A/Prof Lianne Schmaal

Associate Professor Lianne Schmaal is a NHMRC Medical Research Future Fund Career Development Fellow (CDF) at the Centre for Youth Mental Health, and Orygen, The National Centre of Excellence in Youth Mental Health, where she leads the MAPP (Mood and Anxiety, Profiling and Prediction) lab; a research program focused on profiling and prediction of mood disorders, anxiety disorders and suicidality. Her research aims to understand the neurobiological mechanisms underlying the development and course of depression and suicidal thoughts and behaviours.

A key focus of this research program is addressing the heterogeneity of depression by defining profiles or subtypes of depression and suicidal behaviours based on a better understanding of (neuro)biological mechanisms. Her work also focuses on developing prediction algorithms for depression onset, treatment response and suicide attempts. Her research integrates clinical, psychosocial, neurobiological, cognitive and genetic data through computational modelling and machine learning methods. A/Prof. Schmaal also (co-)leads the two largest neuroimaging consortia on depression and suicidal behaviours worldwide, i.e. the ENIGMA Major Depressive Disorder (MDD) consortium and the ENIGMA Suicidal Thoughts and Behaviours consortium. These international consortia pool neuroimaging and clinical data from >20,000 people from ~50 research institutes in 14 different countries worldwide.

Find out more about Lianne Schmaal's experience

Lianne Schmaal's highlights

FEATURED Journal article

Subcortical shape alterations in major depressive disorder: Findings from the ENIGMA major depressive disorder working group.

Lianne Schmaal's selected work

Enigma-Coinstac: Advanced Worldwide Transdiagnostic Analysis Of Valence System Brain Circu..

Research Grant

Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal g..

Journal article

A Global Alliance To Unlock Brain Mechanisms Influencing Suicidal Behaviors Through The En..

Research Grant

Predicting individual clinical trajectories of depression with generative embedding.

Journal article

Enigma-Sd: Understanding Sex Differences In Global Mental Health Through Enigma

Research Contracts

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimagi..

Journal article

Projects

Displaying the 7 most recent projects by Lianne Schmaal.

Enigma-Coinstac: Advanced Worldwide Transdiagnostic Analysis Of Valence System Brain Circuits

2019 - 2020

Active

A Global Alliance To Unlock Brain Mechanisms Influencing Suicidal Behaviors Through The Enigma Consortium

2018 - 2022

Active

A Brain-Based Model Of Anxiety Sensitivity In Panic Disorder

This project will combine advanced brain imaging and brain network modelling to better understand the neurobiology of panic disorder with re..

2018 - 2020

Active

Uncovering Heterogeneity Of Youth Depression Using Neuroimaging-Based Normative Models

2017 - 2017

Completed

7

Projects

Project Types

Research Grant

Internal Research Grant

Research Contracts

Scholarly Works

Displaying the 103 most recent scholarly works by Lianne Schmaal.

Subcortical shape alterations in major depressive disorder: Findings from the ENIGMA major depressive disorder working group.

Tiffany C Ho, Boris Gutman, Elena Pozzi, Hans J Grabe, Norbert Hosten, Katharina Wittfeld, Henry Völzke, Bernhard Baune, Udo Dannlowski, Katharina Förster, Dominik Grotegerd, Ronny Redlich, Andreas Jansen, Tilo Kircher, Axel Krug, Susanne Meinert, Igor Nenadic, Nils Opel, Richard Dinga, Dick J Veltman, et al.

Journal article | 2020 | Human Brain Mapping

Alterations in regional subcortical brain volumes have been investigated as part of the efforts of an international consortium, EN..

Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia

Ida E Sonderby, Omar Gustafsson, Trung Doan Nhat, Derrek P Hibar, Sandra Martin-Brevet, Abdel Abdellaoui, David Ames, Katrin Amunts, Michael Andersson, Nicola J Armstrong, Manon Bernard, Nicholas Blackburn, John Blangero, Dorret Boomsma, Janita Bralten, Hans-Richard Brattbak, Henry Brodaty, Rachel M Brouwer, Robin Buelow, Vince Calhoun, et al.

Journal article | 2020 | Molecular Psychiatry

Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2..

Predicting individual clinical trajectories of depression with generative embedding.

Stefan Frässle, Andre F Marquand, Lianne Schmaal, Richard Dinga, Dick J Veltman, Nic JA van der Wee, Marie-José van Tol, Dario Schöbi, Brenda WJH Penninx, Klaas E Stephan

Journal article | 2020 | NeuroImage: Clinical

Patients with major depressive disorder (MDD) show heterogeneous treatment response and highly variable clinical trajectories: whi..

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

Lianne Schmaal, Anne-Laura van Harmelen, Vasiliki Chatzi, Elizabeth TC Lippard, Yara J Toenders, Lynnette A Averill, Carolyn M Mazure, Hilary P Blumberg

Journal article | 2020 | Molecular Psychiatry

Identifying brain alterations that contribute to suicidal thoughts and behaviors (STBs) are important to develop more targeted and..

A Closer Look at Depression Biotypes: Correspondence Relating to Grosenick et al. (2019).

Richard Dinga, Lianne Schmaal, Andre F Marquand

Journal article | 2020 | Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

Harmonised collection of data in youth mental health: Towards large datasets

Suzie Lavoie, Kelly Allott, Paul Amminger, Cali Bartholomeusz, Maximus Berger, Michael Breakspear, Anjali K Henders, Rico Lee, Ashleigh Lin, Patrick McGorry, Simon Rice, Lianne Schmaal, Stephen J Wood

Journal article | 2020 | Australian & New Zealand Journal of Psychiatry

OBJECTIVE: The current international trend is to create large datasets with existing data and/or deposit newly collected data into..

The impact of depression and anxiety treatment on biological aging and metabolic stress: study protocol of the Mood treatment with antidepressants or running (MOTAR) study

Bianca A Lever-van Milligen, Josine E Verhoeven, Lianne Schmaal, Laura S van Velzen, Dora Revesz, Catherine N Black, Laura KM Han, Melany Horsfall, Neeltje M Batelaan, Anton JLM van Balkom, Digna JF van Schaik, Patricia van Oppen, Brenda WJH Penninx

Journal article | 2019 | BMC Psychiatry

BACKGROUND: Depressive and anxiety disorders have shown to be associated to premature or advanced biological aging and consequentl..

No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis

Carolien GF de Kovel, Lyubomir Aftanas, Andre Aleman, Aaron F Alexander-Bloch, Bernhard T Baune, Ivan Brack, Robin Bulow, Geraldo Busatto Filho, Angela Carballedo, Colm G Connolly, Kathryn R Cullen, Udo Dannlowski, Christopher G Davey, Danai Dima, Katharina Dohm, Tracy Erwin-Grabner, Thomas Frodl, Cynthia HY Fu, Geoffrey B Hall, David C Glahn, et al.

Journal article | 2019 | American Journal of Psychiatry

OBJECTIVE: Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions...

Subcortical surface morphometry in substance dependence: An ENIGMA addiction working group study

Yann Chye, Scott Mackey, Boris A Gutman, Christopher RK Ching, Albert Batalla, Sara Blaine, Samantha Brooks, Elisabeth C Caparelli, Janna Cousijn, Alain Dagher, John J Foxe, Anna E Goudriaan, Robert Hester, Kent Hutchison, Neda Jahanshad, Anne M Kaag, Ozlem Korucuoglu, Chiang-Shan R Li, Edythe D London, Valentina Lorenzetti, et al.

Journal article | 2019 | Addiction Biology

While imaging studies have demonstrated volumetric differences in subcortical structures associated with dependence on various abu..

Deficits in White Matter Microstructure in Major Depressive Disorder: Cause, Consequence, or Correlate?

Lianne Schmaal, Laura S van Velzen

Journal article | 2019 | Biological Psychiatry

Genetic architecture of subcortical brain structures in 38,851 individuals

Claudia L Satizabal, Hieab HH Adams, Derrek P Hibar, Charles C White, Maria J Knol, Jason L Stein, Markus Scholz, Muralidharan Sargurupremraj, Neda Jahanshad, Gennady Roshchupkin, Albert Smith, Joshua C Bis, Xueqiu Jian, Michelle Luciano, Edith Hofer, Alexander Teumer, Sven J van der Lee, Jingyun Yang, Lisa R Yanek, Tom Lee, et al.

Journal article | 2019 | Nature Genetics

Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation ..

Neuroimaging predictors of onset and course of depression in childhood and adolescence: A systematic review of longitudinal studies

Yara J Toenders, Laura S van Velzen, Ivonne Z Heideman, Ben J Harrison, Christopher G Davey, Lianne Schmaal

Journal article | 2019 | Developmental Cognitive Neuroscience

White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group.

Laura S van Velzen, Sinead Kelly, Dmitry Isaev, Andre Aleman, Lyubomir I Aftanas, Jochen Bauer, Bernhard T Baune, Ivan V Brak, Angela Carballedo, Colm G Connolly, Baptiste Couvy-Duchesne, Kathryn R Cullen, Konstantin V Danilenko, Udo Dannlowski, Verena Enneking, Elena Filimonova, Katharina Förster, Thomas Frodl, Ian H Gotlib, Nynke A Groenewold, et al.

Journal article | 2019 | Molecular Psychiatry

Alterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). Ho..

Collaborative Efforts for Understanding the Human Brain

Sook-Lei Liew, Lianne Schmaal, Neda Jahanshad

Journal article | 2019 | Frontiers in Neuroinformatics

Advanced Brain Age and its Clinical Correlates in Bipolar Disorder: A Global, Multi-Site Analysis of Data From the ENIGMA Bipolar Disorders Working Group

Lisa Eyler, Garrett Timmons, Bernhard Baune, Geraldo Busatto, Xavier Caseras, Udo Dannlowski, Dominik Grotegerd, Tim Hahn, Tomas Hajek, Josselin Houenou, Fleur Howells, Mikael Landen, Ulrik Malt, Philip Mitchell, Benson Mwangi, Edith Pomarol-Clotet, Pedro Rosa, Theodore D Satterthwaite, Kang Sim, Jair Soares, et al.

Conference Proceedings | 2019 | Biological Psychiatry

Journal of Affective Disorders Special Issue on Suicide-Related Research: Hopeful progress but much research urgently needed

A-L Van Harmelen, L Schmaal, HP Blumberg

Journal article | 2019 | Journal of Affective Disorders

Subcortical Brain Volume, Regional Cortical Thickness and Surface Area Alterations Across ADHD, ASD, and OCD

Premika Boedhoe, Daan van Rooij, Martine Hoogman, Lianne Schmaal, Paul M Thompson, Dan J Stein, Jan Buitelaar, Barbara Franke, Odile van den Heuvel

Conference Proceedings | 2019 | Biological Psychiatry

Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: mega-analytic findings from a large multi-site cohort.

Leonardo Tozzi, Lisa Garczarek, Deborah Janowitz, Dan J Stein, Katharina Wittfeld, Henrik Dobrowolny, Jim Lagopoulos, Sean N Hatton, Ian B Hickie, Angela Carballedo, Samantha J Brooks, Daniella Vuletic, Anne Uhlmann, Ilya M Veer, Henrik Walter, Robin Bülow, Henry Völzke, Johanna Klinger-König, Knut Schnell, Dieter Schoepf, et al.

Journal article | 2019 | Psychological Medicine

BACKGROUND: Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of ..

Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium.

Xiang-Zhen Kong, Premika SW Boedhoe, Yoshinari Abe, Pino Alonso, Stephanie H Ameis, Paul D Arnold, Francesca Assogna, Justin T Baker, Marcelo C Batistuzzo, Francesco Benedetti, Jan C Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Brian P Brennan, Jan Buitelaar, Rosa Calvo, Yuqi Cheng, Kang Ik K Cho, Sara Dallaspezia, et al.

Journal article | 2019 | Biological Psychiatry

BACKGROUND: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear wh..

Cortical surface area: a potential biological marker for depression onset and poor clinical outcomes?

Lianne Schmaal

Journal article | 2019 | The Lancet Psychiatry

Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?

Theo GM van Erp, Esther Walton, Derrek P Hibar, Lianne Schmaal, Wenhao Jiang, David C Glahn, Godfrey D Pearlson, Nailin Yao, Masaki Fukunaga, Ryota Hashimoto, Naohiro Okada, Hidenaga Yamamori, Vincent P Clark, Bryon A Mueller, Sonja MC de Zwarte, Roel A Ophoff, Neeltje EM van Haren, Ole A Andreassen, Tiril P Gurholt, Oliver Gruber, et al.

Journal article | 2019 | Biological Psychiatry

Neurodevelopmental correlates of the emerging adult self

Christopher G Davey, Alex D Fornito, Jesus Pujol, Michael Breakspear, Lianne Schmaal, Ben J Harrison

Journal article | 2019 | Developmental Cognitive Neuroscience

Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects

Scott Mackey, Nicholas Allgaier, Bader Chaarani, Philip Spechler, Catherine Orr, Janice Bunn, Nicholas B Allen, Nelly Alia-Klein, Albert Batalla, Sara Blaine, Samantha Brooks, Elisabeth Caparelli, Yann Ying Chye, Janna Cousijn, Alain Dagher, Sylvane Desrivieres, Sarah Feldstein-Ewing, John J Foxe, Rita Z Goldstein, Anna E Goudriaan, et al.

Journal article | 2019 | American Journal of Psychiatry

An Empirical Comparison of Meta- and Mega-Analysis With Data From the ENIGMA Obsessive-Compulsive Disorder Working Group

Premika SW Boedhoe, Martijn W Heymans, Lianne Schmaal, Yoshinari Abe, Pino Alonso, Stephanie H Ameis, Alan Anticevic, Paul D Arnold, Marcelo C Batistuzzo, Francesco Benedetti, Jan C Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Rosa Calvo, Yuqi Cheng, Kang lk K Cho, Valentina Ciullo, Sara Dallaspezia, et al.

Journal article | 2019 | Frontiers in Neuroinformatics

Evaluating the evidence for biotypes of depression: Methodological replication and extension of Drysdale et al. (2017)

Richard Dinga, Lianne Schmaal, Brenda WJH Penninx, Marie Jose van Tol, Dick J Veltman, Laura van Velzen, Maarten Mennes, Nic JA van der Wee, Andre F Marquand

Journal article | 2019 | NeuroImage: Clinical

Neuroimaging, genetics, and personalized psychiatry: Developments and opportunities from the ENIGMA consortium

L Schmaal, CRK Ching, AB McMahon, N Jahanshad, PM Thompson

Book Chapter | 2019

Decreased functional connectivity of the insula within the salience network as an indicator for prospective insufficient response to antidepressants.

H Geugies, EM Opmeer, JBC Marsman, CA Figueroa, MJ van Tol, L Schmaal, NJA van der Wee, A Aleman, BWJH Penninx, DJ Veltman, RA Schoevers, HG Ruhé

Journal article | 2019 | NeuroImage: Clinical

Insufficient response to treatment is the main cause of prolonged suffering from major depressive disorder (MDD). Early identifica..

Predicting the naturalistic course of depression from a wide range of clinical, psychological, and biological data: a machine learning approach

Richard Dinga, Andre F Marquand, Dick J Veltman, Aartjan TF Beekman, Robert A Schoevers, Albert M van Hemert, Brenda WJH Penninx, Lianne Schmaal

Journal article | 2018 | Translational Psychiatry

Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium

Theo GM van Erp, Esther Walton, Derrek P Hibar, Lianne Schmaal, Wenhao Jiang, David C Glahn, Godfrey D Pearlson, Nailin Yao, Masaki Fukunaga, Ryota Hashimoto, Naohiro Okada, Hidenaga Yamamori, Juan R Bustillo, Vincent P Clark, Ingrid Agartz, Bryon A Mueller, Wiepke Cahn, Sonja MC de Zwarte, Hilleke E Hulshoff Pol, Rene S Kahn, et al.

Journal article | 2018 | Biological Psychiatry

Improving Mental Health in Young People through Harmonised Collection of Data

Suzie Lavoie, Kelly Allott, Paul Amminger, Maximus Berger, Michael Breakspear, Anjali Henders, Rico Lee, Ashleigh Lin, Patrick McGorry, Simon Rice, Lianne Schmaal, Stephen Wood

Conference Proceedings | 2018 | EARLY INTERVENTION IN PSYCHIATRY

Evaluating the evidence for biotypes of depression: attempted replication of Drysdale et.al. 2017

Richard Dinga, Lianne Schmaal, Brenda Penninx, Marie Jose van Tol, Dick Veltman, Laura van Velzen, Nic van der Wee, Andre Marquand

Journal article | 2018

Abstract Background Psychiatric disorders are highly heterogeneous, defined based on symptoms with little connection to potential ..

The genetic architecture of the human cerebral cortex

Katrina Grasby, Neda Jahanshad, Jodie Painter, Lucía Colodro-Conde, Janita Bralten, Derrek Hibar, Penelope Lind, Fabrizio Pizzagalli, Christopher RK Ching, Mary Agnes McMahon, Natalia Shatokhina, Leo CP Zsembik, Ingrid Agartz, Saud Alhusaini, Marcio AA Almeida, Dag Alnæs, Inge Amlien, Micael Andersson, Tyler Ard, Nicola Armstrong, et al.

Journal article | 2018

The cerebral cortex underlies our complex cognitive capabilities, yet we know little about the specific genetic loci influencing h..

Deep Learning for Quality Control of Subcortical Brain 3D Shape Models

undefined The ENIGMA Consortium, Dmitry Petrov, Boris Gutman, Egor Kuznetsov, Theo GM van Erp, Jessica Turner, Lianne Schmaal, Dick Veltman, Lei Wang, Kathryn Alpert, Dmitry Isaev, Artemis Zavaliangos-Petropulu, Christopher RK Ching, Vince Calhoun, David Glahn, Theodore Satterthwaite, Ole Andreas Andreassen, Stefan Borgwardt, Fleur Howells, Nynke Groenewold, et al.

Journal article | 2018

Abstract We present several deep learning models for assessing the morphometric fidelity of deep grey matter region models extract..

Structural and Functional Brain Abnormalities Associated With Exposure to Different Childhood Trauma Subtypes: A Systematic Review of Neuroimaging Findings

Laura LM Cassiers, Bernard GC Sabbe, Lianne Schmaal, Dick J Veltman, Brenda WJH Penninx, Filip Van den Eede

Journal article | 2018 | Frontiers in Psychiatry

The relation between gray matter volume and the use of alcohol, tobacco, cocaine and cannabis in male polysubstance users

AM Kaag, MHJ Schulte, JM Jansen, G van Wingen, J Homberg, W van den Brink, RW Wiers, L Schmaal, AE Goudriaan, L Reneman

Journal article | 2018 | Drug and Alcohol Dependence

Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium

Xiang-Zhen Kong, Samuel R Mathias, Tulio Guadalupe, David C Glahn, Barbara Franke, Fabrice Crivello, Nathalie Tzourio-Mazoyer, Simon E Fisher, Paul M Thompson, Clyde Francks

Journal article | 2018 | Proceedings of the National Academy of Sciences

Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group

Premika SW Boedhoe, Lianne Schmaal, Yoshinari Abe, Pino Alonso, Stephanie H Ameis, Alan Anticevic, Paul D Arnold, Marcelo C Batistuzzo, Francesco Benedetti, Jan C Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Rosa Calvo, Yuqi Cheng, Kang Ik K Cho, Valentina Ciullo, Sara Dallaspezia, Damiaan Denys, et al.

Journal article | 2018 | American Journal of Psychiatry

Identifying Structural Brain Alterations in Adolescent Depression Based on Individual Deviations From Normative Age-Related Patterns of Brain Structure

Lianne Schmaal, Yara Toenders, Paul Thompson, Dick Veltman, Andre Marquand

Conference Proceedings | 2018 | Biological Psychiatry

Brain Aging in Major Depressive Disorder: Results From the ENIGMA MDD Consortium

Lianne Schmaal, Laura Han, Richard Dinga, Paul Thompson, Dick Veltman, Brenda Penninx

Conference Proceedings | 2018 | Biological Psychiatry

Deep Learning for Quality Control of Subcortical Brain 3D Shape Models

D Petrov, BA Gutman, E Kuznetsov, CRK Ching, K Alpert, A Zavaliangos-Petropulu, D Isaev, JA Turner, TGM van Erp, L Wang, L Schmaal, D Veltman, PM Thompson

Conference Proceedings | 2018 | Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

Childhood maltreatment and non-suicidal self-injury: clinical implications

Lianne Schmaal, Sarah Bendall

Journal article | 2018 | The Lancet Psychiatry

HPA Axis Genes, and Their Interaction with Childhood Maltreatment, are Related to Cortisol Levels and Stress-Related Phenotypes

Lotte Gerritsen, Yuri Milaneschi, Christiaan H Vinkers, Albert M van Hemert, Laura van Velzen, Lianne Schmaal, Brenda WJH Penninx

Journal article | 2017 | Neuropsychopharmacology

Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

Tulio Guadalupe, Samuel R Mathias, Theo GM Vanerp, Christopher D Whelan, Marcel P Zwiers, Yoshinari Abe, Lucija Abramovic, Ingrid Agartz, Ole A Andreassen, Alejandro Arias-Vasquez, Benjamin S Aribisala, Nicola J Armstrong, Volker Arolt, Eric Artiges, Rosa Ayesa-Arriola, Vatche G Baboyan, Tobias Banaschewski, Gareth Barker, Mark E Bastin, Bernhard T Baune, et al.

Journal article | 2017 | Brain Imaging and Behavior

The effect of N-acetylcysteine on brain glutamate and gamma-aminobutyric acid concentrations and on smoking cessation: A randomized, double-blind, placebo-controlled trial

MHJ Schulte, AE Goudriaan, AM Kaag, DP Kooi, W van den Brink, RW Wiers, L Schmaal

Journal article | 2017 | Journal of Psychopharmacology

Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

Xiang-Zhen Kong, Samuel Mathias, Tulio Guadalupe, Christoph Abé, Ingrid Agartz, Theophilus Akudjedu, Aleman Andre, Alhusaini Saud, Nicholas Allen, David Ames, Ole Andreassen, Alejandro Arias Vasquez, Nicola Armstrong, Felipe Bergo, Mark Bastin, Albert Batalla, Jochen Bauer, Bernhard Baune, Ramona Baur, Joseph Biederman, et al.

Journal article | 2017

Abstract Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to ..

Prefrontal Glx and GABA concentrations and impulsivity in cigarette smokers and smoking polysubstance users

Mieke HJ Schulte, Anne Marije Kaag, Reinout W Wiers, Lianne Schmaal, Wim van den Brink, Liesbeth Reneman, Judith R Homberg, Guido A van Wingen, Anna E Goudriaan

Journal article | 2017 | Drug and Alcohol Dependence

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

Claudia Satizabal, Hieab HH Adams, Derrek Hibar, Charles White, Jason Stein, Markus Scholz, Murali Sargurupremraj, Neda Jahanshad, Albert Smith, Joshua Bis, Xueqiu Jian, Michelle Luciano, Edith Hofer, Alexander Teumer, Sven van der Lee, Jingyun Yang, Lisa Yanek, Tom Lee, Shuo Li, Yanhui Hu, et al.

Journal article | 2017

Abstract Subcortical brain structures are integral to motion, consciousness, emotions, and learning. We identified common genetic ..

Machine Learning for Large-Scale Quality Control of 3D Shape Models in Neuroimaging

Dmitry Petrov, Boris Gutman, Shih-Hua (Julie) Yu, Theo GM van Erp, Jessica Turner, Lianne Schmaal, Dick Veltman, Lei Wang, Kathryn Alpert, Dmitry Isaev, Artemis Zavaliangos-Petropulu, Christopher RK Ching, Vince Calhoun, David Glahn, Ted Satterthwaite, Ole Andreas Andreasen, Stefan Borgwardt, Fleur Howells, Nynke Groenewold, Aristotle Voineskos, et al.

Journal article | 2017

Abstract As very large studies of complex neuroimaging phenotypes become more common, human quality assessment of MRI-derived data..

Brain Structural Signatures of Adolescent Depressive Symptom Trajectories: A Longitudinal Magnetic Resonance Imaging Study

Lianne Schmaal, Murat Yucel, Rachel Ellis, Nandita Vijayakumar, Julian G Simmons, Nicholas B Allen, Sarah Whittle

Journal article | 2017 | Journal of the American Academy of Child & Adolescent Psychiatry

Oxidative stress and brain morphology in individuals with depression, anxiety and healthy controls

Laura S van Velzen, Madelief Wijdeveld, Catherine N Black, Marie-Jose van Tol, Nic JA van der Wee, Dick J Veltman, Brenda WJH Penninx, Lianne Schmaal

Journal article | 2017 | Progress in Neuro-Psychopharmacology and Biological Psychiatry

Association and Causation in Brain Imaging in the Case of OCD: Response to McKay et al.

Premika SW Boedhoe, Lianne Schmaal, David Mataix-Cols, Neda Jahanshad, Paul M Thompson, Dan Stein, Odile A van den Heuvel

Journal article | 2017 | American Journal of Psychiatry

Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

L Schmaal, DP Hibar, PG Saemann, GB Hall, BT Baune, N Jahanshad, JW Cheung, TGM van Erp, D Bos, MA Ikram, MW Vernooij, WJ Niessen, H Tiemeier, A Hofman, K Wittfeld, HJ Grabe, D Janowitz, R Buelow, M Selonke, H Voelzke, et al.

Journal article | 2017 | Molecular Psychiatry

Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group

ME Renteria, L Schmaal, DP Hibar, B Couvy-Duchesne, LT Strike, NT Mills, GI de Zubicaray, KL McMahon, SE Medland, NA Gillespie, SN Hatton, J Lagopoulos, DJ Veltman, N van der Wee, TGM van Erp, K Wittfeld, HJ Grabe, A Block, K Hegenscheid, H Voelzke, et al.

Journal article | 2017 | Translational Psychiatry

Childhood adversity impacts on brain subcortical structures relevant to depression

Thomas Frodl, Deborah Janowitz, Lianne Schmaal, Leonardo Tozzi, Henrik Dobrowolny, Dan J Stein, Dick J Veltman, Katharina Wittfeld, Theo GM van Erp, Neda Jahanshad, Andrea Block, Katrin Hegenscheid, Henry Voelzke, Jim Lagopoulos, Sean N Hatton, Ian B Hickie, Eva Maria Frey, Angela Carballedo, Samantha J Brooks, Daniella Vuletic, et al.

Journal article | 2017 | Journal of Psychiatric Research

Immunometabolic dysregulation is associated with reduced cortical thickness of the anterior cingulate cortex

Laura S van Velzen, Lianne Schmaal, Yuri Milaneschi, Marie-Jose van Tol, Nic JA van der Wee, Dick J Veltman, Brenda WJH Penninx

Journal article | 2017 | Brain, Behavior, and Immunity

Novel genetic loci associated with hippocampal volume

Derrek P Hibar, Hieab HH Adams, Neda Jahanshad, Ganesh Chauhan, Jason L Stein, Edith Hofer, Miguel E Renteria, Joshua C Bis, Alejandro Arias-Vasquez, M Kamran Ikram, Sylvane Desrivieres, Meike W Vernooij, Lucija Abramovic, Saud Alhusaini, Najaf Amin, Micael Andersson, Konstantinos Arfanakis, Benjamin S Aribisala, Nicola J Armstrong, Lavinia Athanasiu, et al.

Journal article | 2017 | Nature Communications

ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide

Paul M Thompson, Ole A Andreassen, Alejandro Arias-Vasquez, Carrie E Bearden, Premika S Boedhoe, Rachel M Brouwer, Randy L Buckner, Jan K Buitelaar, Kazima B Bulayeva, Dara M Cannon, Ronald A Cohen, Patricia J Conrod, Anders M Dale, Ian J Deary, Emily L Dennis, Marcel A de Reus, Sylvane Desrivieres, Danai Dima, Gary Donohoe, Simon E Fisher, et al.

Journal article | 2017 | NeuroImage

Classification of major depressive disorder via multi-site weighted LASSO model

D Zhu, BC Riedel, N Jahanshad, NA Groenewold, DJ Stein, IH Gotlib, MD Sacchet, D Dima, JH Cole, CHY Fu, H Walter, IM Veer, T Frodl, L Schmaal, DJ Veltman, PM Thompson

Conference Proceedings | 2017 | Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

An Evolutionary Approach for fMRI Big Data Classification

Amirhessam Tahmassebi, Amir H Gandomi, Ian McCann, Mieke HJ Schulte, Lianne Schmaal, Anna E Goudriaan, Anke Meyer-Baese

Conference Proceedings | 2017 | 2017 IEEE Congress on Evolutionary Computation (CEC)

Large-scale classification of major depressive disorder via distributed Lasso

Dajiang Zhu, Qingyang Li, Brandalyn C Riedel, Neda Jahanshad, Derrek P Hibar, Ilya M Veer, Henrik Walter, Lianne Schmaal, Dick J Veltman, Dominik Grotegerd, Udo Dannlowski, Matthew D Sacchet, Ian H Gotlib, Jieping Ye, Paul M Thompson

Conference Proceedings | 2017 | 12th International Symposium on Medical Information Processing and Analysis

Machine Learning for Large-Scale Quality Control of 3D Shape Models in Neuroimaging

Dmitry Petrov, Boris A Gutman, Shih-Hua Julie Yu, Kathryn Alpert, Artemis Zavaliangos-Petropulu, Dmitry Isaev, Jessica A Turner, Theo GM van Erp, Lei Wang, Lianne Schmaal, Dick Veltman, Paul M Thompson

Conference Proceedings | 2017 | Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

Changes in the cerebral cortex in depression: Results of large-scale research

L Schmaal

Journal article | 2017 | Tijdschrift voor Psychiatrie

Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis

Premika SW Boedhoe, Lianne Schmaal, Yoshinari Abe, Stephanie H Ameis, Paul D Arnold, Marcelo C Batistuzzo, Francesco Benedetti, Jan C Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Yuqi Cheng, Kang Ik K Cho, Sara Dallaspezia, Damiaan Denys, Kate D Fitzgerald, Jean-Paul Fouche, Monica Gimenez, Patricia Gruner, et al.

Journal article | 2017 | American Journal of Psychiatry

Novel genetic loci underlying human intracranial volume identified through genome-wide association

Hieab HH Adams, Derrek P Hibar, Vincent Chouraki, Jason L Stein, Paul A Nyquist, Miguel E Renteria, Stella Trompet, Alejandro Arias-Vasquez, Sudha Seshadri, Sylvane Desrivieres, Ashley H Beecham, Neda Jahanshad, Katharine Wittfeld, Sven J Van der Lee, Lucija Abramovic, Saud Alhusaini, Najaf Amin, Micael Andersson, Konstantinos Arfanakis, Benjamin S Aribisala, et al.

Journal article | 2016 | Nature Neuroscience

Effect of childhood maltreatment and brain-derived neurotrophic factor on brain morphology

Laura S van Velzen, Lianne Schmaal, Rick Jansen, Yuri Milaneschi, Esther M Opmeer, Bernet M Elzinga, Nic JA van der Wee, Dick J Veltman, Brenda WJH Penninx

Journal article | 2016 | Social Cognitive and Affective Neuroscience

Distinguishing medication-free subjects with unipolar disorder from subjects with bipolar disorder: state matters

Maria M Rive, Ronny Redlich, Lianne Schmaal, Andre F Marquand, Udo Dannlowski, Dominik Grotegerd, Dick J Veltman, Aart H Schene, Henricus G Ruhe

Journal article | 2016 | Bipolar Disorders

Size matters; but so does what you do with it! Response

L Schmaal, DJ Veltman, TGM van Erp, PG Saemann, T Frodl, N Jahanshad, E Loehrer, MW Vernooij, WJ Niessen, MA Ikram, K Wittfeld, HJ Grabe, A Block, K Hegenscheid, D Hoehn, M Czisch, J Lagopoulos, SN Hatton, IB Hickie, R Goya-Maldonado, et al.

Journal article | 2016 | Molecular Psychiatry

Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group

L Schmaal, DJ Veltman, TGM van Erp, PG Saemann, T Frodl, N Jahanshad, E Loehrer, H Tiemeier, A Hofman, WJ Niessen, MW Vernooij, MA Ikram, K Wittfeld, HJ Grabe, A Block, K Hegenscheid, H Voelzke, D Hoehn, M Czisch, J Lagopoulos, et al.

Journal article | 2016 | Molecular Psychiatry

Age-specific Subcortical Volumetric Abnormalities in Obsessive-compulsive Disorder (OCD): Findings from the ENIGMA-OCD Working Group

Odile A van den Heuvel, Premika Boedhoe, Lianne Schmaal, Derrek P Hibar, Neda Jahanshad, Dan J Stein, Paul M Thompson