Elizabeth Hartland

Emerging methods in cellular microbiology

Elizabeth L Hartland

Journal article  |  2021  |  CELLULAR MICROBIOLOGY

Genome-wide genetic screen identifies host ubiquitination as important for Legionella pneumophila Dot/Icm effector translocation

Sze Ying Ong, Ralf Schuelein, Rachelia R Wibawa, Daniel W Thomas, Yanny Handoko, Saskia Freytag, Melanie Bahlo, Kaylene J Simpson, Elizabeth L Hartland

Journal article  |  2021  |  CELLULAR MICROBIOLOGY

The Dot/Icm system of Legionella pneumophila is essential for virulence and delivers a large repertoire of effectors into infected..

NleB2 from enteropathogenic Escherichia coli is a novel arginine-glucose transferase effector

Cristina Giogha, Nichollas E Scott, Tania Wong Fok Lung, Georgina L Pollock, Marina Harper, Ethan D Goddard-Borger, Jaclyn S Pearson, Elizabeth L Hartland

Journal article  |  2021  |  PLOS PATHOGENS

During infection, enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC) directly manipulate various aspec..

Effectors Targeting the Unfolded Protein Response during Intracellular Bacterial Infection

Manal H Alshareef, Elizabeth L Hartland, Kathleen McCaffrey

Journal article  |  2021  |  MICROORGANISMS

The unfolded protein response (UPR) is a homeostatic response to endoplasmic reticulum (ER) stress within eukaryotic cells. The UP..

Molecular mechanisms employed by enteric bacterial pathogens to antagonise host innate immunity

Jiyao Gan, Cristina Giogha, Elizabeth L Hartland

Journal article  |  2021  |  CURRENT OPINION IN MICROBIOLOGY

Many Gram-negative enteric pathogens, including enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC), Salmonell..

Legionella pneumophilaInfection Rewires theAcanthamoeba castellaniiTranscriptome, Highlighting a Class of Sirtuin Genes

Pengfei Li, Dane Vassiliadis, Sze Ying Ong, Vicki Bennett-Wood, Chihiro Sugimoto, Junya Yamagishi, Elizabeth L Hartland, Shivani Pasricha

Journal article  |  2020  |  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

Legionella pneumophila is an environmental bacterium that has evolved to survive predation by soil and water amoebae such as Acant..

The Salmonella Effector SseK3 Targets Small Rab GTPases

Jiyao Gan, Nichollas E Scott, Joshua PM Newson, Rachelia R Wibawa, Tania Wong Fok Lung, Georgina L Pollock, Garrett Z Ng, Ian van Driel, Jaclyn S Pearson, Elizabeth L Hartland, Cristina Giogha

Journal article  |  2020  |  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

During infection, Salmonella species inject multiple type III secretion system (T3SS) effector proteins into host cells that media..

A potential new target for autoinflammatory bone disease

Elizabeth L Hartland

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disease mediated by the inflammatory cytokine, IL-1β..

IFN gamma receptor down-regulation facilitates Legionella survival in alveolar macrophages

Chao Yang, Daniel S McDermot, Shivani Pasricha, Sammy Bedoui, Laurel L Lenz, Ian R van Driel, Elizabeth L Hartland

Journal article  |  2019  |  JOURNAL OF LEUKOCYTE BIOLOGY

Legionella pneumophila is an opportunistic human pathogen and causative agent of the acute pneumonia known as Legionnaire's diseas..

Loss of O-Linked Protein Glycosylation in Burkholderia cenocepacia Impairs Biofilm Formation and Siderophore Activity and Alters Transcriptional Regulators

Cameron C Oppy, Leila Jebeli, Miku Kuba, Clare V Oates, Richard Strugnell, Laura E Edgington-Mitchell, Miguel A Valvano, Elizabeth L Hartland, Hayley J Newton, Nichollas E Scott

Journal article  |  2019  |  MSPHERE

O-linked protein glycosylation is a conserved feature of the Burkholderia genus. The addition of the trisaccharide β-Gal-(1,3)-α-G..