Conor Kearney

HOIP limits anti-tumor immunity by protecting against combined TNF and IFN-gamma-induced apoptosis

Andrew J Freeman, Stephin J Vervoort, Jessica Michie, Kelly M Ramsbottom, John Silke, Conor J Kearney, Jane Oliaro

Journal article  |  2021  |  EMBO REPORTS

The success of cancer immunotherapy is limited to a subset of patients, highlighting the need to identify the processes by which t..

MAIT cells regulate NK cell-mediated tumor immunity

Emma Petley, Hui-Fern Koay, Melissa A Henderson, Kevin Sek, Kirsten L Todd, Simon P Keam, Junyun Lai, Imran G House, Jasmine Li, Magnus Zethoven, Amanda XY Chen, Amanda J Oliver, Jessica Michie, Andrew J Freeman, Lauren Giuffrida, Jack D Chan, Angela Pizzolla, Jeffrey YW Mak, Timothy R McCulloch, Fernando Souza-Fonseca-Guimaraes, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor immunity is unclear. Here we show that MAIT ce..

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

Stephin J Vervoort, Sarah A Welsh, Jennifer R Devlin, Elisa Barbieri, Deborah A Knight, Sarah Offley, Stefan Bjelosevic, Matteo Costacurta, Izabela Todorovski, Conor J Kearney, Jarrod J Sandow, Zheng Fan, Benjamin Blyth, Victoria McLeod, Joseph HA Vissers, Karolina Pavic, Ben P Martin, Gareth Gregory, Elena Demosthenous, Magnus Zethoven, et al.

Journal article  |  2021  |  CELL

Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent kinases (CDKs) at discrete checkpoints dur..

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

Simon J Hogg, Olga Motorna, Leonie A Cluse, Timothy M Johanson, Hannah D Coughlan, Ramya Raviram, Robert M Myers, Matteo Costacurta, Izabela Todorovski, Lizzy Pijpers, Stefan Bjelosevic, Tobias Williams, Shannon N Huskins, Conor J Kearney, Jennifer R Devlin, Zheng Fan, Jafar S Jabbari, Ben P Martin, Mohamed Fareh, Madison J Kelly, et al.

Journal article  |  2021  |  MOLECULAR CELL

To separate causal effects of histone acetylation on chromatin accessibility and transcriptional output, we used integrated epigen..

CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory.

Emily J Lelliott, Isabella Y Kong, Magnus Zethoven, Kelly M Ramsbottom, Luciano G Martelotto, Deborah Meyran, Joe Jiang Zhu, Matteo Costacurta, Laura Kirby, Jarrod J Sandow, Lydia Lim, Pilar M Dominguez, Izabela Todorovski, Nicole M Haynes, Paul A Beavis, Paul J Neeson, Edwin D Hawkins, Grant A McArthur, Ian A Parish, Ricky W Johnstone, et al.

Journal article  |  2021  |  Cancer Discov

Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) are an approved treatment for hormone receptor-positive brea..

BET Inhibition Enhances TNF Mediated Anti-Tumor Immunity

Lisa Wellinger, Simon Hogg, Dane Newman, Thomas Friess, Daniela Geiss, Jessica Michie, Kelly Ramsbottom, Marina Bacac, Tanja Fauti, Daniel Marbach, Laura Jarassier, Phillip Thienger, Axel Paehler, Leonie Cluse, Conor Kearney, Stephin Vervoort, Jane Oliaro, Jake Shortt, Astrid Ruefli-Brasse, Daniel Rohle, et al.

Journal article  |  2021

ABSTRACT Targeting chromatin binding proteins and modifying enzymes can concomitantly affect tumor cell proliferation and survival..

SUGAR-seq enables simultaneous detection of glycans, epitopes, and the transcriptome in single cells

Conor J Kearney, Stephin J Vervoort, Kelly M Ramsbottom, Izabela Todorovski, Emily J Lelliott, Magnus Zethoven, Lizzy Pijpers, Ben P Martin, Timothy Semple, Luciano Martelotto, Joseph A Trapani, Ian A Parish, Nichollas E Scott, Jane Oliaro, Ricky W Johnstone

Journal article  |  2021  |  SCIENCE ADVANCES

Multimodal single-cell RNA sequencing enables the precise mapping of transcriptional and phenotypic features of cellular different..

Epigenetic reprogramming of plasmacytoid dendritic cells drives type I interferon-dependent differentiation of acute myeloid leukemias for therapeutic benefit

Jessica Salmon, Izabela Todorovski, Stephin Vervoort, Kym Stanley, Conor Kearney, Luciano Martelotto, Fernando Rossello, Tim Semple, Gisela Mir-Arnau, Magnus Zethoven, Michael Bots, Eva Vidacs, Kate McArthur, Elise Gressier, Nicky de Weerd, Jens Lichte, Madison Kelly, Leonie Cluse, Simon Hogg, Paul Hertzog, et al.

Journal article  |  2020

Pharmacological inhibition of epigenetic enzymes can have therapeutic benefit, particularly against hematological malignancies. Wh..

A PP2A-Integrator complex fine-tunes transcription by opposing CDK9

Stephin Vervoort, Sarah Welsh, Jennifer Devlin, Elisa Barbieri, Deborah Knight, Matteo Costacurta, Izabela Todorovski, Conor Kearney, Jarrod Sandow, Stefan Bjelosevic, Zheng Fan, Joep Vissers, Karolina Pavic, Ben Martin, Gareth Gregory, Isabella Kong, Edwin Hawkins, Simon Hogg, Madison Kelly, Andrea Newbold, et al.

Journal article  |  2020

SUMMARY Gene expression is tightly controlled by Cyclin-dependent kinases (CDKs) which regulate the RNA Polymerase II (RNAPII) tra..

Efficient CRISPR/Cas9 Gene Editing in Uncultured Naive Mouse T Cells for In Vivo Studies

Simone Nussing, Imran G House, Conor J Kearney, Amanda XY Chen, Stephin J Vervoort, Paul A Beavis, Jane Oliaro, Ricky W Johnstone, Joseph A Trapani, Ian A Parish

Journal article  |  2020  |  JOURNAL OF IMMUNOLOGY

CRISPR/Cas9 technologies have revolutionized our understanding of gene function in complex biological settings, including T cell i..