Kim-Anh Le Cao

Interpretation of network-based integration from multi-omics longitudinal data

Antoine Bodein, Marie-Pier Scott-Boyer, Olivier Perin, Kim-Anh Lê Cao, Arnaud Droit

Journal article  |  2020

Abstract Cost reduction of high-throughput technologies has enabled the monitoring of the same biological sample across multiple o..

A multivariate method to correct for batch effects in microbiome data

Yiwen Wang, Kim-Anh Lê Cao

Journal article  |  2020

Abstract Microbial communities are highly dynamic and sensitive to changes in the environment. Thus, microbiome data are highly su..

A simple, scalable approach to building a cross-platform transcriptome atlas

Paul W Angel, Nadia Rajab, Yidi Deng, Chris M Pacheco, Tyrone Chen, Kim-Anh Le Cao, Jarny Choi, Christine A Wells

Journal article  |  2020  |  PLOS Computational Biology

Gene expression atlases have transformed our understanding of the development, composition and function of human tissues. New tech..

Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis

Aimee L Hanson, Damjan Vukcevic, Stephen Leslie, Jessica Harris, Kim-Anh Le Cao, Tony J Kenna, Matthew A Brown

Journal article  |  2020  |  PLoS Genetics

The killer immunoglobulin-like receptors (KIRs), found predominantly on the surface of natural killer (NK) cells and some T-cells,..

Taxonomic and functional assessment using metatranscriptomics reveals the effect of Angus cattle on rumen microbial signatures

ALA Neves, Y Chen, K-A Le Cao, S Mandal, TJ Sharpton, T McAllister, LL Guan

Journal article  |  2020  |  animal

A greater understanding of the rumen microbiota and its function may help find new strategies to improve feed efficiency in cattle..

Integrating independent microbial studies to build predictive models of anaerobic digestion inhibition by ammonia and phenol

Simon Poirier, Sébastien Déjean, Cédric Midoux, Kim-Anh Lê Cao, Olivier Chapleur

Journal article  |  2020

Abstract Anaerobic digestion (AD) is a microbial process that can efficiently degrade organic waste into renewable energies such a..

A simple, scalable approach to building a cross-platform transcriptome atlas

Paul Angel, Nadia Rajab, Yidi Deng, Chris Pacheco, Tyrone Chen, Kim-Anh Lê Cao, Jarny Choi, Christine Wells

Journal article  |  2020

ABSTRACT Gene expression atlases have transformed our understanding of the development, composition and function of human tissues...

The role of gut microbiota and gastrointestinal dysfunction in a mouse model of Huntington's disease

Carolina Gubert, Geraldine Kong, Jamie JM Liew, Chloe Love, Yiwen Wang, Kim-Anh Le Cao, Thibault Renoir, Anthony J Hannan

Conference Proceedings  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY

Integrative analyses to investigate the link between microbial activity and metabolites degradation during anaerobic digestion

Laetitia Cardona, Kim Anh Lê Cao, Francesc Puig-Castellví, Chrystelle Bureau, Céline Madigou, Laurent Mazéas, Olivier Chapleur

Journal article  |  2020

Abstract Anaerobic digestion (AD) is a promising biological process which converts waste into sustainable energy. To fully exploit..

Microbiome profiling reveals gut dysbiosis in a transgenic mouse model of Huntington's disease

Geraldine Kong, Le Cao Kim-Anh, Louise M Judd, ShanShan Li, Thibault Renoir, Anthony J Hannan

Journal article  |  2020  |  Neurobiology of Disease

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a trinucleotide repeat expansion in the huntingtin..