Andrew Kueh

HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells.

Andrew J Kueh, Samantha Eccles, Leonie Tang, Alexandra L Garnham, Rose E May, Marco J Herold, Gordon K Smyth, Anne K Voss, Tim Thomas

Journal article  |  2020  |  Molecular and Cellular Biology

HBO1 (MYST2/KAT7) is essential for histone 3 lysine 14 acetylation (H3K14ac) but is dispensable for H4 acetylation and DNA replica..

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Najoua Lalaoui, Steven E Boyden, Hirotsugu Oda, Geryl M Wood, Deborah L Stone, Diep Chau, Lin Liu, Monique Stoffels, Tobias Kratina, Kate E Lawlor, Kristien JM Zaal, Patrycja M Hoffmann, Nima Etemadi, Kristy Shield-Artin, Christine Biben, Wanxia Li Tsai, Mary D Blake, Hye Sun Kuehn, Dan Yang, Holly Anderton, et al.

Journal article  |  2020  |  Nature

RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post..

Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation

Brianna J Klein, Suk Min Jang, Catherine Lachance, Wenyi Mi, Jie Lyu, Shun Sakuraba, Krzysztof Krajewski, Wesley W Wang, Simone Sidoli, Jiuyang Liu, Yi Zhang, Xiaolu Wang, Becka M Warfield, Andrew J Kueh, Anne K Voss, Tim Thomas, Benjamin A Garcia, Wenshe R Liu, Brian D Strahl, Hidetoshi Kono, et al.

Journal article  |  2019  |  Nature Communications

Acetylation of histone H3K23 has emerged as an essential posttranslational modification associated with cancer and learning and me..

BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals

Rahul Srivastava, Zhipeng Cao, Christina Nedeva, Samara Naim, Daniel Bachmann, Tatiana Rabachini, Lahiru Gangoda, Sanjay Shahi, Jason Glab, Joseph Menassa, Laura Osellame, Tao Nelson, Yuniel Fernandez-Marrero, Fiona Brown, Andrew Wei, Francine Ke, Lorraine O'Reilly, Marcel Doerflinger, Cody Allison, Andrew Kueh, et al.

Journal article  |  2019  |  Proceedings of the National Academy of Sciences

BCL-2 family proteins regulate the mitochondrial apoptotic pathway. BOK, a multidomain BCL-2 family protein, is generally believed..

TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1

Loic Lionnard, Pauline Duc, Margs S Brennan, Andrew J Kueh, Martin Pal, Francesca Guardia, Barbara Mojsa, Maria-Alessandra Damiano, Stephan Mora, Irena Lassot, Ramya Ravichandran, Claude Cochet, Abdel Aouacheria, Patrick Ryan Potts, Marco J Herold, Solange Desagher, Jerome Kucharczak

Journal article  |  2019  |  Cell Death & Differentiation

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia

Helen M McRae, Alexandra L Garnham, Yifang Hu, Matthew T Witkowski, Mark A Corbett, Mathew P Dixon, Rose E May, Bilal N Sheikh, William Chiang, Andrew J Kueh, Tan A Nguyen, Kevin Man, Renee Gloury, Brandon J Aubrey, Antonia Policheni, Ladina Di Rago, Warren S Alexander, Daniel HD Gray, Andreas Strasser, Edwin D Hawkins, et al.

Journal article  |  2019  |  Blood

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects

Alex RD Delbridge, Andrew J Kueh, Francine Ke, Natasha M Zamudio, Farrah El-Saafin, Natasha Jansz, Gao-Yuan Wang, Megan Iminitoff, Tamara Beck, Sue Haupt, Yifang Hu, Rose E May, Lachlan Whitehead, Lin Tai, William Chiang, Marco J Herold, Ygal Haupt, Gordon K Smyth, Tim Thomas, Marnie E Blewitt, et al.

Journal article  |  2019  |  Cell Reports

Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT

Michael Chopin, Aaron T Lun, Yifan Zhan, Jaring Schreuder, Hannah Coughlan, Angela D'Amico, Lisa A Mielke, Francisca F Almeida, Andrew J Kueh, Ross A Dickins, Gabrielle T Belz, Shalin H Naik, Andrew M Lew, Phillipe Bouillet, Marco J Herold, Gordon K Smyth, Lynn M Corcoran, Stephen L Nutt

Journal article  |  2019  |  Immunity

Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

Nai Yang Fu, Bhupinder Pal, Yunshun Chen, Felicity C Jackling, Michael Milevskiy, Francois Vaillant, Bianca D Capaldo, Fusheng Guo, Kevin H Liu, Anne C Rios, Nicholas Lim, Andrew J Kueh, David M Virshup, Marco J Herold, Haley O Tucker, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2018  |  Developmental Cell

VDAC2 enables BAX to mediate apoptosis and limit tumor development

Hui San Chin, Mark X Li, Iris KL Tan, Robert L Ninnis, Boris Reljic, Kristen Scicluna, Laura F Dagley, Jarrod J Sandow, Gemma L Kelly, Andre L Samson, Stephane Chappaz, Seong L Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M Hall, Andrew J Kueh, Michael T Ryan, et al.

Journal article  |  2018  |  Nature Communications

Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor development

Brandon J Aubrey, Ana Janic, Yunshun Chen, Catherine Chang, Elizabeth C Lieschke, Sarah T Diepstraten, Andrew J Kueh, Jonathan P Bernardini, Grant Dewson, Lorraine A O'Reilly, Lachlan Whitehead, Anne K Voss, Gordon K Smyth, Andreas Strasser, Gemma L Kelly

Journal article  |  2018  |  Genes & Development

Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities

Stephanie Grabow, Andrew J Kueh, Francine Ke, Hannah K Vanyai, Bilal N Sheikh, Michael A Dengler, William Chiang, Samantha Eccles, Ian M Smyth, Lynelle K Jones, Frederic J de Sauvage, Mark Scott, Lachlan Whitehead, Anne K Voss, Andreas Strasser

Journal article  |  2018  |  Cell Reports

Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins

Stephanie Trezise, Alexander Karnowski, Pasquale L Fedele, Sridurga Mithraprabhu, Yang Liao, Kathy D'Costa, Andrew J Kueh, Matthew P Hardy, Catherine M Owczarek, Marco J Herold, Andrew Spencer, Wei Shi, Simon N Willis, Stephen L Nutt, Lynn M Corcoran

Journal article  |  2018  |  International Journal of Molecular Sciences

DNA repair processes are critical mediators of p53-dependent tumor suppression

Ana Janic, Liz J Valente, Matthew J Wakefield, Leon Di Stefano, Liz Milla, Stephen Wilcox, Haoyu Yang, Lin Tai, Cassandra J Vandenberg, Andrew J Kueh, Shinsuke Mizutani, Margs S Brennan, Robyn L Schenk, Lisa M Lindqvist, Anthony T Papenfuss, Liam O'Connor, Andreas Strasser, Marco J Herold

Journal article  |  2018  |  Nature Medicine

CRISPR/Cas9: A tool for immunological research

Katharina Hochheiser, Andrew J Kueh, Thomas Gebhardt, Marco J Herold

Journal article  |  2018  |  European Journal of Immunology

Loss of NF-kappa B1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner

Lorraine A O'Reilly, Tracy L Putoczki, Lisa A Mielke, Jun T Low, Ann Lin, Adele Preaudet, Marco J Herold, Kelvin Yaprianto, Lin Tai, Andrew Kueh, Guido Pacini, Richard L Ferrero, Raffi Gugasyan, Yifang Hu, Michael Christie, Stephen Wilcox, Raelene Grumont, Michael DW Griffin, Liam O'Connor, Gordon K Smyth, et al.

Journal article  |  2018  |  Immunity

A point mutation in the Ncr1 signal peptide impairs the development of innate lymphoid cell subsets

Francisca F Almeida, Sara Tognarelli, Antoine Marcais, Andrew J Kueh, Miriam E Friede, Yang Liao, Simon N Willis, Kylie Luong, Fabrice Faure, Francois E Mercier, Justine Galluso, Matthew Firth, Emilie Narni-Mancinelli, Bushra Rais, David T Scadden, Francesco Spallotta, Sandra Weil, Ariane Giannattasio, Franziska Kalensee, Tobias Zoeller, et al.

Journal article  |  2018  |  OncoImmunology

An update on using CRISPR/Cas9 in the one-cell stage mouse embryo for generating complex mutant alleles

Andrew J Kueh, Martin Pal, Lin Tai, Yang Liao, Gordon K Smyth, Wei Shi, Marco J Herold

Journal article  |  2017  |  Cell Death & Differentiation

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis

Jason A Glab, Marcel Doerflinger, Christina Nedeva, Irvin Jose, George W Mbogo, James C Paton, Adrienne W Paton, Andrew J Kueh, Marco J Herold, David CS Huang, David Segal, Gabriella Brumatti, Hamsa Puthalakath

Journal article  |  2017  |  Cell Death & Differentiation

A non-canonical function of Ezh2 preserves immune homeostasis

Ajithkumar Vasanthakumar, Dakang Xu, Aaron TL Lun, Andrew J Kueh, Klaas PJM van Gisbergen, Nadia Iannarella, Xiaofang Li, Liang Yu, Die Wang, Bryan RG Williams, Stanley CW Lee, Ian J Majewski, Dale I Godfrey, Gordon K Smyth, Warren S Alexander, Marco J Herold, Axel Kallies, Stephen L Nutt, Rhys S Allan

Journal article  |  2017  |  EMBO reports

Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7

Isobel D Lawrenson, Danielle L Krebs, Edmond M Linossi, Jian-Guo Zhang, Tamara J McLennan, Caitlin Collin, Helen M Mcrae, Tatiana B Kolesnik, Katrina Koh, Joanne M Britto, Andrew J Kueh, Bilal N Sheikh, Farrah El-Saafin, Nicos A Nicola, Seong-Seng Tan, Jeffrey J Babon, Sandra E Nicholson, Warren S Alexander, Tim Thomas, Anne K Voss

Journal article  |  2017  |  Cerebral Cortex

Male sterility in Mcl-1-flox mice is not due to enhanced Mcl1 protein stability

Casey Ah-Cann, Maximilien Tailler, Andrew J Kueh, Marco J Herold, Joseph T Opferman, Marie-Liesse Asselin-Labat, Philippe Bouillet

Journal article  |  2016  |  Cell Death & Disease

Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM

Leona Rohrbeck, Jia-Nan Gong, Erinna F Lee, Andrew J Kueh, Andreas Behren, Lin Tai, Guillaume Lessene, David CS Huang, Walter D Fairlie, Andreas Strasser, Marco J Herold

Journal article  |  2016  |  Cell Death & Differentiation

The new editor-targeted genome engineering in the absence of homology-directed repair

AJ Kueh, MJ Herold

Journal article  |  2016  |  Cell Death Discovery

Using CRISPR/Cas9 Technology for Manipulating Cell Death Regulators.

Andrew J Kueh, Marco J Herold

Journal article  |  2016  |  Methods in molecular biology (Clifton, N.J.)

Clustered, regularly interspaced, short palindromic repeats (CRISPR)/Cas9 technology has been demonstrated to be a useful tool for..

MOZ (MYST3, KAT6A) inhibits senescence via the INK4A-ARF pathway

BN Sheikh, B Phipson, F El-Saafin, HK Vanyai, NL Downer, MJ Bird, AJ Kueh, RE May, GK Smyth, AK Voss, T Thomas

Journal article  |  2015  |  Oncogene

MOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo

Bilal N Sheikh, Natalie L Downer, Belinda Phipson, Hannah K Vanyai, Andrew J Kueh, Davis J McCarthy, Gordon K Smyth, Tim Thomas, Anne K Voss

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

An Inducible Lentiviral Guide RNA Platform Enables the Identification of Tumor-Essential Genes and Tumor-Promoting Mutations In Vivo

Brandon J Aubrey, Gemma L Kelly, Andrew J Kueh, Margs S Brennan, Liam O'Connor, Liz Milla, Stephen Wilcox, Lin Tai, Andreas Strasser, Marco J Herold

Journal article  |  2015  |  Cell Reports

Excessive versus Physiologically Relevant Levels of Retinoic Acid in Embryonic Stem Cell Differentiation

Bilal N Sheikh, Natalie L Downer, Andrew J Kueh, Tim Thomas, Anne K Voss

Journal article  |  2014  |  Stem Cells

Chromatin Immunoprecipitation of Mouse Embryos

Anne K Voss, Mathew P Dixon, Tamara McLennan, Andrew J Kueh, Tim Thomas

Journal article  |  2012  |  Methods in Molecular Biology

HBO1 Is Required for H3K14 Acetylation and Normal Transcriptional Activity during Embryonic Development

Andrew J Kueh, Mathew P Dixon, Anne K Voss, Tim Thomas

Journal article  |  2011  |  Molecular and Cellular Biology

Mof (MYST1 or KAT8) is essential for progression of embryonic development past the blastocyst stage and required for normal chromatin architecture

Tim Thomas, Mathew P Dixon, Andrew J Kueh, Anne K Voss

Journal article  |  2008  |  Molecular and Cellular Biology