Prof Scott Mueller

Associate Professor Scott Mueller is an NHMRC Senior Research Fellow and laboratory head in the Department of Microbiology and Immunology, The University of Melbourne, at the Doherty Institute. Scott is a world leader in basic immunology research, using advanced microscopy methods to visualise the cells of the immune system.

Dr Mueller trained at Monash University and then the University of Melbourne where he completed a PhD, before heading to the USA where he completed postdoctoral training at Emory University, Atlanta, GA. He then spent time working at the National Institutes of Health before returning to Australia as an ARC Queen Elizabeth II Fellow to set up his laboratory. His research is focused on dissecting the fundamental cellular processes involved in immune responses to infectious diseases and cancer in order to identify new targets for vaccine design and therapeutics. Current research in his lab is also dissecting crosstalk between the immune system and the nervous system and identifying the roles of mesenchymal stromal cells in immunity to infection and cancer.

Find out more about Scott Mueller's experience

Scott Mueller's highlights

FEATURED Journal article

Liver-Resident Memory CD8( ) T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

Scott Mueller's selected work

The Neuro-Immune Interface In Lymphoid Tissues

Research Grant

Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue rem..

Journal article

A Cellular Hub For The Organisation Of T Cell Priming

Research Grant

Systemic inflammation suppresses lymphoid tissue remodelling and B cell immunity during co..

Journal article

Defining The Role Of Xcr1 Dendritic Cells (Referral To Legal Services Tp706284 (Interim Ta..

Research Contracts

T cell and dendritic cell interactions in lymphoid organs: More than just being in the rig..

Journal article

Projects

Displaying the 18 most recent projects by Scott Mueller.

The Neuro-Immune Interface In Lymphoid Tissues

2019 - 2021

Active

A Cellular Hub For The Organisation Of T Cell Priming

This project aims to delineate the cellular interactions involved in the initiation of immune responses by utilising advanced in vivo imagin..

2019 - 2021

Active

Defining The Role Of Xcr1 Dendritic Cells (Referral To Legal Services Tp706284 (Interim Ta38371)

2018

Active

Protecting Against Malaria Through Liver-Resident Memory T Cells

We have shown that formation of liver-resident memory T cells (Trm), a newly discovered type of immune cells, can be induced by an innovativ..

2018 - 2021

Active

Protecting Against Malaria Through Liver-Resident Memory T Cells

We have shown that formation of liver-resident memory T cells (Trm), a newly discovered type of immune cells, can be induced by an innovativ..

2018 - 2021

Active

Defining The Coordination Of Immune Responses To Pathogens

Understanding how immune responses are coordinated is critical for the design of new therapies and vaccines to target infectious diseases an..

2018 - 2022

Active

Immune Surveillance Of The Cns During Malaria Infection

Infections in the central nervous system (CNS) can have profound neurological complications. Neurological disease caused by cerebral malaria..

2017 - 2019

Completed

Targeting Antigen To Clec9a On Dendritic Cell For Humoral Immunity

Dendritic cells capture infectious organisms and display them to other immune cells to initiate immunity. The process of capturing organisms..

2017 - 2019

Completed

Neural Regulation Of T Cell Functions

Immune responses to pathogens are generated in lymphoid tissues that are innervated by the sympathetic nervous system, which functions durin..

2015 - 2017

Completed

Defining The Immunological Roles Of Stromal Cells Within Lymphoid Tissues

The populations of endothelial and mesenchymal cells that construct the lymphoid tissues are being revealed as key players in the priming an..

2014 - 2016

Completed

An Advanced In Vivo Imaging Facility

This project will establish an advanced In Vivo Imaging Facility (IVIF) for examining host-microbe interactions and associated immunological..

2014 - 2015

Completed

An Advanced In Vivo Imaging Facility

This project will establish an advanced In Vivo Imaging Facility (IVIF) for examining host-microbe interactions and associated immunological..

2014 - 2015

Completed

Imaging The Generation And Recall Of Protective Antiviral Immune Responses In Vivo

Our understanding of the in vivo dynamics of cellular immune responses to infectious diseases is poor. This project will utilise advanced in..

2014 - 2017

Completed

Imaging The Generation And Recall Of Protective Antiviral Immune Responses In Vivo

Our understanding of the in vivo dynamics of cellular immune responses to infectious diseases is poor. This project will utilise advanced in..

2014 - 2017

Completed

Imaging Of T Cell Responses To Malaria Infection

2012 - 2013

Completed

Visulising Virus-Specific Immune Responses In The Skin

Effective vaccination against many viral infections such as Herpes Simplex Virus (HSV) may be achieved by directing the cells of the immune ..

2012 - 2014

Completed

A Dendritic Cell Subset Targeting Approach For Generating Humoral Immunity

Potent vaccination might be achieved by using monoclonal antibodies as magic bullets to target vaccines to special cells in the body. We sho..

2011 - 2013

Completed

Imaging Of Immune Responses To Pathogens In Vivo.

This proposal represents an excellent opportunity for Australian science to participate in state-of-the-art research into the immune system ..

2009 - 2014

Completed

18

Projects

Project Types

Research Grant

Internal Research Grant

Research Contracts

Scholarly Works

Displaying the 89 most recent scholarly works by Scott Mueller.

Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling

Caleb A Dawson, Bhupinder Pal, Francois Vaillant, Luke C Gandolfo, Zhaoyuan Liu, Camille Bleriot, Florent Ginhoux, Gordon K Smyth, Geoffrey J Lindeman, Scott N Mueller, Anne C Rios, Jane E Visvader

Journal article | 2020 | Nature Cell Biology

Macrophages are diverse immune cells that reside in all tissues. Although macrophages have been implicated in mammary-gland functi..

Systemic inflammation suppresses lymphoid tissue remodelling and B cell immunity during concomitant local infection

Yannick Alexandre, Sapna Devi, Simone Park, Laura Mackay, William Heath, Scott Mueller

Journal article | 2019

Abstract Concurrent infection with multiple pathogens occurs frequently in individuals and can result in exacerbated infections an..

T cell and dendritic cell interactions in lymphoid organs: More than just being in the right place at the right time

Milas Ugur, Scott N Mueller

Journal article | 2019 | Immunological Reviews

Tissue-resident memory T cells mediate melanoma surveillance and are targets of immunotherapy

Simone L Park, Anthony Buzzai, Jyh Liang Hor, Maike Effern, Susan N Christo, Scott N Mueller, Michael Holzel, Jason Waithman, Laura K Mackay, Thomas Gebhardt

Conference Proceedings | 2019 | JOURNAL OF IMMUNOLOGY

IL-17 instructs lymphoid stromal cells

Scott N Mueller

Journal article | 2019 | Nature Immunology

Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging

Anne C Rios, Bianca D Capaldo, Francois Vaillant, Bhupinder Pal, Ravian van Ineveld, Caleb A Dawson, Yunshun Chen, Emma Nolan, Nai Yang Fu, Felicity C Jackling, Sapna Devi, David Clouston, Lachlan Whitehead, Gordon K Smyth, Scott N Mueller, Geoffrey J Lindeman, Jane E Visvader, Jamie R Flynn, William M Palmer, Antony P Martin, et al.

Journal article | 2019 | Cancer Cell

The Interplay Between Lymphatic Vessels and Chemokines

Rae H Farnsworth, Tara Karnezis, Simon J Maciburko, Scott N Mueller, Steven A Stacker

Journal article | 2019 | Frontiers in Immunology

Tissue-resident memory CD8( ) T cells promote melanoma-immune equilibrium in skin

Simone L Park, Anthony Buzzai, Jai Rautela, Jyh Liang Hor, Katharina Hochheiser, Maike Effern, Nathan McBain, Teagan Wagner, Jarem Edwards, Robyn McConville, James S Wilmott, Richard A Scolyer, Thomas Tueting, Umaimainthan Palendria, David Gyorki, Scott N Mueller, Nicholas D Huntington, Sammy Bedoui, Michael Hoelzel, Laura K Mackay, et al.

Journal article | 2019 | Nature

Cerebral Malaria in Mouse and Man

Nazanin Ghazanfari, Scott N Mueller, William R Heath

Journal article | 2018 | Frontiers in Immunology

Stromal cell networks coordinate immune response generation and maintenance

Yannick O Alexandre, Scott N Mueller

Journal article | 2018 | Immunological Reviews

Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses

Simone L Park, Ali Zaid, Jyh Liang Hor, Susan N Christo, Julia E Prier, Brooke Davies, Yannick O Alexandre, Julia L Gregory, Tiffany A Russell, Thomas Gebhardt, Francis R Carbone, David C Tscharke, William R Heath, Scott N Mueller, Laura K Mackay

Journal article | 2018 | Nature Immunology

Skin-resident memory T cells and melanoma surveillance

S Park, A Buzzai, K Hochheiser, J Rautela, JL Hor, M Effern, N McBain, P Whitney, S Mueller, N Huntington, T Tuting, M Herold, M Holzel, S Bedoui, L Mackay, J Waithman, T Gebhardt

Conference Proceedings | 2017 | EUROPEAN JOURNAL OF IMMUNOLOGY

Migratory CD11b( ) conventional dendritic cells induce T follicular helper cell-dependent antibody responses

Jayendra Kumar Krishnaswamy, Uthaman Gowthaman, Biyan Zhang, Johan Mattsson, Louis Szeponik, Dong Liu, Renee Wu, Theresa White, Samuele Calabro, Lan Xu, Magalie A Collet, Marina Yurieva, Samuel Alsen, Per Fogelstrand, Anne Walter, William R Heath, Scott N Mueller, Ulf Yrlid, Adam Williams, Stephanie C Eisenbarth

Journal article | 2017 | Science Immunology

Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling

Steven P Williams, Adam F Odell, Tara Karnezis, Rae H Farnsworth, Cathryn M Gould, Jason Li, Sophie Paquet-Fifield, Nicole C Harris, Anne Walter, Julia L Gregory, Sara F Lamont, Ruofei Liu, Elena A Takano, Cameron J Nowell, Neil I Bower, Daniel Resnick, Gordon K Smyth, Leigh Coultas, Benjamin M Hogan, Stephen B Fox, et al.

Journal article | 2017 | Science Signaling

Spreading the load: Antigen transfer between migratory and lymph node-resident dendritic cells promotes T-cell priming

Scott N Mueller

Journal article | 2017 | European Journal of Immunology

Chemokine Receptor-Dependent Control of Skin Tissue-Resident Memory T Cell Formation

Ali Zaid, Jyh Liang Hor, Susan N Christo, Joanna R Groom, William R Heath, Laura K Mackay, Scott N Mueller

Journal article | 2017 | The Journal of Immunology

Isolation and Analysis of Stromal Cell Populations from Mouse Lymph Nodes

Yannick O Alexandre, Scott N Mueller

Journal article | 2017 | BIO-PROTOCOL

Control of lymphoid stromal cell responses during virus infections. Control of lymphoid stromal cell responses during virus infections

YO Alexandre, S Devi, SN Mueller

Conference Proceedings | 2017 | SWISS MEDICAL WEEKLY

Neutrophils are dispensable in the modulation of T cell immunity against cutaneous HSV-1 infection

Jyh Liang Hor, William R Heath, Scott N Mueller

Journal article | 2017 | Scientific Reports

Infection Programs Sustained Lymphoid Stromal Cell Responses and Shapes Lymph Node Remodeling upon Secondary Challenge

Julia L Gregory, Anne Walter, Yannick O Alexandre, Jyh Liang Hor, Ruijie Liu, Joel Z Ma, Sapna Devi, Nobuko Tokuda, Yuji Owada, Laura K Mackay, Gordon K Smyth, William R Heath, Scott N Mueller

Journal article | 2017 | Cell Reports

LIVER-RESIDENT MEMORY T CELLS CAN BE HARNESSED FOR UNPRECEDENTED PROTECTION AGAINST MALARIA

Daniel Fernandez-Ruiz, Wei Yi Ng, Lauren Holz, Anton Cozijnsen, Vanessa Mollard, Roghieh Skandari, Jonathan H Manton, Szun Szun Tay, David G Bowen, Friedrich Koch-Nolte, Bjorn Rissiek, Francis R Carbone, Brendan S Crabb, Scott N Mueller, Patrick Bertolino, Geoffrey I McFadden, Irina Caminschi, William R Heath

Conference Proceedings | 2017 | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Grand Challenges in Immunological Memory.

Scott N Mueller

Journal article | 2017 | Frontiers in Immunology

Liver-Resident Memory CD8( ) T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

Daniel Fernandez-Ruiz, Wei Yi Ng, Lauren E Holz, Joel Z Ma, Ali Zaid, Yik Chun Wong, Lei Shong Lau, Vanessa Mollard, Anton Cozijnsen, Nicholas Collins, Jessica Li, Gayle M Davey, Yu Kato, Sapna Devi, Roghieh Skandari, Michael Pauley, Jonathan H Manton, Dale I Godfrey, Asolina Braun, Szun Szun Tay, et al.

Journal article | 2016 | Immunity