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Displaying the 4 most recent projects by Conor Kearney.
Exploring The Inflammatory Signature Of The Anti-Cancer Smac-Mimetic, Birinapant, And The Contribution Of This Signature To Birinapant Anti-Tumour Activity
Programmed cell death (PCD) is an essential process for the removal of cancer cells. Defects in PCD are now known to be a causal factor in c..
Displaying the 16 most recent scholarly works by Conor Kearney.
PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours
Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron T Dodd, Pei K Goh, Conor Kearney, Deborah Meyran, Paul A Beavis, Melissa A Henderson, Simone L Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip K Darcy, Tony Tiganis
Journal article | 2020 | The EMBO Journal
PTPN2 deletion in T cells promotes anti-tumour immunity and CAR T cell efficacy in solid tumours
Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron Dodd, Pei Goh, Conor Kearney, Deborah Meyran, Paul Beavis, Melissa Henderson, Simone Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip Darcy, Tony Tiganis
Journal article | 2019
ABSTRACT Although adoptive T cell therapy has shown remarkable clinical efficacy in hematological malignancies, its success in com..
Antagonism of inhibitor of apoptosis proteins enhances CAR T-cell efficacy
J Michie, PA Beavis, AJ Freeman, SJ Vervoort, KM Ramsbottom, V Narasimhan, N Lalaoui, RG Ramsay, RW Johnstone, J Silke, PK Darcy, I Voskoboinik, CJ Kearney, J Oliaro
Conference Proceedings | 2019 | BRITISH JOURNAL OF PHARMACOLOGY
Protection from EAE in DOCK8 mutant mice occurs despite increased Th17 cell frequencies in the periphery
Alicia S Wilson, Hsei Di Law, Christiane B Knobbe-Thomsen, Conor J Kearney, Jane Oliaro, Carole Binsfeld, Gaetan Burgio, Lora Starrs, Dirk Brenner, Katrina L Randall, Anne Brustle
Journal article | 2019 | European Journal of Immunology
Antagonism of IAPs Enhances CAR T-cell Efficacy
Jessica Michie, Paul A Beavis, Andrew J Freeman, Stephin J Vervoort, Kelly M Ramsbottom, Vignesh Narasimhan, Emily J Lelliott, Najoua Lalaoui, Robert G Ramsay, Ricky W Johnstone, John Silke, Phillip K Darcy, Ilia Voskoboinik, Conor J Kearney, Jane Oliaro
Journal article | 2019 | Cancer Immunology Research
Tumor immune evasion arises through loss of TNF sensitivity
Conor J Kearney, Stephin J Vervoort, Simon J Hogg, Kelly M Ramsbottom, Andrew J Freeman, Najoua Lalaoui, Lizzy Pijpers, Jessica Michie, Kristin K Brown, Deborah A Knight, Vivien Sutton, Paul A Beavis, Ilia Voskoboinik, Phil K Darcy, John Silke, Joseph A Trapani, Ricky W Johnstone, Jane Oliaro
Journal article | 2018 | Science Immunology
DOCK8 Drives Src-Dependent NK Cell Effector Function
Conor J Kearney, Stephin J Vervoort, Kelly M Ramsbottom, Andrew J Freeman, Jessica Michie, Jane Peake, Jean-Laurent Casanova, Capucine Picard, Stuart G Tangye, Cindy S Ma, Ricky W Johnstone, Katrina L Randall, Jane Oliaro
Journal article | 2017 | The Journal of Immunology
The Sir Peter Maccallum Department Of Oncology