Conor Kearney

Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction

Kenji M Fujihara, Bonnie Z Zhang, Thomas D Jackson, Moses O Ogunkola, Brunda Nijagal, Julia Milne, David A Sallman, Ching-Seng Ang, Iva Nikolic, Conor J Kearney, Simon J Hogg, Carlos S Cabalag, Vivien R Sutton, Sally Watt, Asuka T Fujihara, Joseph A Trapani, Kaylene J Simpson, Diana Stojanovski, Silke Leimkuhler, Sue Haupt, et al.

Journal article  |  2022  |  SCIENCE ADVANCES

The mechanism of action of eprenetapopt (APR-246, PRIMA-1MET) as an anticancer agent remains unresolved, although the clinical dev..

NKG7 Enhances CD8 T Cell Synapse Efficiency to Limit Inflammation

Emily J Lelliott, Kelly M Ramsbottom, Mark R Dowling, Carolyn Shembrey, Tahereh Noori, Conor J Kearney, Jessica Michie, Ian A Parish, Margaret A Jordan, Alan G Baxter, Neil D Young, Amelia J Brennan, Jane Oliaro

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

Cytotoxic lymphocytes are essential for anti-tumor immunity, and for effective responses to cancer immunotherapy. Natural killer c..

Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML

Jessica M Salmon, Izabela Todorovski, Kym L Stanley, Claudia Bruedigam, Conor J Kearney, Luciano G Martelotto, Fernando Rossello, Timothy Semple, Gisela Mir Arnau, Magnus Zethoven, Michael Bots, Stefan Bjelosevic, Leonie A Cluse, Peter J Fraser, Veronique Litalien, Eva Vidacs, Kate McArthur, Antony Y Matthews, Elise Gressier, Nicole A de Weerd, et al.

Journal article  |  2022  |  CANCER DISCOVERY

UNLABELLED: Pharmacologic inhibition of epigenetic enzymes can have therapeutic benefit against hematologic malignancies. In addit..

BET Inhibition Enhances TNF-Mediated Antitumor Immunity

Lisa C Wellinger, Simon J Hogg, Dane M Newman, Thomas Friess, Daniela Geiss, Jessica Michie, Kelly M Ramsbottom, Marina Bacac, Tanja Fauti, Daniel Marbach, Laura Jarassier, Phillip Thienger, Axel Paehler, Leonie A Cluse, Conor J Kearney, Stephin J Vervoort, Joseph A Trapani, Jane Oliaro, Jake Shortt, Astrid Ruefli-Brasse, et al.

Journal article  |  2022  |  CANCER IMMUNOLOGY RESEARCH

Targeting chromatin binding proteins and modifying enzymes can concomitantly affect tumor cell proliferation and survival, as well..

Unleashing TNF cytotoxicity to enhance cancer immunotherapy

Andrew J Freeman, Conor J Kearney, John Silke, Jane Oliaro

Journal article  |  2021  |  TRENDS IN IMMUNOLOGY

Tumor necrosis factor (TNF) is a proinflammatory cytokine that is produced and secreted by cytotoxic lymphocytes upon tumor target..

CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory

Emily J Lelliott, Isabella Y Kong, Magnus Zethoven, Kelly M Ramsbottom, Luciano G Martelotto, Deborah Meyran, Joe Jiang Zhu, Matteo Costacurta, Laura Kirby, Jarrod J Sandow, Lydia Lim, Pilar M Dominguez, Izabela Todorovski, Nicole M Haynes, Paul A Beavis, Paul J Neeson, Edwin D Hawkins, Grant A McArthur, Ian A Parish, Ricky W Johnstone, et al.

Journal article  |  2021  |  CANCER DISCOVERY

Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) are an approved treatment for hormone receptor-positive brea..

HOIP limits anti-tumor immunity by protecting against combined TNF and IFN-gamma-induced apoptosis

Andrew J Freeman, Stephin J Vervoort, Jessica Michie, Kelly M Ramsbottom, John Silke, Conor J Kearney, Jane Oliaro

Journal article  |  2021  |  EMBO REPORTS

The success of cancer immunotherapy is limited to a subset of patients, highlighting the need to identify the processes by which t..

MAIT cells regulate NK cell-mediated tumor immunity

Emma Petley, Hui-Fern Koay, Melissa A Henderson, Kevin Sek, Kirsten L Todd, Simon P Keam, Junyun Lai, Imran G House, Jasmine Li, Magnus Zethoven, Amanda XY Chen, Amanda J Oliver, Jessica Michie, Andrew J Freeman, Lauren Giuffrida, Jack D Chan, Angela Pizzolla, Jeffrey YW Mak, Timothy R McCulloch, Fernando Souza-Fonseca-Guimaraes, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor immunity is unclear. Here we show that MAIT ce..

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

Stephin J Vervoort, Sarah A Welsh, Jennifer R Devlin, Elisa Barbieri, Deborah A Knight, Sarah Offley, Stefan Bjelosevic, Matteo Costacurta, Izabela Todorovski, Conor J Kearney, Jarrod J Sandow, Zheng Fan, Benjamin Blyth, Victoria McLeod, Joseph HA Vissers, Karolina Pavic, Ben P Martin, Gareth Gregory, Elena Demosthenous, Magnus Zethoven, et al.

Journal article  |  2021  |  CELL

Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent kinases (CDKs) at discrete checkpoints dur..

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

Simon J Hogg, Olga Motorna, Leonie A Cluse, Timothy M Johanson, Hannah D Coughlan, Ramya Raviram, Robert M Myers, Matteo Costacurta, Izabela Todorovski, Lizzy Pijpers, Stefan Bjelosevic, Tobias Williams, Shannon N Huskins, Conor J Kearney, Jennifer R Devlin, Zheng Fan, Jafar S Jabbari, Ben P Martin, Mohamed Fareh, Madison J Kelly, et al.

Journal article  |  2021  |  MOLECULAR CELL

To separate causal effects of histone acetylation on chromatin accessibility and transcriptional output, we used integrated epigen..