Marcel Doerflinger

Caspase-2 does not play a critical role in cell death induction and bacterial clearance during Salmonella infection

Sven Engel, Marcel Doerflinger, Ariane R Lee, Andreas Strasser, Marco J Herold, Sammy Bedoui, Annabell Bachem

Journal article  |  2021  |  CELL DEATH AND DIFFERENTIATION

Macrophage and neutrophil death programs differentially confer resistance to tuberculosis

Michael Dominic Stutz, Cody Charles Allison, Samar Ojaimi, Simon Peter Preston, Marcel Doerflinger, Philip Arandjelovic, Lachlan Whitehead, Stefanie M Bader, Daniel Batey, Marie-Liesse Asselin-Labat, Marco J Herold, Andreas Strasser, Nicholas P West, Marc Pellegrini

Journal article  |  2021  |  IMMUNITY

Apoptosis can potently defend against intracellular pathogens by directly killing microbes and eliminating their replicative niche..

Procalcitonin and Interleukin-10 May Assist in Early Prediction of Bacteraemia in Children With Cancer and Febrile Neutropenia

Marcel Doerflinger, Gabrielle M Haeusler, Connie SN Li-Wai-Suen, Julia E Clark, Monica Slavin, Franz E Babl, Zoe Allaway, Francoise Mechinaud, Gordon K Smyth, Richard De Abreu Lourenco, Bob Phillips, Marc Pellegrini, Karin A Thursky

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

Objectives: Febrile neutropenia (FN) causes treatment disruption and unplanned hospitalization in children with cancer. Serum biom..

Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice

Phillip Pymm, Amy Adair, Li-Jin Chan, James P Cooney, Francesca L Mordant, Cody C Allison, Ester Lopez, Ebene R Haycroft, Matthew T O'Neill, Li Lynn Tan, Melanie H Dietrich, Damien Drew, Marcel Doerflinger, Michael A Dengler, Nichollas E Scott, Adam K Wheatley, Nicholas A Gherardin, Hariprasad Venugopal, Deborah Cromer, Miles P Davenport, et al.

Journal article  |  2021  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutralizing antibodies are important for immunity against SARS-CoV-2 and as therapeutics for the prevention and treatment of COVI..

Successful identification of predictive profiles for infection utilising systems-level immune analysis: a pilot study in patients with relapsed and refractory multiple myeloma

Marcel Doerflinger, Alexandra L Garnham, Saskia Freytag, Simon J Harrison, H Miles Prince, Hang Quach, Monica A Slavin, Marc Pellegrini, Benjamin W Teh

Journal article  |  2021  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Objectives: Patients with multiple myeloma (MM) are at increased risk for infection. Clinical assessment of infection risk is incr..

The role of MKK4 in T-cell development and immunity to viral infections

Simon P Preston, Marcel Doerflinger, Hamish W Scott, Cody C Allison, Miles Horton, James Cooney, Marc Pellegrini

Journal article  |  2020  |  IMMUNOLOGY AND CELL BIOLOGY

The stress-activated protein kinases (SAPKs)/c-Jun-N-terminal-kinases (JNK) are members of the mitogen-activated protein kinase fa..

Pseudotumor presentation of CMV disease: Diagnostic dilemma and association with immunomodulating therapy

Olivia C Smibert, Cody C Allison, Marcel Doerflinger, Marc Pellegrini, Danny Rischin, Alesha Thai, Monica A Slavin, Camille N Kotton

Journal article  |  2020  |  TRANSPLANT INFECTIOUS DISEASE

Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in the immunocompromised host. Atypical presentations whic..

TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis

Christina Nedeva, Joseph Menassa, Mubing Duan, Chuanxin Liu, Marcel Doerflinger, Andrew J Kueh, Marco J Herold, Pamali Fonseka, Thanh Kha Phan, Pierre Faou, Harinda Rajapaksha, Weisan Chen, Mark D Hulett, Hamsa Puthalakath

Journal article  |  2020  |  NATURE IMMUNOLOGY

Sepsis is a biphasic disease characterized by an acute inflammatory response, followed by a prolonged immunosuppressive phase. The..

Circulating BiP/Grp78 is a novel prognostic marker for sepsis-mediated immune cell death

Marcel Doerflinger, Boris Reljic, Joseph Menassa, Christina Nedeva, Irvin Jose, Pierre Faou, Liana Mackiewicz, Ashley Mansell, Marc Pellegrini, Richard Hotchkiss, Hamsa Puthalakath

Journal article  |  2020  |  FEBS JOURNAL

Sepsis remains to be a major contributor to mortality in ICUs, and immune suppression caused by immune cell apoptosis determines t..

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang, et al.

Journal article  |  2020  |  IMMUNITY

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..