Andrew Cox

YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth

Srimayee Vaidyanathan, Talhah M Salmi, Rasan M Sathiqu, Malcolm J McConville, Andrew G Cox, Kristin K Brown

Journal article  |  2022  |  DEVELOPMENTAL CELL

The coordinated regulation of growth control and metabolic pathways is required to meet the energetic and biosynthetic demands ass..

Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK Dependent Cell Death

Sylvain Garciaz, Andrew A Guirguis, Sebastian Muller, Fiona C Brown, Yih-Chih Chan, Ali Motazediani, Caitlin L Rowe, James A Kuzich, Kah Lok Chan, Kevin Tran, Lorey Smith, Laura MacPherson, Brian Liddicoat, Enid YN Lam, Tatiana Caneque, Marian L Burr, Veronique Litalien, Giovanna Pomilio, Mathilde Poplineau, Estelle Duprez, et al.

Journal article  |  2022  |  CANCER DISCOVERY

UNLABELLED: Cancer cell metabolism is increasingly recognized as providing an exciting therapeutic opportunity. However, a drug th..

Pharmacological Reduction of Mitochondrial Iron in AML Triggers a BAX/BAK Dependent Non-Canonical Cell Death Synergistic with Venetoclax

Sylvain Garciaz, Sebastian Muller, Andew Guirguis, Fiona C Brown, Yih Chih Chan, Mathilde Paplineau, Kevin Tran, Kah-Lok Chan, Laura Mac Pherson, Brian Liddicoat, Enid YN Lam, Tatiana Caneque, Marian L Burr, Veronique Litalien, Giovanna Pomilio, Estelle Duprez, David CS Huang, Sarah-Jane Dawson, Georg Ramm, Andrew G Cox, et al.

Conference Proceedings  |  2021  |  BLOOD

Abstract Although the BCL2 inhibitor venetoclax have been transformative in the management of AML, therapeutic resi..

Identification of NQO2 As a Protein Target in Small Molecule Modulation of Hepatocellular Function

Arnout G Schepers, Jing Shan, Andrew G Cox, Ada Huang, Helen Evans, Chad Walesky, Heather E Fleming, Wolfram Goessling, Sangeeta N Bhatia

Journal article  |  2021  |  ACS CHEMICAL BIOLOGY

The utility of in vitro human disease models is mainly dependent on the availability and functional maturity of tissue-specific ce..

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

K Watt, DC Henstridge, M Ziemann, CB Sim, MK Montgomery, D Samocha-Bonet, BL Parker, GT Dodd, ST Bond, TM Salmi, RS Lee, RE Thomson, A Hagg, JR Davey, H Qian, R Koopman, A El-Osta, JR Greenfield, MJ Watt, MA Febbraio, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Obesity is a major risk factor underlying the development of metabolic disease and a growing public health concern globally. Strat..

Imaging Mass Spectrometry Reveals Tumor Metabolic Heterogeneity

Yang Zhang, Christelle Guillermier, Thomas De Raedt, Andrew G Cox, Ophelia Maertens, Dean Yimlamai, Mingyue Lun, Adam Whitney, Richard L Maas, Wolfram Goessling, Karen Cichowski, Matthew L Steinhauser

Journal article  |  2020  |  ISCIENCE

Malignant tumors exhibit high degrees of genomic heterogeneity at the cellular level, leading to the view that subpopulations of t..

3039 – YAP REGULATES HEMATOPOIETIC STEM CELL FORMATION IN RESPONSE TO THE BIOMECHANICAL FORCES OF BLOOD FLOW

Wade Sugden, Vanessa Lundin, Lindsay Theodore, Patricia Sousa, Areum Han, Stephanie Chou, Paul Wrighton, Andrew Cox, Donald Ingber, Wolfram Goessling, George Daley, Trista North

Conference Proceedings  |  2020  |  Experimental Hematology

Yap reprograms de novo lipogenesis to fuel liver cancer

Talhah M Salmi, Srimayee Vaidyanathan, Malcolm J McConville, Kristin K Brown, Andrew G Cox

Conference Proceedings  |  2020  |  CANCER RESEARCH

Abstract Hepatocellular carcinoma (HCC) is the most common form of liver cancer, originating from liver cells known..

YAP REGULATES HEMATOPOIETIC STEM CELL FORMATION IN RESPONSE TO THE BIOMECHANICAL FORCES OF BLOOD FLOW

Wade Sugden, Vanessa Lundin, Lindsay Theodore, Patricia Sousa, Areum Han, Stephanie Chou, Paul Wrighton, Andrew Cox, Donald Ingber, Wolfram Goessling, George Daley, Trista North

Conference Proceedings  |  2020  |  EXPERIMENTAL HEMATOLOGY

Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer.

Sahar Nissim, Ignaty Leshchiner, Joseph Mancias, Matthew Greenblatt, Ophelia Maertens, Christopher Cassa, Jill Rosenfeld, Andrew Cox, John Hedgepeth, Julia Wucherpfennig, Andrew Kim, Jake Henderson, Patrick Gonyo, Anthony Brandt, Ellen Lorimer, Bethany Unger, Gad Getz, Shamil Sunyaev, Wade Harper, Karen Cichowski, et al.

Conference Proceedings  |  2020  |  MOLECULAR CANCER RESEARCH