopadhyay, Ann-Marie Patch, Mark Hogarth, James Beeson, James McCarthy, Ashraful Haque, Christian Engwerda, Michelle Boyle

Journal article  |  2020

The most advanced malaria vaccine only has approximately 30% efficacy in target populations, and avenues to improve next generatio..

Malaria Parasite Clearance: What Are We Really Measuring?

David S Khoury, Sophie G Zaloumis, Matthew J Grigg, Ashraful Haque, Miles P Davenport

Journal article  |  2020  |  Trends in Parasitology

Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations

Rebecca J Austin, Jasmin Straube, Claudia Bruedigam, Gabor Pali, Sebastien Jacquelin, Therese Vu, Joanne Green, Julius Graesel, Lianne Lansink, Leanne Cooper, Shin-Jye Lee, Nien-Tsu Chen, Chung-Wei Lee, Ashraful Haque, Florian H Heidel, Richard D'Andrea, Geoff R Hill, Ann Mullally, Michael D Milsom, Megan Bywater, et al.

Journal article  |  2020  |  Leukemia

JAK2V617F is the most common mutation in patients with BCR-ABL negative myeloproliferative neoplasms (MPNs). The eradication of JA..

COVID-19: searching for clues among other respiratory viruses

Catriona Nguyen-Robertson, Ashraful Haque, Justine Mintern, Anne C La Flamme

Journal article  |  2020  |  Immunology and Cell Biology

Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis

Rajiv Kumar, Patrick T Bunn, Siddharth Sankar Singh, Susanna S Ng, Marcela Montes de Oca, Fabian De labastida Rivera, Shashi Bhushan Chauhan, Neetu Singh, Rebecca J Faleiro, Chelsea L Edwards, Teija CM Frame, Meru Sheel, Rebecca J Austin, Steven W Lane, Tobias Bald, Mark J Smyth, Geoffrey R Hill, Shannon E Best, Ashraful Haque, Dillon Corvino, et al.

Journal article  |  2020  |  Cell Reports

Type I interferons (IFNs) play critical roles in anti-viral and anti-tumor immunity. However, they also suppress protective immune..

Using single-cell RNA-seq to lineage trace effector to memory transitions in CD4( ) T cells during malaria

MSF Soon, HJ Lee, J Engel, K James, T Lonnberg, V Svensson, J Straube, X Chen, S Teichmann, A Haque

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection

Damian A Oyong, Jessica R Loughland, Arya SheelaNair, Dean Andrew, Fabian DL Rivera, Kim A Piera, Timothy William, Matthew J Grigg, Bridget E Barber, Ashraful Haque, Christian R Engwerda, James S McCarthy, Nicholas M Anstey, Michelle J Boyle

Journal article  |  2019  |  Malaria Journal

BACKGROUND: Anaemia is a major consequence of malaria, caused by the removal of both infected and uninfected red blood cells (RBCs..