Niall Geoghegan

Alectinib induces marked red cell spheroacanthocytosis in a near-ubiquitous fashion and is associated with reduced eosin-5-maleimide binding

James A Kuzich, Sarah Heynemann, Niall Geoghegan, Cindy Evelyn, Susan O'Mahoney, Susan Wilson, Janine Campbell, Kelly Rogers, Benjamin Solomon, David Westerman, Sant-Rayn Pasricha

Journal article  |  2021  |  PATHOLOGY

We reviewed haematological investigations for 43 patients treated at a single centre with alectinib, an inhibitor of anaplastic ly..

4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation

Niall D Geoghegan, Cindy Evelyn, Lachlan W Whitehead, Michal Pasternak, Phoebe McDonald, Tony Triglia, Danushka S Marapana, Daryan Kempe, Jennifer K Thompson, Michael J Mlodzianoski, Julie Healer, Mate Biro, Alan F Cowman, Kelly L Rogers

Journal article  |  2021  |  NATURE COMMUNICATIONS

Host membrane remodeling is indispensable for viruses, bacteria, and parasites, to subvert the membrane barrier and obtain entry i..

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang, et al.

Journal article  |  2020  |  IMMUNITY

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

Andre L Samson, Ying Zhang, Niall D Geoghegan, Xavier J Gavin, Katherine A Davies, Michael J Mlodzianoski, Lachlan W Whitehead, Daniel Frank, Sarah E Garnish, Cheree Fitzgibbon, Anne Hempel, Samuel N Young, Annette V Jacobsen, Wayne Cawthorne, Emma J Petrie, Maree C Faux, Kristy Shield-Artin, Najoua Lalaoui, Joanne M Hildebrand, John Silke, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-medi..

Characterisation of GLUT4 trafficking in HeLa cells: comparable kinetics and orthologous trafficking mechanisms to 3T3-L1 adipocytes.

Silke Morris, Niall D Geoghegan, Jessica BA Sadler, Anna M Koester, Hannah L Black, Marco Laub, Lucy Miller, Linda Heffernan, Jeremy C Simpson, Cynthia C Mastick, Jon Cooper, Nikolaj Gadegaard, Nia J Bryant, Gwyn W Gould

Journal article  |  2020  |  PeerJ

Insulin-stimulated glucose transport is a characteristic property of adipocytes and muscle cells and involves the regulated delive..

Smchd1 Targeting to the Inactive X Is Dependent on the Xist-HnrnpK-PRC1 Pathway

Natasha Jansz, Tatyana Nesterova, Andrew Keniry, Megan Iminitoff, Peter F Hickey, Greta Pintacuda, Osamu Masui, Simon Kobelke, Niall Geoghegan, Kelsey A Breslin, Tracy A Willson, Kelly Rogers, Graham F Kay, Archa H Fox, Haruhiko Koseki, Neil Brockdorff, James M Murphy, Marnie E Blewitt

Journal article  |  2018  |  CELL REPORTS

We and others have recently reported that the SMC protein Smchd1 is a regulator of chromosome conformation. Smchd1 is critical for..

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

Kate McArthur, Lachlan W Whitehead, John M Heddleston, Lucy Li, Benjamin S Padman, Viola Oorschot, Niall D Geoghegan, Stephane Chappaz, Sophia Davidson, Hui San Chin, Rachael M Lane, Marija Dramicanin, Tahnee L Saunders, Canny Sugiana, Romina Lessene, Laura D Osellame, Teng-Leong Chew, Grant Dewson, Michael Lazarou, Georg Ramm, et al.

Journal article  |  2018  |  SCIENCE

Mitochondrial apoptosis is mediated by BAK and BAX, two proteins that induce mitochondrial outer membrane permeabilization, leadin..

The reinvention of twentieth century microscopy for three-dimensional imaging

Lachlan W Whitehead, Kate McArthur, Niall D Geoghegan, Kelly L Rogers

Journal article  |  2017  |  IMMUNOLOGY AND CELL BIOLOGY

In just over a decade, the field of biomedical research has witnessed a radical evolution in technologies for the 3- and 4-dimensi..

Imaging phase separation in model lipid membranes through the use of BODIPY based molecular rotors.

Michael R Dent, Ismael López-Duarte, Callum J Dickson, Niall D Geoghegan, Jonathan M Cooper, Ian R Gould, Rob Krams, James A Bull, Nicholas J Brooks, Marina K Kuimova

Journal article  |  2015  |  Phys Chem Chem Phys

In order to fully understand the dynamics of processes within biological lipid membranes, it is necessary to possess an intimate k..