Conor Kearney

Efficient CRISPR/Cas9 Gene Editing in Uncultured Naive Mouse T Cells for In Vivo Studies

Simone Nussing, Imran G House, Conor J Kearney, Amanda XY Chen, Stephin J Vervoort, Paul A Beavis, Jane Oliaro, Ricky W Johnstone, Joseph A Trapani, Ian A Parish

Journal article  |  2020  |  The Journal of Immunology

CRISPR/Cas9 technologies have revolutionized our understanding of gene function in complex biological settings, including T cell i..

PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours

Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron T Dodd, Pei K Goh, Conor Kearney, Deborah Meyran, Paul A Beavis, Melissa A Henderson, Simone L Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip K Darcy, Tony Tiganis

Journal article  |  2020  |  The EMBO Journal

The Immuno-Modulatory Effects of Inhibitor of Apoptosis Protein Antagonists in Cancer Immunotherapy

Jessica Michie, Conor Kearney, Edwin D Hawkins, John Silke, Jane Oliaro

Journal article  |  2020  |  Cells

One of the hallmarks of cancer cells is their ability to evade cell death via apoptosis. The inhibitor of apoptosis proteins (IAPs..

Antagonism of IAPs enhances CAR T cell efficacy

J Michie, PA Beavis, AJ Freeman, SJ Vervoort, KM Ramsbottom, V Narasimhan, EJ Lelliott, N Lalaoui, RG Ramsay, RW Johnstone, J Silke, PK Darcy, I Voskoboinik, CJ Kearney, J Oliaro

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion

Andrew J Freeman, Stephin J Vervoort, Kelly M Ramsbottom, Madison J Kelly, Jessica Michie, Lizzy Pijpers, Ricky W Johnstone, Conor J Kearney, Jane Oliaro

Journal article  |  2019  |  Cell Reports

PTPN2 deletion in T cells promotes anti-tumour immunity and CAR T cell efficacy in solid tumours

Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron Dodd, Pei Goh, Conor Kearney, Deborah Meyran, Paul Beavis, Melissa Henderson, Simone Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip Darcy, Tony Tiganis

Journal article  |  2019

ABSTRACT Although adoptive T cell therapy has shown remarkable clinical efficacy in hematological malignancies, its success in com..

Protection from EAE in DOCK8 mutant mice occurs despite increased Th17 cell frequencies in the periphery

A Wilson, HD Law, CB Knobbe-Thomsen, CJ Kearney, J Oliaro, C Binsfeld, G Burgio, L Starrs, D Brenner, KL Randall, A Brustlel

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Antagonism of inhibitor of apoptosis proteins enhances CAR T-cell efficacy

J Michie, PA Beavis, AJ Freeman, SJ Vervoort, KM Ramsbottom, V Narasimhan, N Lalaoui, RG Ramsay, RW Johnstone, J Silke, PK Darcy, I Voskoboinik, CJ Kearney, J Oliaro

Conference Proceedings  |  2019  |  BRITISH JOURNAL OF PHARMACOLOGY

Protection from EAE in DOCK8 mutant mice occurs despite increased Th17 cell frequencies in the periphery

Alicia S Wilson, Hsei Di Law, Christiane B Knobbe-Thomsen, Conor J Kearney, Jane Oliaro, Carole Binsfeld, Gaetan Burgio, Lora Starrs, Dirk Brenner, Katrina L Randall, Anne Brustle

Journal article  |  2019  |  European Journal of Immunology

Antagonism of IAPs Enhances CAR T-cell Efficacy

Jessica Michie, Paul A Beavis, Andrew J Freeman, Stephin J Vervoort, Kelly M Ramsbottom, Vignesh Narasimhan, Emily J Lelliott, Najoua Lalaoui, Robert G Ramsay, Ricky W Johnstone, John Silke, Phillip K Darcy, Ilia Voskoboinik, Conor J Kearney, Jane Oliaro

Journal article  |  2019  |  Cancer Immunology Research

TNF in anti-tumour immunity and resistance to immunotherapy

Jane Oliaro, Conor Kearney, Stephin Vervoort, Simon Hogg, Najoua Lalaoui, Kristin Brown, John Silke, Ricky Johnstone

Conference Proceedings  |  2018  |  CANCER SCIENCE

Tumor immune evasion arises through loss of TNF sensitivity

Conor J Kearney, Stephin J Vervoort, Simon J Hogg, Kelly M Ramsbottom, Andrew J Freeman, Najoua Lalaoui, Lizzy Pijpers, Jessica Michie, Kristin K Brown, Deborah A Knight, Vivien Sutton, Paul A Beavis, Ilia Voskoboinik, Phil K Darcy, John Silke, Joseph A Trapani, Ricky W Johnstone, Jane Oliaro

Journal article  |  2018  |  Science Immunology

PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF

Conor J Kearney, Najoua Lalaoui, Andrew J Freeman, Kelly M Ramsbottom, John Silke, Jane Oliaro

Journal article  |  2017  |  Cell Death & Differentiation

DOCK8 Drives Src-Dependent NK Cell Effector Function

Conor J Kearney, Stephin J Vervoort, Kelly M Ramsbottom, Andrew J Freeman, Jessica Michie, Jane Peake, Jean-Laurent Casanova, Capucine Picard, Stuart G Tangye, Cindy S Ma, Ricky W Johnstone, Katrina L Randall, Jane Oliaro

Journal article  |  2017  |  The Journal of Immunology

DOCK8 regulates signal transduction events to control immunity

Conor J Kearney, Katrina L Randall, Jane Oliaro

Journal article  |  2017  |  Cellular & Molecular Immunology

An Inflammatory Perspective on Necroptosis

Conor J Kearney, Seamus J Martin

Journal article  |  2017  |  Molecular Cell

Loss of DNAM-1 ligand expression by acute myeloid leukemia cells renders them resistant to NK cell killing

Conor J Kearney, Kelly M Ramsbottom, Ilia Voskoboinik, Phillip K Darcy, Jane Oliaro

Journal article  |  2016  |  OncoImmunology

The Role of the Immunological Synapse Formed by Cytotoxic Lymphocytes in Immunodeficiency and Anti-Tumor Immunity

Conor J Kearney, Amelia J Brennan, Phillip K Darcy, Jane Oliaro

Journal article  |  2015  |  Critical Reviews in Immunology