Kim-Anh Le Cao

Streptococcus species enriched in the oral cavity of patients with RA are a source of peptidoglycan-polysaccharide polymers that can induce arthritis in mice.

Rabia Moentadj, Yiwen Wang, Kate Bowerman, Linda Rehaume, Hendrik Nel, Paraic O Cuiv, Juliette Stephens, Amalina Baharom, Muralidhara Maradana, Vanessa Lakis, Mark Morrison, Timothy Wells, Philip Hugenholtz, Helen Benham, Kim-Anh Le Cao, Ranjeny Thomas

Journal article  |  2021  |  Annals of the Rheumatic Diseases

OBJECTIVES: Analysis of oral dysbiosis in individuals sharing genetic and environmental risk factors with rheumatoid arthritis (RA..

An integrated metagenomics and metabolomics approach implicates the microbiota-gut-brain axis in the pathogenesis of Huntington's disease

Geraldine Kong, Susan Ellul, Vinod K Narayana, Komal Kanojia, Harvey Tran Thai Ha, Shanshan Li, Thibault Renoir, Le Cao Kim-Anh, Anthony J Hannan

Journal article  |  2021  |  Neurobiology of Disease

BACKGROUND: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder with onset and severity of symptoms infl..

constclust: Consistent Clusters for scRNA-seq

Isaac Virshup, Jarny Choi, Kim-Anh Lê Cao, Christine Wells

Journal article  |  2020

1 Unsupervised clustering to identify distinct cell types is a crucial step in the analysis of scRNA-seq data. Current clustering ..

Interpretation of network-based integration from multi-omics longitudinal data

Antoine Bodein, Marie-Pier Scott-Boyer, Olivier Perin, Kim-Anh Lê Cao, Arnaud Droit

Journal article  |  2020

Cost reduction of high-throughput technologies has enabled the monitoring of the same biological sample across multiple omics stud..

Integrating independent microbial studies to build predictive models of anaerobic digestion inhibition by ammonia and phenol.

Simon Poirier, Sébastien Déjean, Cédric Midoux, Kim-Anh Lê Cao, Olivier Chapleur

Journal article  |  2020  |  Bioresource Technology

Anaerobic digestion (AD) is a process that can efficiently degrade organic waste into renewable energies. AD failure is however co..

Managing batch effects in microbiome data

Yiwen Wang, Kim-Anh Lecao

Journal article  |  2020  |  Briefings in Bioinformatics

Microbial communities have been increasingly studied in recent years to investigate their role in ecological habitats. However, mi..

A multivariate method to correct for batch effects in microbiome data

Yiwen Wang, Kim-Anh Lê Cao

Journal article  |  2020

Microbial communities are highly dynamic and sensitive to changes in the environment. Thus, microbiome data are highly susceptible..

Integrative Analyses to Investigate the Link between Microbial Activity and Metabolite Degradation during Anaerobic Digestion

Laetitia Cardona, Kim Anh Le Cao, Francesc Puig-Castellvi, Chrystelle Bureau, Celine Madigou, Laurent Mazeas, Olivier Chapleur

Journal article  |  2020  |  Journal of Proteome Research

A simple, scalable approach to building a cross-platform transcriptome atlas

Paul W Angel, Nadia Rajab, Yidi Deng, Chris M Pacheco, Tyrone Chen, Kim-Anh Le Cao, Jarny Choi, Christine A Wells

Journal article  |  2020  |  PLoS Computational Biology

Gene expression atlases have transformed our understanding of the development, composition and function of human tissues. New tech..

Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis

Aimee L Hanson, Damjan Vukcevic, Stephen Leslie, Jessica Harris, Kim-Anh Le Cao, Tony J Kenna, Matthew A Brown

Journal article  |  2020  |  PLoS Genetics

The killer immunoglobulin-like receptors (KIRs), found predominantly on the surface of natural killer (NK) cells and some T-cells,..