Jennifer Juno

Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19

Jennifer A Juno, Hyon-Xhi Tan, Wen Shi Lee, Arnold Reynaldi, Hannah G Kelly, Kathleen Wragg, Robyn Esterbauer, Helen E Kent, C Jane Batten, Francesca L Mordant, Nicholas A Gherardin, Phillip Pymm, Melanie H Dietrich, Nichollas E Scott, Wai-Hong Tham, Dale Godfrey, Kanta Subbarao, Miles P Davenport, Stephen J Kent, Adam K Wheatley

Journal article  |  2020  |  Nature Medicine

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has dramatically expedited global vaccine development ef..

High CD26 and Low CD94 Expression Identifies an IL-23 Responsive V delta 2( ) T Cell Subset with a MAIT Cell-like Transcriptional Profile

Kathleen M Wragg, Hyon-Xhi Tan, Anne B Kristensen, Catriona Nguyen-Robertson, Anthony D Kelleher, Matthew S Parsons, Adam K Wheatley, Stuart P Berzins, Daniel G Pellicci, Stephen J Kent, Jennifer A Juno

Journal article  |  2020  |  Cell Reports

Vδ2+ T cells play a critical role in immunity to micro-organisms and cancer but exhibit substantial heterogeneity in humans. Here,..

Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.

Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Yi Ju, Wenbo Jiang, Verena C Wimmer, Brigette C Duckworth, Joanna R Groom, Frank Caruso, Masaru Kanekiyo, Stephen J Kent, Adam K Wheatley

Journal article  |  2020  |  JCI Insight

Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mecha..

What Can Gamma Delta T Cells Contribute to an HIV Cure?

Jennifer A Juno, Stephen J Kent

Journal article  |  2020  |  Frontiers in Cellular and Infection Microbiology

Elimination of the latent HIV reservoir remains a major barrier to achieving an HIV cure. In this review, we discuss the cytolytic..

MAIT cells are functionally impaired in a Mauritian cynomolgus macaque model of SIV and Mtb co-infection

Amy L Ellis, Alexis J Balgeman, Erica C Larson, Mark A Rodgers, Cassaundra Ameel, Tonilynn Baranowski, Nadean Kannal, Pauline Maiello, Jennifer A Juno, Charles A Scanga, Shelby L O'Connor

Journal article  |  2020  |  PLOS Pathogens

Mucosal-associated invariant T (MAIT) cells can recognize and respond to some bacterially infected cells. Several in vitro and in ..

Short Communication: Effect of Seminal Plasma on Functions of Monocytes and Granulocytes

Kevin J Selva, Jennifer A Juno, Matthew J Worley, Amy W Chung, Gilda Tachedjian, Stephen J Kent, Matthew S Parsons

Journal article  |  2019  |  AIDS Research and Human Retroviruses

Modulation of the CCR5 Receptor/Ligand Axis by Seminal Plasma and the Utility of In Vitro versus In Vivo Models

Jennifer A Juno, Kathleen M Wragg, Anne B Kristensen, Wen Shi Lee, Kevin J Selva, Renee M van der Sluis, Anthony D Kelleher, Benjamin R Bavinton, Andrew E Grulich, Sharon R Lewin, Stephen J Kent, Matthew S Parsons

Journal article  |  2019  |  JOURNAL OF VIROLOGY

Identification of murine antigen-specific T follicular helper cells using an activation-induced marker assay

Wenbo Jiang, Kathleen M Wragg, Hyon-Xhi Tan, Hannah G Kelly, Adam K Wheatley, Stephen J Kent, Jennifer A Juno

Journal article  |  2019  |  Journal of Immunological Methods

Protective antibody (Ab) responses induced by natural infection or vaccination play a central role in defense against invasive pat..

MAIT Cells Upregulate alpha 4 beta 7 in Response to Acute Simian Immunodeficiency Virus/Simian HIV Infection but Are Resistant to Peripheral Depletion in Pigtail Macaques

Jennifer A Juno, Kathleen M Wragg, Thakshila Amarasena, Bronwyn S Meehan, Jeffrey YW Mak, Ligong Liu, David P Fairlie, James McCluskey, Sidonia BG Eckle, Stephen J Kent

Journal article  |  2019  |  The Journal of Immunology

Inducible Bronchus-Associated Lymphoid Tissues (iBALT) Serve as Sites of B Cell Selection and Maturation Following Influenza Infection in Mice

Hyon-Xhi Tan, Robyn Esterbauer, Hillary A Vanderven, Jennifer A Juno, Stephen J Kent, Adam K Wheatley

Journal article  |  2019  |  Frontiers in Immunology

Perturbation of mucosal-associated invariant T cells and iNKT cells in HIV infection

Jennifer A Juno, Chansavath Phetsouphanh, Paul Klenerman, Stephen J Kent

Journal article  |  2019  |  Current Opinion in HIV and AIDS

Influenza Virus Infection Enhances Antibody-Mediated NK Cell Functions via Type I Interferon-Dependent Pathways

Sinthujan Jegaskanda, Hillary A Vanderven, Hyon-Xhi Tan, Sheilajen Alcantara, Kathleen M Wragg, Matthew S Parsons, Amy W Chung, Jennifer A Juno, Stephen J Kent

Journal article  |  2019  |  Journal of Virology

Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem

Hyon-Xhi Tan, Sinthujan Jegaskanda, Jennifer A Juno, Robyn Esterbauer, Julius Wong, Hannah G Kelly, Yi Liu, Danielle Tilmanis, Aeron C Hurt, Jonathan W Yewdell, Stephen J Kent, Adam K Wheatley

Journal article  |  2019  |  Journal of Clinical Investigation

gamma delta T-cell responses during HIV infection and antiretroviral therapy

Jennifer A Juno, Emily M Eriksson

Journal article  |  2019  |  Clinical & Translational Immunology

HIV infection is associated with a rapid and sustained inversion of the Vδ1:Vδ2 T-cell ratio in peripheral blood. Studies of antir..

Mucosal-Associated Invariant T Cells Are Depleted and Exhibit Altered Chemokine Receptor Expression and Elevated Granulocyte Macrophage-Colony Stimulating Factor Production During End-Stage Renal Disease

Jennifer A Juno, Jillian LM Waruk, Kathleen M Wragg, Christine Mesa, Carmen Lopez, Joe Bueti, Stephen J Kent, T Blake Ball, Sandra A Kiazyk

Journal article  |  2018  |  Frontiers in Immunology

gamma delta T-cell function is inhibited in end-stage renal disease and impacted by latent tuberculosis infection

Jennifer A Juno, Jillian LM Waruk, Angela Harris, Christine Mesa, Carmen Lopez, Joe Bueti, T Blake Ball, Sandra A Kiazyk

Journal article  |  2017  |  Kidney International

Cytotoxic CD4 T Cells-Friend or Foe during Viral Infection?

Jennifer A Juno, David van Bockel, Stephen J Kent, Anthony D Kelleher, John J Zaunders, C Mee Ling Munier

Journal article  |  2017  |  Frontiers in Immunology

IFN-gamma promoter polymorphisms do not affect QuantiFERON((R)) TB Gold In-Tube test results in a Canadian population

S Kiazyk, L Larcombe, C Lopez, S Matyas, C Mesa, P Orr, J Juno, J Waruk, M Sharma, TB Ball

Journal article  |  2016  |  The International Journal of Tuberculosis and Lung Disease

IFN- promoter polymorphisms do not affect QuantiFERON TB Gold In-Tube test results in a Canadian population.

S Kiazyk, L Larcombe, C Lopez, S Matyas, C Mesa, P Orr, J Juno, J Waruk, M Sharma, TB Ball

Journal article  |  2016  |  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

BACKGROUND: Several studies have shown polymorphisms within the interferon-gamma (IFN-) promoter influence cytokine expression. Th..

Maintenance of Mycobacterium tuberculosis-specific T cell responses in End Stage Renal Disease (ESRD) and implications for diagnostic efficacy

Jennifer A Juno, Jillian LM Waruk, Christine Mesa, Carmen Lopez, Joe Bueti, T Blake Ball, Sandra A Kiazyk

Journal article  |  2016  |  Clinical Immunology

Cytokine and chemokine expression profiles in response to Mycobacterium tuberculosis stimulation are altered in HIV-infected compared to HIV-uninfected subjects with active tuberculosis

Jillian LM Waruk, Zipporah Machuki, Christine Mesa, Jennifer A Juno, Omu Anzala, Meenu Sharma, T Blake Ball, Julius Oyugi, Sandra Kiazyk

Journal article  |  2015  |  Tuberculosis

Short Communication: Low Expression of Activation and Inhibitory Molecules on NK Cells and CD4( ) T Cells Is Associated with Viral Control

Natalia A Taborda, Juan C Hernandez, Julie Lajoie, Jennifer A Juno, Joshua Kimani, Maria T Rugeles, Keith R Fowke

Journal article  |  2015  |  AIDS Research and Human Retroviruses

Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment

Jennifer A Juno, Andrew T Stalker, Jillian LM Waruk, Julius Oyugi, Makobu Kimani, Francis A Plummer, Joshua Kimani, Keith R Fowke

Journal article  |  2015  |  Retrovirology

Enrichment of LAG-3, but not PD-1, on Double Negative T Cells at the Female Genital Tract

Jennifer A Juno, Julie Lajoie, Andrew T Stalker, Julius Oyugi, Makobu Kimani, Joshua Kimani, Francis A Plummer, Keith R Fowke

Journal article  |  2014  |  American Journal of Reproductive Immunology

Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples

Jennifer A Juno, Genevieve Boily-Larouche, Julie Lajoie, Keith R Fowke

Journal article  |  2014  |  Journal of Visualized Experiments

High HIV risk in a cohort of male sex workers from Nairobi, Kenya

Lyle R McKinnon, Gloria Gakii, Jennifer A Juno, Preston Izulla, Julius Munyao, Naomi Ireri, Cecilia W Kariuki, Souradet Y Shaw, Nico JD Nagelkerke, Lawrence Gelmon, Helgar Musyoki, Nicholas Muraguri, Rupert Kaul, Rob Lorway, Joshua Kimani

Journal article  |  2014  |  Sexually Transmitted Infections

Invariant NKT Cells: Regulation and Function during Viral Infection

Jennifer A Juno, Yoav Keynan, Keith R Fowke

Journal article  |  2012  |  PLoS Pathogens

C868T Single Nucleotide Polymorphism and HIV Type 1 Disease Progression Among Postpartum Women in Kenya

Robert Y Choi, Keith R Fowke, Jennifer Juno, Barbara Lohman-Payne, Julius O Oyugi, Elizabeth R Brown, Rose Bosire, Grace John-Stewart, Carey Farquhar

Journal article  |  2012  |  AIDS Research and Human Retroviruses

A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers

J Lajoie, J Juno, A Burgener, S Rahman, K Mogk, C Wachihi, J Mwanjewe, FA Plummer, J Kimani, TB Ball, KR Fowke

Journal article  |  2012  |  Mucosal Immunology

The role of G protein gene GNB3 C825T Polymorphism in HIV-1 acquisition, progression and immune activation

Jennifer Juno, Jeffrey Tuff, Robert Choi, Catherine Card, Joshua Kimani, Charles Wachihi, Sandra Koesters-Kiazyk, T Blake Ball, Carey Farquhar, Francis A Plummer, Grace John-Stewart, Ma Luo, Keith R Fowke

Journal article  |  2012  |  Retrovirology

Immunogenetic Factors Associated with Severe Respiratory Illness Caused by Zoonotic H1N1 and H5N1 Influenza Viruses

Jennifer Juno, Keith R Fowke, Yoav Keynan

Journal article  |  2012  |  Clinical and Developmental Immunology

Immunogenetic factors associated with severe respiratory illness caused by pandemic A/H1N1 influenza

Y Keynan, J Juno, KR Fowke

Journal article  |  2011  |  Current Trends in Immunology

Targeting the Chemokine Receptor CCR5: Good for HIV, What about Other Viruses?

Yoav Keynan, Jennifer Juno, Ken Kasper, Ethan Rubinstein, Keith R Fowke

Journal article  |  2011  |  The Journal of Infectious Diseases

Chemokine Receptor 5 Delta 32 Allele in Patients with Severe Pandemic (H1N1) 2009

Yoav Keynan, Jennifer Juno, Adrienne Meyers, T Blake Ball, Anand Kumar, Ethan Rubinstein, Keith R Fowke

Journal article  |  2010  |  Emerging Infectious Diseases

Clarifying the Role of G Protein Signaling in HIV Infection: New Approaches to an Old Question

Jennifer A Juno, Keith R Fowke

Journal article  |  2010  |  AIDS Reviews

Infant CD4 C868T polymorphism is associated with increased human immunodeficiency virus (HIV-1) acquisition

RY Choi, C Farquhar, J Juno, D Mbori-Ngacha, B Lohman-Payne, F Vouriot, S Wayne, J Tuff, R Bosire, G John-Stewart, K Fowke

Journal article  |  2010  |  Clinical & Experimental Immunology

Immunogenic profile of SARS-CoV-2 spike in individuals recovered from COVID-19

Jennifer A Juno, Hyon-Xhi Tan, Wen Shi Lee, Arnold Reynaldi, Hannah G Kelly, Kathleen Wragg, Robyn Esterbauer, Helen E Kent, C Jane Batten, Francesca L Mordant, Nicholas A Gherardin, Phillip Pymm, Melanie H Dietrich, Nichollas E Scott, Wai-Hong Tham, Dale I Godfrey, Kanta Subbarao, Miles P Davenport, Stephen J Kent, Adam K Wheatley

Journal article

The rapid global spread of SARS-CoV-2 and resultant mortality and social disruption have highlighted the need to better understand..