Edward Smith

alpha Klotho-FGF23 interactions and their role in kidney disease: a molecular insight

Edward R Smith, Stephen G Holt, Tim D Hewitson

Journal article  |  2019  |  Cellular and Molecular Life Sciences

Following the serendipitous discovery of the ageing suppressor, αKlotho (αKl), several decades ago, a growing body of evidence has..

Serum Calcification Propensity and Clinical Events in CKD.

Joshua D Bundy, Xuan Cai, Rupal C Mehta, Julia J Scialla, Ian H de Boer, Chi-Yuan Hsu, Alan S Go, Mirela A Dobre, Jing Chen, Panduranga S Rao, Mary B Leonard, James P Lash, Geoffrey A Block, Raymond R Townsend, Harold I Feldman, Edward R Smith, Andreas Pasch, Tamara Isakova, undefined CRIC Study Investigators

Journal article  |  2019  |  Clinical Journal of the American Society of Nephrology

BACKGROUND AND OBJECTIVES: Patients with CKD are at high risk for cardiovascular disease, ESKD, and mortality. Vascular calcificat..

Diagnostic Tests for Vascular Calcification

Edward R Smith, Tim D Hewitson, Stephen G Holt

Journal article  |  2019  |  Advances in Chronic Kidney Disease

Vascular calcification (VC) is the heterogeneous endpoint of multiple vascular insults, which varies by arterial bed, the layer of..

Profiling histone modifications in the normal mouse kidney and after unilateral ureteric obstruction

Timothy D Hewitson, Stephen G Holt, Chrishan S Samuel, Belinda Wigg, Edward R Smith

Journal article  |  2019  |  American Journal of Physiology-Renal Physiology

Serum Calcification Propensity and Coronary Artery Calcification Among Patients With CKD: The CRIC (Chronic Renal Insufficiency Cohort) Study.

Joshua D Bundy, Xuan Cai, Julia J Scialla, Mirela A Dobre, Jing Chen, Chi-Yuan Hsu, Mary B Leonard, Alan S Go, Panduranga S Rao, James P Lash, Raymond R Townsend, Harold I Feldman, Ian H de Boer, Geoffrey A Block, Myles Wolf, Edward R Smith, Andreas Pasch, Tamara Isakova, undefined CRIC Study Investigators

Journal article  |  2019  |  American Journal of Kidney Diseases

RATIONALE & OBJECTIVE: Coronary artery calcification (CAC) is prevalent among patients with chronic kidney disease (CKD) and incre..

Pre-analytical stability of FGF23 with the contemporary immunoassays

Niek F Dirks, Edward R Smith, Natasja M van Schoor, Marc G Vervloet, Mariette T Ackermans, Robert de Jonge, Annemieke C Heijboer

Journal article  |  2019  |  Clinica Chimica Acta

TGF-beta 1 modifies histone acetylation and acetyl-coenzyme A metabolism in renal myofibroblasts

Edward R Smith, Belinda Wigg, Stephen G Holt, Timothy D Hewitson

Journal article  |  2019  |  American Journal of Physiology-Renal Physiology

Cellular Clearance and Biological Activity of Calciprotein Particles Depend on Their Maturation State and Crystallinity

Sina Koppert, Andrea Buescher, Anne Babler, Ahmed Ghallab, Eva M Buhl, Eicke Latz, Jan G Hengstler, Edward R Smith, Willi Jahnen-Dechent

Journal article  |  2018  |  Frontiers in Immunology

Current and potential therapeutic strategies for the management of vascular calcification in patients with chronic kidney disease including those on dialysis

Irene Ruderman, Stephen G Holt, Tim D Hewitson, Edward R Smith, Nigel D Toussaint

Journal article  |  2018  |  Seminars in Dialysis

Untangling the thread of life spun by alpha Klotho

Edward R Smith

Journal article  |  2018  |  Journal of Molecular Medicine

CALCIPROTEIN PARTICLE FORMATION IN PERITONEAL DIALYSIS EFFLUENT IS DEPENDENT ON DIALYSATE CALCIUM CONCENTRATION

Michael MX Cai, Edward R Smith, Annette Kent, Louis Huang, Timothy D Hewitson, Lawrence P McMahon, Stephen G Holt

Journal article  |  2018  |  Peritoneal Dialysis International

Longitudinal changes in bone and mineral metabolism after cessation of cinacalcet in dialysis patients with secondary hyperparathyroidism

Irene Ruderman, Edward R Smith, Nigel D Toussaint, Tim D Hewitson, Stephen G Holt

Journal article  |  2018  |  BMC Nephrology

Biochemical transformation of calciprotein particles in uraemia

Edward R Smith, Tim D Hewitson, Eric Hanssen, Stephen G Holt

Journal article  |  2018  |  Bone

Phosphate, Calcification in Blood, and Mineral Stress: The Physiologic Blood Mineral Buffering System and Its Association with Cardiovascular Risk

Andreas Pasch, Willi Jahnen-Dechent, Edward R Smith

Journal article  |  2018  |  International Journal of Nephrology

FGF23 activates injury-primed renal fibroblasts via FGFR4-dependent signalling and enhancement of TGF-beta autoinduction

Edward R Smith, Stephen G Holt, Tim D Hewitson

Journal article  |  2017  |  The International Journal of Biochemistry & Cell Biology

Fetuin-A in the peritoneal effluent of patients with encapsulating peritoneal sclerosis-more than a protein?

Edward R Smith, Tim D Hewitson, Michael MX Cai, Stephen G Holt

Journal article  |  2017  |  Kidney International

Hydrogen sulfide attenuates calcification of vascular smooth muscle cells via KEAP1/NRF2/NQO1 activation.

Parisa Aghagolzadeh, Ramin Radpour, Matthias Bachtler, Harry van Goor, Edward R Smith, Adam Lister, Alex Odermatt, Martin Feelisch, Andreas Pasch

Journal article  |  2017  |  Atherosclerosis

BACKGROUND AND AIMS: Vascular calcification is a common health problem related to oxidative stress, inflammation, and circulating ..

Progression of Tubulointerstitial Fibrosis and the Chronic Kidney Disease Phenotype - Role of Risk Factors and Epigenetics

Timothy D Hewitson, Stephen G Holt, Edward R Smith

Journal article  |  2017  |  Frontiers in Pharmacology

A novel fluorescent probe-based flow cytometric assay for mineral-containing nanoparticles in serum

Edward R Smith, Tim D Hewitson, Michael MX Cai, Parisa Aghagolzadeh, Matthias Bachtler, Andreas Pasch, Stephen G Holt

Journal article  |  2017  |  Scientific Reports

FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts

Edward R Smith, Sven-Jean Tan, Stephen G Holt, Tim D Hewitson

Journal article  |  2017  |  Scientific Reports

Soluble klotho may be a marker of phosphate reabsorption

Sven-Jean Tan, Edward R Smith, Stephen G Holt, Tim D Hewitson, Nigel D Toussaint

Journal article  |  2017  |  Clinical Kidney Journal

Epigenetic Modifications to H3K9 in Renal Tubulointerstitial Cells after Unilateral Ureteric Obstruction and TGF-beta 1 Stimulation

Timothy D Hewitson, Stephen G Holt, Sven-Jean Tan, Belinda Wigg, Chrishan S Samuel, Edward R Smith

Journal article  |  2017  |  Frontiers in Pharmacology

Blood Calcification Propensity, Cardiovascular Events, and Survival in Patients Receiving Hemodialysis in the EVOLVE Trial.

Andreas Pasch, Geoffrey A Block, Matthias Bachtler, Edward R Smith, Wilhelm Jahnen-Dechent, Spyridon Arampatzis, Glenn M Chertow, Patrick Parfrey, Xiaoye Ma, Juergen Floege

Journal article  |  2017  |  Clinical Journal of the American Society of Nephrology

BACKGROUND AND OBJECTIVES: Patients receiving hemodialysis are at risk of cardiovascular events. A novel blood test (T50 test) det..

Parenteral iron polymaltose changes i:c-terminal FGF23 ratios in iron deficiency, but not in dialysis patients

S-J Tan, S Satake, ER Smith, ND Toussaint, TD Hewitson, SG Holt

Journal article  |  2017  |  European Journal of Clinical Nutrition

Fetuin-A-containing calciprotein particles in mineral trafficking and vascular disease

Stephen G Holt, Edward R Smith

Journal article  |  2016  |  Nephrology Dialysis Transplantation

Estrogens do not protect, but androgens exacerbate, collagen accumulation in the female mouse kidney after ureteric obstruction

Tim D Hewitson, Wah Chin Boon, Evan R Simpson, Edward R Smith, Chrishan S Samuel

Journal article  |  2016  |  Life Sciences

The Isolation and Quantitation of Fetuin-A-Containing Calciprotein Particles from Biological Fluids.

Edward R Smith

Book Chapter  |  2016  |  Methods in Molecular Biology

Multiple overlapping systemic and local inhibitory networks have evolved to prevent the unwanted deposition of mineral at ectopic ..

Vascular Calcification in Uremia: New-Age Concepts about an Old-Age Problem.

Edward R Smith

Book Chapter  |  2016  |  Methods in Molecular Biology

A hallmark of aging, and major contributor to the increased prevalence of cardiovascular disease in patients with chronic kidney d..

Relationship between timed and spot urine collections for measuring phosphate excretion

Sven-Jean Tan, Edward R Smith, Michael MX Cai, Stephen G Holt, Tim D Hewitson, Nigel D Toussaint

Journal article  |  2016  |  International Urology and Nephrology

Laser Capture Microdissection of Archival Kidney Tissue for qRT-PCR

Tim D Hewitson, Michael Christie, Edward R Smith

Book Chapter  |  2016  |  Methods in Molecular Biology

Animal models to study links between cardiovascular disease and renal failure and their relevance to human pathology

Tim D Hewitson, Stephen G Holt, Edward R Smith

Journal article  |  2015  |  Frontiers in Immunology

Diurnal variation and short-term pre-analytical stability of serum soluble -klotho in healthy volunteers: a pilot study

Sven-Jean Tan, Edward R Smith, Tim D Hewitson, Stephen G Holt, Nigel D Toussaint

Journal article  |  2015  |  Annals of Clinical Biochemistry: An international journal of biochemistry and laboratory medicine

Assessing the utility of testing aluminum levels in dialysis patients

Ashish K Sharma, Nigel D Toussaint, Janice Pickering, Tony Beeston, Edward R Smith, Stephen G Holt

Journal article  |  2015  |  Hemodialysis International

Relative abundance of fetuin- A in peritoneal dialysis effluent and its association with in situ formation of calciprotein particles: An observational pilot study

Michael MX Cai, Belinda Wigg, Edward R Smith, Timothy D Hewitson, Lawrence P McMahon, Stephen G Holt

Journal article  |  2015  |  Nephrology

Qualitative and quantitative analysis of fibrosis in the kidney

Tim D Hewitson, Edward R Smith, Chrishan S Samuel

Journal article  |  2014  |  Nephrology

The importance of klotho in phosphate metabolism and kidney disease

Sven-Jean Tan, Edward R Smith, Tim D Hewitson, Stephen G Holt, Nigel D Toussaint

Journal article  |  2014  |  Nephrology

The use of fibroblast growth factor 23 testing in patients with kidney disease.

Edward R Smith

Journal article  |  2014  |  Clinical Journal of the American Society of Nephrology

The emergence of fibroblast growth factor 23 as a potentially modifiable risk factor in CKD has led to growing interest in its mea..

Fibroblast growth factor 23

Edward R Smith, Lawrence P McMahon, Stephen G Holt

Journal article  |  2014  |  Annals of Clinical Biochemistry

Serum Calcification Propensity Predicts All-Cause Mortality in Predialysis CKD

Edward R Smith, Martin L Ford, Laurie A Tomlinson, Emma Bodenham, Lawrence P McMahon, Stefan Farese, Chakravarthi Rajkumar, Stephen G Holt, Andreas Pasch

Journal article  |  2014  |  Journal of the American Society of Nephrology

Fetuin-A-containing calciprotein particle levels can be reduced by dialysis, sodium thiosulphate and plasma exchange. Potential therapeutic implications for calciphylaxis?

Michael MX Cai, Edward R Smith, Catherine Brumby, Lawrence P McMahon, Stephen G Holt

Journal article  |  2013  |  Nephrology

Method-specific differences in plasma fibroblast growth factor 23 measurement using four commercial ELISAs

Edward R Smith, Lawrence P McMahon, Stephen G Holt

Journal article  |  2013  |  Clinical Chemistry and Laboratory Medicine

Cystatin C - More than a filtration marker?

Edward R Smith

Journal article  |  2013  |  Atherosclerosis

The value of urinary neutrophil gelatinase-associated lipocalin in risk prediction of renal decline in patients with chronic kidney disease.

Edward R Smith, Lawrence P McMahon, Stephen G Holt

Journal article  |  2013  |  Kidney International

C-terminal FGF23 fragments: present but not seen?

ER Smith, LP McMahon, SG Holt

Journal article  |  2013  |  Osteoporosis International

Large vessel calcification in Takayasu arteritis

A Gujadhur, ER Smith, LP McMahon, M Spanger, J Chuen, SG Holt

Journal article  |  2013  |  INTERNAL MEDICINE JOURNAL

Fetuin-A-Containing Calciprotein Particles Reduce Mineral Stress in the Macrophage

Edward R Smith, Eric Hanssen, Lawrence P McMahon, Stephen G Holt

Journal article  |  2013  |  PLoS One

Serum fetuin-A concentration and fetuin-A-containing calciprotein particles in patients with chronic inflammatory disease and renal failure

Edward R Smith, Michael M Cai, Lawrence P McMahon, Eugenie Pedagogos, Nigel D Toussaint, Catherine Brumby, Stephen G Holt

Journal article  |  2013  |  Nephrology

FGF23: instability may affect accuracy and interpretation.

ER Smith, LP McMahon, SG Holt

Journal article  |  2013  |  Osteoporosis International

Pro-inflammatory cytokines IL-1β and TNF-α are not associated with plasma homocysteine concentration in Alzheimer's disease.

Leon Veryard, Emma Jones, Gary Weaving, Edward Smith, Liz Cheek, Anuprabha Wickramasinghe, Naji Tabet

Journal article  |  2013  |  Current Alzheimer Research

Increased concentrations of pro-inflammatory blood cytokines and plasma homocysteine (Hcy) are frequently reported in Alzheimer's ..

FGF23 adds value to risk prediction in patients with chronic kidney disease.

Edward R Smith, Martin L Ford, Laurie A Tomlinson, Lawrence P McMahon, Chakravarthi Rajkumar, Stephen G Holt

Journal article  |  2012  |  Bone

Simultaneous measurement of urinary albumin and total protein may facilitate decision-making in HIV-infected patients with proteinuria

A Samarawickrama, M Cai, ER Smith, K Nambiar, C Sabin, M Fisher, Y Gilleece, SG Holt

Journal article  |  2012  |  HIV Medicine

Biological variability of plasma intact and C-terminal FGF23 measurements.

Edward R Smith, Michael M Cai, Lawrence P McMahon, Stephen G Holt

Journal article  |  2012  |  The Journal of Clinical Endocrinology & Metabolism

CONTEXT: FGF23 measurement may have a role in the management of patients with chronic kidney disease (CKD). OBJECTIVE: Our objecti..

Reply

ER Smith, MM Cai, LP McMahon, DA Wright, SG Holt

Journal article  |  2012  |  Nephrology Dialysis Transplantation

Hyperparathyroidism in chronic kidney disease: complexities within the commonplace

Michael M Cai, Lawrence P McMahon, Edward R Smith, David S Williams, Stephen G Holt

Journal article  |  2012  |  Clinical Medicine

Elastin degradation is associated with progressive aortic stiffening and all-cause mortality in predialysis chronic kidney disease.

Edward R Smith, Laurie A Tomlinson, Martin L Ford, Lawrence P McMahon, Chakravarthi Rajkumar, Stephen G Holt

Journal article  |  2012  |  Hypertension

In the large conduit arteries, elastin is important in maintaining vascular compliance. Studies in animal models suggest that elas..

Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in patients with pre-dialysis CKD.

Edward R Smith, Martin L Ford, Laurie A Tomlinson, Chakravarthi Rajkumar, Lawrence P McMahon, Stephen G Holt

Journal article  |  2012  |  Nephrology Dialysis Transplantation

BACKGROUND: Vascular stiffening occurs in normal ageing and is accelerated in chronic kidney disease (CKD). Vascular calcification..

The value of simultaneous measurements of urinary albumin and total protein in proteinuric patients.

Edward R Smith, Michael MX Cai, Lawrence P McMahon, David A Wright, Stephen G Holt

Journal article  |  2012  |  Nephrology Dialysis Transplantation

BACKGROUND: Proteinuria is a common pathological finding in renal disease. Examining the urinary protein electrophoretic pattern g..

FGF-23 and osteoprotegerin are independently associated with myocardial damage in chronic kidney disease stages 3 and 4. Another link between chronic kidney disease-mineral bone disorder and the heart.

Martin L Ford, Edward R Smith, Laurie A Tomlinson, Prabal K Chatterjee, Chakravarthi Rajkumar, Stephen G Holt

Journal article  |  2012  |  Nephrology Dialysis Transplantation

BACKGROUND: Extra-skeletal calcification and disordered phosphate metabolism are hallmarks of chronic kidney disease-mineral bone ..

Factors associated with increasing vascular stiffness in PD.

Edward R Smith, Martin L Ford, Laurie A Tomlinson, Gary Weaving, Stephen G Holt, Chakravarthi Rajkumar, Prabal K Chatterjee

Journal article  |  2011  |  Nephrology Dialysis Transplantation

Instability of fibroblast growth factor-23 (FGF-23): Implications for clinical studies

Edward R Smith, Martin L Ford, Laurie A Tomlinson, Gary Weaving, Bernard F Rocks, Chakravarthi Rajkumar, Stephen G Holt

Journal article  |  2011  |  Clinica Chimica Acta

Plasma fetuin-A is associated with the severity of cognitive impairment in mild-to-moderate Alzheimer's disease.

Edward R Smith, Ramin Nilforooshan, Gary Weaving, Naji Tabet

Journal article  |  2011  |  Journal of Alzheimer's Disease

The significance of vascular risk factors in the development and progression of Alzheimer's disease (AD) is now widely recognized...

Important differences in measurement of fetuin-A.

Edward R Smith, Stephen G Holt

Journal article  |  2010  |  Annals of Internal Medicine

Poor agreement between commercial ELISAs for plasma fetuin-A: An effect of protein glycosylation?

Edward R Smith, Martin L Ford, Laurie A Tomlinson, Bernard F Rocks, Chakravarthi Rajkumar, Stephen G Holt

Journal article  |  2010  |  Clinica Chimica Acta

BACKGROUND: Fetuin-A is a circulating inhibitor of ectopic calcification. Low plasma levels have been associated in some studies w..

Reply

ER Smith, ML Ford, LA Tomlinson, C Rajkumar, SG Holt

Journal article  |  2010  |  Nephrology Dialysis Transplantation

Fetuin-A is an independent determinant of change of aortic stiffness over 1 year in non-diabetic patients with CKD stages 3 and 4.

Martin L Ford, Laurie A Tomlinson, Edward R Smith, Chakravarthi Rajkumar, Stephen G Holt

Journal article  |  2010  |  Nephrology Dialysis Transplantation

BACKGROUND: Vascular calcification is highly prevalent in chronic kidney disease (CKD) patients. This calcification leads to arter..

Analytical considerations in the investigation of mixed cryoglobulinemia.

Edward R Smith

Journal article  |  2010  |  Clinical Chemistry