Andrew Kueh

A Hypomorphic Dars1(D367Y) Model Recapitulates Key Aspects of the Leukodystrophy HBSL

Dominik Frohlich, Marisa I Mendes, Andrew J Kueh, Andre Bongers, Marco J Herold, Gajja S Salomons, Gary D Housley, Matthias Klugmann

Journal article  |  2021  |  Frontiers in Cellular Neuroscience

Hypomyelination with brain stem and spinal cord involvement and leg spasticity (HBSL) is a leukodystrophy caused by missense mutat..

Severe Impairment of TNF Post-transcriptional Regulation Leads to Embryonic Death

Elise Clayer, Destiny Dalseno, Andrew Kueh, Derek Lacey, Minhsuang Tsai, Elysa Carr, Verena C Wimmer, Philippe Bouillet

Journal article  |  2020  |  iScience

Post-transcriptional regulation mechanisms control mRNA stability or translational efficiency via ribosomes, and recent evidence i..

TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis

Christina Nedeva, Joseph Menassa, Mubing Duan, Chuanxin Liu, Marcel Doerflinger, Andrew J Kueh, Marco J Herold, Pamali Fonseka, Thanh Kha Phan, Pierre Faou, Harinda Rajapaksha, Weisan Chen, Mark D Hulett, Hamsa Puthalakath

Journal article  |  2020  |  Nature Immunology

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang, et al.

Journal article  |  2020  |  Immunity

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..

The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

Susanna S Ng, Fabian De Labastida Rivera, Juming Yan, Dillon Corvino, Indrajit Das, Ping Zhang, Rachel Kuns, Shashi Bhushan Chauhan, Jiajie Hou, Xian-Yang Li, Teija CM Frame, Benjamin A McEnroe, Eilish Moore, Jinrui Na, Jessica A Engel, Megan SF Soon, Bhawana Singh, Andrew J Kueh, Marco J Herold, Marcela Montes de Oca, et al.

Journal article  |  2020  |  Nature Immunology

Targeting platelets for improved outcome in KRAS-driven lung adenocarcinoma

Stephanie R Hyslop, Marliese Alexander, Alesha A Thai, Ariena Kersbergen, Andrew J Kueh, Marco J Herold, Jason Corbin, Pradnya Gangatirkar, Ashley P Ng, Benjamin J Solomon, Warren S Alexander, Kate D Sutherland, Emma C Josefsson

Journal article  |  2020  |  Oncogene

Elevated platelet count is associated with poor survival in certain solid cancers, including lung cancer. In addition, experimenta..

An Erg-driven transcriptional program controls B cell lymphopoiesis.

Ashley P Ng, Hannah D Coughlan, Soroor Hediyeh-Zadeh, Kira Behrens, Timothy M Johanson, Michael Sze Yuan Low, Charles C Bell, Omer Gilan, Yih-Chih Chan, Andrew J Kueh, Thomas Boudier, Rebecca Feltham, Anna Gabrielyan, Ladina DiRago, Craig D Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark A Dawson, et al.

Journal article  |  2020  |  Nature Communications

B lymphoid development is initiated by the differentiation of hematopoietic stem cells into lineage committed progenitors, ultimat..

HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells

Andrew J Kueh, Samantha Eccles, Leonie Tang, Alexandra L Garnham, Rose E May, Marco J Herold, Gordon K Smyth, Anne K Voss, Tim Thomas

Journal article  |  2020  |  Molecular and Cellular Biology

HBO1 (MYST2/KAT7) is essential for histone 3 lysine 14 acetylation (H3K14ac) but is dispensable for H4 acetylation and DNA replica..

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Najoua Lalaoui, Steven E Boyden, Hirotsugu Oda, Geryl M Wood, Deborah L Stone, Diep Chau, Lin Liu, Monique Stoffels, Tobias Kratina, Kate E Lawlor, Kristien JM Zaal, Patrycja M Hoffmann, Nima Etemadi, Kristy Shield-Artin, Christine Biben, Wanxia Li Tsai, Mary D Blake, Hye Sun Kuehn, Dan Yang, Holly Anderton, et al.

Journal article  |  2020  |  Nature

RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post..

Therapeutic blockade of CXCR2 rapidly clears inflammation in arthritis and atopic dermatitis models: demonstration with surrogate and humanized antibodies

Md Jahangir Alam, Liang Xiea, Caroline Ang, Farnaz Fahimi, Stephen B Willingham, Andrew J Kueh, Marco J Herold, Charles R Mackay, Remy Robert

Journal article  |  2020  |  mAbs

Neutrophils are the most abundant effector cells of the innate immune system and represent the first line of defense against infec..