Chitrarth Lav

A microfluidic method to investigate platelet mechanotransduction under extensional strain.

Nurul A Zainal Abidin, Mariia Timofeeva, Crispin Szydzik, Farzan Akbaridoust, Chitrarth Lav, Ivan Marusic, Arnan Mitchell, Justin R Hamilton, Andrew SH Ooi, Warwick S Nesbitt

Journal article  |  2023  |  Res Pract Thromb Haemost

BACKGROUND: Blood platelets have evolved a complex mechanotransduction machinery to rapidly respond to hemodynamic conditions. A v..

An extensional strain sensing mechanosome drives adhesion-independent platelet activation at supraphysiological hemodynamic gradients

Nurul A Zainal Abidin, Eric KW Poon, Crispin Szydzik, Mariia Timofeeva, Farzan Akbaridoust, Rose J Brazilek, Francisco J Tovar Lopez, Xiao Ma, Chitrarth Lav, Ivan Marusic, Philip E Thompson, Arnan Mitchell, Andrew SH Ooi, Justin R Hamilton, Warwick S Nesbitt

Journal article  |  2022  |  BMC BIOLOGY

BACKGROUND: Supraphysiological hemodynamics are a recognized driver of platelet activation and thrombosis at high-grade stenosis a..

Momentum boundary-layer characterisation from a pulsed impinging jet

Chitrarth Lav, Richard D Sandberg, Koichi Tanimoto, Kiyoshi Terakado

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF HEAT AND FLUID FLOW

The development of the unsteady boundary layer produced from an impinging jet with a temporal puslation forms part of the complex ..

Pulsed impinging jets: Momentum and heat-transfer

Chitrarth Lav, Richard D Sandberg, Koichi Tanimoto, Kiyoshi Terakado

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER

With increasing efficiencies of internal combustion engines, the accurate prediction of the heat transfer across walls, such as fr..

Experimental and Computational Study of 2D Smooth Wall Turbulent Boundary Layers in Pressure Gradient

DJ Fritsch, V Vishwanathan, CJ Roy, KT Lowe, WJ Devenport, Y Nishi, T Knopp, P Ströer, A Krumbein, RD Sandberg, C Lav, RE Bensow, L Eça, SL Toxopeus, M Kerkvliet, M Slama, L Bordier

Conference Proceedings  |  2022  |  AIAA Science and Technology Forum and Exposition, AIAA SciTech Forum 2022

This paper describes a collaborative experimental and computational study of smooth wall boundary layers in a systematic family of..

RANS predictions of trailing-edge slot flows using heatflux closures developed with CFD-driven machine learning

Chitrarth Lav, Ali Haghiri, Richard D Sandberg

Journal article  |  2021  |  JOURNAL OF THE GLOBAL POWER AND PROPULSION SOCIETY

Accurate prediction of the wall temperature downstream of the trailing-edge slot is crucial to designing turbine blades that can w..

LES of unsteady boundary-layer development from a pulsed impinging jet

Chitrarth Lav, Richard D Sandberg, Koichi Tanimoto, Kiyoshi Terakado

Conference Proceedings  |  2020  |  Australasian Fluid Mechanics Conference (AFMC)

A-priori evaluation of data-driven models for large-eddy simulations in natural convection

Liyuan Liu, Chitrarth Lav, Richard Sandberg

Conference Proceedings  |  2020  |  Australasian Fluid Mechanics Conference (AFMC)

UNSTEADY SIMULATIONS OF A TRAILING-EDGE SLOT USING MACHINE-LEARNT TURBULENCE STRESS AND HEAT-FLUX CLOSURES

Chitrarth Lav, Richard Sandberg

Conference Proceedings  |  2020  |  Proceedings of ASME Turbo Expo 2020: Turbomachinery Technical Conference & Exposition GT2020

The trailing edge slot is a canonical representation of the pressure-side bleed flow encountered in high pressure turbines. Predic..

Compressible plane turbulent wakes under pressure gradients evolving in a constant area section

C Lav, J Philip, RD Sandberg

Journal article  |  2020  |  Journal of Fluid Mechanics

Development of statistically two-dimensional (2-D) turbulent wakes under pressure gradients is a common feature of many industrial..