Elizabeth Hartland

Cigarette smoke depletes alveolar macrophages and delays clearance of Legionella pneumophila.

Markus Fleischmann, Andrew G Jarnicki, Andrew S Brown, Chao Yang, Gary P Anderson, Natalio Garbi, Elizabeth L Hartland, Ian R van Driel, Garrett Z Ng

Journal article  |  2023  |  Am J Physiol Lung Cell Mol Physiol

Legionella pneumophila is the main etiological agent of Legionnaires' disease, a severe bacterial pneumonia. L. pneumophila is ini..

Manipulation of epithelial cell architecture by the bacterial pathogens Listeria and Shigella

Elizabeth L Hartland, Debnath Ghosal, Cristina Giogha

Journal article  |  2022  |  CURRENT OPINION IN CELL BIOLOGY

Subversion of the host cell cytoskeleton is a virulence attribute common to many bacterial pathogens. On mucosal surfaces, bacteri..

Targeting of microvillus protein Eps8 by the NleH effector kinases from enteropathogenic E. coli.

Georgina L Pollock, Andrey M Grishin, Cristina Giogha, Jiyao Gan, Clare V Oates, Paul J McMillan, Isabella Gaeta, Matthew J Tyska, Jaclyn S Pearson, Nichollas E Scott, Miroslaw Cygler, Elizabeth L Hartland

Journal article  |  2022  |  Proc Natl Acad Sci U S A

Attaching and effacing (AE) lesion formation on enterocytes by enteropathogenic Escherichia coli (EPEC) requires the EPEC type III..

Emerging technologies in microbiology.

Elizabeth L Hartland

Journal article  |  2022  |  Mol Microbiol

Using Genomic Deletion Mutants to Investigate Effector-Triggered Immunity During Legionella pneumophila Infection.

Rachelia R Wibawa, Pengfei Li, Kathleen McCaffrey, Elizabeth L Hartland

Journal article  |  2022  |  Methods Mol Biol

Legionella pneumophila is an intracellular bacterial pathogen that uses a type IV secretion system (T4SS), termed Dot/Icm, to secr..

Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages

Thao Thanh Tran, Carmen D Mathmann, Marcela Gatica-Andrades, Rachel F Rollo, Melanie Oelker, Johanna K Ljungberg, Tam TK Nguyen, Alina Zamoshnikova, Lalith K Kummari, Orry JK Wyer, Katharine M Irvine, Javier Melo-Bolivar, Annette Gross, Darren Brown, Jeffrey YW Mak, David P Fairlie, Karl A Hansford, Matthew A Cooper, Rabina Giri, Veronika Schreiber, et al.

Journal article  |  2022  |  PLOS PATHOGENS

A hallmark of Listeria (L.) monocytogenes pathogenesis is bacterial escape from maturing entry vacuoles, which is required for rap..

Structural and Functional Characterization of Legionella pneumophila Effector MavL

Kevin Voth, Shivani Pasricha, Ivy Yeuk Wah Chung, Rachelia R Wibawa, Engku Nuraishah Huda E Zainudin, Elizabeth L Hartland, Miroslaw Cygler

Journal article  |  2021  |  BIOMOLECULES

Legionella pneumophila is a Gram-negative intracellular pathogen that causes Legionnaires' disease in elderly or immunocompromised..

Emerging methods in cellular microbiology

Elizabeth L Hartland

Journal article  |  2021  |  CELLULAR MICROBIOLOGY

Genome-wide genetic screen identifies host ubiquitination as important for Legionella pneumophila Dot/Icm effector translocation

Sze Ying Ong, Ralf Schuelein, Rachelia R Wibawa, Daniel W Thomas, Yanny Handoko, Saskia Freytag, Melanie Bahlo, Kaylene J Simpson, Elizabeth L Hartland

Journal article  |  2021  |  CELLULAR MICROBIOLOGY

The Dot/Icm system of Legionella pneumophila is essential for virulence and delivers a large repertoire of effectors into infected..

NleB2 from enteropathogenic Escherichia coli is a novel arginine-glucose transferase effector

Cristina Giogha, Nichollas E Scott, Tania Wong Fok Lung, Georgina L Pollock, Marina Harper, Ethan D Goddard-Borger, Jaclyn S Pearson, Elizabeth L Hartland

Journal article  |  2021  |  PLOS PATHOGENS

During infection, enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC) directly manipulate various aspec..