Marcel Doerflinger

TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis

Christina Nedeva, Joseph Menassa, Mubing Duan, Chuanxin Liu, Marcel Doerflinger, Andrew J Kueh, Marco J Herold, Pamali Fonseka, Thanh Kha Phan, Pierre Faou, Harinda Rajapaksha, Weisan Chen, Mark D Hulett, Hamsa Puthalakath

Journal article  |  2020  |  Nature Immunology

Circulating BiP/Grp78 is a novel prognostic marker for sepsis-mediated immune cell death

Marcel Doerflinger, Boris Reljic, Joseph Menassa, Christina Nedeva, Irvin Jose, Pierre Faou, Liana Mackiewicz, Ashley Mansell, Marc Pellegrini, Richard Hotchkiss, Hamsa Puthalakath

Journal article  |  2020  |  The FEBS Journal

Sepsis remains to be a major contributor to mortality in ICUs and immune suppression caused by immune cell apoptosis determines th..

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang, et al.

Journal article  |  2020  |  Immunity

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2

Theresa Klemm, Gregor Ebert, Dale J Calleja, Cody C Allison, Lachlan W Richardson, Jonathan P Bernardini, Bernadine GC Lu, Nathan W Kuchel, Christoph Grohmann, Yuri Shibata, Zhong Yan Gan, James P Cooney, Marcel Doerflinger, Amanda E Au, Timothy R Blackmore, Gerbrand J van der Heden van Noort, Paul P Geurink, Huib Ovaa, Janet Newman, Alan Riboldi-Tunnicliffe, et al.

Journal article  |  2020  |  The EMBO Journal

Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection

Gregor Ebert, Sash Lopaticki, Matthew T O'Neill, Ryan WJ Steel, Marcel Doerflinger, Pravin Rajasekaran, Annie SP Yang, Sara Erickson, Lisa Ioannidis, Philip Arandjelovic, Liana Mackiewicz, Cody Allison, John Silke, Marc Pellegrini, Justin A Boddey

Journal article  |  2020  |  Cell Reports

Plasmodium sporozoites infect the liver and develop into exoerythrocytic merozoites that initiate blood-stage disease. The hepatoc..

Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria

Ann Ly, Yang Liao, Halina Pietrzak, Lisa J Ioannidis, Tom Sidwell, Renee Gloury, Marcel Doerflinger, Tony Triglia, Raymond Z Qin, Joanna R Groom, Gabrielle T Belz, Kim L Good-Jacobson, Wei Shi, Axel Kallies, Diana S Hansen

Journal article  |  2019  |  Cell Reports

Despite the key role that antibodies play in protection, the cellular processes mediating the acquisition of humoral immunity agai..

Current and emerging therapies to combat persistent intracellular pathogens

Philip Arandjelovic, Marcel Doerflinger, Marc Pellegrini

Journal article  |  2019  |  Current Opinion in Pharmacology

Intracellular pathogens such as HIV, hepatitis B virus, and Mycobacterium tuberculosis are responsible for millions of deaths worl..

BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals

Rahul Srivastava, Zhipeng Cao, Christina Nedeva, Samara Naim, Daniel Bachmann, Tatiana Rabachini, Lahiru Gangoda, Sanjay Shahi, Jason Glab, Joseph Menassa, Laura Osellame, Tao Nelson, Yuniel Fernandez-Marrero, Fiona Brown, Andrew Wei, Francine Ke, Lorraine O'Reilly, Marcel Doerflinger, Cody Allison, Andrew Kueh, et al.

Journal article  |  2019  |  Proceedings of the National Academy of Sciences of USA

BCL-2 family proteins regulate the mitochondrial apoptotic pathway. BOK, a multidomain BCL-2 family protein, is generally believed..

Unexpected overlapping roles of multiple caspases and programmed cell death pathways in the response to bacterial infection

Ranja Salvamoser, Paul G Whitney, Marcel Doerflinger, Sammy Bedoui, Andreas Strasser, Clare Bryant, Marco J Herold

Conference Proceedings  |  2019  |  CELL DEATH DISCOVERY

CRISPR/Cas9 screens identify novel Mycobacterium tuberculosis host cell death restriction factors as potential drug targets for treatment of Tuberculosis

M Doerflinger, M Stutz, L Milla, MJ Herold, M Pellegrini

Conference Proceedings  |  2019  |  CELL DEATH DISCOVERY