Edmond Linossi

State of the structure address on MET receptor activation by HGF.

Edmond M Linossi, Gabriella O Estevam, Masaya Oshima, James S Fraser, Eric A Collisson, Natalia Jura

Journal article  |  2021  |  Biochem Soc Trans

The MET receptor tyrosine kinase (RTK) and its cognate ligand hepatocyte growth factor (HGF) comprise a signaling axis essential f..

A survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics.

Jessica Knox, Nicolas Joly, Edmond M Linossi, José A Carmona-Negrón, Natalia Jura, Lionel Pintard, William Zuercher, Peter J Roy

Journal article  |  2021  |  Sci Rep

Over one billion people are currently infected with a parasitic nematode. Symptoms can include anemia, malnutrition, developmental..

Identification of a second binding site on the TRIM25 B30.2 domain

Akshay A D'Cruz, Nadia J Kershaw, Thomas J Hayman, Edmond M Linossi, Jessica J Chiang, May K Wang, Laura F Dagley, Tatiana B Kolesnik, Jian-Guo Zhang, Seth L Masters, Michael DW Griffin, Michaela U Gack, James M Murphy, Nicos A Nicola, Jeffrey J Babon, Sandra E Nicholson

Journal article  |  2018  |  BIOCHEMICAL JOURNAL

The retinoic acid-inducible gene-I (RIG-I) receptor recognizes short 5'-di- and triphosphate base-paired viral RNA and is a critic..

Understanding SOCS protein specificity

Edmond M Linossi, Dale J Calleja, Sandra E Nicholson

Journal article  |  2018  |  GROWTH FACTORS

The development and activity of our immune system are largely controlled by the action of pleiotropic cytokines and growth factors..

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling

Lukasz Kedzierski, Michelle D Tate, Alan C Hsu, Tatiana B Kolesnik, Edmond M Linossi, Laura Dagley, Zhaoguang Dong, Sarah Freeman, Giuseppe Infusini, Malcolm R Starkey, Nicola L Bird, Simon M Chatfield, Jeffrey J Babon, Nicholas Huntington, Gabrielle Belz, Andrew webb, Peter AB Wark, Nicos A Nicola, Jianqing Xu, Katherine Kedzierska, et al.

Journal article  |  2017  |  ELIFE

Influenza virus infections have a significant impact on global human health. Individuals with suppressed immunity, or suffering fr..

Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7

Isobel D Lawrenson, Danielle L Krebs, Edmond M Linossi, Jian-Guo Zhang, Tamara J McLennan, Caitlin Collin, Helen M Mcrae, Tatiana B Kolesnik, Katrina Koh, Joanne M Britto, Andrew J Kueh, Bilal N Sheikh, Farrah El-Saafin, Nicos A Nicola, Seong-Seng Tan, Jeffrey J Babon, Sandra E Nicholson, Warren S Alexander, Tim Thomas, Anne K Voss

Journal article  |  2017  |  CEREBRAL CORTEX

Mutations of the reelin gene cause severe defects in cerebral cortex development and profound intellectual impairment. While many ..

CIS is a potent checkpoint in NK cell-mediated tumor immunity

Rebecca B Delconte, Tatiana B Kolesnik, Laura F Dagley, Jai Rautela, Wei Shi, Eva M Putz, Kimberley Stannard, Jian-Guo Zhang, Charis Teh, Matt Firth, Takashi Ushiki, Christopher E Andoniou, Mariapia A Degli-Esposti, Phillip P Sharp, Caroline E Sanvitale, Giuseppe Infusini, Nicholas PD Liau, Edmond M Linossi, Christopher J Burns, Sebastian Carotta, et al.

Journal article  |  2016  |  NATURE IMMUNOLOGY

The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of signals from activating and inhib..

Structure and Functional Characterization of the Conserved JAK Interaction Region in the Intrinsically Disordered N-Terminus of SOCS5

Indu R Chandrashekaran, Biswaranjan Mohanty, Edmond M Linossi, Laura F Dagley, Eleanor WW Leung, James M Murphy, Jeffrey J Babon, Sandra E Nicholson, Raymond S Norton

Journal article  |  2015  |  BIOCHEMISTRY

SOCS5 can negatively regulate both JAK/STAT and EGF-receptor pathways and has therefore been implicated in regulating both the imm..

Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling (SOCS) proteins

Edmond M Linossi, Sandra E Nicholson

Journal article  |  2015  |  IMMUNOLOGICAL REVIEWS

The suppressor of cytokine signaling (SOCS) family of proteins are key negative regulators of cytokine and growth factor signaling..

Key Role of Suppressor of Cytokine Signaling 3 in Regulating gp130 Cytokine-Induced Signaling and Limiting Chondrocyte Responses During Murine Inflammatory Arthritis

Xiao Liu, Ben A Croker, Ian K Campbell, Stephanie J Gauci, Warren S Alexander, Brett A Tonkin, Nicole C Walsh, Edmond M Linossi, Sandra E Nicholson, Kate E Lawlor, Ian P Wicks

Journal article  |  2014  |  ARTHRITIS & RHEUMATOLOGY

OBJECTIVE: To examine the impact of the gp130 cytokine family on murine articular cartilage and to explore a potential regulatory ..