Carmine Onofrillo

Free-form co-axial bioprinting of a gelatin methacryloyl bio-ink by direct in situ photo-crosslinking during extrusion

CD O'Connell, S Konate, C Onofrillo, R Kapsa, C Baker, S Duchi, T Eekel, Z Yue, S Beirne, G Barnsley, C Di Bella, PF Choong, GG Wallace

Journal article  |  2020  |  Bioprinting

Concise review: Human articular cartilage repair: Sources and detection of cytotoxicity and genotoxicity in photo-crosslinkable hydrogel bioscaffolds

Cheryl Lee, Cathal D O'Connell, Carmine Onofrillo, Peter FM Choong, Claudia Di Bella, Serena Duchi

Journal article  |  2019  |  STEM CELLS TRANSLATIONAL MEDICINE

Three-dimensional biofabrication using photo-crosslinkable hydrogel bioscaffolds has the potential to revolutionize the need for t..

Evaluation of sterilisation methods for bio-ink components: gelatin, gelatin methacryloyl, hyaluronic acid and hyaluronic acid methacryloyl

Cathal D O'Connell, Carmine Onofrillo, Serena Duchi, Xin Li, Yifan Zhang, Peilin Tian, Lanyita Lu, Anna Trengove, Anita Quigley, Sanjeev Gambhir, Afsaneh Khansari, Tajanka Mladenovska, Andrea O'Connor, Claudia Di Bella, Peter F Choong, Gordon G Wallace

Journal article  |  2019  |  Biofabrication

Reliable and scalable sterilisation of hydrogels is critical to the clinical translation of many biofabrication approaches, such a..

Protocols for Culturing and Imaging a Human Ex Vivo Osteochondral Model for Cartilage Biomanufacturing Applications

Serena Duchi, Stephanie Doyle, Timon Eekel, Cathal D O'Connell, Cheryl Augustine, Peter Choong, Carmine Onofrillo, Claudia Di Bella

Journal article  |  2019  |  MATERIALS

Alternative Overexpression of NRF2 or MYC Defines a Subgroup of Poor Prognosis Acute Myeloid Leukemia and Suggests a Novel Therapeutic Strategy By Combined Bromodomain Inhibition and Forced NRF2 Pathway Activation

Giorgia Simonetti, Samantha Bruno, Carmine Onofrillo, Cristina Papayannidis, Giovanni Marconi, Michele Cavo, Lorenzo Montanaro, Giovanni Martinelli

Conference Proceedings  |  2018  |  Blood

BROMODOMAIN INHIBITION TARGETS ACUTE MYELOID LEUKEMIA CELLS UNDER HYPOXIA AND ALTERS THE REGULATION OF KEAP1/NRF2 PATHWAY AT TRANSCRIPTIONAL, TRANSLATIONAL AND POST-TRANSLATIONAL LEVEL

G Simonetti, S Bruno, C Onofrillo, C Papayannidis, G Marconi, M Cavo, L Montanaro, G Martinelli

Conference Proceedings  |  2018  |  HAEMATOLOGICA

Biofabrication of human articular cartilage: a path towards the development of a clinical treatment

Carmine Onofrillo, Serena Duchi, Cathal D O'Connell, Romane Blanchard, Andrea J O'Connor, Mark Scott, Gordon G Wallace, Peter FM Choong, Claudia Di Bella

Journal article  |  2018  |  Biofabrication

Design, Fabrication and Validation of a Precursor Pulsed Electromagnetic Field Device for Bone Fracture Repair.

Christian Daish, Romane Blanchard, Serena Duchi, Carmine Onofrillo, Cheryl Augustine, Kate Fox, Peter Pivonka, Elena Pirogova

Journal article  |  2018  |  2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Pulsed electromagnetic field (PEMF) stimulation has been utilized in the medical field since the early 20th century. A number of t..

Tailoring the mechanical properties of gelatin methacryloyl hydrogels through manipulation of the photocrosslinking conditions

Cathal D O'Connell, Binbin Zhang, Carmine Onofrillo, Serena Duchi, Romane Blanchard, Anita Quigley, Justin Bourke, Sanjeev Gambhir, Robert Kapsa, Claudia Di Bella, Peter Choong, Gordon G Wallace

Journal article  |  2018  |  Soft Matter

In situ handheld three-dimensional bioprinting for cartilage regeneration

Claudia Di Bella, Serena Duchi, Cathal D O'Connell, Romane Blanchard, Cheryl Augustine, Zhilian Yue, Fletcher Thompson, Christopher Richards, Stephen Beirne, Carmine Onofrillo, Sebastien H Bauquier, Stewart D Ryan, Peter Pivonka, Gordon G Wallace, Peter F Choong

Journal article  |  2018  |  Journal of Tissue Engineering and Regenerative Medicine

Adipose-Derived Mesenchymal Stem Cells in the Use of Cartilage Tissue Engineering: The Need for a Rapid Isolation Procedure

Sam L Francis, Serena Duchi, Carmine Onofrillo, Claudia Di Bella, Peter FM Choong

Journal article  |  2018  |  STEM CELLS INTERNATIONAL

Bromodomain Inhibition Is Effective Against Acute Myeloid Leukemia Cells Under Hypoxia and Induces Genome-Dependent Metabolic Perturbations

Giorgia Simonetti, Samantha Bruno, Carmine Onofrillo, Marco Malferrari, Cristina Papayannidis, Giovanni Marconi, Michele Cavo, Stefania Rapino, Lorenzo Montanaro, Giovanni Martinelli

Conference Proceedings  |  2017  |  BLOOD

Innovative Cartilage Regeneration for in situ Co-axial 3D Bioprinting

S Duchi, C Onofrillo, CD O'Connell, R Blanchard, AF Quigley, RM Kapsa, GG Wallace, C Di Bella, PF Choong

Conference Proceedings  |  2017  |  TISSUE ENGINEERING PART A

In situ 3D Bioprinting for cartilage regeneration

C Di Bella, C O'Connell, R Blanchard, S Duchi, S Ryan, Z Yue, C Onofrillo, G Wallace, P Choong

Conference Proceedings  |  2017  |  TISSUE ENGINEERING PART A

Rapid Photocrosslinking of Core/shell Bioink for in situ Intra-surgical application

C Onofrillo, S Duchi, C O'Connell, R Blanchard, A Quigley, RM Kapsa, GG Wallace, C Di Bella, PF Choong

Conference Proceedings  |  2017  |  TISSUE ENGINEERING PART A

Handheld Co-Axial Bioprinting: Application to in situ surgical cartilage repair

Serena Duchi, Carmine Onofrillo, Cathal D O'Connell, Romane Blanchard, Cheryl Augustine, Anita F Quigley, Robert MI Kapsa, Peter Pivonka, Gordon Wallace, Claudia Di Bella, Peter FM Choong

Journal article  |  2017  |  SCIENTIFIC REPORTS

Epigenetic up-regulation of ribosome biogenesis and more aggressive phenotype triggered by the lack of the histone demethylase JHDM1B in mammary epithelial cells

Alice Galbiati, Marianna Penzo, Maria Giulia Bacalini, Carmine Onofrillo, Ania Naila Guerrieri, Paolo Garagnani, Claudio Franceschi, Davide Trere, Lorenzo Montanaro

Journal article  |  2017  |  Oncotarget

Cap-independent protein synthesis is enhanced by betaine under hypertonic conditions

Domenica Carnicelli, Valentina Arfilli, Carmine Onofrillo, Roberta R Alfieri, Pier Giorgio Petronini, Lorenzo Montanaro, Maurizio Brigotti

Journal article  |  2017  |  Biochemical and Biophysical Research Communications

The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition

Carmine Onofrillo, Alice Galbiati, Lorenzo Montanaro, Massimo Derenzini

Journal article  |  2017  |  Oncotarget

Therapeutic dosages of aspirin counteract the IL-6 induced pro-tumorigenic effects by slowing down the ribosome biogenesis rate

Elisa Brighenti, Ferdinando Antonino Giannone, Francesca Fornari, Carmine Onofrillo, Marzia Govoni, Lorenzo Montanaro, Davide Trere, Massimo Derenzini

Journal article  |  2016  |  Oncotarget

p53-dependent and p53-independent anticancer activity of a new indole derivative in human osteosarcoma cells

C Cappadone, C Stefanelli, E Malucelli, M Zini, C Onofrillo, A Locatelli, M Rambaldi, A Sargenti, L Merolle, G Farruggia, A Graziadio, L Montanaro, S Iotti

Journal article  |  2015  |  Biochemical and Biophysical Research Communications

Human ribosomes from cells with reduced dyskerin levels are intrinsically altered in translation

Marianna Penzo, Laura Rocchi, Sabine Brugiere, Domenica Carnicelli, Carmine Onofrillo, Yohann Coute, Maurizio Brigotti, Lorenzo Montanaro

Journal article  |  2015  |  The FASEB Journal

Inhibition of human dyskerin as a new approach to target ribosome biogenesis

Armenio J Moura Barbosa, Laura Rocchi, Carmine Onofrillo, Lorenzo Montanaro, Alberto Del Rio

Conference Proceedings  |  2014  |  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of Human Dyskerin as a New Approach to Target Ribosome Biogenesis

Laura Rocchi, Armenio JM Barbosa, Carmine Onofrillo, Alberto Del Rio, Lorenzo Montanaro

Journal article  |  2014  |  PLOS ONE