Samantha Emery

Multimodal regulation of encystation in Giardia duodenalis revealed by deep proteomics

Balu Balan, Samantha J Emery-Corbin, Jarrod J Sandow, Brendan Robert E Ansell, Swapnil Tichkule, Andrew Webb, Staffan G Svard, Aaron R Jex

Journal article  |  2021  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

Cyst formation in the parasitic protist Giardia duodenalis is critical to its transmission. Existing proteomic data quantifies onl..

In vitro selection of Giardia duodenalis for Albendazole resistance identifies a -tubulin mutation at amino acid E198K

Samantha J Emery-Corbin, Qiao Su, Swapnil Tichkule, Louise Baker, Ernest Lacey, Aaron R Jex

Journal article  |  2021  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE

Benzimidazole-2-carbamate (BZ) compounds, including Albendazole (Alb), are one of just two drug classes approved to treat the gast..

Eukaryote-conserved histone post-translational modification landscape in Giardia duodenalis revealed by mass spectrometry

Samantha J Emery-Corbin, Joshua J Hamey, Balu Balan, Laura Rojas-Lopez, Staffan G Svard, Aaron R Jex

Journal article  |  2021  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

Diarrheal disease caused by Giardia duodenalis is highly prevalent, causing over 200 million cases globally each year. The process..

TriTOX: A novel Trichomonas vaginalis assay platform for high-throughput screening of compound libraries

Alexander YF Lam, Daniel Vuong, Aaron R Jex, Andrew M Piggott, Ernest Lacey, Samantha J Emery-Corbin

Journal article  |  2021  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE

Trichomonas vaginalis is a neglected urogenital parasitic protist that causes 170 million cases of trichomoniasis annually, making..

Eukaryote-ConservedMethylarginine Is Absent in Diplomonads and Functionally Compensated in Giardia

Samantha J Emery-Corbin, Joshua J Hamey, Brendan RE Ansell, Balu Balan, Swapnil Tichkule, Andreas J Stroehlein, Crystal Cooper, Bernie McInerney, Soroor Hediyeh-Zadeh, Daniel Vuong, Andrew Crombie, Ernest Lacey, Melissa J Davis, Marc R Wilkins, Melanie Bahlo, Staffan G Svard, Robin B Gasser, Aaron R Jex

Journal article  |  2020  |  MOLECULAR BIOLOGY AND EVOLUTION

Methylation is a common posttranslational modification of arginine and lysine in eukaryotic proteins. Methylproteomes are best cha..

Recent advances in functional research in Giardia intestinalis

Aaron R Jex, Staffan Svard, Kari D Hagen, Hannah Starcevich, Samantha J Emery-Corbin, Balu Balan, Chris Nosala, Scott C Dawson

Book Chapter  |  2020  |  Advances in Parasitology

This review considers current advances in tools to investigate the functional biology of Giardia, it's coding and non-coding genes..

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malaria.

Aaron Jex, Ivo Mueller, Stefan Kappe, Sebastian Mikolajczak, Jetsumon Sattabongkot, Rapatbhorn Patrapuvich, Scott Lindner, Erika Flannery, Cristian Koepfli, Brendan Ansell, Anita Lerch, Samantha Emery, Sarah Charnaud, Jeffrey Smith, Nicholas Merrienne, Kristian Swearingen, Robert Moritz, Michaela Petter, M Duffy, Veruda Chuenchob

Journal article  |  2019  |  International Journal for Parasitology

Plasmodium vivax is the key obstacle to malaria elimination in Asia and Latin America, largely attributed to its ability to form r..

Annotation of the Giardia proteome through structure-based homology and machine learning

Brendan RE Ansell, Bernard J Pope, Peter Georgeson, Samantha J Emery-Corbin, Aaron R Jex

Journal article  |  2019  |  GIGASCIENCE

BACKGROUND: Large-scale computational prediction of protein structures represents a cost-effective alternative to empirical struct..

Proteomic diversity in a prevalent human-infective Giardia duodenalis sub-species

Samantha J Emery-Corbin, Daniel Vuong, Ernest Lacey, Staffan G Svard, Brendan RE Ansell, Aaron R Jex

Journal article  |  2018  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

Giardia duodenalis a species complex of gastrointestinal protists, with assemblages A and B infective to humans. To date, post-gen..

Extracellular vesicles from early stage Plasmodium falciparum-infected red blood cells contain PfEMP1 and induce transcriptional changes in human monocytes

Natalia G Sampaio, Samantha J Emery, Alexandra L Garnham, Qiao Y Tan, Xavier Sisquella, Matthew A Pimentel, Aaron R Jex, Neta Regev-Rudzki, Louis Schofield, Emily M Eriksson

Journal article  |  2018  |  CELLULAR MICROBIOLOGY

Pathogens can release extracellular vesicles (EVs) for cell-cell communication and host modulation. EVs from Plasmodium falciparum..