Niall Geoghegan

PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum

Stephen W Scally, Tony Triglia, Cindy Evelyn, Benjamin A Seager, Michal Pasternak, Pailene S Lim, Julie Healer, Niall D Geoghegan, Amy Adair, Wai-Hong Tham, Laura F Dagley, Kelly L Rogers, Alan F Cowman

Journal article  |  2022  |  NATURE MICROBIOLOGY

The most severe form of malaria is caused by Plasmodium falciparum. These parasites invade human erythrocytes, and an essential st..

Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission (vol 13, 1400, 2022)

Sash Lopaticki, Robyn McConville, Alan John, Niall Geoghegan, Shihab Deen Mohamed, Lisa Verzier, Ryan WJ Steel, Cindy Evelyn, Matthew T O'Neill, Niccolay Madiedo Soler, Nichollas E Scott, Kelly L Rogers, Ethan D Goddard-Borger, Justin A Boddey

Journal article  |  2022  |  NATURE COMMUNICATIONS

The original version of this Article incorrectly cited reference 85 instead of reference 84 in the methods section ‘An. stephensi ..

Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission

Sash Lopaticki, Robyn McConville, Alan John, Niall Geoghegan, Shihab Deen Mohamed, Lisa Verzier, Ryan WJ Steel, Cindy Evelyn, Matthew T O'Neill, Niccolay Madiedo Soler, Nichollas E Scott, Kelly L Rogers, Ethan D Goddard-Borger, Justin A Boddey

Journal article  |  2022  |  NATURE COMMUNICATIONS

Tryptophan C-mannosylation stabilizes proteins bearing a thrombospondin repeat (TSR) domain in metazoans. Here we show that Plasmo..

RhopH2 and RhopH3 export enables assembly of the RhopH complex on P. falciparum-infected erythrocyte membranes

Michal Pasternak, Julie MJ Verhoef, Wilson Wong, Tony Triglia, Michael J Mlodzianoski, Niall Geoghegan, Cindy Evelyn, Ahmad Z Wardak, Kelly Rogers, Alan F Cowmarc

Journal article  |  2022  |  COMMUNICATIONS BIOLOGY

RhopH complexes consists of Clag3, RhopH2 and RhopH3 and are essential for growth of Plasmodium falciparum inside infected erythro..

Activation mechanism of PINK1n (vol 602, pg 328, 2022)

Zhong Yan Gan, Sylvie Callegari, Simon A Cobbold, Thomas R Cotton, Michael J Mlodzianoski, Alexander F Schubert, Niall D Geoghegan, Kelly L Rogers, Andrew Leis, Grant Dewson, Alisa Glukhova, David Komander

Journal article  |  2022  |  NATURE

This article was originally published on 21 December 2021 with Open Access under a Creative Commons Attribution (CC BY) 4.0 Intern..

Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24

Sophia Davidson, Chien-Hsiung Yu, Annemarie Steiner, Frederic Ebstein, Paul J Baker, Valentina Jarur-Chamy, Katja Hrovat Schaale, Pawat Laohamonthonkul, Klara Kong, Dale J Calleja, Cassandra R Harapas, Katherine R Balka, Jacob Mitchell, Jacob T Jackson, Niall D Geoghegan, Fiona Moghaddas, Kelly L Rogers, Katrin D Mayer-Barber, Adriana A De Jesus, Dominic De Nardo, et al.

Journal article  |  2022  |  SCIENCE IMMUNOLOGY

Proteasome dysfunction can lead to autoinflammatory disease associated with elevated type I interferon (IFN-αβ) and NF-κB signalin..

Activation mechanism of PINK1

Zhong Yan Gan, Sylvie Callegari, Simon A Cobbold, Thomas R Cotton, Michael J Mlodzianoski, Alexander F Schubert, Niall D Geoghegan, Kelly L Rogers, Andrew Leis, Grant Dewson, Alisa Glukhova, David Komander

Journal article  |  2021  |  NATURE

Mutations in the protein kinase PINK1 lead to defects in mitophagy and cause autosomal recessive early onset Parkinson's disease1,..

Alectinib induces marked red cell spheroacanthocytosis in a near-ubiquitous fashion and is associated with reduced eosin-5-maleimide binding

James A Kuzich, Sarah Heynemann, Niall Geoghegan, Cindy Evelyn, Susan O'Mahoney, Susan Wilson, Janine Campbell, Kelly Rogers, Benjamin Solomon, David Westerman, Sant-Rayn Pasricha

Journal article  |  2021  |  PATHOLOGY

We reviewed haematological investigations for 43 patients treated at a single centre with alectinib, an inhibitor of anaplastic ly..

4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation

Niall D Geoghegan, Cindy Evelyn, Lachlan W Whitehead, Michal Pasternak, Phoebe McDonald, Tony Triglia, Danushka S Marapana, Daryan Kempe, Jennifer K Thompson, Michael J Mlodzianoski, Julie Healer, Mate Biro, Alan F Cowman, Kelly L Rogers

Journal article  |  2021  |  NATURE COMMUNICATIONS

Host membrane remodeling is indispensable for viruses, bacteria, and parasites, to subvert the membrane barrier and obtain entry i..

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang, et al.

Journal article  |  2020  |  IMMUNITY

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..