Dezerae Cox

Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells.

Rebecca San Gil, Dezerae Cox, Luke McAlary, Tracey Berg, Adam K Walker, Justin J Yerbury, Lezanne Ooi, Heath Ecroyd

Journal article  |  2020  |  Journal of Cell Science

Protein aggregates that result in inclusion formation are a pathological hallmark common to many neurodegenerative diseases, inclu..

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA

Angelique R Ormsby, Dezerae Cox, James Daly, David Priest, Elizabeth Hinde, Danny M Hatters

Journal article  |  2020  |  PLoS One

Mutations that cause Huntington's Disease involve a polyglutamine (polyQ) sequence expansion beyond 35 repeats in exon 1 of Huntin..

N- and C-terminal regions of ?B-crystallin and Hsp27 mediate inhibition of amyloid nucleation, fibril binding, and fibril disaggregation

Emily E Selig, Courtney O Zlatic, Dezerae Cox, Yee-Foong Mok, Paul R Gooley, Heath Ecroyd, Michael DW Griffin

Journal article  |  2020  |  Journal of Biological Chemistry

Small heat-shock proteins (sHSPs) are ubiquitously expressed molecular chaperones that inhibit amyloid fibril formation; however, ..

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control

Angelique Ormsby, Dezerae Cox, James Daly, David Priest, Elizabeth Hinde, Danny Hatters

Journal article  |  2020

Abstract Mutations that cause Huntington’s Disease involve a polyglutamine (polyQ) sequence expansion beyond 35 repeats in exon 1 ..

Arginine in C9ORF72 Dipolypeptides Mediates Promiscuous Proteome Binding and Multiple Modes of Toxicity

Mona Radwan, Ching-Seng Ang, Angelique R Ormsby, Dezerae Cox, James C Daly, Gavin E Reid, Danny M Hatters

Journal article  |  2020  |  Molecular and Cellular Proteomics

C9ORF72-associated Motor Neuron Disease patients feature abnormal expression of 5 dipeptide repeat (DPR) polymers. Here we used qu..

Protein aggregation in cell biology: An aggregomics perspective of health and disease

Dezerae Cox, Candice Raeburn, Xiaojing Sui, Danny M Hatters

Journal article  |  2020  |  Seminars in Cell & Developmental Biology

Maintaining protein homeostasis (proteostasis) is essential for cellular health and is governed by a network of quality control ma..

Widespread remodeling of proteome solubility in response to different protein homeostasis stresses

Xiaojing Sui, Douglas EV Pires, Angelique R Ormsby, Dezerae Cox, Shuai Nie, Giulia Vecchi, Michele Vendruscolo, David B Ascher, Gavin E Reid, Danny M Hatters

Journal article  |  2020  |  Proceedings of the National Academy of Sciences

The accumulation of protein deposits in neurodegenerative diseases has been hypothesized to depend on a metastable subproteome vul..

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic alpha-Synuclein Oligomers

Daniel R Whiten, Dezerae Cox, Mathew H Horrocks, Christopher G Taylor, Suman De, Patrick Flagmeier, Laura Tosatto, Janet R Kumita, Heath Ecroyd, Christopher M Dobson, David Klenerman, Mark R Wilson

Journal article  |  2018  |  Cell Reports

The small heat shock protein Hsp27 binds alpha-synuclein fibrils, preventing elongation and cytotoxicity

Dezerae Cox, Daniel R Whiten, James WP Brown, Mathew H Horrocks, Rebecca San Gil, Christopher M Dobson, David Klenerman, Antoine M van Oijen, Heath Ecroyd

Journal article  |  2018  |  Journal of Biological Chemistry

A biosensor-based framework to measure latent proteostasis capacity

Rebecca J Wood, Angelique R Ormsby, Mona Radwan, Dezerae Cox, Abhishek Sharma, Tobias Voepel, Simon Ebbinghaus, Mikael Oliveberg, Gavin E Reid, Alex Dickson, Danny M Hatters

Journal article  |  2018  |  NATURE COMMUNICATIONS