Scott Mueller

An optimized protocol for the isolation of rare stromal cell populations from the mouse spleen.

Yannick O Alexandre, Scott N Mueller

Journal article  |  2022  |  STAR Protoc

Lymphoid tissue stromal cells are important regulators of spleen homeostasis and immune responses. Here, we present an optimized p..

Runx3 drives a CD8( ) T cell tissue residency program that is absent in CD4( ) T cells

Raissa Fonseca, Thomas N Burn, Luke C Gandolfo, Sapna Devi, Simone L Park, Andreas Obers, Maximilien Evrard, Susan N Christo, Frank A Buquicchio, Caleb A Lareau, Keely M McDonald, Sarah K Sandford, Natasha M Zamudio, Nagela G Zanluqui, Ali Zaid, Terence P Speed, Ansuman T Satpathy, Scott N Mueller, Francis R Carbone, Laura K Mackay

Journal article  |  2022  |  NATURE IMMUNOLOGY

Tissue-resident memory T cells (TRM cells) provide rapid and superior control of localized infections. While the transcription fac..

Transfusion-Related Renal Dysfunction After Cardiac Surgery The Role of Myeloid-Related Protein_14 in Neutrophil-Mediated Tubular Damage

Mickael Vourc'h, Antoine Roquilly, Adrien Foucher, Christelle Retiere, Fanny Feuillet, Sapna Devi, Hamish EG McWilliam, Cecile Braudeau, Geraldine Bourreille, Abderrahman Hachani, Dermot O'Kane, Scott N Mueller, Joseph Ischia, Jean-Christian Roussel, Jean-Christophe Rigal, Regis Josien, Bertrand Rozec, Jose A Villadangos, Karim Asehnoune

Journal article  |  2022  |  JACC-BASIC TO TRANSLATIONAL SCIENCE

Transfusion is a specific cause of acute kidney injury (AKI) after cardiac surgery. Whether there is an association between the co..

Abstract 2036: Multi-omic dissection of immunotherapy response groups in non-small cell lung cancer (NSCLC)

Arutha Kulasinghe, James Monkman, Honesty Kim, Aaron Mayer, Ahmed Mehdi, Nicholas Matigian, Marie Cumberbatch, Milan Bhagat, Rahul Ladwa, Scott Mueller, Mark Adams, Ken O'Byrne

Journal article  |  2022  |  Cancer Research

Abstract Immunotherapies have led to long term benefits in a subset of non-small cell lung cancer (NSCLC) patients...

Corneal tissue-resident memory T cells form a unique immune compartment at the ocular surface

Joon Keit Loi, Yannick O Alexandre, Kirthana Senthil, Dominik Schienstock, Sarah Sandford, Sapna Devi, Susan N Christo, Laura K Mackay, Holly R Chinnery, Peregrine B Osborne, Laura E Downie, Erica K Sloan, Scott N Mueller

Journal article  |  2022  |  CELL REPORTS

The eye is considered immune privileged such that immune responses are dampened to protect vision. As the most anterior compartmen..

Persistence of Virus-Specific Antibody after Depletion of Memory B Cells

William A Langley, Andreas Wieland, Hasan Ahmed, Mohammed Ata ur Rasheed, Carl W Davis, Jaturong Sewatanon, Scott N Mueller, Mark J Shlomchik, Veronika I Zarnitsyna, Rustom Antia, Rafi Ahmed

Journal article  |  2022  |  JOURNAL OF VIROLOGY

Humoral immunity is a major component of the adaptive immune response against viruses and other pathogens with pathogen-specific a..

Differential location of NKT and MAIT cells within lymphoid tissue

Darryl N Johnson, Zheng Ruan, Emma Petley, Sapna Devi, Lauren E Holz, Adam P Uldrich, Jeffrey YW Mak, Jyh Liang Hor, Scott N Mueller, James McCluskey, David P Fairlie, Phillip K Darcy, Paul A Beavis, William R Heath, Dale Godfrey

Journal article  |  2022  |  SCIENTIFIC REPORTS

Natural Killer T (NKT) cells and Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells that express semi-invariant α..

Neural control of immune cell trafficking

Scott N Mueller

Journal article  |  2022  |  JOURNAL OF EXPERIMENTAL MEDICINE

Leukocyte trafficking between blood and tissues is an essential function of the immune system that facilitates humoral and cellula..

CD169( )macrophages in lymph node and spleen critically depend on dual RANK and LTbetaR signaling

Abdouramane Camara, Alice C Lavanant, Jun Abe, Henri Lee Desforges, Yannick O Alexandre, Erika Girardi, Zinaida Igamberdieva, Kenichi Asano, Masato Tanaka, Thomas Hehlgans, Klaus Pfeffer, Sebastien Pfeffer, Scott N Mueller, Jens Stein, Christopher G Mueller

Journal article  |  2022  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD169+ macrophages reside in lymph node (LN) and spleen and play an important role in the immune defense against pathogens. As res..

A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity

Yannick O Alexandre, Dominik Schienstock, Hyun Jae Lee, Luke C Gandolfo, Cameron G Williams, Sapna Devi, Bhupinder Pal, Joanna R Groom, Wang Cao, Susan N Christo, Claire L Gordon, Graham Starkey, Rohit D'Costa, Laura K Mackay, Ashraful Haque, Burkhard Ludewig, Gabrielle T Belz, Scott N Mueller

Journal article  |  2022  |  SCIENCE IMMUNOLOGY

The spleen is a compartmentalized organ that serves as a blood filter and safeguard of systemic immune surveillance. Labyrinthine ..