Marcel Doerflinger

Successful identification of predictive profiles for infection utilising systems-level immune analysis: a pilot study in patients with relapsed and refractory multiple myeloma

Marcel Doerflinger, Alexandra L Garnham, Saskia Freytag, Simon J Harrison, H Miles Prince, Hang Quach, Monica A Slavin, Marc Pellegrini, Benjamin W Teh

Journal article  |  2021  |  Clinical & Translational Immunology

Objectives: Patients with multiple myeloma (MM) are at increased risk for infection. Clinical assessment of infection risk is incr..

The role of MKK4 in T-cell development and immunity to viral infections

Simon P Preston, Marcel Doerflinger, Hamish W Scott, Cody C Allison, Miles Horton, James Cooney, Marc Pellegrini

Journal article  |  2020  |  Immunology and Cell Biology

The Stress activated protein kinases (SAPKs)/c-Jun-N-terminal-kinases (JNK) are members of the mitogen activated protein kinase (M..

Pseudotumor presentation of CMV disease: Diagnostic dilemma and association with immunomodulating therapy

Olivia C Smibert, Cody C Allison, Marcel Doerflinger, Marc Pellegrini, Danny Rischin, Alesha Thai, Monica A Slavin, Camille N Kotton

Journal article  |  2020  |  Transplant Infectious Disease

Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in the immunocompromised host. Atypical presentations whic..

TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis

Christina Nedeva, Joseph Menassa, Mubing Duan, Chuanxin Liu, Marcel Doerflinger, Andrew J Kueh, Marco J Herold, Pamali Fonseka, Thanh Kha Phan, Pierre Faou, Harinda Rajapaksha, Weisan Chen, Mark D Hulett, Hamsa Puthalakath

Journal article  |  2020  |  Nature Immunology

Circulating BiP/Grp78 is a novel prognostic marker for sepsis-mediated immune cell death

Marcel Doerflinger, Boris Reljic, Joseph Menassa, Christina Nedeva, Irvin Jose, Pierre Faou, Liana Mackiewicz, Ashley Mansell, Marc Pellegrini, Richard Hotchkiss, Hamsa Puthalakath

Journal article  |  2020  |  The FEBS Journal

Sepsis remains to be a major contributor to mortality in ICUs and immune suppression caused by immune cell apoptosis determines th..

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang, et al.

Journal article  |  2020  |  Immunity

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2

Theresa Klemm, Gregor Ebert, Dale J Calleja, Cody C Allison, Lachlan W Richardson, Jonathan P Bernardini, Bernadine GC Lu, Nathan W Kuchel, Christoph Grohmann, Yuri Shibata, Zhong Yan Gan, James P Cooney, Marcel Doerflinger, Amanda E Au, Timothy R Blackmore, Gerbrand J van der Heden van Noort, Paul P Geurink, Huib Ovaa, Janet Newman, Alan Riboldi-Tunnicliffe, et al.

Journal article  |  2020  |  The EMBO Journal

Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection

Gregor Ebert, Sash Lopaticki, Matthew T O'Neill, Ryan WJ Steel, Marcel Doerflinger, Pravin Rajasekaran, Annie SP Yang, Sara Erickson, Lisa Ioannidis, Philip Arandjelovic, Liana Mackiewicz, Cody Allison, John Silke, Marc Pellegrini, Justin A Boddey

Journal article  |  2020  |  Cell Reports

Plasmodium sporozoites infect the liver and develop into exoerythrocytic merozoites that initiate blood-stage disease. The hepatoc..

Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria

Ann Ly, Yang Liao, Halina Pietrzak, Lisa J Ioannidis, Tom Sidwell, Renee Gloury, Marcel Doerflinger, Tony Triglia, Raymond Z Qin, Joanna R Groom, Gabrielle T Belz, Kim L Good-Jacobson, Wei Shi, Axel Kallies, Diana S Hansen

Journal article  |  2019  |  Cell Reports

Despite the key role that antibodies play in protection, the cellular processes mediating the acquisition of humoral immunity agai..

Current and emerging therapies to combat persistent intracellular pathogens

Philip Arandjelovic, Marcel Doerflinger, Marc Pellegrini

Journal article  |  2019  |  Current Opinion in Pharmacology

Intracellular pathogens such as HIV, hepatitis B virus, and Mycobacterium tuberculosis are responsible for millions of deaths worl..