Nicole Messina

Mycobacterium ulcerans-specific immune response after immunisation with bacillus Calmette-Guerin (BCG) vaccine

Laure F Pittet, Marc Tebruegge, Binita Dutta, Susan Donath, Nicole Messina, Dan Casalaz, Willem A Hanekom, Warwick J Britton, Roy Robins-Browne, Nigel Curtis, Nicole Ritz

Journal article  |  2021  |  VACCINE

BACKGROUND: Bacillus Calmette-Guérin (BCG) vaccine provides partial protection against Buruli ulcer caused by Mycobacterium ulcera..

Mycobacterium tuberculosis-specific cytokine biomarkers to differentiate active TB and LTBI: A systematic review

Eva L Sudbury, Vanessa Clifford, Nicole L Messina, Rinn Song, Nigel Curtis

Journal article  |  2020  |  JOURNAL OF INFECTION

Objectives New tests are needed to overcome the limitations of existing immunodiagnostic tests for tuberculosis (TB) infection, in..

The impact of human single nucleotide polymorphisms on Bacillus Calmette-Guerin responses

Nicole L Messina, Mihai G Netea, Nigel Curtis

Journal article  |  2020  |  VACCINE

The influence of genetic variability on human immune responses has major implications for the understanding of disease mechanisms ..

A Potential Role for Epigenetically Mediated Trained Immunity in Food Allergy

Samira Imran, Melanie R Neeland, Rebecca Shepherd, Nicole Messina, Kirsten P Perrett, Mihai G Netea, Nigel Curtis, Richard Saffery, Boris Novakovic

Journal article  |  2020  |  ISCIENCE

The prevalence of IgE-mediated food allergy is increasing at a rapid pace in many countries. The association of high food allergy ..

Neonatal BCG Vaccination Reduces Interferon-gamma Responsiveness to Heterologous Pathogens in Infants From a Randomized Controlled

Bridget Freyne, Nicole L Messina, Susan Donath, Susie Germano, Rhian Bonnici, Kaya Gardiner, Dan Casalaz, Roy M Robins-Browne, Mihai G Netea, Katie L Flanagan, Toby Kollmann, Nigel Curtis

Journal article  |  2020  |  JOURNAL OF INFECTIOUS DISEASES

BACKGROUND: BCG vaccination has beneficial nonspecific (heterologous) effects that protect against nonmycobacterial infections. We..

The role of antibodies in Bacille Calmette Guérin-mediated immune responses and protection against tuberculosis in humans: A systematic review.

Matthew R Bright, Nigel Curtis, Nicole L Messina

Journal article  |  2020  |  Tuberculosis (Edinb)

BACKGROUND: The mechanisms underlying Bacille Calmette-Guérin (BCG) vaccine's protective effects against tuberculosis (TB) are inc..

Risk Factors for Carriage of Antibiotic-resistant Bacteria in Healthy Children in the Community A Systematic Review

Nicole L Messina, Deborah A Williamson, Roy Robins-Browne, Penelope A Bryant, Nigel Curtis

Journal article  |  2020  |  PEDIATRIC INFECTIOUS DISEASE JOURNAL

BACKGROUND: In addition to health care settings, antibiotic resistance has also been increasing in the community. Healthy children..

The emerging role of epigenetics in the immune response to vaccination and infection: a systematic review

Samantha Bannister, Nicole L Messina, Boris Novakovic, Nigel Curtis

Journal article  |  2020  |  EPIGENETICS

Extensive research has highlighted the role of infection-induced epigenetic events in the development of cancer. More recently, at..

The impact of vaccines on heterologous adaptive immunity

NL Messina, P Zimmermann, N Curtis

Journal article  |  2019  |  CLINICAL MICROBIOLOGY AND INFECTION

BACKGROUND: Vaccines induce antigen-specific memory in adaptive immune cells that enables long-lived protection against the target..

Study protocol for the Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR), a randomised controlled trial to determine the non-specific effects of neonatal BCG vaccination in a low-mortality setting

Nicole L Messina, Kaya Gardiner, Susan Donath, Katie Flanagan, Anne-Louise Ponsonby, Frank Shann, Roy Robins-Browne, Bridget Freyne, Veronica Abruzzo, Clare Morison, Lianne Cox, Susie Germano, Christel Zufferey, Petra Zimmermann, Katie J Allen, Peter Vuillermin, Mike South, Dan Casalaz, Nigel Curtis

Journal article  |  2019  |  BMJ OPEN

INTRODUCTION: BCG vaccination reduces all-cause infant mortality in high-mortality settings by more than can be attributed to prot..