Ester Lopez

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain

Adam K Wheatley, Phillip Pymm, Robyn Esterbauer, Melanie H Dietrich, Wen Shi Lee, Damien Drew, Hannah G Kelly, Li-Jin Chan, Francesca L Mordant, Katrina A Black, Amy Adair, Hyon-Xhi Tan, Jennifer A Juno, Kathleen M Wragg, Thakshila Amarasena, Ester Lopez, Kevin J Selva, Ebene R Haycroft, James P Cooney, Hariprasad Venugopal, et al.

Journal article  |  2021  |  CELL REPORTS

Potent neutralizing monoclonal antibodies are one of the few agents currently available to treat COVID-19. SARS-CoV-2 variants of ..

A systems approach to elucidate personalized mechanistic complexities of antibody-Fc receptor activation post-vaccination

Melissa M Lemke, Milla R McLean, Christina Y Lee, Ester Lopez, Emily R Bozich, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Sven Kratochvil, Bruce D Wines, P Mark Hogarth, Stephen J Kent, Amy W Chung, Kelly B Arnold

Journal article  |  2021  |  CELL REPORTS MEDICINE

Immunoglobulin G (IgG) antibodies that activate Fc-mediated immune functions have been correlated with vaccine efficacy, but it is..

Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 variants via multiplex assay

Ester Lopez, Ebene R Haycroft, Amy Adair, Francesca L Mordant, Matthew T O'Neill, Phillip Pymm, Samuel J Redmond, Wen Shi Lee, Nicholas A Gherardin, Adam K Wheatley, Jennifer A Juno, Kevin J Selva, Samantha K Davis, Samantha L Grimley, Leigh Harty, Damian FJ Purcell, Kanta Subbarao, Dale Godfrey, Stephen J Kent, Wai-Hong Tham, et al.

Journal article  |  2021  |  JCI INSIGHT

The SARS-CoV-2 receptor binding domain (RBD) is both the principal target of neutralizing antibodies and one of the most rapidly e..

Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice

Phillip Pymm, Amy Adair, Li-Jin Chan, James P Cooney, Francesca L Mordant, Cody C Allison, Ester Lopez, Ebene R Haycroft, Matthew T O'Neill, Li Lynn Tan, Melanie H Dietrich, Damien Drew, Marcel Doerflinger, Michael A Dengler, Nichollas E Scott, Adam K Wheatley, Nicholas A Gherardin, Hariprasad Venugopal, Deborah Cromer, Miles P Davenport, et al.

Journal article  |  2021  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutralizing antibodies are important for immunity against SARS-CoV-2 and as therapeutics for the prevention and treatment of COVI..

Antibody mediated activation of natural killer cells in malaria exposed pregnant women

Timon Damelang, Elizabeth H Aitken, Wina Hasang, Ester Lopez, Martin Killian, Holger W Unger, Ali Salanti, Alexis Shub, Elizabeth McCarthy, Katherine Kedzierska, Martha Lappas, Stephen J Kent, Stephen J Rogerson, Amy W Chung

Journal article  |  2021  |  SCIENTIFIC REPORTS

Immune effector responses against Plasmodium falciparum include antibody-mediated activation of innate immune cells, which can ind..

Low pH Exposure During Immunoglobulin G Purification Methods Results in Aggregates That Avidly Bind Fcg Receptors: Implications for Measuring Fc Dependent Antibody Functions

Ester Lopez, Nichollas E Scott, Bruce D Wines, P Mark Hogarth, Adam K Wheatley, Stephen J Kent, Amy W Chung

Journal article  |  2019  |  FRONTIERS IN IMMUNOLOGY

Evaluating the biophysical and functional nature of IgG is key to defining correlates of protection in infectious disease, and aut..

IgA Inhibits HIV-specific Antibody-dependent Neutrophil Phagocytosis

Matthew Worley, Ester Lopez, Anthony Kelleher, Stephen Kent, Amy Chung

Conference Proceedings  |  2018  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

The Multifaceted Nature of Immunoglobulin A and Its Complex Role in HIV

Ester Lopez, Robin J Shattock, Stephen J Kent, Amy W Chung

Journal article  |  2018  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

IgA is the most abundant immunoglobulin in mucosal secretions, and understanding the role of IgA in both protection from HIV acqui..

HIV-1 Env- and Vpu-Specific Antibody-Dependent Cellular Cytotoxicity Responses Associated with Elite Control of HIV

Vijaya Madhavi, Bruce D Wines, Janaki Amin, Sean Emery, Ester Lopez, Anthony Kelleher, Rob J Center, P Mark Hogarth, Amy W Chung, Stephen J Kent, Ivan Stratov

Journal article  |  2017  |  JOURNAL OF VIROLOGY

Studying HIV-infected individuals who control HIV replication (elite controllers [ECs]) enables exploration of effective anti-HIV ..

Immunization against GnRF in adult cattle: a prospective field study

Gaby Hirsbrunner, Sarah Rigert, Fredi Janett, Juerg Huesler, Philipp Schnydrig, Ester Lopez, Sue Amatayakul-Chantler, Adrian Steiner

Journal article  |  2017  |  BMC VETERINARY RESEARCH

BACKGROUND: Suppression of cyclic activity in cattle is often desired in alpine farming and for feedlot cattle, not intended for b..