Huiling Xu

Using Genomic Sequencing to Explain an Exceptional Response to Therapy in a Malignant Phyllodes Tumor

Ciara Conduit, Stephen Luen, Huiling Xu, David Byrne, Stephen Fox, Jayesh Desai, Anne Hamilton

Journal article  |  2020  |  JCO PRECISION ONCOLOGY

A MXI1-NUTM1 fusion protein with MYC-like activity suggests a novel oncogenic mechanism in a subset ofNUTM1-rearranged tumors

Christopher R McEvoy, Holly Holliday, Niko Thio, Catherine Mitchell, David Y Choong, Bhargavi Yellapu, Hui San Leong, Huiling Xu, Stephen Lade, Judy Browning, Elena A Takano, David J Byrne, Anthony J Gill, Cuong P Duong, Jason Li, Andrew P Fellowes, Stephen B Fox, Alexander Swarbrick, Owen WJ Prall

Journal article  |  2020  |  LABORATORY INVESTIGATION

Most NUTM1-rearranged neoplasms (NRNs) have fusions between NUTM1 and BRD (bromodomain-containing) family members and are termed N..

Dual Targeting of CDK4/6 and BCL2 Pathways Augments Tumor Response in Estrogen Receptor-Positive Breast Cancer

James R Whittle, Francois Vaillant, Elliot Surgenor, Antonia N Policheni, Goknur Giner, Bianca D Capaldo, Huei-Rong Chen, He K Liu, Johanna F Dekkers, Norman Sachs, Hans Clevers, Andrew Fellowes, Thomas Green, Huiling Xu, Stephen B Fox, Marco J Herold, Gordon K Smyth, Daniel HD Gray, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2020  |  CLINICAL CANCER RESEARCH

PURPOSE: Although cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors significantly extend tumor response in patients with metasta..

Comparison of Variant Detection Abilities between the TSO500 Pan-Cancer Panel and an In-House Comprehensive Cancer Panel

CR McEvoy, H Xu, DY Choong, R Legaie, SB Fox, AP Fellowes

Conference Proceedings  |  2020  |  JOURNAL OF MOLECULAR DIAGNOSTICS

RAF1 rearrangements are common in pancreatic acinar cell carcinomas

Owen WJ Prall, Violeta Nastevski, Huiling Xu, Christopher RE McEvoy, Joep HA Vissers, David J Byrne, Elena Takano, Satwica Yerneni, Sarah Ellis, Thomas Green, Catherine A Mitchell, William K Murray, Clare L Scott, Sean M Grimmond, Oliver Hofmann, Anthony Papenfuss, Damien Kee, Andrew Fellowes, Ian S Brown, Gregory Miller, et al.

Journal article  |  2020  |  MODERN PATHOLOGY

There is now evidence that gene fusions activating the MAPK pathway are relatively common in pancreatic acinar cell carcinoma with..

Peter Mac experience with comprehensive genomic profiling – The new standard of care in tissue pathology?

Andrew Fellowes, Christopher McEvoy, Huiling Xu, Anna Tanska, Ain Roesley, David Choong, Roxane Legaie, Stephen B Fox

Journal article  |  2020  |  Pathology

51. Adult brainstem anaplastic astrocytoma with an unusual molecular profile

J Clark, J Lokan, AP Fellowes, H Xu, K Smith, H Gan, L Cher, J Desai, T Leong, SB Fox

Conference Proceedings  |  2020  |  Pathology

Potentially actionable FGFR2 high-level amplification in thymic sebaceous carcinoma

Stefan Porubsky, Peter Jessup, Damien Kee, Rajiv Sharma, Ayame Ochi, Huiling Xu, Jens J Froelich, Louise Nott, Clare Scott, Raef Awad, Cristina Moldovan, Ashutosh A Hardikar, Hanibal Bohnenberger, Stefan Kueffer, Philipp Stroebel, Alexander Marx

Journal article  |  2020  |  VIRCHOWS ARCHIV

Our aim was to investigate sebaceous differentiation in thymus tumours and to identify new actionable genomic alterations. To this..

A Malignant Neoplasm From the Jejunum With a MALAT1-GLI1 Fusion and 26-Year Survival History

Owen William John Prall, Christopher Robert Edward McEvoy, David John Byrne, Amir Iravani, Judy Browning, David Yew-Huong Choong, Bhargavi Yellapu, Sophie O'Haire, Kortnye Smith, Stephen James Luen, Paul Leslie Ross Mitchell, Jayesh Desai, Stephen Bernard Fox, Andrew Fellowes, Huiling Xu

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY

The transcription factor GLI1 is a critical effector of the sonic hedgehog pathway. Gene fusions that activate GLI1 have recently ..

Improved next-generation sequencing pre-capture library yields and sequencing parameters using on-bead PCR

Christopher R McEvoy, Timothy Semple, Bhargavi Yellapu, David Y Choong, Huiling Xu, Gisela Mir Arnau, Andrew P Fellowes, Stephen B Fox

Journal article  |  2020  |  BIOTECHNIQUES

Tumor DNA sequencing results can have important clinical implications. However, its use is often limited by low DNA input, owing t..