Samantha Emery

Recent advances in functional research in Giardia intestinalis

Aaron R Jex, Staffan Svard, Kari D Hagen, Hannah Starcevich, Samantha J Emery-Corbin, Balu Balan, Chris Nosala, Scott C Dawson

Book Chapter  |  2020  |  Advances in Parasitology

This review considers current advances in tools to investigate the functional biology of Giardia, it's coding and non-coding genes..

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malaria.

Aaron Jex, Ivo Mueller, Stefan Kappe, Sebastian Mikolajczak, Jetsumon Sattabongkot, Rapatbhorn Patrapuvich, Scott Lindner, Erika Flannery, Cristian Koepfli, Brendan Ansell, Anita Lerch, Samantha Emery, Sarah Charnaud, Jeffrey Smith, Nicholas Merrienne, Kristian Swearingen, Robert Moritz, Michaela Petter, M Duffy, Veruda Chuenchob

Journal article  |  2019  |  International Journal for Parasitology

Plasmodium vivax is the key obstacle to malaria elimination in Asia and Latin America, largely attributed to its ability to form r..

Annotation of the Giardia proteome through structure-based homology and machine learning

Brendan RE Ansell, Bernard J Pope, Peter Georgeson, Samantha J Emery-Corbin, Aaron R Jex

Journal article  |  2019  |  GIGASCIENCE

Background: Large-scale computational prediction of protein structures represents a cost-effective alternative to empirical struct..

Proteomic diversity in a prevalent human-infective Giardia duodenalis sub-species

Samantha J Emery-Corbin, Daniel Vuong, Ernest Lacey, Staffan G Svard, Brendan RE Ansell, Aaron R Jex

Journal article  |  2018  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

Giardia duodenalis a species complex of gastrointestinal protists, with assemblages A and B infective to humans. To date, post-gen..

Extracellular vesicles from early stage Plasmodium falciparum-infected red blood cells contain PfEMP1 and induce transcriptional changes in human monocytes

Natalia G Sampaio, Samantha J Emery, Alexandra L Garnham, Qiao Y Tan, Xavier Sisquella, Matthew A Pimentel, Aaron R Jex, Neta Regev-Rudzki, Louis Schofield, Emily M Eriksson

Journal article  |  2018  |  CELLULAR MICROBIOLOGY

Pathogens can release extracellular vesicles (EVs) for cell-cell communication and host modulation. EVs from Plasmodium falciparum..

Differential protein expression and post-translational modifications in metronidazole-resistant Giardia duodenalis

Samantha J Emery, Louise Baker, Brendan RE Ansell, Mehdi Mirzaei, Paul A Haynes, Malcom J McConville, Staffan G Svard, Aaron R Jex

Journal article  |  2018  |  GIGASCIENCE

Background: Metronidazole (Mtz) is the frontline drug treatment for multiple anaerobic pathogens, including the gastrointestinal p..

Transcriptomics Indicates Active and Passive Metronidazole Resistance Mechanisms in Three Seminal Giardia Lines

Brendan RE Ansell, Louise Baker, Samantha J Emery, Malcolm J McConville, Staffan G Svard, Robin B Gasser, Aaron R Jex

Journal article  |  2017  |  FRONTIERS IN MICROBIOLOGY

Giardia duodenalis is an intestinal parasite that causes 200-300 million episodes of diarrhoea annually. Metronidazole (Mtz) is a ..

Divergent Transcriptional Responses to Physiological and Xenobiotic Stress in Giardia duodenalis

Brendan RE Ansell, Malcolm J McConville, Louise Baker, Pasi K Korhonen, Samantha J Emery, Staffan G Svard, Robin B Gasser, Aaron R Jex

Journal article  |  2016  |  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Understanding how parasites respond to stress can help to identify essential biological processes. Giardia duodenalis is a parasit..

Quantitative proteomics in Giardia duodenalis-Achievements and challenges

Samantha J Emery, Ernest Lacey, Paul A Haynes

Journal article  |  2016  |  MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Giardia duodenalis (syn. G. lamblia and G. intestinalis) is a protozoan parasite of vertebrates and a major contributor to the glo..

Induction of virulence factors in Giardia duodenalis independent of host attachment.

Samantha J Emery, Mehdi Mirzaei, Daniel Vuong, Dana Pascovici, Joel M Chick, Ernest Lacey, Paul A Haynes

Journal article  |  2016  |  Sci Rep

Giardia duodenalis is responsible for the majority of parasitic gastroenteritis in humans worldwide. Host-parasite interaction mod..