Tom Weber

Non-genetic determinants of malignant clonal fitness at single-cell resolution

Katie A Fennell, Dane Vassiliadis, Enid YN Lam, Luciano G Martelotto, Jesse J Balic, Sebastian Hollizeck, Tom S Weber, Timothy Semple, Qing Wang, Denise C Miles, Laura MacPherson, Yih-Chih Chan, Andrew A Guirguis, Lev M Kats, Emily S Wong, Sarah-Jane Dawson, Shalin H Naik, Mark A Dawson

Journal article  |  2021  |  NATURE

All cancers emerge after a period of clonal selection and subsequent clonal expansion. Although the evolutionary principles impart..

Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development

Luyi Tian, Sara Tomei, Jaring Schreuder, Tom S Weber, Daniela Amann-Zalcenstein, Dawn S Lin, Jessica Tran, Cindy Audiger, Mathew Chu, Andrew Jarratt, Tracy Willson, Adrienne Hilton, Ee Shan Pang, Timothy Patton, Madison Kelly, Shian Su, Quentin Gouil, Peter Diakumis, Melanie Bahlo, Toby Sargeant, et al.

Journal article  |  2021  |  IMMUNITY

Despite advances in single-cell multi-omics, a single stem or progenitor cell can only be tested once. We developed clonal multi-o..

Sample path properties of the average generation of a Bellman-Harris process

Gianfelice Meli, Tom S Weber, Ken R Duffy

Journal article  |  2019  |  JOURNAL OF MATHEMATICAL BIOLOGY

Motivated by a recently proposed design for a DNA coded randomised algorithm that enables inference of the average generation of a..

Benchmarking single cell RNA-sequencing analysis pipelines using mixture control experiments

Luyi Tian, Xueyi Dong, Saskia Freytag, Kim-Anh Le Cao, Shian Su, Abolfazl JalalAbadi, Daniela Amann-Zalcenstein, Tom S Weber, Azadeh Seidi, Jafar S Jabbari, Shalin H Naik, Matthew E Ritchie

Journal article  |  2019  |  NATURE METHODS

Single cell RNA-sequencing (scRNA-seq) technology has undergone rapid development in recent years, leading to an explosion in the ..

Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer

D Merino, TS Weber, A Serrano, F Vaillant, K Liu, B Pal, L Di Stefano, J Schreuder, D Lin, Y Chen, ML Asselin-Labat, TN Schumacher, D Cameron, GK Smyth, AT Papenfuss, GJ Lindeman, JE Visvader, SH Naik

Journal article  |  2019  |  NATURE COMMUNICATIONS

Primary triple negative breast cancers (TNBC) are prone to dissemination but sub-clonal relationships between tumors and resulting..

Cell Cycle-associated CXCr4 expression in Germinal Center B Cells and its implications on affinity Maturation

Tom S Weber

Journal article  |  2018  |  FRONTIERS IN IMMUNOLOGY

Adaptation of antibody-mediated immunity occurs in germinal centers (GC). It is where affinity maturation, class switching, memory..

Proliferation dynamics of acute myeloid leukaemia and haematopoietic progenitors competing for bone marrow space

O Akinduro, TS Weber, H Ang, MLR Haltalli, N Ruivo, D Duarte, NM Rashidi, ED Hawkins, KR Duffy, C Lo Celso

Journal article  |  2018  |  NATURE COMMUNICATIONS

Leukaemia progressively invades bone marrow (BM), outcompeting healthy haematopoiesis by mechanisms that are not fully understood...

Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML

Delfim Duarte, Edwin D Hawkins, Olufolake Akinduro, Heather Ang, Katia De Filippo, Isabella Y Kong, Myriam Haltalli, Nicola Ruivo, Lenny Straszkowski, Stephin J Vervoort, Catriona McLean, Tom S Weber, Reema Khorshed, Chiara Pirillo, Andrew Wei, Saravana K Ramasamy, Anjali P Kusumbe, Ken Duffy, Ralf H Adams, Louise E Purton, et al.

Journal article  |  2018  |  CELL STEM CELL

Bone marrow vascular niches sustain hematopoietic stem cells (HSCs) and are drastically remodeled in leukemia to support pathologi..