Leo Lee

Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model

Leo YY Lee, Jie Zhou, Paulina Koszalka, Rebecca Frise, Rubaiyea Farrukee, Keiko Baba, Shahjahan Miah, Takao Shishido, Monica Galiano, Takashi Hashimoto, Shinya Omoto, Takeki Uehara, Edin J Mifsud, Neil Collinson, Klaus Kuhlbusch, Barry Clinch, Steffen Wildum, Wendy S Barclay, Aeron C Hurt

Journal article  |  2021  |  PLOS PATHOGENS

Baloxavir is approved in several countries for the treatment of uncomplicated influenza in otherwise-healthy and high-risk patient..

BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection

Richard J Mills, Sean J Humphrey, Patrick RJ Fortuna, Mary Lor, Simon R Foster, Gregory A Quaife-Ryan, Rebecca L Johnston, Troy Dumenil, Cameron Bishop, Rajeev Rudraraju, Daniel J Rawle, Thuy Le, Wei Zhao, Leo Lee, Charley Mackenzie-Kludas, Neda R Mehdiabadi, Christopher Halliday, Dean Gilham, Li Fu, Stephen J Nicholls, et al.

Journal article  |  2021  |  CELL

Cardiac injury and dysfunction occur in COVID-19 patients and increase the risk of mortality. Causes are ill defined but could be ..

Baloxavir treatment of ferrets infected with influenza A(H1N1)pdm09 virus reduces onward transmission

Leo Yi Yang Lee, Jie Zhou, Rebecca Frise, Daniel H Goldhill, Paulina Koszalka, Edin J Mifsud, Kaoru Baba, Takahiro Noda, Yoshinori Ando, Kenji Sato, Aoe-Ishikawa Yuki, Takao Shishido, Takeki Uehara, Steffen Wildum, Elke Zwanziger, Neil Collinson, Klaus Kuhlbusch, Barry Clinch, Aeron C Hurt, Wendy S Barclay

Journal article  |  2020  |  PLOS PATHOGENS

Influenza viruses cause seasonal outbreaks and pose a continuous pandemic threat. Although vaccines are available for influenza co..

Genetic variations on 31 and 450 residues of influenza A nucleoprotein affect viral replication and translation

Su-Jhen Hung, Yin-Mei Hsu, Sheng-Wen Huang, Huey-Pin Tsai, Leo Yi Yang Lee, Aeron C Hurt, Ian G Barr, Shin-Ru Shih, Jen-Ren Wang

Journal article  |  2020  |  JOURNAL OF BIOMEDICAL SCIENCE

BACKGROUND: Influenza A viruses cause epidemics/severe pandemics that pose a great global health threat. Among eight viral RNA seg..

A Review of DNA Vaccines Against Influenza

Leo Yi Yang Lee, Leonard Izzard, Aeron C Hurt

Journal article  |  2018  |  FRONTIERS IN IMMUNOLOGY

The challenges of effective vaccination against influenza are gaining more mainstream attention, as recent influenza seasons have ..