Adam Deane

Metabolic support in sepsis: corticosteroids and vitamins: the why, the when, the how

Tomoko Fujii, Adam M Deane, Priya Nair

Journal article  |  2020  |  Current Opinion in Critical Care

PURPOSE OF REVIEW: Sepsis is a global health issue, and there is a need for effective, low-cost adjunct metabolic treatments. Cort..

Quantifying Response to Nutrition Therapy During Critical Illness: Implications for Clinical Practice and Research? A Narrative Review

Kate Fetterplace, Emma J Ridley, Lisa Beach, Yasmine Ali Abdelhamid, Jeffrey J Presneill, Christopher M MacIsaac, Adam M Deane

Journal article  |  2020  |  Journal of Parenteral and Enteral Nutrition

Critical illness causes substantial muscle loss that adversely impacts recovery and health related quality of life. Treatments are..

Long term outcomes for Aboriginal and Torres Strait Islander Australians after hospital intensive care

William G Mitchell, Adam Deane, Alex Brown, Shailesh Bihari, Hao Wong, Rajaram Ramadoss, Mark Finnis

Journal article  |  2020  |  Medical Journal of Australia

OBJECTIVES: To assess long term outcomes for Aboriginal and Torres Strait Islander (Indigenous) Australians admitted non-electivel..

Effects of Routine Position Changes and Tracheal Suctioning on Intracranial Pressure in Traumatic Brain Injury Patients

Anatole Harrois, James R Anstey, Adam M Deane, Sally Craig, Andrew A Udy, Robert McNamara, Rinaldo Bellomo

Journal article  |  2020  |  Journal of Neurotrauma

Patient position change and tracheal suctioning are routine interventions in mechanically ventilated traumatic brain injury (TBI) ..

Energy-dense vs routine enteral nutrition in New Zealand Europeans, Māori, and Pacific Peoples who are critically ill.

Alice L Reid, Marianne J Chapman, Sandra L Peake, Rinaldo Bellomo, Andrew Davies, Adam M Deane, Michael Horowitz, Sally Hurford, Kylie Lange, Lorraine Little, Diane Mackle, Stephanie N O'Connor, Emma J Ridley, Patricia J Williams, Paul J Young

Journal article  |  2020  |  The New Zealand medical journal

AIMS: To evaluate the effect of energy-dense vs routine enteral nutrition on day-90 mortality by ethnic group in critically ill ad..

Reply to: Too Many Calories for All?

Adam M Deane, Rinaldo Bellomo, Marianne J Chapman, Kylie Lange, Sandra L Peake, Paul Young, Theodore J Iwashyna

Journal article  |  2020  |  American Journal of Respiratory and Critical Care Medicine

Faecal diversion system usage in an adult intensive care unit.

Nicholas Wilson, Rinaldo Bellomo, Tyler Hay, Timothy Fazio, Jasmine Entwistle, Jeffrey J Presneill, Yasmine Ali Abdelhamid, Adam M Deane

Journal article  |  2020  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

OBJECTIVE: To determine the frequency, indications and complications associated with the use of faecal diversion systems (rectal t..

Outcome Measures in Critical Care Nutrition Interventional Trials: A Systematic Review

Lee-anne S Chapple, Matthew J Summers, Luke M Weinel, Adam M Deane

Journal article  |  2020  |  Nutrition in Clinical Practice

Historically, randomized controlled trials (RCTs) in critical care have used mortality as the primary outcome, yet most show no ef..

Characteristics and Outcomes of Critically III Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Australia and New Zealand

Freya Berenyi, Daniel P Steinfort, Yasmine Ali Abdelhamid, Michael J Bailey, David Pilcher, Rinaldo Bellomo, Mark E Finnis, Paul J Young, Adam M Deane

Journal article  |  2020  |  Annals of the American Thoracic Society

Rationale: The characteristics and outcomes of patients presenting with an acute exacerbation of chronic obstructive pulmonary dis..

Study protocol and statistical analysis plan for the Liberal Glucose Control in Critically Ill Patients with Pre-existing Type 2 Diabetes (LUCID) trial.

Alexis P Poole, Mark E Finnis, James Anstey, Rinaldo Bellomo, Shailesh Bihari, Vishwanath Biradar, Sarah Doherty, Glenn Eastwood, Simon Finfer, Craig J French, Angaj Ghosh, Simon Heller, Michael Horowitz, Palash Kar, Peter S Kruger, Matthew J Maiden, Johan Mårtensson, Colin J McArthur, Shay P McGuinness, Paul J Secombe, et al.

Journal article  |  2020  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

BACKGROUND: Contemporary glucose management of intensive care unit (ICU) patients with type 2 diabetes is based on trial data deri..

Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intensive Care Medicine

Annika Reintam Blaser, Jean-Charles Preiser, Sonja Fruhwald, Alexander Wilmer, Jan Wernerman, Carina Benstoem, Michael P Casaer, Joel Starkopf, Arthur van Zanten, Olav Rooyackers, Stephan M Jakob, Cecilia I Loudet, Danielle E Bear, Gunnar Elke, Matthias Kott, Ingmar Lautenschlaeger, Joern Schaeper, Jan Gunst, Christian Stoppe, Leda Nobile, et al.

Journal article  |  2020  |  Critical Care

BACKGROUND: Gastrointestinal (GI) dysfunction is frequent in the critically ill but can be overlooked as a result of the lack of s..

Systematic Review With Meta-Analysis of Patient-Centered Outcomes, Comparing International Guideline-Recommended Enteral Protein Delivery With Usual Care

Kate Fetterplace, Benjamin MT Gill, Lee-anne S Chapple, Jeffrey J Presneill, Christopher MacIsaac, Adam M Deane

Journal article  |  2020  |  Journal of Parenteral and Enteral Nutrition

BACKGROUND: International guidelines recommend that protein be administered enterally to critically ill patients at doses between ..

Outcomes Six Months after Delivering 100% or 70% of Enteral Calorie Requirements during Critical Illness (TARGET) A Randomized Controlled Trial

Adam M Deane, Lorraine Little, Rinaldo Bellomo, Marianne J Chapman, Andrew R Davies, Suzie Ferrie, Michael Horowitz, Sally Hurford, Kylie Lange, Edward Litton, Diane Mackle, Stephanie O'Connor, Jane Parker, Sandra L Peake, Jeffrey J Presneill, Emma J Ridley, Vanessa Singh, Frank van Haren, Patricia Williams, Paul Young, et al.

Journal article  |  2020  |  American Journal of Respiratory and Critical Care Medicine

Rationale: The long-term effects of delivering approximately 100% of recommended calorie intake via the enteral route during criti..

Update on nutritional assessment and therapy in critical care

Annika Reintam Blaser, Todd W Rice, Adam M Deane

Journal article  |  2020  |  Current Opinion in Critical Care

PURPOSE OF REVIEW: To summarize recent data regarding nutritional assessment and interventions in the ICU. RECENT FINDINGS: Curren..

Conservative Oxygen Therapy during Mechanical Ventilation in the ICU

Diane Mackle, MN Rinaldo Bellomo, Michael Bailey, Richard Beasley, Adam Deane, Glenn Eastwood, Simon Finfer, Ross Freebairn, Victoria King, Natalie Linke, Edward Litton, Colin McArthur, Shay McGuinness, Rakshit Panwar, Paul Young

Journal article  |  2020  |  New England Journal of Medicine

BACKGROUND: Patients who are undergoing mechanical ventilation in the intensive care unit (ICU) often receive a high fraction of i..

An observational study investigating the use of patient-owned technology to quantify physical activity in survivors of critical illness

Samuel Gluck, Matthew James Summers, Mark Edward Finnis, Alice Andrawos, Thomas Paul Goddard, Carol Lynette Hodgson, Theodore John Iwashyna, Adam Michael Deane

Journal article  |  2020  |  Australian Critical Care

BACKGROUND: Physical activity after intensive care unit (ICU) discharge is challenging to measure but could inform research and pr..

Is Energy Delivery Guided by Indirect Calorimetry Associated With Improved Clinical Outcomes in Critically Ill Patients? A Systematic Review and Meta-analysis

Oana A Tatucu-Babet, Kate Fetterplace, Kate Lambell, Eliza Miller, Adam M Deane, Emma J Ridley

Journal article  |  2020  |  Nutrition and Metabolic Insights

Background: Indirect calorimetry (IC) is recommended to guide energy delivery over predictive equations in critical illness due to..

Autonomic function, postprandial hypotension and falls in older adults at one year after critical illness.

Yasmine Ali Abdelhamid, Luke M Weinel, Seva Hatzinikolas, Matthew Summers, Thu Anh Ngoc Nguyen, Palash Kar, Liza K Phillips, Michael Horowitz, Adam M Deane, Karen L Jones

Journal article  |  2020  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

OBJECTIVE: Postprandial hypotension occurs frequently in older survivors of critical illness at 3 months after discharge. We aimed..

Angiotensin I and angiotensin II concentrations and their ratio in catecholamine-resistant vasodilatory shock

Rinaldo Bellomo, Richard G Wunderink, Harold Szerlip, Shane W English, Laurence W Busse, Adam M Deane, Ashish K Khanna, Michael T McCurdy, Marlies Ostermann, Paul J Young, Damian R Handisides, Lakhmir S Chawla, George F Tidmarsh, Timothy E Albertson

Journal article  |  2020  |  Critical Care

BACKGROUND: In patients with vasodilatory shock, plasma concentrations of angiotensin I (ANG I) and II (ANG II) and their ratio ma..

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock The VITAMINS Randomized Clinical Trial

Tomoko Fujii, Nora Luethi, Paul J Young, Daniel R Frei, Glenn M Eastwood, Craig J French, Adam M Deane, Yahya Shehabi, Ludhmila A Hajjar, Gisele Oliveira, Andrew A Udy, Neil Orford, Samantha J Edney, Anna L Hunt, Harriet L Judd, Laurent Bitker, Luca Cioccari, Thummaporn Naorungroj, Fumitaka Yanase, Samantha Bates, et al.

Journal article  |  2020  |  JAMA

Importance: It is unclear whether vitamin C, hydrocortisone, and thiamine are more effective than hydrocortisone alone in expediti..

The effects of ulimorelin, a ghrelin agonist, on liquid gastric emptying and colonic transit in humans

Joyce James, Stuart Mair, Walter Doll, Erik Sandefer, David Wurtman, Alan Maurer, Adam M Deane, M Scott Harris

Journal article  |  2020  |  Neurogastroenterology & Motility

BACKGROUND: Ulimorelin, a small molecule ghrelin agonist and prokinetic agent, was effective in animal models of gastroparesis and..

Blinded, Double-Dummy, Parallel-Group, Phase 2a Randomized Clinical Trial to Evaluate the Efficacy and Safety of a Highly Selective 5-Hydroxytryptamine Type 4 Receptor Agonist in Critically Ill Patients With Enteral Feeding Intolerance

Marianne J Chapman, Karen L Jones, Cristina Almansa, Chris N Barnes, Deanna Nguyen, Adam M Deane

Journal article  |  2020  |  Journal of Parenteral and Enteral Nutrition

BACKGROUND: Delayed gastric emptying is the leading cause of enteral feeding intolerance (EFI) in critical illness. This phase 2a ..

Conservative oxygen therapy for mechanically ventilated adults with sepsis: a post hoc analysis of data from the intensive care unit randomized trial comparing two approaches to oxygen therapy (ICU-ROX)

Paul Young, Diane Mackle, Rinaldo Bellomo, Michael Bailey, Richard Beasley, Adam Deane, Glenn Eastwood, Simon Finfer, Ross Freebairn, Victoria King, Natalie Linke, Edward Litton, Colin McArthur, Shay McGuinness, Rakshit Panwar

Journal article  |  2020  |  INTENSIVE CARE MEDICINE

PURPOSE: Sepsis is a common reason for intensive care unit (ICU) admission and mortality in ICU patients. Despite increasing inter..

Measuring nutrition-related outcomes in a cohort of multi-trauma patients following intensive care unit discharge

K Wittholz, K Fetterplace, M Clode, ES George, CM Maclsaac, R Judson, JJ Presneill, AM Deane

Journal article  |  2019  |  Journal of Human Nutrition and Dietetics

Pharmacokinetic data support 6-hourly dosing of intravenous vitamin C to critically ill patients with septic shock

Elizabeth P Hudson, Jake TB Collie, Tomoko Fujii, Nora Luethi, Andrew A Udy, Sarah Doherty, Glenn Eastwood, Fumitaka Yanase, Thummaporn Naorungroj, Laurent Bitker, Yasmine Ali Abdelhamid, Ronda F Greaves, Adam M Deane, Rinaldo Bellomo

Journal article  |  2019  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

OBJECTIVES: To study vitamin C pharmacokinetics in septic shock. DESIGN: Prospective pharmacokinetic study. SETTING: Two intensive..

Associations between nutritional energy delivery, bioimpedance spectroscopy and functional outcomes in survivors of critical illness

K Fetterplace, LJ Beach, C MacIsaac, J Presneill, L Edbrooke, SM Parry, T Rechnitzer, R Curtis, S Berney, AM Deane, L Denehy

Journal article  |  2019  |  Journal of Human Nutrition and Dietetics

BACKGROUND: Patients who survive critical illness frequently develop muscle weakness that can impact on quality of life; nutrition..

HAS FLAIR Investigators Reply to Fluid Resuscitation After Cardiac Surgery: The Quest for the Ideal Fluid

Geoffrey Wigmore, James Anstey, Adam Deane, Rinaldo Bellomo

Journal article  |  2019  |  Journal of Cardiothoracic and Vascular Anesthesia

20% Human Albumin Solution Fluid Bolus Administration Therapy in Patients After Cardiac Surgery (the HAS FLAIR Study)

Geoffrey J Wigmore, James R Anstey, Ashley St John, Joel Greaney, Marc Morales-Codina, Jeffrey J Presneill, Adam M Deane, Christopher M MacIsaac, Michael Bailey, James Tatoulis, Rinaldo Bellomo

Journal article  |  2019  |  Journal of Cardiothoracic and Vascular Anesthesia

OBJECTIVE: To compare the effects of fluid bolus therapy using 20% albumin versus crystalloid on fluid balance, hemodynamic parame..

Are point-of-care measurements of glycated haemoglobin accurate in the critically ill?

Luke M Weinel, Matthew J Summers, Mark E Finnis, Alexis Poole, Palash Kar, Marianne J Chapman, Adam M Deane, Yasmine Ali Abdelhamid

Journal article  |  2019  |  Australian Critical Care

INTRODUCTION: Critically ill patients with type 2 diabetes mellitus (T2DM) and chronic hyperglycaemia may benefit from a more libe..

Metabolic support in the critically ill: a consensus of 19

Jan Wernerman, Kenneth B Christopher, Djillali Annane, Michael P Casaer, Craig M Coopersmith, Adam M Deane, Elisabeth De Waele, Gunnar Elke, Carole Ichai, Constantine J Karvellas, Stephen A McClave, Heleen M Oudemans-van Straaten, Olav Rooyackers, Renee D Stapleton, Jukka Takala, Arthur RH van Zanten, Paul E Wischmeyer, Jean-Charles Preiser, Jean-Louis Vincent

Journal article  |  2019  |  Critical Care

Opinions and practices of blood glucose control in critically ill patients with pre-existing type 2 diabetes in Australian and New Zealand intensive care units

Alexis P Poole, James Anstey, Rinaldo Bellomo, Vishwanath Biradar, Adam M Deane, Simon R Finfer, Mark E Finnis, Craig J French, Palash Kar, Peter S Kruger, Matthew J Maiden, Johan Martensson, Colin J McArthur, Shay P McGuinness, Paul J Secombe, Antony E Tobin, Andrew A Udy, Glenn M Eastwood

Journal article  |  2019  |  Australian Critical Care

BACKGROUND: Approximately 9000 patients with type-2 diabetes mellitus (T2DM) are admitted to an intensive care unit (ICU) in Austr..

Any news from the prokinetic front?

Adam M Deane, Marianne J Chapman, Yasmine Ali Abdelhamid

Journal article  |  2019  |  Current Opinion in Critical Care

PURPOSE OF REVIEW: This review provides an update of recently conducted studies and randomized controlled trials evaluating prokin..

Translating the European Society for Clinical Nutrition and Metabolism 2019 guidelines into practice

Annika Reintam Blaser, Adam M Deane, Joel Starkopf

Journal article  |  2019  |  Current Opinion in Critical Care

PURPOSE OF REVIEW: To present a pragmatic approach to facilitate clinician's implementing the recent European Society for Clinical..

Constipation, diarrhea, and prophylactic laxative bowel regimens in the critically ill: A systematic review and meta-analysis

Tyler Hay, Rinaldo Bellomo, Tom Rechnitzer, Emily See, Yasmine Ali Abdelhamid, Adam M Deane

Journal article  |  2019  |  Journal of Critical Care

The hospital-based evaluation of laxative prophylaxis in ICU (HELP-ICU): A pilot cluster-crossover randomized clinical trial

Tyler Hay, Adam M Deane, Tom Rechnitzer, Kate Fetterplace, Rebecca Reilly, Melissa Ankravs, Michael Bailey, Timothy Fazio, James Anstey, Rohit D'Costa, Jeffrey J Presneill, Christopher M Maclsaac, Rinaldo Bellomo

Journal article  |  2019  |  Journal of Critical Care

Hospital-acquired complications in intensive care unit patients with diabetes: A before-and-after study of a conventional versus liberal glucose control protocol

Nora Luethi, Luca Cioccari, Glenn Eastwood, Peter Biesenbach, Rhys Morgan, Stephanie Sprogis, Helen Young, Leah Peck, Christine Knee Chong, Sandra Moore, Kylie Moon, Elif I Ekinci, Adam M Deane, Rinaldo Bellomo, Johan Martensson

Journal article  |  2019  |  Acta Anaesthesiologica Scandinavica

Gallbladder Dyskinesia Is Associated With an Impaired Postprandial Fibroblast Growth Factor 19 Response in Critically Ill Patients

Kiran VK Koelfat, Mark P Plummer, Frank G Schaap, Martin Lenicek, Peter LM Jansen, Adam M Deane, Steven WM Olde Damink

Journal article  |  2019  |  Hepatology

Observed appetite and nutrient intake three months after ICU discharge

Lee-anne S Chapple, Luke M Weinel, Yasmine Ali Abdelhamid, Matthew J Summers, Nguyen Thu, Palash Kar, Kylie Lange, Marianne J Chapman, Adam M Deane

Journal article  |  2019  |  Clinical Nutrition

BACKGROUND & AIMS: Oral intake is diminished immediately after ICU discharge, yet factors affecting nutritional intake after hospi..

The effect of a low carbohydrate formula on glycaemia in critically ill enterally-fed adult patients with hyperglycaemia: A blinded randomised feasibility trial

Ra'eesa Doola, Adam M Deane, Debbie M Tolcher, Jeffrey J Presneill, Helen L Barrett, Josephine M Forbes, Alwyn S Todd, Satomi Okano, David J Sturgess

Journal article  |  2019  |  Clinical Nutrition ESPEN

Obesity in the critically ill: a narrative review

Miet Schetz, Audrey De Jong, Adam M Deane, Wilfried Druml, Pleun Hemelaar, Paolo Pelosi, Peter Pickkers, Annika Reintam-Blaser, Jason Roberts, Yasser Sakr, Samir Jaber

Journal article  |  2019  |  Intensive Care Medicine

Vitamin C, Hydrocortisone and Thiamine in Patients with Septic Shock (VITAMINS) trial: study protocol and statistical analysis plan

Tomoko Fujii, Andrew A Udy, Adam M Deane, Nora Luethi, Michael Bailey, Glenn M Eastwood, Daniel Frei, Craig French, Neil Orford, Yahya Shehabi, Paul J Young, Rinaldo Bellomo

Journal article  |  2019  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

BACKGROUND: Septic shock is associated with poor outcomes. Vitamin C (ascorbic acid) is a cellular antioxidant and has anti-inflam..

A retrospective evaluation of nutrition support in relation to clinical outcomes in critically ill patients with an open abdomen

Rosalie Yandell, Susan Wang, Peter Bautz, Alison Shanks, Stephanie O'Connor, Adam Deane, Kylie Lange, Marianne Chapman

Journal article  |  2019  |  Australian Critical Care

BACKGROUND: Optimising nutrition support in critically ill patients with an open abdomen is challenging. OBJECTIVES: The aims of t..

Incretin Physiology and Pharmacology in the Intensive Care Unit

Mark P Plummer, Jeroen Hermanides, Adam M Deane

Journal article  |  2019  |  Critical Care Clinics

Gut dysmotility in the ICU: diagnosis and therapeutic options

Mark P Plummer, Annika Reintam Blaser, Adam M Deane

Journal article  |  2019  |  Current Opinion in Critical Care

PURPOSE OF REVIEW: To provide a comprehensive update of diagnosis and treatment of gastrointestinal dysmotility in the critically ..

Pathophysiology and Treatment of Gastrointestinal Motility Disorders in the Acutely Ill

Adam M Deane, Marianne J Chapman, Annika Reintam Blaser, Stephen A McClave, Anton Emmanuel

Journal article  |  2019  |  Nutrition in Clinical Practice

Incident Diabetes in Survivors of Critical Illness and Mechanisms Underlying Persistent Glucose Intolerance: A Prospective Cohort Study

Palash Kar, Mark P Plummer, Yasmine Ali Abdelhamid, Emma J Giersch, Matthew J Summers, Luke M Weinel, Mark E Finnis, Liza K Phillips, Karen L Jones, Michael Horowitz, Adam M Deane

Journal article  |  2019  |  Critical Care Medicine

What Happens to Nutrition Intake in the Post-Intensive Care Unit Hospitalization Period? An Observational Cohort Study in Critically Ill Adults

Emma J Ridley, Rachael L Parke, Andrew R Davies, Michael Bailey, Carol Hodgson, Adam M Deane, Shay McGuinness, D James Cooper

Journal article  |  2019  |  Journal of Parenteral and Enteral Nutrition

Delivery of full predicted energy from nutrition and the effect on mortality in critically ill adults: A systematic review and meta-analysis of randomised controlled trials

Emma J Ridley, Andrew R Davies, Carol L Hodgson, Adam Deane, Michael Bailey, D Jamie Cooper

Journal article  |  2018  |  Clinical Nutrition

What should we target after TARGET?

Paul J Young, Rinaldo Bellomo, Marianne J Chapman, Adam M Deane, Sandra L Peake

Journal article  |  2018  |  Critical Care and Resuscitation

Systematic review of incretin therapy during peri-operative and intensive care

Abraham H Hulst, Mark P Plummer, Markus W Hollmann, J Hans DeVries, Benedikt Preckel, Adam M Deane, Jeroen Hermanides

Journal article  |  2018  |  Critical Care

BACKGROUND: Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are incretin hormones. By lowering ..

Energy-Dense versus Routine Enteral Nutrition in the Critically Ill

Marianne Chapman, Sandra L Peake, Rinaldo Bellomo, Andrew Davies, Adam Deane, Michael Horowitz, Sally Hurford, Kylie Lange, Lorraine Little, Diane Mackle, Stephanie O'Connor, Jeffrey Presneill, Emma Ridley, Patricia Williams, Paul Young

Journal article  |  2018  |  New England Journal of Medicine

Targeted Full Energy and Protein Delivery in Critically Ill Patients: A Pilot Randomized Controlled Trial (FEED Trial)

Kate Fetterplace, Adam M Deane, Audrey Tierney, Lisa J Beach, Laura D Knight, Jeffrey Presneill, Thomas Rechnitzer, Adrienne Forsyth, Benjamin MT Gill, Marina Mourtzakis, Christopher MacIsaac

Journal article  |  2018  |  Journal of Parenteral and Enteral Nutrition

Nutrition Therapy in Australia and New Zealand Intensive Care Units: An International Comparison Study

Emma J Ridley, Sandra L Peake, Matthew Jarvis, Adam M Deane, Kylie Lange, Andrew R Davies, Marianne Chapman, Daren Heyland

Journal article  |  2018  |  Journal of Parenteral and Enteral Nutrition

Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database

Andrew J Boyle, Fabiana Madotto, John G Laffey, Giacomo Bellani, Pham Tai, Antonio Pesenti, B Taylor Thompson, Cecilia M O'Kane, Adam M Deane, Daniel F McAuley

Journal article  |  2018  |  Critical Care

Understanding the rationale for parenteral ascorbate (vitamin C) during an acute inflammatory reaction: a biochemical perspective

Robert McNamara, Adam M Deane, James Anstey, Rinaldo Bellomo

Journal article  |  2018  |  Critical Care and Resuscitation

Outcomes in Patients with Vasodilatory Shock and Renal Replacement Therapy Treated with Intravenous Angiotensin II (vol 46, pg 949, 2018)

JA Tumlin, R Murugan, AM Deane

Journal article  |  2018  |  Critical Care Medicine

Nutrition Adequacy Therapeutic Enhancement in the Critically Ill: A Randomized Double-Blind, Placebo-Controlled Trial of the Motilin Receptor Agonist Camicinal (GSK962040): The NUTRIATE Study

Adam M Deane, Francois Lamontagne, George E Dukes, David Neil, Lakshmi Vasist, Matthew E Barton, Kimberley Hacquoil, Xiaoling Ou, Duncan Richards, Henry T Stelfox, Sangeeta Mehta, Andrew G Day, Marianne J Chapman, Daren K Heyland

Journal article  |  2018  |  Journal of Parenteral and Enteral Nutrition

Postprandial hypotension in older survivors of critical illness

Anh Ngoc Nguyen Thu, Yasmine Ali Abdelhamid, Luke M Weinel, Seva Hatzinikolas, Palash Kar, Matthew J Summers, Liza K Phillips, Michael Horowitz, Karen L Jones, Adam M Deane

Journal article  |  2018  |  Journal of Critical Care

PURPOSE: In older people postprandial hypotension occurs frequently; and is an independent risk factor for falls, cardiovascular e..

\ Liberal Glucose Control in ICU Patients With Diabetes: A Before-and-After Study

Nora Luethi, Luca Cioccari, Peter Biesenbach, Luca Lucchetta, Hidetoshi Kagaya, Rhys Morgan, Francesca Di Muzio, Barbara Presello, Duaa Gaafar, Alison Hay, Marco Crisman, Roisin Toohey, Hollie Russell, Neil J Glassford, Glenn M Eastwood, Elif I Ekinci, Adam M Deane, Rinaldo Bellomo, Johan Martensson

Journal article  |  2018  |  Critical Care Medicine

Outcomes in Patients with Vasodilatory Shock and Renal Replacement Therapy Treated with Intravenous Angiotensin II

James A Tumlin, Raghavan Murugan, Adam M Deane, Marlies Ostermann, Laurence W Busse, Kealy R Ham, Kianoush Kashani, Harold M Szerlip, John R Prowle, Azra Bihorac, Kevin W Finkel, Alexander Zarbock, Lui G Forni, Shannan J Lynch, Jeff Jensen, Stew Kroll, Lakhmir S Chawla, George F Tidmarsh, Rinaldo Bellomo

Journal article  |  2018  |  Critical Care Medicine

EFFICACY AND SAFETY OF TAK-954 IN CRITICALLY ILL PATIENTS WITH ENTERAL FEEDING INTOLERANCE: A RANDOMIZED PHASE 2A CLINICAL TRIAL

Marianne Chapman, Adam M Deane, Karen L Jones, Chris Barnes, Deanna Nguyen, Cristina Almansa

Conference Proceedings  |  2018  |  GASTROENTEROLOGY

ULIMORELIN, AN IV GHRELIN AGONIST, HAS POTENT PROKINETIC EFFECTS IN THE HUMAN STOMACH BUT NOT COLON: WHY AN ACTIVE DRUG MAY HAVE FAILED IN CLINICAL TRIALS

Joyce James, Walter J Doll, Adam M Deane, Stuart J Mair, Alan H Maurer, Scott Harris

Conference Proceedings  |  2018  |  GASTROENTEROLOGY

Fluids in sepsis

JR Anstey, AM Deane, R Bellomo

Book Chapter  |  2018

Diabetes-Specific Formulae Versus Standard Formulae as Enteral Nutrition to Treat Hyperglycemia in Critically Ill Patients: Protocol for a Randomized Controlled Feasibility Trial

Ra'eesa Doola, Alwyn S Todd, Josephine M Forbes, Adam M Deane, Jeffrey J Presneill, David J Sturgess

Journal article  |  2018  |  JMIR Research Protocols

From dysmotility to virulent pathogens: implications of opioid use in the ICU

Lee-anne Chapple, Adam Deane

Journal article  |  2018  |  Current Opinion in Critical Care

Protocol summary and statistical analysis plan for the intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX)

Diane M Mackle, Michael J Bailey, Richard W Beasley, Rinaldo Bellomo, Victoria L Bennett, Adam M Deane, Glenn M Eastwood, Simon Finfer, Ross C Freebairn, Edward Litton, Natalie J Linke, Colin J McArthur, Shay P McGuinness, Rakshit Panwar, Paul J Young

Journal article  |  2018  |  Critical Care and Resuscitation

The disconnect between nutrition guidelines and evidence: how much protein should I prescribe to this critically ill patient?

Adam M Deane, Sandra L Peake, Marianne J Chapman

Journal article  |  2018  |  Critical Care and Resuscitation

Barriers to Nutrition Intervention for Patients With a Traumatic Brain Injury: Views and Attitudes of Medical and Nursing Practitioners in the Acute Care Setting

Lee-anne Chapple, Marianne Chapman, Natalie Shalit, Andrew Udy, Adam Deane, Lauren Williams

Journal article  |  2018  |  Journal of Parenteral and Enteral Nutrition

Post-pyloric feeding tube placement in critically ill patients: Extending the scope of practice for Australian dietitians

Rosalie Yandell, Marianne Chapman, Stephanie O'Connor, Alison Shanks, Kylie Lange, Adam Deane

Journal article  |  2018  |  Nutrition & Dietetics

AIM: To determine whether the placement of a post-pyloric feeding tube (PPFT) can be taught safely and effectively to a critical c..

Glycaemic control targets after traumatic brain injury: a systematic review and meta-analysis

Jeroen Hermanides, Mark P Plummer, Mark Finnis, Adam M Deane, Jonathan P Coles, David K Menon

Journal article  |  2018  |  Critical Care

BACKGROUND: Optimal glycaemic targets in traumatic brain injury (TBI) remain unclear. We performed a systematic review and meta-an..

Targeted full energy and protein delivery in critically ill patients: a study protocol for a pilot randomised control trial (FEED Trial).

Kate Fetterplace, Adam M Deane, Audrey Tierney, Lisa Beach, Laura D Knight, Thomas Rechnitzer, Adrienne Forsyth, Marina Mourtzakis, Jeffrey Presneill, Christopher MacIsaac

Journal article  |  2018  |  Pilot Feasibility Stud

Background: Current guidelines for the provision of protein for critically ill patients are based on incomplete evidence, due to l..

Glycated haemoglobin is increased in critically ill patients with stress hyperglycaemia: Implications for risk of diabetes in survivors of critical illness

Yang T Du, Palash Kar, Yasmine Ali Abdelhamid, Michael Horowitz, Adam M Deane

Journal article  |  2018  |  Diabetes Research and Clinical Practice

It remains uncertain if stress hyperglycaemia (SH) indicates a long-term predisposition to the development of type 2 diabetes. We ..

Efficacy and safety of stress ulcer prophylaxis in critically ill patients: a network meta-analysis of randomized trials

Waleed Alhazzani, Fayez Alshamsi, Emilie Belley-Cote, Diane Heels-Ansdell, Romina Brignardello-Petersen, Mustafa Alquraini, Anders Perner, Morten Hylander Moller, Mette Krag, Saleh Almenawer, Bram Rochwerg, Joanna Dionne, Roman Jaeschke, Mohammed Alshahrani, Adam Deane, Dan Perri, Lehana Thebane, Awad Al-Omari, Simon Finfer, Deborah Cook, et al.

Journal article  |  2018  |  Intensive Care Medicine

PURPOSE: Stress ulcer prophylaxis (SUP) is commonly prescribed in the intensive care unit. However, data from systematic reviews a..

Intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX): results of the pilot phase

Paul J Young, Diane M Mackie, Michael J Bailey, Richard W Beasley, Victoria L Bennett, Adam M Deane, Glenn M Eastwood, Simon Finfer, Ross C Freebairn, Edward Litton, Natalie J Linke, Colin J McArthur, Shay P McGuinness, Rakshit Panwar, Rinaldo Bellomo

Journal article  |  2017  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

Long-term mortality of critically ill patients with diabetes who survive admission to the intensive care unit

Yasmine Ali Abdelhamid, Mark P Plummer, Mark E Finnis, Vishwanath Biradar, Shailesh Bihari, Palash Kar, Stewart Moodie, Michael Horowitz, Jonathan E Shaw, Liza K Phillips, Adam M Deane

Journal article  |  2017  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

OBJECTIVE: Long-term outcomes of critically ill patients with diabetes are unknown. Our objectives were to evaluate the effect of ..

Medical Emergency Team (MET) Criteria in the Intensive Care Unit Setting

Logan Denny, Adam Deane, Peter T Morley

Conference Proceedings  |  2017  |  CIRCULATION

Antecedent Hypoglycemia Does Not Attenuate the Acceleration of Gastric Emptying by Hypoglycemia

Palash Kar, Karen L Jones, Mark P Plummer, Yasmine Ali Abdelhamid, Emma J Giersch, Matthew J Summers, Seva Hatzinikolas, Simon Heller, Michael Horowitz, Adam M Deane

Journal article  |  2017  |  The Journal of Clinical Endocrinology & Metabolism

Context: Acute hypoglycemia accelerates gastric emptying and increases cardiac contractility. However, antecedent hypoglycemia att..

Intensity of early correction of hyperglycaemia and outcome of critically ill patients with diabetic ketoacidosis

Johan Martensson, Michael Bailey, Balasubramanian Venkatesh, David Pilcher, Adam Deane, Yasmine Ali Abdelhamid, Marco Crisman, Brij Verma, Christopher MacIsaac, Geoffrey Wigmore, Yahya Shehabi, Takafumi Suzuki, Craig French, Neil Orford, Nima Kakho, Johannes Prins, Elif I Ekinci, Rinaldo Bellomo

Journal article  |  2017  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

A scoping review of use of wearable devices to evaluate outcomes in survivors of critical illness

Samuel Gluck, Lee-Anne S Chapple, Marianne J Chapman, Theodore J Iwashyna, Adam M Deane

Journal article  |  2017  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

OBJECTIVE: Wearable devices using new technology may be a cost-effective method to assess functional outcomes in survivors of crit..

Glycated haemoglobin is increased in critically ill patients with stress hyperglycaemia: implications for risk of diabetes in survivors of critical illness

YT Du, P Kar, Y Ali Abdelhamid, M Horowitz, AM Deane

Conference Proceedings  |  2017  |  DIABETOLOGIA

Angiotensin II for the Treatment of Vasodilatory Shock

Ashish Khanna, Shane W English, Xueyuan S Wang, Kealy Ham, James Tumlin, Harold Szerlip, Laurence W Busse, Laith Altaweel, Timothy E Albertson, Caleb Mackey, Michael T McCurdy, David W Boldt, Stefan Chock, Paul J Young, Kenneth Krell, Richard G Wunderink, Marlies Ostermann, Raghavan Murugan, Michelle N Gong, Rakshit Panwar, et al.

Journal article  |  2017  |  New England Journal of Medicine

Mechanisms Controlling Glucose-Induced GLP-1 Secretion in Human Small Intestine

Emily W Sun, Dayan de Fontgalland, Philippa Rabbitt, Paul Hollington, Luigi Sposato, Steven L Due, David A Wattchow, Christopher K Rayner, Adam M Deane, Richard L Young, Damien J Keating

Journal article  |  2017  |  Diabetes

Intestinal glucose stimulates secretion of the incretin hormone glucagon-like peptide 1 (GLP-1). The mechanisms underlying this pa..

Intensive care discharge delay is associated with increased hospital length of stay: A multicentre prospective observational study

Ravindranath Tiruvoipati, John Botha, Jason Fletcher, Himangsu Gangopadhyay, Mainak Majumdar, Sanjiv Vij, Eldho Paul, David Pilcher

Journal article  |  2017  |  PLOS ONE

BACKGROUND: Some patients experience a delayed discharge from the intensive care unit (ICU) where the intended and actual discharg..

The rapid and accurate categorisation of critically ill patients (RACE) to identify outcomes of interest for longitudinal studies: a feasibility study

AM Deane, CL Hodgson, P Young, L Little, V Singh, A Poole, M Young, D Mackle, K Lange, P Williams, SL Peake, MJ Chapman, TJ Iwashyna

Journal article  |  2017  |  Anaesthesia and Intensive Care

Withholding Pantoprazole for Stress Ulcer Prophylaxis in Critically Ill Patients: A Pilot Randomized Clinical Trial and Meta-Analysis

Waleed Alhazzani, Gordon Guyatt, Mohammed Alshahrani, Adam M Deane, John C Marshall, Richard Hall, John Muscedere, Shane W English, Francois Lauzier, Lehana Thabane, Yaseen M Arabi, Tim Karachi, Bram Rochwerg, Simon Finfer, Nick Daneman, Fayez Alshamsi, Nicole Zytaruk, Diane Heel-Ansdell, Deborah Cook

Journal article  |  2017  |  Critical Care Medicine

INTRODUCTION: A decreased frequency of upper gastrointestinal bleeding and a possible association of proton pump inhibitor use wit..

Weekend days are not required to accurately measure oral intake in hospitalised patients

LS Chapple, AM Deane, K Lange, AJ Kranz, LT Williams, MJ Chapman

Journal article  |  2017  |  Journal of Human Nutrition and Dietetics

BACKGROUND: Nutrition studies in patients admitted to hospital frequently disregard oral intake because measurement is time-intens..

Longitudinal changes in anthropometrics and impact on self-reported physical function after traumatic brain injury

Lee-Anne S Chapple, Adam M Deane, Lauren T Williams, Richard Strickland, Chris Schultz, Kylie Lange, Daren K Heyland, Marianne J Chapman

Journal article  |  2017  |  Critical Care and Resuscitation

BACKGROUND AND AIMS: Patients admitted to the ICU with a traumatic brain injury (TBI) are at risk of muscle wasting but this has n..

Exogenous glucagon-like peptide-1 attenuates glucose absorption and reduces blood glucose concentration after small intestinal glucose delivery in critical illness

Asaf Miller, Adam M Deane, Mark P Plummer, Caroline E Cousins, Lee-Anne S Chapple, Michael Horowitz, Marianne J Chapman

Journal article  |  2017  |  Critical Care and Resuscitation

OBJECTIVE: To evaluate the effect of exogenous glucagonlike peptide-1 (GLP-1) on small intestinal glucose absorption and blood glu..

Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines

Annika Reintam Blaser, Joel Starkopf, Waleed Alhazzani, Mette M Berger, Michael P Casaer, Adam M Deane, Sonja Fruhwald, Michael Hiesmayr, Carole Ichai, Stephan M Jakob, Cecilia I Loudet, Manu LNG Malbrain, Juan C Montejo Gonzalez, Catherine Paugam-Burtz, Martijn Poeze, Jean-Charles Preiser, Pierre Singer, Arthur RH Van Zanten, Jan De Waele, Julia Wendon, et al.

Journal article  |  2017  |  Intensive Care Medicine

PURPOSE: To provide evidence-based guidelines for early enteral nutrition (EEN) during critical illness. METHODS: We aimed to comp..

Physiological and clinical outcomes associated with fluid bolus therapy administered at rapid response calls for hypotension; a retrospective observational study

Sarah Doherty, Diane Chamberlain, Adam Deane, Mark Finnis

Conference Proceedings  |  2017  |  Australian Critical Care

Longitudinal changes in body composition and impact on self-reported physical function following traumatic brain injury

Lee-Anne Chapple, Adam Deane, Lauren Williams, Richard Strickland, Chris Schultz, Kylie Lange, Daren Heyland, Marianne Chapman

Conference Proceedings  |  2017  |  Australian Critical Care

A comparison of subjective and objective reporting of patient physical activity prior to critical illness

Samuel Gluck, Matthew Summers, Thomas Goddard, Natalie Smith, Alice Andrewos, Theodore Iwashyna, Adam Deane

Conference Proceedings  |  2017  |  Australian Critical Care

Nutrient stimulation of mesenteric blood flow - implications for older critically ill patients.

Thu An Nguyen, Yasmine Ali Abdelhamid, Liza K Phillips, Leeanne S Chapple, Michael Horowitz, Karen L Jones, Adam M Deane

Journal article  |  2017  |  World Journal of Critical Care Medicine

Nutrient ingestion induces a substantial increase in mesenteric blood flow. In older persons (aged ≥ 65 years), particularly those..

Occult upper gastrointestinal mucosal abnormalities in critically ill patients

C Ovenden, MP Plummer, S Selvanderan, TA Donaldson, NQ Nguyen, LM Weinel, ME Finnis, MJ Summers, Y Ali Abdelhamid, MJ Chapman, CK Rayner, AM Deane

Journal article  |  2017  |  Acta Anaesthesiologica Scandinavica

BACKGROUND: The objectives of this study were to estimate the frequency of occult upper gastrointestinal abnormalities, presence o..

Barriers to Nutrition Intervention for Patients With a Traumatic Brain Injury.

Lee-Anne Chapple, Marianne Chapman, Natalie Shalit, Andrew Udy, Adam Deane, Lauren Williams

Journal article  |  2017  |  Journal of Parenteral and Enteral Nutrition

BACKGROUND: Nutrition delivered to patients with a traumatic brain injury (TBI) is typically below prescribed amounts. While the d..

Energy and protein deficits throughout hospitalization in patients admitted with a traumatic brain injury

Lee-anne S Chapple, Adam M Deane, Daren K Heyland, Kylie Lange, Amelia J Kranz, Lauren T Williams, Marianne J Chapman

Journal article  |  2016  |  Clinical Nutrition

BACKGROUND AND AIMS: Patients with traumatic brain injury (TBI) experience considerable energy and protein deficits in the intensi..

Re-evaluating the Inhibition of Stress Erosions (REVISE): a protocol for pilot randomized controlled trial

Waleed Alhazzani, Gordon Guyatt, John C Marshall, Richard Hall, John Muscedere, Francois Lauzier, Lehana Thabane, Mohammed Alshahrani, Shane W English, Yaseen M Arabi, Adam M Deane, Tim Karachi, Bram Rochwerg, Simon Finfer, Nick Daneman, Nicole Zytaruk, Diane Heel-Ansdell, Deborah Cook

Journal article  |  2016  |  Annals of Saudi Medicine

INTRODUCTION: Clinicians routinely administer stress ulcer prophylaxis to mechanically ventilated patients in the intensive care u..

Stress Induced Hyperglycemia and the Subsequent Risk of Type 2 Diabetes in Survivors of Critical Illness

Mark P Plummer, Mark E Finnis, Liza K Phillips, Palash Kar, Shailesh Bihari, Vishwanath Biradar, Stewart Moodie, Michael Horowitz, Jonathan E Shaw, Adam M Deane

Journal article  |  2016  |  PLOS ONE

OBJECTIVE: Stress induced hyperglycemia occurs in critically ill patients who have normal glucose tolerance following resolution o..

Pantoprazole or Placebo for Stress Ulcer Prophylaxis (POP-UP): Randomized Double-Blind Exploratory Study

Shane P Selvanderan, Matthew J Summers, Mark E Finnis, Mark P Plummer, Yasmine Ali Abdelhamid, Michael B Anderson, Marianne J Chapman, Christopher K Rayner, Adam M Deane

Journal article  |  2016  |  Critical Care Medicine

OBJECTIVES: Pantoprazole is frequently administered to critically ill patients for prophylaxis against gastrointestinal bleeding. ..

Stress hyperglycaemia in critically ill patients and the subsequent risk of diabetes: a systematic review and meta-analysis

Yasmine Ali Abdelhamid, Palash Kar, Mark E Finnis, Liza K Phillips, Mark P Plummer, Jonathan E Shaw, Michael Horowitz, Adam M Deane

Journal article  |  2016  |  Critical Care

BACKGROUND: Hyperglycaemia occurs frequently in critically ill patients without diabetes. We conducted a systematic review and met..

Prior exposure to hyperglycaemia attenuates the relationship between glycaemic variability during critical illness and mortality

Mark P Plummer, Mark E Finnis, Matthew Horsfall, Marleesa Ly, Palash Kar, Yasmine Ali Abdelhamid, Adam M Deane

Journal article  |  2016  |  Critical Care and Resuscitation

OBJECTIVE: Our primary objective was to determine the impact of prior exposure to hyperglycaemia on the association between glycae..

Liberal Versus Conventional Glucose Targets in Critically III Diabetic Patients: An Exploratory Safety Cohort Assessment

Francesca Di Muzio, Barbara Presello, Neil J Glassford, Isabela Y Tsuji, Glenn M Eastwood, Adam M Deane, Elif I Ekinci, Rinaldo Bellomo, Johan Martensson

Journal article  |  2016  |  CRITICAL CARE MEDICINE

Liberal Glycemic Control in Critically III Patients With Type 2 Diabetes: An Exploratory Study

Palash Kar, Mark P Plummer, Rinaldo Bellomo, Alicia J Jenkins, Andrzej S Januszewski, Marianne J Chapman, Karen L Jones, Michael Horowitz, Adam M Deane

Journal article  |  2016  |  Critical Care Medicine

Critical Illness Is Associated With Impaired Gallbladder Emptying as Assessed by 3D Ultrasound

Mark P Plummer, Palash Kar, Caroline E Cousins, Trygve Hausken, Kylie Lange, Marianne J Chapman, Karen L Jones, Michael Horowitz, Adam M Deane

Journal article  |  2016  |  Critical Care Medicine

OBJECTIVE: To quantify gallbladder dysfunction during critical illness. DESIGN: Prospective observational comparison study of nutr..

Energy-Dense Formulae May Slow Gastric Emptying in the Critically Ill

Palash Kar, Mark P Plummer, Marianne J Chapman, Caroline E Cousins, Kylie Lange, Michael Horowitz, Karen L Jones, Adam M Deane

Journal article  |  2016  |  Journal of Parenteral and Enteral Nutrition

BACKGROUND: Enteral feed intolerance occurs frequently in critically ill patients and can be associated with adverse outcomes. "En..

Individualizing endpoints in randomized clinical trials to better inform individual patient care: the TARGET proposal

Theodore J Iwashyna, Adam M Deane

Journal article  |  2016  |  Critical Care

DPP-4 Inhibition and the Known Unknown

Michael Horowitz, Tongzhi Wu, Adam M Deane, Karen L Jones, Christopher K Rayner

Journal article  |  2016  |  Diabetes

Effects of antecedent hypoglycaemia on gastric and cardiac responses to subsequent hypoglycaemia in health

P Kar, MP Plummer, E Giersch, MJ Summers, S Hatzinikolas, M Horowitz, MJ Chapman, KL Jones, SR Heller, A Deane

Conference Proceedings  |  2016  |  DIABETOLOGIA

The effect of camicinal (GSK962040), a motilin agonist, on gastric emptying and glucose absorption in feed-intolerant critically ill patients: a randomized, blinded, placebo-controlled, clinical trial

Marianne J Chapman, Adam M Deane, Stephanie L O'Connor, Nam Q Nguyen, Robert JL Fraser, Duncan B Richards, Kimberley E Hacquoil, Lakshmi S Vasist Johnson, Matthew E Barton, George E Dukes

Journal article  |  2016  |  Critical Care

BACKGROUND: The promotility agents currently available to treat gastroparesis and feed intolerance in the critically ill are limit..

Preliminary observations of gastric emptying in diabetic ketoacidosis

LK Phillips, C Marathe, L Trahair, MJ Bound, S Hatzinikolas, LE Mignone, AM Deane, CK Rayner, KL Jones, M Horowitz

Conference Proceedings  |  2016  |  DIABETOLOGIA

A prospective observational study of the effect of critical illness on ultrastructural and microscopic morphology of duodenal mucosa

Victor Y Liew, Marianne J Chapman, Nam Q Nguyen, Caroline E Cousins, Mark P Plummer, Lee-Anne S Chapple, Yasmine Ali Abdelhamid, Nicholas D Manton, Adam Swalling, Peter Sutton-Smith, Alastair D Burt, Adam M Deane

Journal article  |  2016  |  Critical Care and Resuscitation

OBJECTIVE: Disturbed intestinal barrier function due to 'leaky' tight junctions may cause secondary sepsis via paracellular transl..

Dysglycemia and Glucose Control During Sepsis

Mark P Plummer, Adam M Deane

Journal article  |  2016  |  Clinics in Chest Medicine

Sepsis predisposes to disordered metabolism and dysglycemia; the latter is a broad term that includes hyperglycemia, hypoglycemia,..

Stress ulcer prophylaxis in critical illness: a Canadian survey

Melissa Shears, Waleed Alhazzani, John C Marshall, John Muscedere, Richard Hall, Shane W English, Peter M Dodek, Francois Lauzier, Salmaan Kanji, Mark Duffett, Jeffrey Barletta, Mohammed Alshahrani, Yaseen Arabi, Adam Deane, Deborah J Cook

Journal article  |  2016  |  Canadian Journal of Anesthesia/Journal canadien d'anesthésie

PURPOSE: Stress ulcer prophylaxis (SUP) using histamine-2-receptor antagonists has been a standard of care in intensive care units..

The insulinotropic effect of pulsatile compared with continuous intravenous delivery of GLP-1

Mark P Plummer, Palash Kar, Caroline E Cousins, Kylie Lange, Marianne J Chapman, Michael A Nauck, Michael Horowitz, Juris J Meier, Adam M Deane

Journal article  |  2016  |  Diabetologia

AIMS/HYPOTHESIS: In healthy individuals, both insulin and glucagon-like peptide 1 (GLP-1) are secreted in a pulsatile fashion. Ins..

The effect of augmenting early nutritional energy delivery on quality of life and employment status one year after ICU admission

DB Reid, LS Chapple, SN O'Connor, R Bellomo, H Buhr, MJ Chapman, AR Davies, GM Eastwood, S Ferrie, K Lange, J McIntyre, DM Needham, SL Peake, S Rai, EJ Ridley, H Rodgers, AM Deane

Journal article  |  2016  |  Anaesthesia and Intensive Care

Administration of Stress Ulcer Prophylaxis May Cause Harm in Critically Ill Patients: A Randomized Double Blind Exploratory Study

Shane P Selvanderan, Matthew Summers, Mark Finnis, Mark Plummer, Yasmine Ali Abdelhamid, Michael Anderson, Marianne Chapman, Chris Rayner, Adam M Deane

Conference Proceedings  |  2016  |  Gastroenterology

Event-rate and delta inflation when evaluating mortality as a primary outcome from randomized controlled trials of nutritional interventions during critical illness: a systematic review

Matthew J Summers, Lee-Anne S Chapple, Stephen A McClave, Adam M Deane

Journal article  |  2016  |  The American Journal of Clinical Nutrition

BACKGROUND: There is a lack of high-quality evidence that proves that nutritional interventions during critical illness reduce mor..

Nutrition support practices in critically ill head-injured patients: a global perspective

Lee-anne S Chapple, Marianne J Chapman, Kylie Lange, Adam M Deane, Daren K Heyland

Journal article  |  2016  |  Critical Care

BACKGROUND: Critical illness following head injury is associated with a hypermetabolic state but there are insufficient epidemiolo..

Enhanced Protein-Energy Provision via the Enteral Route Feeding (PEPuP) protocol in critically ill surgical patients: a multicentre prospective evaluation

B Declercq, AM Deane, M Wang, MJ Chapman, DK Heyland

Journal article  |  2016  |  Anaesthesia and Intensive Care

Suboptimal levels of feeding in critically ill patients are associated with poor clinical outcomes. The Enhanced Protein-Energy Pr..

Peri-operative nutrition

Y Ali Abdelhamid, MJ Chapman, AM Deane

Journal article  |  2016  |  Anaesthesia

Patients are frequently malnourished or are at risk of malnutrition before surgery. Peri-operative nutritional support can improve..

Survivors of intensive care with type 2 diabetes and the effect of shared care follow-up clinics: study protocol for the SWEET-AS randomised controlled feasibility study.

Yasmine Ali Abdelhamid, Liza Phillips, Michael Horowitz, Adam Deane

Journal article  |  2016  |  Pilot and Feasibility Studies

BACKGROUND: Many patients who survive the intensive care unit (ICU) experience long-term complications such as peripheral neuropat..

Enterohormones and the response to critical illness

MP Plummer, AR Blaser, AM Deane

Book Chapter  |  2016

Supplemental parenteral nutrition in critically ill patients: a study protocol for a phase II randomised controlled trial

Emma J Ridley, Andrew R Davies, Rachael Parke, Michael Bailey, Colin McArthur, Lyn Gillanders, David J Cooper, Shay McGuinness

Journal article  |  2015  |  Trials

Attenuated platelet aggregation in patients with septic shock is independent from the activity state of myosin light chain phosphorylation or a reduction in Rho kinase-dependent inhibition of myosin light chain phosphatase.

Benjamin Aj Reddi, Samantha M Iannella, Stephanie N O'Connor, Adam M Deane, Scott R Willoughby, David P Wilson

Journal article  |  2015  |  Intensive Care Medicine Experimental

BACKGROUND: Impaired coagulation contributes to the morbidity and mortality associated with septic shock. Whether abnormal platele..

Personalised glucose therapy: glucose targets in critically ill patients with pre-existing poorly controlled type 2 diabetes.

P Kar, MP Plummer, R Bellomo, AJ Jenkins, AS Januszewski, K Lange, MJ Chapman, M Horowitz, AM Deane

Journal article  |  2015  |  Intensive Care Medicine Experimental

The incidence of ocular candidiasis and evaluation of routine ophthalmic examination in critically ill patients with candidaemia

S Gluck, WG Headdon, DWS Tang, IB Bastian, MJ Goggin, AM Deane

Journal article  |  2015  |  Anaesthesia and Intensive Care

Despite a paucity of data regarding both the incidence of ocular candidiasis and the utility of ophthalmic examination in critical..

Effect of Critical Illness on Triglyceride Absorption

Yasmine Ali Abdelhamid, Caroline E Cousins, Jennifer A Sim, Max S Bellon, Nam Q Nguyen, Michael Horowitz, Marianne J Chapman, Adam M Deane

Journal article  |  2015  |  Journal of Parenteral and Enteral Nutrition

BACKGROUND: Adequate nutrition support for critically ill patients optimizes outcome, and enteral feeding is the preferred route o..

Comparison of different definitions of feeding intolerance: A retrospective observational study

Annika Reintam Blaser, Liis Starkopf, Adam M Deane, Martijn Poeze, Joel Starkopf

Journal article  |  2015  |  Clinical Nutrition

BACKGROUND & AIMS: While feeding intolerance (FI) is clinically important in the critically ill it is inconsistently defined. By e..

Preclinical research in critical care - the Australasian perspective

Shailesh Bihari, Matthew Maiden, Adam Deane, Ralph Fuchs, John Fraser, Andrew D Bersten, Rinaldo Bellomo

Journal article  |  2015  |  Critical Care and Resuscitation

Measurement of gastric emptying in the critically ill

Palash Kar, Karen L Jones, Michael Horowitz, Marianne J Chapman, Adam M Deane

Journal article  |  2015  |  Clinical Nutrition

BACKGROUND & AIMS: Enteral nutrition is important in critically ill patients and is usually administered via a nasogastric tube. A..

Effects of exogenous glucagon-like peptide-1 on blood pressure, heart rate, gastric emptying, mesenteric blood flow and glycaemic responses to oral glucose in older individuals with normal glucose tolerance or type 2 diabetes

Laurence G Trahair, Michael Horowitz, Julie E Stevens, Christine Feinle-Bisset, Scott Standfield, Diana Piscitelli, Christopher K Rayner, Adam M Deane, Karen L Jones

Journal article  |  2015  |  Diabetologia

AIMS/HYPOTHESIS: A postprandial fall in BP occurs frequently in older individuals and in patients with type 2 diabetes. The magnit..

Trials on stress ulcer prophylaxis: finding the balance between benefit and harm. Response to Krag et al.

Adam M Deane, Gordon H Guyatt

Journal article  |  2015  |  Intensive Care Medicine

Management of critically ill patients with type 2 diabetes: The need for personalised therapy

Palash Kar, Karen L Jones, Michael Horowitz, Adam M Deane

Journal article  |  2015  |  World Journal of Diabetes

Critical illness in patients with pre-existing diabetes frequently causes deterioration in glycaemic control. Despite the prevalen..

Hyperglycemia Potentiates the Slowing of Gastric Emptying Induced by Exogenous GLP-1

Mark P Plummer, Karen L Jones, Caroline E Cousins, Laurence G Trahair, Juris J Meier, Marianne J Chapman, Michael Horowitz, Adam M Deane

Journal article  |  2015  |  Diabetes Care

OBJECTIVE: Acute hyperglycemia markedly slows gastric emptying. Exogenous GLP-1 also slows gastric emptying, leading to diminished..

Hyperglycemia Potentiates the Slowing of Gastric Emptying Induced by Exogenous GLP-1

Mark P Plummer, Karen L Jones, Caroline E Cousins, Laurence G Trahair, Juris J Meier, Marianne J Chapman, Michael Horowitz, Adam M Deane

Conference Proceedings  |  2015  |  DIABETES

Prevalence, Risk Factors, Clinical Consequences, and Treatment of Enteral Feed Intolerance During Critical Illness

Usha Gungabissoon, Kimberley Hacquoil, Chanchal Bains, Michael Irizarry, George Dukes, Russell Williamson, Adam M Deane, Daren K Heyland

Journal article  |  2015  |  Journal of Parenteral and Enteral Nutrition

BACKGROUND: We aimed to determine the incidence of enteral feed intolerance and factors associated with intolerance and to assess ..

International observational study of nutritional support in mechanically ventilated patients following burn injury

Adam Czapran, William Headdon, Adam M Deane, Kylie Lange, Marianne J Chapman, Daren K Heyland

Journal article  |  2015  |  Burns

INTRODUCTION: It has been proposed that nutritional therapy in critically ill patients after major burn reduces mortality. However..

Primum non nocere and challenging conventional treatment

Adam M Deane, Gordon H Guyatt

Journal article  |  2015  |  Intensive Care Medicine

Incretins: Player or Stayer?

Adam M Deane, Michael Horowitz

Journal article  |  2015  |  Journal of Intensive Care Medicine

Diarrhoea in the critically ill

Annika Reintam Blaser, Adam M Deane, Sonja Fruhwald

Journal article  |  2015  |  Current Opinion in Critical Care

PURPOSE OF REVIEW: To summarize existing evidence on definition, epidemiology, mechanisms, risk factors, consequences, outcome and..

Gastrointestinal dysfunction relating to the provision of nutrition in the critically ill

Marianne J Chapman, Adam M Deane

Journal article  |  2015  |  Current Opinion in Clinical Nutrition and Metabolic Care

PURPOSE OF REVIEW: During critical illness, enteral nutrition remains central to clinical care and an understanding of gut dysfunc..

Accelerated Intestinal Glucose Absorption in Morbidly Obese Humans: Relationship to Glucose Transporters, Incretin Hormones, and Glycemia

Nam Q Nguyen, Tamara L Debreceni, Jenna E Bambrick, Bridgette Chia, Judith Wishart, Adam M Deane, Chris K Rayner, Michael Horowitz, Richard L Young

Journal article  |  2015  |  The Journal of Clinical Endocrinology & Metabolism

CONTEXT: Intestinal glucose absorption is mediated by sodium-dependent glucose transporter 1 (SGLT-1) and glucose transporter 2 (G..

Gastric emptying and glycaemia in health and diabetes mellitus

Liza K Phillips, Adam M Deane, Karen L Jones, Chris K Rayner, Michael Horowitz

Journal article  |  2015  |  Nature Reviews Endocrinology

The rate of gastric emptying is a critical determinant of postprandial glycaemia and, accordingly, is fundamental to maintaining b..

Effects of glucose-dependent insulinotropic polypeptide on gastric emptying, glycaemia and insulinaemia during critical illness: a prospective, double blind, randomised, crossover study

Palash Kar, Caroline E Cousins, Christopher E Annink, Karen L Jones, Marianne J Chapman, Juris J Meier, Michael A Nauck, Michael Horowitz, Adam M Deane

Journal article  |  2015  |  Critical Care

INTRODUCTION: Insulin is used to treat hyperglycaemia in critically ill patients but can cause hypoglycaemia, which is associated ..

The relationship between fasting plasma citrulline concentration and small intestinal function in the critically ill

Alexis Poole, Adam Deane, Matthew Summers, Janice Fletcher, Marianne Chapman

Journal article  |  2015  |  Critical Care

INTRODUCTION: In this study, we aimed to evaluate whether fasting plasma citrulline concentration predicts subsequent glucose abso..

Full predicted energy from nutrition and the effect on mortality and infectious complications in critically ill adults: a protocol for a systematic review and meta-analysis of parallel randomised controlled trials

Emma J Ridley, Andrew R Davies, Carol Hodgson, Adam Deane, Michael Bailey, D James Cooper

Journal article  |  2015  |  Systematic Reviews

Toward a sustainable intensive care training program

Yasmine Ali Abdelhamid, Mary G White, Adam M Deane

Journal article  |  2014  |  Critical Care and Resuscitation

Understanding incretins

Adam M Deane, Palle B Jeppesen

Journal article  |  2014  |  Intensive Care Medicine

Upregulation of Intestinal Glucose Transporters after Roux-en-Y Gastric Bypass to Prevent Carbohydrate Malabsorption

Nam Q Nguyen, Tamara L Debreceni, Jenna E Bambrick, Bridgette Chia, Adam M Deane, Gary Wittert, Chris K Rayner, Michael Horowitz, Richard L Young

Journal article  |  2014  |  Obesity

OBJECTIVE: To determine the effect of Roux-en-Y gastric bypass (RYGB) on the expression of intestinal sweet taste receptors (STRs)..

THE EFFECT OF EXOGENOUS GLUCAGON LIKE PEPTIDE-1 (GLP-1) ON SMALL INTESTINAL GLUCOSE MISORPTION UN THE CRITICALLY ILL

CE Cousins, A Miller, MP Plummer, AM Deane, M Horowitz, MJ Chapman

Conference Proceedings  |  2014  |  INTENSIVE CARE MEDICINE

INCREASING CALORIE CONTENT SLOWS GASTRIC EMPTYING IN THE CRITICALLY ILL

MP Plummer, P Kar, MJ Chapman, CE Cousins, DK Heyland, M Horowitz, KL Jones, AM Deane

Conference Proceedings  |  2014  |  INTENSIVE CARE MEDICINE

Definition, prevalence, and outcome of feeding intolerance in intensive care: a systematic review and meta-analysis

A Reintam Blaser, J Starkopf, Ue Kirsimaegi, AM Deane

Journal article  |  2014  |  Acta Anaesthesiologica Scandinavica

Clinicians and researchers frequently use the phrase 'feeding intolerance' (FI) as a descriptive term in enterally fed critically ..

Use of a concentrated enteral nutrition solution to increase calorie delivery to critically ill patients: a randomized, double-blind, clinical trial

Sandra L Peake, Andrew R Davies, Adam M Deane, Kylie Lange, John L Moran, Stephanie N O'Connor, Emma J Ridley, Patricia J Williams, Marianne J Chapman

Journal article  |  2014  |  The American Journal of Clinical Nutrition

Dysglycaemia in the critically ill and the interaction of chronic and acute glycaemia with mortality

Mark P Plummer, Rinaldo Bellomo, Caroline E Cousins, Christopher E Annink, Krishnaswamy Sundararajan, Benjamin AJ Reddi, John P Raj, Marianne J Chapman, Michael Horowitz, Adam M Deane

Journal article  |  2014  |  INTENSIVE CARE MEDICINE

Impact of delirium and suture-less securement on accidental vascular catheter removal in the ICU

K Sundararajan, S Wills, B Chacko, G Kanabar, S O'Connor, AM Deane

Journal article  |  2014  |  Anaesthesia and Intensive Care

The objectives were to describe the incidence of accidental vascular catheter removal (AVCR) in an Australian Intensive Care Unit ..

Glucagon-Like Peptide 1 Attenuates the Acceleration of Gastric Emptying Induced by Hypoglycemia in Healthy Subjects

Mark P Plummer, Karen L Jones, Chris E Annink, Caroline E Cousins, Juris J Meier, Marianne J Chapman, Michael Horowitz, Adam M Deane

Journal article  |  2014  |  Diabetes Care

OBJECTIVE: Exogenous GLP-1 slows gastric emptying in health and diabetes leading to diminished glycemic excursions. Gastric emptyi..

Intensivists under threat: who's in charge here?

Adam M Deane

Journal article  |  2014  |  Critical Care and Resuscitation

The model currently used in public hospitals in Australia and New Zealand - of closed, mixed medical-surgical ICUs, led by consult..

Accelerated Glucose Absorption in Proximal Intestine and Its Relationship to Glucose Transporters, Incretin Hormones and Glycaemia in Morbidly Obese Humans: the "X-Factor" of the Foregut Theory?

Nam Q Nguyen, Tamara L Debreceni, Jenna E Bambrick, Bridgette Chia, Judith M Wishart, Adam M Deane, Gary A Wittert, Chris Rayner, Michael Horowitz, Richard L Young

Conference Proceedings  |  2014  |  GASTROENTEROLOGY

Is Incretin-Based Therapy Ready for the Care of Hospitalized Patients With Type 2 Diabetes?

Adam M Deane, Michael Horowitz

Journal article  |  2014  |  Diabetes Care

Endogenous amylin and glucagon-like peptide-1 concentrations are not associated with gastric emptying in critical illness

MJ Summers, AE Di Bartolomeo, AV Zaknic, MJ Chapman, NQ Nguyen, B Zacharakis, CK Rayner, M Horowitz, AM Deane

Journal article  |  2014  |  Acta Anaesthesiologica Scandinavica

BACKGROUND: In health, the hormones amylin and glucagon-like peptide-1 (GLP-1) slow gastric emptying (GE) and modulate glycaemia. ..

Comparative Effects of Prolonged and Intermittent Stimulation of the Glucagon-Like Peptide 1 Receptor on Gastric Emptying and Glycemia

Mahesh M Umapathysivam, Michael Y Lee, Karen L Jones, Christopher E Annink, Caroline E Cousins, Laurence G Trahair, Chris K Rayner, Marianne J Chapman, Michael A Nauck, Michael Horowitz, Adam M Deane

Journal article  |  2014  |  Diabetes

Acute administration of glucagon-like peptide 1 (GLP-1) and its agonists slows gastric emptying, which represents the major mechan..

Incretins and the intensivist: what are they and what does an intensivist need to know about them?

Mark P Plummer, Marianne J Chapman, Michael Horowitz, Adam M Deane

Journal article  |  2014  |  Critical Care

Hyperglycaemia occurs frequently in the critically ill, even in those patients without a history of diabetes. The mechanisms under..

The Effects of Critical Illness on Intestinal Glucose Sensing, Transporters, and Absorption

Adam M Deane, Chris K Rayner, Alex Keeshan, Nada Cvijanovic, Zelia Marino, Nam Q Nguyen, Bridgette Chia, Matthew J Summers, Jennifer A Sim, Theresia van Beek, Marianne J Chapman, Michael Horowitz, Richard L Young

Journal article  |  2014  |  Critical Care Medicine

OBJECTIVES: Providing effective enteral nutrition is important during critical illness. In health, glucose is absorbed from the sm..

Stress ulceration: prevalence, pathology and association with adverse outcomes

Mark P Plummer, Annika Reintam Blaser, Adam M Deane

Journal article  |  2014  |  Critical Care

The Impact Of Premorbid Glycemia On The Association Between Acute Hyperglycemia And Mortality In Critically Ill Patients

AM Deane, MP Plummer, CE Cousins, CE Annink, K Sundararajan, BA Reddi, JP Raj, MJ Chapman, M Horowitz, R Bellomo

Conference Proceedings  |  2014  |  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The effect of glucose-dependent insulinotropic polypeptide (GIP) in critically ill patients

Palash Kar, Chris Annink, Caroline Cousins, Karen Jones, Marianne Chapman, Michael Horowitz, Adam Deane

Conference Proceedings  |  2013  |  Critical Care Medicine

Dysregulation of intestinal glucose absorption and glucose transporters in morbidly obesity: potential molecular mechanisms of weight gain and diabetes in obesity

NQ Nguyen, TL Debreceni, B Chia, CM Burgstad, M Neo, AM Deane, GA Wittert, M Horowitz, RL Young

Conference Proceedings  |  2013  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Abnormal intestinal glucose transport & absorption in obesity: implication in weight gain & diabetes

Nguyen Namq, Tamaral Debreceni, Bridgette Chia, Carlym Burgstad, Melissa Neo, Adam Deane, Gary Wittert, Michael Horowitz, Richard Young

Conference Proceedings  |  2013  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The Effect of Exogenous Glucose-Dependent Insulinotropic Polypeptide in Combination With Glucagon-Like Peptide-1 on Glycemia in the Critically Ill

Michael Y Lee, Jonathan D Fraser, Marianne J Chapman, Krishnaswamy Sundararajan, Mahesh M Umapathysivam, Matthew J Summers, Antony V Zaknic, Christopher K Rayner, Juris J Meier, Michael Horowitz, Adam M Deane

Journal article  |  2013  |  Diabetes Care

OBJECTIVE: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) have additive insulinotropic eff..

THE PREVALENCE OF UNRECOGNISED DIABETES AND CRITICAL-ILLNESS INDUCED HYPERGLYCAEMIA IN CRITICALLY ILL PATIENTS: A PROSPECTIVE OBSERVATIONAL STUDY

MP Plummer, AV Zaknic, BA Reddi, J Raj, K Sundararajan, MJ Chapman, M Horowitz, AM Deane

Conference Proceedings  |  2013  |  INTENSIVE CARE MEDICINE

Modulation of individual components of gastric motor response to duodenal glucose

Adam M Deane, Laura K Besanko, Carly M Burgstad, Marianne J Chapman, Michael Horowitz, Robert JL Fraser

Journal article  |  2013  |  World Journal of Gastroenterology

AIM: To evaluate individual components of the antro-pyloro-duodenal (APD) motor response to graded small intestinal glucose infusi..

Dysglycaemia in the critically ill - significance and management

AM Deane, M Horowitz

Journal article  |  2013  |  Diabetes, Obesity and Metabolism

Hyperglycaemia frequently occurs in the critically ill, in patients with diabetes, as well as those who were previously glucose-to..

GLP-1 attenuates the acceleration of gastric emptying induced by hypoglycaemia in healthy subjects

MP Plummer, TD Crowhurst, CE Annink, CE Cousins, RR Sardana, JJ Meier, MJ Chapman, M Horowitz, KL Jones, AM Deane

Conference Proceedings  |  2013  |  DIABETOLOGIA

Gastric emptying measurement of liquid nutrients using the C-13-octanoate breath test in critically ill patients: a comparison with scintigraphy

Nam Q Nguyen, Laura K Bryant, Carly M Burgstad, Marianne Chapman, Adam Deane, Max Bellon, Kylie Lange, Dylan Bartholomeuz, Michael Horowitz, Richard H Holloway, Robert J Fraser

Journal article  |  2013  |  Intensive Care Medicine

PURPOSE: Scintigraphy is considered the most accurate technique for the measurement of gastric emptying (GE) but, for patients in ..

The Effect of Exogenous GIP in Combination With GLP-1 on Glycaemia in Critically Ill Patients

Michael Lee, Mahesh Umapathysivam, Adam M Deane, Marianne Chapman, Krishnaswamy Sundararajan, Jonathan Fraser, Caroline Cousins, Christopher Annink, Michael Horowitz, Juris J Meier, Christopher K Rayner

Conference Proceedings  |  2013  |  DIABETES

The Effect of Prolonged Glucagon-Like Peptide-1 Receptor Stimulation on Gastric Emptying and Glycemia

Mahesh M Umapathysivam, Michael Y Lee, Karen L Jones, Christopher Annink, Caroline E Cousins, Raj Sardana, Laurence Trahair, Marianne Chapman, Christopher K Rayner, Michael A Nauck, Michael Horowitz, Adam M Deane

Conference Proceedings  |  2013  |  DIABETES

Comparisons between intragastric and small intestinal delivery of enteral nutrition in the critically ill: a systematic review and meta-analysis.

Adam M Deane, Rupinder Dhaliwal, Andrew G Day, Emma J Ridley, Andrew R Davies, Daren K Heyland

Journal article  |  2013  |  Critical Care

INTRODUCTION: The largest cohort of critically ill patients evaluating intragastric and small intestinal delivery of nutrients was..

Intestinal Sweet Taste Receptor and Transporter Expression, Post-Prandial Glycemia and Glucose Absorption in Morbidly Obese Subjects

Nam Q Nguyen, Tamara L Debreceni, Bridgette Chia, Carly M Burgstad, Melissa Neo, Adam M Deane, Gary A Wittert, Michael Horowitz, Richard L Young

Conference Proceedings  |  2013  |  GASTROENTEROLOGY

Sucrose Malabsorption and Impaired Mucosal Integrity in Enterally Fed Critically Ill Patients: A Prospective Cohort Observational Study

Carly M Burgstad, Laura K Besanko, Adam M Deane, Nam Q Nguyen, Khaschayar Saadat-Gilani, Geoff Davidson, Esther Burt, Anthony Thomas, Richard H Holloway, Marianne J Chapman, Robert JL Fraser

Journal article  |  2013  |  Critical Care Medicine

OBJECTIVE: Inadequate nutrition is common in critical illness due in part to gastric stasis. However, recent data suggest that alt..

Fasting citrulline concentrations are not predictive of absorptive function in the critically ill

A Poole, A Deane, J Magarey, S O'Connor, S Millington, J Fletcher, A Zaknic, M Summers, M Chapman

Conference Proceedings  |  2013  |  Australian Critical Care

Should hospitals have intensivist consultants in-house 24 hours a day?

Sean L Kelly, Roger D Harris, Anthony R Burrell, Adam M Deane, Mary G White

Journal article  |  2013  |  Medical Journal of Australia

Should hospitals have intensivist consultants in-house 24 hours a 01? - No.

Adam M Deane, Mary G White

Journal article  |  2013  |  Medical Journal of Australia

Gastrointestinal dysmotility: evidence and clinical management

Marianne J Chapman, Nam Q Nguyen, Adam M Deane

Journal article  |  2013  |  Current Opinion in Clinical Nutrition and Metabolic Care

Mesenteric blood flow, glucose absorption and blood pressure responses to small intestinal glucose in critically ill patients older than 65 years

Jennifer A Sim, M Horowitz, MJ Summers, LG Trahair, RS Goud, AV Zaknic, T Hausken, JD Fraser, MJ Chapman, KL Jones, AM Deane

Journal article  |  2013  |  Intensive Care Medicine

The gut-brain axis in the critically ill: Is glucagon like peptide-1 protective in neurocritical care?

Mark P Plummer, Juris J Meier, Adam M Deane

Journal article  |  2013  |  Critical Care

Enteral nutrient is a potent glucagon-like peptide-1 (GLP-1) secretagogue. In vitro and animal studies indicate that GLP-1 has imm..

An evaluation of the safety and success of placing postpyloric feeding tubes by a dietitian in critically ill patients with gastroparesis

Rosalie Yandell, Stephanie O'Connor, Alison Shanks, Marianne Chapman, Adam Deane

Conference Proceedings  |  2012  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Glucose malabsorption in critical illness: A molecular defect in intestinal sweet taste sensing?

R Young, A Deane, B Chia, M Horowitz, R Christopher

Conference Proceedings  |  2012  |  NEUROGASTROENTEROLOGY AND MOTILITY

Randomized double-blind crossover study to determine the effects of erythromycin on small intestinal nutrient absorption and transit in the critically ill

Adam M Deane, Gerald L Wong, Michael Horowitz, Antony V Zaknic, Matthew J Summers, Anna E Di Bartolomeo, Jennifer A Sim, Anne F Maddox, Max S Bellon, Christopher K Rayner, Marianne J Chapman, Robert JL Fraser

Journal article  |  2012  |  The American Journal of Clinical Nutrition

Comparative effects on glucose absorption of intragastric and post-pyloric nutrient delivery in the critically ill

Anna E Di Bartolomeo, Marianne J Chapman, Antony V Zaknic, Matthew J Summers, Karen L Jones, Nam Q Nguyen, Christopher K Rayner, Michael Horowitz, Adam M Deane

Journal article  |  2012  |  Critical Care

INTRODUCTION: Studies in the critically ill that evaluate intragastric and post-pyloric delivery of nutrient have yielded conflict..

Gastrointestinal Dysmotility: Clinical Consequences and Management of the Critically Ill Patient

Marianne J Chapman, Nam Q Nguyen, Adam M Deane

Journal article  |  2011  |  Gastroenterology Clinics of North America

Glucose absorption and small intestinal transit in critical illness

Adam M Deane, Matthew J Summers, Antony V Zaknic, Marianne J Chapman, Anna E Di Bartolomeo, Max Bellon, Anne Maddox, Antoinette Russo, Michael Horowitz, Robert JL Fraser

Journal article  |  2011  |  Critical Care Medicine

Dysregulation of Intestinal Glucose Transporter and Sweet Taste Receptor Expression in Critical Illness

Richard L Young, Adam M Deane, Bridgette Chia, Michael Horowitz, L Ashley Blackshaw, Chris Rayner

Conference Proceedings  |  2011  |  GASTROENTEROLOGY

Enteral nutrition in patients with an "open abdomen"-A retrospective cohort study

R Yandell, S Wang, P Bautz, A Shanks, S O'Connor, A Deane, K Lange, M Chapman

Conference Proceedings  |  2011  |  Australian Critical Care

Nasogastric feeding intolerance in the critically ill-A prospective observational study

S O'Connor, J Rivett, A Poole, A Deane, K Lange, R Yandell, R Fraser, M Chapman

Conference Proceedings  |  2011  |  Australian Critical Care

Exogenous glucagon-like peptide-1 attenuates the glycaemic response to postpyloric nutrient infusion in critically ill patients with type-2 diabetes

Adam M Deane, Matthew J Summers, Antony V Zaknic, Marianne J Chapman, Robert JL Fraser, Anna E Di Bartolomeo, Judith M Wishart, Michael Horowitz

Journal article  |  2011  |  Critical Care

GLUCOSE ABSORPTION FOLLOWING INTRA-GASTRIC AND SMALL INTESTINAL ADMINISTRATION IN CRITICAL ILLNESS

Antony Zaknic, Matthew Summers, Anna DiBartolomeo, Marianne Chapman, Robert Fraser, Michael Horowitz, Adam Deane

Conference Proceedings  |  2010  |  CRITICAL CARE MEDICINE

SECRETION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE IS DEPENDENT ON THE RATE OF GASTRIC EMPTYING AND A DETERMINANT OF THE PLASMA INSULIN RESPONSE IN THE CRITICALLY ILL

Adam Deane, Antony Zaknic, Michael Horowitz, Matthew Summers, Marianne Chapman

Conference Proceedings  |  2010  |  CRITICAL CARE MEDICINE

A REDUCTION IN FASTING PLASMA GHRELIN CONCENTRATION IS ASSOCIATED WITH DELAYED GASTRIC EMPTYING IN THE CRITICALLY ILL

Adam Deane, Antony Zaknic, Matthew Summers, Marianne Chapman, Michael Horowitz

Conference Proceedings  |  2010  |  CRITICAL CARE MEDICINE

ABSORPTION AND TRANSIT OF NUTRIENT IN CRITICAL ILLNESS

Adam Deane, Antony Zaknic, Matthew Summers, Marianne Chapman, Michael Horowitz, Robert Fraser

Conference Proceedings  |  2010  |  CRITICAL CARE MEDICINE

Intrasubject variability of gastric emptying in the critically ill using a stable isotope breath test

Adam M Deane, Antony V Zaknic, Matthew Summers, Marianne J Chapman, Kylie Lange, Mark A Ritz, Geoff Davidson, Michael Horowitz, Robert JL Fraser

Journal article  |  2010  |  Clinical Nutrition

EXOGENOUS GLUCAGON-LIKE PEPTIDE-1 ATTENUATES THE GLYCAEMIC RESPONSE TO ENTERAL NUTRIENT IN CRITICALLY ILL PATIENTS WITH PRE-EXISTING TYPE-2 DIABETES MELLITUS

A Deane, MJ Chapman, RJ Fraser, MJ Summers, AV Zaknic, A DiBartolomeo, M Horowitz

Conference Proceedings  |  2010  |  INTENSIVE CARE MEDICINE

TRANSIT OF NUTRIENT THROUGH THE SMALL INTESTINE IN THE CRITICALLY ILL

A Deane, A Zaknic, MJ Summers, M Bellon, A Russo, A Maddox, A DiBartolomeo, M Horowitz, KL Jones, MJ Chapman, RJ Fraser

Conference Proceedings  |  2010  |  INTENSIVE CARE MEDICINE

Effects of exogenous glucagon-like peptide-1 on gastric emptying and glucose absorption in the critically ill: Relationship to glycemia

Adam M Deane, Marianne J Chapman, Robert JL Fraser, Matthew J Summers, Antony V Zaknic, James P Storey, Karen L Jones, Christopher K Rayner, Michael Horowitz

Journal article  |  2010  |  Critical Care Medicine

Loin pain haematuria syndrome RESPONSE

M Ahmed, P Acher, AM Deane

Journal article  |  2010  |  The Annals of The Royal College of Surgeons of England

Ureteric bupivicaine infusion for loin pain haematuria syndrome

M Ahmed, P Acher, AM Deane

Journal article  |  2010  |  The Annals of The Royal College of Surgeons of England

Endogenous Glucagon-Like Peptide-1 Slows Gastric Emptying in Healthy Subjects, Attenuating Postprandial Glycemia

Adam M Deane, Nam Q Nguyen, Julie E Stevens, Robert JL Fraser, Richard H Holloway, Laura K Besanko, Carly Burgstad, Karen L Jones, Marianne J Chapman, Chris K Rayner, Michael Horowitz

Journal article  |  2010  |  The Journal of Clinical Endocrinology & Metabolism

Bench-to-bedside review: The gut as an endocrine organ in the critically ill

Adam Deane, Marianne J Chapman, Robert JL Fraser, Michael Horowitz

Journal article  |  2010  |  Critical Care

In health, hormones secreted from the gastrointestinal tract have an important role in regulating gastrointestinal motility, gluco..

The therapeutic potential of a venomous lizard: the use of glucagon-like peptide-1 analogues in the critically ill

Adam M Deane, Marianne J Chapman, Michael Horowitz

Journal article  |  2010  |  Critical Care

Evaluation of a bedside technique for postpyloric placement of feeding catheters

Adam M Deane, Robert J Fraser, Robert J Young, Benita Foreman, Stephanie N O'Conner, Marianne J Chapman

Journal article  |  2009  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

Effects of endogenous glucagon-like peptide-1 on gastric emptying in healthy subjects - relationship to glycaemia

AM Deane, NQ Nguyen, JE Stevens, RJL Fraser, RH Holloway, KL Jones, LK Besanko, C Burgstad, M Summers, A Zaknic, MJ Chapman, M Horowitz

Conference Proceedings  |  2009  |  DIABETOLOGIA

Prokinetic drugs for feed intolerance in critical illness: current and potential therapies

Adam M Deane, Robert J Fraser, Marianne J Chapman

Journal article  |  2009  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

The effect of exogenous glucagon-like peptide-1 on the glycaemic response to small intestinal nutrient in the critically ill: a randomised double-blind placebo-controlled cross over study

Adam M Deane, Marianne J Chapman, Robert JL Fraser, Carly M Burgstad, Laura K Besanko, Michael Horowitz

Journal article  |  2009  |  Critical Care

Modulation of individual components of the distal gastric motor response to duodenal glucose infusion in healthy humans

Laura Bryant, Carly M Burgstad, Adam Deane, Marianne Chapman, Richard H Holloway, Michael Horowitz, Robert Fraser

Conference Proceedings  |  2008  |  GASTROENTEROLOGY

A clinical audit of the efficacy of tegaserod as a prokinetic agent in the intensive care unit.

Adam Deane, Robert Young, Marianne Chapman, Robert Fraser

Journal article  |  2008  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

Predicted body weight during mechanical ventilation: using arm demispan to aid clinical assessment.

Adam M Deane, David A Reid, Antony E Tobin

Journal article  |  2008  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

INTRODUCTION: Recent research suggests an association between the development of acute lung injury (ALI) and mechanical ventilatio..

Comment on: The use of erythromycin as a gastrointestinal prokinetic agent in adult critical care: benefits versus risks

Adam Deane, Robert Young

Journal article  |  2008  |  Journal of Antimicrobial Chemotherapy

Predicted body weight during mechanical ventilation: Using arm demispan to aid clinical assessment

AM Deane, DA Reid, AE Tobin

Journal article  |  2008  |  Critical Care and Resuscitation

Mechanisms underlying feed intolerance, in the critically ill: Implications for treatment

Adam Deane, Marianne J Chapman, Robert J Fraser, Laura K Bryant, Carly Burgstad, Nam Q Nguyen

Journal article  |  2007  |  World Journal of Gastroenterology

Malnutrition is associated with poor outcomes in critically ill patients. Although nutritional support is yet to be proven to impr..

Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia

CN Harrison, PJ Campbell, G Buck, K Wheatley, CL East, D Bareford, BS Wilkins, JD van der Walt, JT Reilly, AP Grigg, P Revell, BE Woodcock, AR Green, TC Pearson, E Conneally, C Crawley, NCP Cross, G Hall, B Hunt, G Lucas, et al.

Journal article  |  2005  |  New England Journal of Medicine

Laparoscopic splenectomy: single-centre experience of a district general hospital

T Bernard, M Rhodes, GE Turner, JZ Wimperis, AM Deane

Journal article  |  1999  |  British Journal of Haematology

IDENTIFIABLE FACTORS IN POSTPROSTATECTOMY HEMORRHAGE - THE ROLE OF ASPIRIN

CJE WATSON, AM DEANE, PT DOYLE, KN BULLOCK

Journal article  |  1990  |  British Journal of Urology

COMPUTED-TOMOGRAPHY AND MAGNETIC-RESONANCE-IMAGING BEFORE SALVAGE CYSTECTOMY

AK DIXON, AM DEANE, PT DOYLE

Journal article  |  1990  |  British Journal of Urology

URETERIC MEATOTOMY GUIDED BY ANTEGRADE INSERTION OF A DOUBLE J-SPLINT

G COOKSEY, AM DEANE, A THOMAS, MH ASHKEN

Journal article  |  1989  |  British Journal of Urology

DIATHERMY HOOK ABLATION OF POSTERIOR URETHRAL VALVES IN NEONATES AND INFANTS

AM DEANE, RH WHITAKER, T SHERWOOD

Journal article  |  1988  |  British Journal of Urology

UNDIVERSION IN YOUNG-ADULTS

CR WOODHOUSE, AM DEANE, R COX, J CUMMING, J SHAH

Conference Proceedings  |  1986  |  JOURNAL OF UROLOGY

ENDOSCOPIC TEFLON INJECTION FOR A REFLUXING URETERIC STUMP AFTER SIMPLE NEPHRECTOMY

KN BULLOCK, AM DEANE, MH ASHKEN

Journal article  |  1985  |  BMJ

FEMALE CHRONIC URINARY RETENTION

AM DEANE, PHL WORTH

Journal article  |  1985  |  British Journal of Urology

TEFLON INJECTION IN STRESS-INCONTINENCE

AM DEANE, P ENGLISH, M HEHIR, JP WILLIAMS, PHL WORTH

Journal article  |  1985  |  British Journal of Urology

HISTOLOGICAL-CHANGES IN ILEAL CONDUITS

AM DEANE, CRJ WOODHOUSE, MC PARKINSON

Journal article  |  1984  |  Journal of Urology

RECTOCOLECTOMY WITH ANAL CONSERVATION IN INFLAMMATORY COLITIS

AM DEANE, LR CELESTIN

Journal article  |  1983  |  Annals of the Royal College of Surgeons of England

IDIOPATHIC RETROPERITONEAL FIBROSIS - THE ROLE OF AUTO-TRANSPLANTATION

AM DEANE, JC GINGELL, BD PENTLOW

Journal article  |  1983  |  British Journal of Urology

BLADDER INSTABILITY - IS THE PRIMARY DEFECT IN THE URETHRA

JR HINDMARSH, PT GOSLING, AM DEANE

Journal article  |  1983  |  British Journal of Urology

ABSENT VAS-DEFERENS IN ASSOCIATION WITH RENAL ABNORMALITIES

AM DEANE, RE MAY

Journal article  |  1982  |  British Journal of Urology

A NEUROVASCULAR TRACTION INJURY INVOLVING THE SUBCLAVIAN ARTERY AND BRACHIAL-PLEXUS IN A MOTORCYCLIST

AM DEANE

Journal article  |  1981  |  The British journal of clinical practice

CATALYTIC ACTIVITY OF ION-IMPLANTED SINGLE-CRYSTAL SUPPORTS - NEW TOOL IN CATALYSIS STUDIES

P RABETTE, AM DEANE, AJ TENCH, M CHE

Journal article  |  1979  |  Chemical Physics Letters

OXIDIZING PROPERTIES OF MGO FORMED BY THERMAL-DECOMPOSITION OF MG(OH)2

H PRALIAUD, S COLUCCIA, AM DEANE, AJ TENCH

Journal article  |  1979  |  Chemical Physics Letters

PHOTO-LUMINESCENT SPECTRA OF SURFACE-STATES IN ALKALINE-EARTH OXIDES

S COLUCCIA, AM DEANE, AJ TENCH

Journal article  |  1978  |  Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases

INFRARED STUDY OF INTERACTION OF HYDROGEN-SULFIDE AND WATER WITH A MAGNESIUM-OXIDE SURFACE

AM DEANE, DL GRIFFITHS, IA LEWIS, JA WINTER, AJ TENCH

Journal article  |  1975  |  Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases

SPECTROSCOPIC TECHNIQUES OF THICKNESS MEASUREMENTS

AM DEANE, EW RICHARDS

Journal article  |  1971  |  Non-Destructive Testing

BOND ORIENTATIONS IN URANYL NITRATE HEXAHYDRATE USING ATTENUATED TOTAL REFLECTION

AM DEANE, EW RICHARDS, IG STEPHEN

Journal article  |  1966  |  Spectrochimica Acta

PREPARATION AND PROPERTIES OF A POLYNUCLEAR URANYL NITRATE

JL WOODHEAD, AM DEANE, AC FOX, JM FLETCHER

Journal article  |  1966  |  Journal of Inorganic and Nuclear Chemistry

INFRA-RED SPECTRA OF INORGANIC SOLIDS - A SAMPLE MOUNTING TECHNIQUE

AM DEANE

Journal article  |  1965  |  Journal of Inorganic and Nuclear Chemistry

URANIUM(IV) PERCHLORATE

KW BAGNALL, AM DEANE, D BROWN

Journal article  |  1962  |  Journal of the Chemical Society (Resumed)

SOME ACETAMIDE COMPLEXES OF ACTINIDE TETRACHLORIDES .1. URANIUM, NEPTUNIUM, AND PLUTONIUM

KW BAGNALL, AM DEANE, PS ROBINSON, TL MARKIN, MAA STEWART

Journal article  |  1961  |  Journal of the Chemical Society (Resumed)

THE INFRA-RED SPECTRA AND STRUCTURES OF SOME HYDRATED URANIUM TRIOXIDES AND AMMONIUM DIURANATES

AM DEANE

Journal article  |  1961  |  Journal of Inorganic and Nuclear Chemistry

THE INFRA-RED SPECTRA OF URANIUM SPECIES IN CARBON TETRACHLORIDE SOLUTIONS OF URANIUM(VI), DIBUTYL PHOSPHORIC ACID AND TRI-NORMAL-OCTYL PHOSPHINE OXIDE

J KENNEDY, AM DEANE

Journal article  |  1961  |  Journal of Inorganic and Nuclear Chemistry

THE PREPARATION AND SPECTRUM OF TETRABUTYL AMMONIUM URANYL DIBUTYL PHOSPHATE [BU4N UO2(DBP)3]

J KENNEDY, AM DEANE

Journal article  |  1961  |  Journal of Inorganic and Nuclear Chemistry

SYNERGISM IN THE EXTRACTION OF URANIUM (UVI) FROM AQUEOUS SOLUTION BY COMBINATIONS OF ACIDIC AND NON-IONIC PHOSPHORYLATED REAGENTS

AM DEANE, J KENNEDY, PG SAMMES

Journal article  |  1960  |  CHEMISTRY & INDUSTRY

Round-celled sarcoma of pancreas in an infant.

A Deane

Journal article  |  1926  |  BRITISH MEDICAL JOURNAL

Diabetes-Specific Formulae Versus Standard Formulae as Enteral Nutrition to Treat Hyperglycemia in Critically Ill Patients: Protocol for a Randomized Controlled Feasibility Trial

Ra'eesa Doola, Alwyn S Todd, Josephine M Forbes, Adam M Deane, Jeffrey J Presneill, David J Sturgess

Journal article

Diabetes-Specific Formulae Versus Standard Formulae as Enteral Nutrition to Treat Hyperglycemia in Critically Ill Patients: Protocol for a Randomized Controlled Feasibility Trial

Ra'eesa Doola, Alwyn S Todd, Josephine M Forbes, Adam M Deane, Jeffrey J Presneill, David J Sturgess

Journal article