Adam Deane

Outcomes Six-Months After 100% or 70% of Enteral Calorie Requirements During Critical Illness (TARGET): A Randomized Controlled Trial.

Adam M Deane, Lorraine Little, Rinaldo Bellomo, Marianne J Chapman, Andrew R Davies, Suzie Ferrie, Michael Horowitz, Sally Hurford, Kylie Lange, Edward Litton, Diane Mackle, Stephanie O'Connor, Jane Parker, Sandra L Peake, Jeffrey J Presneill, Emma J Ridley, Vanessa Singh, Frank van Haren, Patricia Williams, Paul Young, et al.

Journal article  |  2020  |  American Journal of Respiratory and Critical Care Medicine

RATIONALE: The long-term effects of delivering approximately 100% of recommended calorie intake via the enteral route during criti..

Conservative oxygen therapy for mechanically ventilated adults with sepsis: a post hoc analysis of data from the intensive care unit randomized trial comparing two approaches to oxygen therapy (ICU-ROX).

Paul Young, Diane Mackle, Rinaldo Bellomo, Michael Bailey, Richard Beasley, Adam Deane, Glenn Eastwood, Simon Finfer, Ross Freebairn, Victoria King, Natalie Linke, Edward Litton, Colin McArthur, Shay McGuinness, Rakshit Panwar, undefined ICU-ROX Investigators the Australian New Zealand Intensive Care Society Clinical Trials Group

Journal article  |  2020  |  Intensive Care Medicine

PURPOSE: Sepsis is a common reason for intensive care unit (ICU) admission and mortality in ICU patients. Despite increasing inter..

Measuring nutrition-related outcomes in a cohort of multi-trauma patients following intensive care unit discharge

K Wittholz, K Fetterplace, M Clode, ES George, CM Maclsaac, R Judson, JJ Presneill, AM Deane

Journal article  |  2019  |  Journal of Human Nutrition and Dietetics

Pharmacokinetic data support 6-hourly dosing of intravenous vitamin C to critically ill patients with septic shock

Elizabeth P Hudson, Jake TB Collie, Tomoko Fujii, Nora Luethi, Andrew A Udy, Sarah Doherty, Glenn Eastwood, Fumitaka Yanase, Thummaporn Naorungroj, Laurent Bitker, Yasmine Ali Abdelhamid, Ronda F Greaves, Adam M Deane, Rinaldo Bellomo

Journal article  |  2019  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

OBJECTIVES: To study vitamin C pharmacokinetics in septic shock. DESIGN: Prospective pharmacokinetic study. SETTING: Two intensive..

Associations between nutritional energy delivery, bioimpedance spectroscopy and functional outcomes in survivors of critical illness

K Fetterplace, LJ Beach, C MacIsaac, J Presneill, L Edbrooke, SM Parry, T Rechnitzer, R Curtis, S Berney, AM Deane, L Denehy

Journal article  |  2019  |  Journal of Human Nutrition and Dietetics

BACKGROUND: Patients who survive critical illness frequently develop muscle weakness that can impact on quality of life; nutrition..

20% Human Albumin Solution Fluid Bolus Administration Therapy in Patients After Cardiac Surgery (the HAS FLAIR Study)

Geoffrey J Wigmore, James R Anstey, Ashley St John, Joel Greaney, Marc Morales-Codina, Jeffrey J Presneill, Adam M Deane, Christopher M MacIsaac, Michael Bailey, James Tatoulis, Rinaldo Bellomo

Journal article  |  2019  |  Journal of Cardiothoracic and Vascular Anesthesia

OBJECTIVE: To compare the effects of fluid bolus therapy using 20% albumin versus crystalloid on fluid balance, hemodynamic parame..

HAS FLAIR Investigators Reply to Fluid Resuscitation After Cardiac Surgery: The Quest for the Ideal Fluid

Geoffrey Wigmore, James Anstey, Adam Deane, Rinaldo Bellomo

Journal article  |  2019  |  Journal of Cardiothoracic and Vascular Anesthesia

Are point-of-care measurements of glycated haemoglobin accurate in the critically ill?

Luke M Weinel, Matthew J Summers, Mark E Finnis, Alexis Poole, Palash Kar, Marianne J Chapman, Adam M Deane, Yasmine Ali Abdelhamid

Journal article  |  2019  |  Australian Critical Care

INTRODUCTION: Critically ill patients with type 2 diabetes mellitus (T2DM) and chronic hyperglycaemia may benefit from a more libe..

Systematic Review With Meta-Analysis of Patient-Centered Outcomes, Comparing International Guideline-Recommended Enteral Protein Delivery With Usual Care.

Kate Fetterplace, Benjamin MT Gill, Lee-Anne S Chapple, Jeffrey J Presneill, Christopher MacIsaac, Adam M Deane

Journal article  |  2019  |  Journal of Parenteral and Enteral Nutrition

BACKGROUND: International guidelines recommend that protein be administered enterally to critically ill patients at doses between ..

Conservative Oxygen Therapy during Mechanical Ventilation in the ICU.

undefined ICU-ROX Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group, Diane Mackle, Rinaldo Bellomo, Michael Bailey, Richard Beasley, Adam Deane, Glenn Eastwood, Simon Finfer, Ross Freebairn, Victoria King, Natalie Linke, Edward Litton, Colin McArthur, Shay McGuinness, Rakshit Panwar, Paul Young

Journal article  |  2019  |  New England Journal of Medicine

BACKGROUND: Patients who are undergoing mechanical ventilation in the intensive care unit (ICU) often receive a high fraction of i..

Metabolic support in the critically ill: a consensus of 19

Jan Wernerman, Kenneth B Christopher, Djillali Annane, Michael P Casaer, Craig M Coopersmith, Adam M Deane, Elisabeth De Waele, Gunnar Elke, Carole Ichai, Constantine J Karvellas, Stephen A McClave, Heleen M Oudemans-van Straaten, Olav Rooyackers, Renee D Stapleton, Jukka Takala, Arthur RH van Zanten, Paul E Wischmeyer, Jean-Charles Preiser, Jean-Louis Vincent

Journal article  |  2019  |  Critical Care

Opinions and practices of blood glucose control in critically ill patients with pre-existing type 2 diabetes in Australian and New Zealand intensive care units

Alexis P Poole, James Anstey, Rinaldo Bellomo, Vishwanath Biradar, Adam M Deane, Simon R Finfer, Mark E Finnis, Craig J French, Palash Kar, Peter S Kruger, Matthew J Maiden, Johan Martensson, Colin J McArthur, Shay P McGuinness, Paul J Secombe, Antony E Tobin, Andrew A Udy, Glenn M Eastwood

Journal article  |  2019  |  Australian Critical Care

BACKGROUND: Approximately 9000 patients with type-2 diabetes mellitus (T2DM) are admitted to an intensive care unit (ICU) in Austr..

Any news from the prokinetic front?

Adam M Deane, Marianne J Chapman, Yasmine Ali Abdelhamid

Journal article  |  2019  |  Current Opinion in Critical Care

PURPOSE OF REVIEW: This review provides an update of recently conducted studies and randomized controlled trials evaluating prokin..

Translating the European Society for Clinical Nutrition and Metabolism 2019 guidelines into practice

Annika Reintam Blaser, Adam M Deane, Joel Starkopf

Journal article  |  2019  |  Current Opinion in Critical Care

PURPOSE OF REVIEW: To present a pragmatic approach to facilitate clinician's implementing the recent European Society for Clinical..

Constipation, diarrhea, and prophylactic laxative bowel regimens in the critically ill: A systematic review and meta-analysis

Tyler Hay, Rinaldo Bellomo, Tom Rechnitzer, Emily See, Yasmine Ali Abdelhamid, Adam M Deane

Journal article  |  2019  |  Journal of Critical Care

The hospital-based evaluation of laxative prophylaxis in ICU (HELP-ICU): A pilot cluster-crossover randomized clinical trial

Tyler Hay, Adam M Deane, Tom Rechnitzer, Kate Fetterplace, Rebecca Reilly, Melissa Ankravs, Michael Bailey, Timothy Fazio, James Anstey, Rohit D'Costa, Jeffrey J Presneill, Christopher M Maclsaac, Rinaldo Bellomo

Journal article  |  2019  |  Journal of Critical Care

Hospital-acquired complications in intensive care unit patients with diabetes: A before-and-after study of a conventional versus liberal glucose control protocol

Nora Luethi, Luca Cioccari, Glenn Eastwood, Peter Biesenbach, Rhys Morgan, Stephanie Sprogis, Helen Young, Leah Peck, Christine Knee Chong, Sandra Moore, Kylie Moon, Elif I Ekinci, Adam M Deane, Rinaldo Bellomo, Johan Martensson

Journal article  |  2019  |  Acta Anaesthesiologica Scandinavica

Gallbladder Dyskinesia Is Associated With an Impaired Postprandial Fibroblast Growth Factor 19 Response in Critically Ill Patients

Kiran VK Koelfat, Mark P Plummer, Frank G Schaap, Martin Lenicek, Peter LM Jansen, Adam M Deane, Steven WM Olde Damink

Journal article  |  2019  |  Hepatology

Observed appetite and nutrient intake three months after ICU discharge.

Lee-Anne S Chapple, Luke M Weinel, Yasmine Ali Abdelhamid, Matthew J Summers, Thu Nguyen, Palash Kar, Kylie Lange, Marianne J Chapman, Adam M Deane

Journal article  |  2019  |  Clinical Nutrition

BACKGROUND & AIMS: Oral intake is diminished immediately after ICU discharge, yet factors affecting nutritional intake after hospi..

The effect of a low carbohydrate formula on glycaemia in critically ill enterally-fed adult patients with hyperglycaemia: A blinded randomised feasibility trial

Ra'eesa Doola, Adam M Deane, Debbie M Tolcher, Jeffrey J Presneill, Helen L Barrett, Josephine M Forbes, Alwyn S Todd, Satomi Okano, David J Sturgess

Journal article  |  2019  |  Clinical Nutrition ESPEN

Obesity in the critically ill: a narrative review

Miet Schetz, Audrey De Jong, Adam M Deane, Wilfried Druml, Pleun Hemelaar, Paolo Pelosi, Peter Pickkers, Annika Reintam-Blaser, Jason Roberts, Yasser Sakr, Samir Jaber

Journal article  |  2019  |  Intensive Care Medicine

Vitamin C, Hydrocortisone and Thiamine in Patients with Septic Shock (VITAMINS) trial: study protocol and statistical analysis plan

Tomoko Fujii, Andrew A Udy, Adam M Deane, Nora Luethi, Michael Bailey, Glenn M Eastwood, Daniel Frei, Craig French, Neil Orford, Yahya Shehabi, Paul J Young, Rinaldo Bellomo

Journal article  |  2019  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

BACKGROUND: Septic shock is associated with poor outcomes. Vitamin C (ascorbic acid) is a cellular antioxidant and has anti-inflam..

A retrospective evaluation of nutrition support in relation to clinical outcomes in critically ill patients with an open abdomen.

Rosalie Yandell, Susan Wang, Peter Bautz, Alison Shanks, Stephanie O'Connor, Adam Deane, Kylie Lange, Marianne Chapman

Journal article  |  2019  |  Australian Critical Care

BACKGROUND: Optimising nutrition support in critically ill patients with an open abdomen is challenging. OBJECTIVES: The aims of t..

Incretin Physiology and Pharmacology in the Intensive Care Unit

Mark P Plummer, Jeroen Hermanides, Adam M Deane

Journal article  |  2019  |  Critical Care Clinics

Gut dysmotility in the ICU: diagnosis and therapeutic options

Mark P Plummer, Annika Reintam Blaser, Adam M Deane

Journal article  |  2019  |  Current Opinion in Critical Care

PURPOSE OF REVIEW: To provide a comprehensive update of diagnosis and treatment of gastrointestinal dysmotility in the critically ..

An observational study investigating the use of patient-owned technology to quantify physical activity in survivors of critical illness.

Samuel Gluck, Matthew James Summers, Mark Edward Finnis, Alice Andrawos, Thomas Paul Goddard, Carol Lynette Hodgson, Theodore John Iwashyna, Adam Michael Deane

Journal article  |  2019  |  Australian Critical Care

BACKGROUND: Physical activity after intensive care unit (ICU) discharge is challenging to measure but could inform research and pr..

Pathophysiology and Treatment of Gastrointestinal Motility Disorders in the Acutely Ill

Adam M Deane, Marianne J Chapman, Annika Reintam Blaser, Stephen A McClave, Anton Emmanuel

Journal article  |  2019  |  Nutrition in Clinical Practice

Incident Diabetes in Survivors of Critical Illness and Mechanisms Underlying Persistent Glucose Intolerance: A Prospective Cohort Study

Palash Kar, Mark P Plummer, Yasmine Ali Abdelhamid, Emma J Giersch, Matthew J Summers, Luke M Weinel, Mark E Finnis, Liza K Phillips, Karen L Jones, Michael Horowitz, Adam M Deane

Journal article  |  2019  |  Critical Care Medicine

What Happens to Nutrition Intake in the Post-Intensive Care Unit Hospitalization Period? An Observational Cohort Study in Critically Ill Adults

Emma J Ridley, Rachael L Parke, Andrew R Davies, Michael Bailey, Carol Hodgson, Adam M Deane, Shay McGuinness, D James Cooper

Journal article  |  2019  |  Journal of Parenteral and Enteral Nutrition

Delivery of full predicted energy from nutrition and the effect on mortality in critically ill adults: A systematic review and meta-analysis of randomised controlled trials

Emma J Ridley, Andrew R Davies, Carol L Hodgson, Adam Deane, Michael Bailey, D Jamie Cooper

Journal article  |  2018  |  Clinical Nutrition

What should we target after TARGET?

Paul J Young, Rinaldo Bellomo, Marianne J Chapman, Adam M Deane, Sandra L Peake

Journal article  |  2018  |  Critical Care and Resuscitation

Systematic review of incretin therapy during peri-operative and intensive care.

Abraham H Hulst, Mark P Plummer, Markus W Hollmann, J Hans DeVries, Benedikt Preckel, Adam M Deane, Jeroen Hermanides

Journal article  |  2018  |  Critical Care

BACKGROUND: Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are incretin hormones. By lowering ..

Energy-Dense versus Routine Enteral Nutrition in the Critically Ill

Marianne Chapman, Sandra L Peake, Rinaldo Bellomo, Andrew Davies, Adam Deane, Michael Horowitz, Sally Hurford, Kylie Lange, Lorraine Little, Diane Mackle, Stephanie O'Connor, Jeffrey Presneill, Emma Ridley, Patricia Williams, Paul Young

Journal article  |  2018  |  New England Journal of Medicine

Targeted Full Energy and Protein Delivery in Critically Ill Patients: A Pilot Randomized Controlled Trial (FEED Trial)

Kate Fetterplace, Adam M Deane, Audrey Tierney, Lisa J Beach, Laura D Knight, Jeffrey Presneill, Thomas Rechnitzer, Adrienne Forsyth, Benjamin MT Gill, Marina Mourtzakis, Christopher MacIsaac

Journal article  |  2018  |  Journal of Parenteral and Enteral Nutrition

Nutrition Therapy in Australia and New Zealand Intensive Care Units: An International Comparison Study

Emma J Ridley, Sandra L Peake, Matthew Jarvis, Adam M Deane, Kylie Lange, Andrew R Davies, Marianne Chapman, Daren Heyland

Journal article  |  2018  |  Journal of Parenteral and Enteral Nutrition

Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database

Andrew J Boyle, Fabiana Madotto, John G Laffey, Giacomo Bellani, Pham Tai, Antonio Pesenti, B Taylor Thompson, Cecilia M O'Kane, Adam M Deane, Daniel F McAuley

Journal article  |  2018  |  Critical Care

Understanding the rationale for parenteral ascorbate (vitamin C) during an acute inflammatory reaction: a biochemical perspective

Robert McNamara, Adam M Deane, James Anstey, Rinaldo Bellomo

Journal article  |  2018  |  Critical Care and Resuscitation

Nutrition Adequacy Therapeutic Enhancement in the Critically Ill: A Randomized Double-Blind, Placebo-Controlled Trial of the Motilin Receptor Agonist Camicinal (GSK962040): The NUTRIATE Study

Adam M Deane, Francois Lamontagne, George E Dukes, David Neil, Lakshmi Vasist, Matthew E Barton, Kimberley Hacquoil, Xiaoling Ou, Duncan Richards, Henry T Stelfox, Sangeeta Mehta, Andrew G Day, Marianne J Chapman, Daren K Heyland

Journal article  |  2018  |  Journal of Parenteral and Enteral Nutrition

Postprandial hypotension in older survivors of critical illness.

Thu Anh Ngoc Nguyen, Yasmine Ali Abdelhamid, Luke M Weinel, Seva Hatzinikolas, Palash Kar, Matthew J Summers, Liza K Phillips, Michael Horowitz, Karen L Jones, Adam M Deane

Journal article  |  2018  |  Journal of Critical Care

PURPOSE: In older people postprandial hypotension occurs frequently; and is an independent risk factor for falls, cardiovascular e..

\ Liberal Glucose Control in ICU Patients With Diabetes: A Before-and-After Study

Nora Luethi, Luca Cioccari, Peter Biesenbach, Luca Lucchetta, Hidetoshi Kagaya, Rhys Morgan, Francesca Di Muzio, Barbara Presello, Duaa Gaafar, Alison Hay, Marco Crisman, Roisin Toohey, Hollie Russell, Neil J Glassford, Glenn M Eastwood, Elif I Ekinci, Adam M Deane, Rinaldo Bellomo, Johan Martensson

Journal article  |  2018  |  Critical Care Medicine

Outcomes in Patients with Vasodilatory Shock and Renal Replacement Therapy Treated with Intravenous Angiotensin II

James A Tumlin, Raghavan Murugan, Adam M Deane, Marlies Ostermann, Laurence W Busse, Kealy R Ham, Kianoush Kashani, Harold M Szerlip, John R Prowle, Azra Bihorac, Kevin W Finkel, Alexander Zarbock, Lui G Forni, Shannan J Lynch, Jeff Jensen, Stew Kroll, Lakhmir S Chawla, George F Tidmarsh, Rinaldo Bellomo

Journal article  |  2018  |  Critical Care Medicine

Diabetes-Specific Formulae Versus Standard Formulae as Enteral Nutrition to Treat Hyperglycemia in Critically Ill Patients: Protocol for a Randomized Controlled Feasibility Trial

Ra'eesa Doola, Alwyn S Todd, Josephine M Forbes, Adam M Deane, Jeffrey J Presneill, David J Sturgess

Journal article  |  2018  |  JMIR Research Protocols

From dysmotility to virulent pathogens: implications of opioid use in the ICU

Lee-anne Chapple, Adam Deane

Journal article  |  2018  |  Current Opinion in Critical Care

Protocol summary and statistical analysis plan for the intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX)

Diane M Mackle, Michael J Bailey, Richard W Beasley, Rinaldo Bellomo, Victoria L Bennett, Adam M Deane, Glenn M Eastwood, Simon Finfer, Ross C Freebairn, Edward Litton, Natalie J Linke, Colin J McArthur, Shay P McGuinness, Rakshit Panwar, Paul J Young

Journal article  |  2018  |  Critical Care and Resuscitation

The disconnect between nutrition guidelines and evidence: how much protein should I prescribe to this critically ill patient?

Adam M Deane, Sandra L Peake, Marianne J Chapman

Journal article  |  2018  |  Critical Care and Resuscitation

Barriers to Nutrition Intervention for Patients With a Traumatic Brain Injury: Views and Attitudes of Medical and Nursing Practitioners in the Acute Care Setting

Lee-anne Chapple, Marianne Chapman, Natalie Shalit, Andrew Udy, Adam Deane, Lauren Williams

Journal article  |  2018  |  Journal of Parenteral and Enteral Nutrition

Post-pyloric feeding tube placement in critically ill patients: Extending the scope of practice for Australian dietitians.

Rosalie Yandell, Marianne Chapman, Stephanie O'Connor, Alison Shanks, Kylie Lange, Adam Deane

Journal article  |  2018  |  Nutrition & Dietetics

AIM: To determine whether the placement of a post-pyloric feeding tube (PPFT) can be taught safely and effectively to a critical c..

Glycaemic control targets after traumatic brain injury: a systematic review and meta-analysis.

Jeroen Hermanides, Mark P Plummer, Mark Finnis, Adam M Deane, Jonathan P Coles, David K Menon

Journal article  |  2018  |  Critical Care

BACKGROUND: Optimal glycaemic targets in traumatic brain injury (TBI) remain unclear. We performed a systematic review and meta-an..

Targeted full energy and protein delivery in critically ill patients: a study protocol for a pilot randomised control trial (FEED Trial).

Kate Fetterplace, Adam M Deane, Audrey Tierney, Lisa Beach, Laura D Knight, Thomas Rechnitzer, Adrienne Forsyth, Marina Mourtzakis, Jeffrey Presneill, Christopher MacIsaac

Journal article  |  2018  |  Pilot and Feasibility Studies

Background: Current guidelines for the provision of protein for critically ill patients are based on incomplete evidence, due to l..

Glycated haemoglobin is increased in critically ill patients with stress hyperglycaemia: Implications for risk of diabetes in survivors of critical illness.

Yang T Du, Palash Kar, Yasmine Ali Abdelhamid, Michael Horowitz, Adam M Deane

Journal article  |  2018  |  Diabetes Research and Clinical Practice

It remains uncertain if stress hyperglycaemia (SH) indicates a long-term predisposition to the development of type 2 diabetes. We ..

Efficacy and safety of stress ulcer prophylaxis in critically ill patients: a network meta-analysis of randomized trials.

Waleed Alhazzani, Fayez Alshamsi, Emilie Belley-Cote, Diane Heels-Ansdell, Romina Brignardello-Petersen, Mustafa Alquraini, Anders Perner, Morten Hylander Møller, Mette Krag, Saleh Almenawer, Bram Rochwerg, Joanna Dionne, Roman Jaeschke, Mohammed Alshahrani, Adam Deane, Dan Perri, Lehana Thebane, Awad Al-Omari, Simon Finfer, Deborah Cook, et al.

Journal article  |  2018  |  Intensive Care Medicine

PURPOSE: Stress ulcer prophylaxis (SUP) is commonly prescribed in the intensive care unit. However, data from systematic reviews a..

Intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX): results of the pilot phase

Paul J Young, Diane M Mackie, Michael J Bailey, Richard W Beasley, Victoria L Bennett, Adam M Deane, Glenn M Eastwood, Simon Finfer, Ross C Freebairn, Edward Litton, Natalie J Linke, Colin J McArthur, Shay P McGuinness, Rakshit Panwar, Rinaldo Bellomo

Journal article  |  2017  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

Long-term mortality of critically ill patients with diabetes who survive admission to the intensive care unit.

Yasmine Ali Abdelhamid, Mark P Plummer, Mark E Finnis, Vishwanath Biradar, Shailesh Bihari, Palash Kar, Stewart Moodie, Michael Horowitz, Jonathan E Shaw, Liza K Phillips, Adam M Deane

Journal article  |  2017  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

OBJECTIVE: Long-term outcomes of critically ill patients with diabetes are unknown. Our objectives were to evaluate the effect of ..

Antecedent Hypoglycemia Does Not Attenuate the Acceleration of Gastric Emptying by Hypoglycemia.

Palash Kar, Karen L Jones, Mark P Plummer, Yasmine Ali Abdelhamid, Emma J Giersch, Matthew J Summers, Seva Hatzinikolas, Simon Heller, Michael Horowitz, Adam M Deane

Journal article  |  2017  |  The Journal of Clinical Endocrinology & Metabolism

Context: Acute hypoglycemia accelerates gastric emptying and increases cardiac contractility. However, antecedent hypoglycemia att..

Intensity of early correction of hyperglycaemia and outcome of critically ill patients with diabetic ketoacidosis

Johan Martensson, Michael Bailey, Balasubramanian Venkatesh, David Pilcher, Adam Deane, Yasmine Ali Abdelhamid, Marco Crisman, Brij Verma, Christopher MacIsaac, Geoffrey Wigmore, Yahya Shehabi, Takafumi Suzuki, Craig French, Neil Orford, Nima Kakho, Johannes Prins, Elif I Ekinci, Rinaldo Bellomo

Journal article  |  2017  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

A scoping review of use of wearable devices to evaluate outcomes in survivors of critical illness.

Samuel Gluck, Lee-Anne S Chapple, Marianne J Chapman, Theodore J Iwashyna, Adam M Deane

Journal article  |  2017  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

OBJECTIVE: Wearable devices using new technology may be a cost-effective method to assess functional outcomes in survivors of crit..

Angiotensin II for the Treatment of Vasodilatory Shock

Ashish Khanna, Shane W English, Xueyuan S Wang, Kealy Ham, James Tumlin, Harold Szerlip, Laurence W Busse, Laith Altaweel, Timothy E Albertson, Caleb Mackey, Michael T McCurdy, David W Boldt, Stefan Chock, Paul J Young, Kenneth Krell, Richard G Wunderink, Marlies Ostermann, Raghavan Murugan, Michelle N Gong, Rakshit Panwar, et al.

Journal article  |  2017  |  New England Journal of Medicine

Mechanisms Controlling Glucose-Induced GLP-1 Secretion in Human Small Intestine.

Emily W Sun, Dayan de Fontgalland, Philippa Rabbitt, Paul Hollington, Luigi Sposato, Steven L Due, David A Wattchow, Christopher K Rayner, Adam M Deane, Richard L Young, Damien J Keating

Journal article  |  2017  |  Diabetes

Intestinal glucose stimulates secretion of the incretin hormone glucagon-like peptide 1 (GLP-1). The mechanisms underlying this pa..

The rapid and accurate categorisation of critically ill patients (RACE) to identify outcomes of interest for longitudinal studies: a feasibility study

AM Deane, CL Hodgson, P Young, L Little, V Singh, A Poole, M Young, D Mackle, K Lange, P Williams, SL Peake, MJ Chapman, TJ Iwashyna

Journal article  |  2017  |  Anaesthesia and Intensive Care

Withholding Pantoprazole for Stress Ulcer Prophylaxis in Critically Ill Patients: A Pilot Randomized Clinical Trial and Meta-Analysis.

Waleed Alhazzani, Gordon Guyatt, Mohammed Alshahrani, Adam M Deane, John C Marshall, Richard Hall, John Muscedere, Shane W English, François Lauzier, Lehana Thabane, Yaseen M Arabi, Tim Karachi, Bram Rochwerg, Simon Finfer, Nick Daneman, Fayez Alshamsi, Nicole Zytaruk, Diane Heel-Ansdell, Deborah Cook, undefined Canadian Critical Care Trials Group

Journal article  |  2017  |  Critical Care Medicine

INTRODUCTION: A decreased frequency of upper gastrointestinal bleeding and a possible association of proton pump inhibitor use wit..

Weekend days are not required to accurately measure oral intake in hospitalised patients.

LS Chapple, AM Deane, K Lange, AJ Kranz, LT Williams, MJ Chapman

Journal article  |  2017  |  Journal of Human Nutrition and Dietetics

BACKGROUND: Nutrition studies in patients admitted to hospital frequently disregard oral intake because measurement is time-intens..

Longitudinal changes in anthropometrics and impact on self-reported physical function after traumatic brain injury.

Lee-Anne S Chapple, Adam M Deane, Lauren T Williams, Richard Strickland, Chris Schultz, Kylie Lange, Daren K Heyland, Marianne J Chapman

Journal article  |  2017  |  Critical Care and Resuscitation

BACKGROUND AND AIMS: Patients admitted to the ICU with a traumatic brain injury (TBI) are at risk of muscle wasting but this has n..

Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines.

Annika Reintam Blaser, Joel Starkopf, Waleed Alhazzani, Mette M Berger, Michael P Casaer, Adam M Deane, Sonja Fruhwald, Michael Hiesmayr, Carole Ichai, Stephan M Jakob, Cecilia I Loudet, Manu LNG Malbrain, Juan C Montejo González, Catherine Paugam-Burtz, Martijn Poeze, Jean-Charles Preiser, Pierre Singer, Arthur RH van Zanten, Jan De Waele, Julia Wendon, et al.

Journal article  |  2017  |  Intensive Care Medicine

PURPOSE: To provide evidence-based guidelines for early enteral nutrition (EEN) during critical illness. METHODS: We aimed to comp..

Exogenous glucagon-like peptide-1 attenuates glucose absorption and reduces blood glucose concentration after small intestinal glucose delivery in critical illness.

Asaf Miller, Adam M Deane, Mark P Plummer, Caroline E Cousins, Lee-Anne S Chapple, Michael Horowitz, Marianne J Chapman

Journal article  |  2017  |  Critical Care and Resuscitation

OBJECTIVE: To evaluate the effect of exogenous glucagonlike peptide-1 (GLP-1) on small intestinal glucose absorption and blood glu..

Nutrient stimulation of mesenteric blood flow - implications for older critically ill patients.

Thu An Nguyen, Yasmine Ali Abdelhamid, Liza K Phillips, Leeanne S Chapple, Michael Horowitz, Karen L Jones, Adam M Deane

Journal article  |  2017  |  World Journal of Critical Care Medicine

Nutrient ingestion induces a substantial increase in mesenteric blood flow. In older persons (aged ≥ 65 years), particularly those..

Occult upper gastrointestinal mucosal abnormalities in critically ill patients.

C Ovenden, MP Plummer, S Selvanderan, TA Donaldson, NQ Nguyen, LM Weinel, ME Finnis, MJ Summers, Y Ali Abdelhamid, MJ Chapman, CK Rayner, AM Deane

Journal article  |  2017  |  Acta Anaesthesiologica Scandinavica

BACKGROUND: The objectives of this study were to estimate the frequency of occult upper gastrointestinal abnormalities, presence o..

Barriers to Nutrition Intervention for Patients With a Traumatic Brain Injury.

Lee-Anne Chapple, Marianne Chapman, Natalie Shalit, Andrew Udy, Adam Deane, Lauren Williams

Journal article  |  2017  |  Journal of Parenteral and Enteral Nutrition

BACKGROUND: Nutrition delivered to patients with a traumatic brain injury (TBI) is typically below prescribed amounts. While the d..

Intensive care discharge delay is associated with increased hospital length of stay: A multicentre prospective observational study.

Ravindranath Tiruvoipati, John Botha, Jason Fletcher, Himangsu Gangopadhyay, Mainak Majumdar, Sanjiv Vij, Eldho Paul, David Pilcher, undefined Australia and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group

Journal article  |  2017  |  PLOS ONE

BACKGROUND: Some patients experience a delayed discharge from the intensive care unit (ICU) where the intended and actual discharg..

Energy and protein deficits throughout hospitalization in patients admitted with a traumatic brain injury.

Lee-Anne S Chapple, Adam M Deane, Daren K Heyland, Kylie Lange, Amelia J Kranz, Lauren T Williams, Marianne J Chapman

Journal article  |  2016  |  Clinical Nutrition

BACKGROUND AND AIMS: Patients with traumatic brain injury (TBI) experience considerable energy and protein deficits in the intensi..

Re-evaluating the Inhibition of Stress Erosions (REVISE): a protocol for pilot randomized controlled trial.

Waleed Alhazzani, Gordon Guyatt, John C Marshall, Richard Hall, John Muscedere, Francois Lauzier, Lehana Thabane, Mohammed Alshahrani, Shane W English, Yaseen M Arabi, Adam M Deane, Tim Karachi, Bram Rochwerg, Simon Finfer, Nick Daneman, Nicole Zytaruk, Diane Heel-Ansdell, Deborah Cook, On Behalf Of

Journal article  |  2016  |  Annals of Saudi Medicine

INTRODUCTION: Clinicians routinely administer stress ulcer prophylaxis to mechanically ventilated patients in the intensive care u..

Pantoprazole or Placebo for Stress Ulcer Prophylaxis (POP-UP): Randomized Double-Blind Exploratory Study.

Shane P Selvanderan, Matthew J Summers, Mark E Finnis, Mark P Plummer, Yasmine Ali Abdelhamid, Michael B Anderson, Marianne J Chapman, Christopher K Rayner, Adam M Deane

Journal article  |  2016  |  Critical Care Medicine

OBJECTIVES: Pantoprazole is frequently administered to critically ill patients for prophylaxis against gastrointestinal bleeding. ..

Stress hyperglycaemia in critically ill patients and the subsequent risk of diabetes: a systematic review and meta-analysis.

Yasmine Ali Abdelhamid, Palash Kar, Mark E Finnis, Liza K Phillips, Mark P Plummer, Jonathan E Shaw, Michael Horowitz, Adam M Deane

Journal article  |  2016  |  Critical Care

BACKGROUND: Hyperglycaemia occurs frequently in critically ill patients without diabetes. We conducted a systematic review and met..

Prior exposure to hyperglycaemia attenuates the relationship between glycaemic variability during critical illness and mortality.

Mark P Plummer, Mark E Finnis, Matthew Horsfall, Marleesa Ly, Palash Kar, Yasmine Ali Abdelhamid, Adam M Deane

Journal article  |  2016  |  Critical Care and Resuscitation

OBJECTIVE: Our primary objective was to determine the impact of prior exposure to hyperglycaemia on the association between glycae..

Liberal Versus Conventional Glucose Targets in Critically III Diabetic Patients: An Exploratory Safety Cohort Assessment

Francesca Di Muzio, Barbara Presello, Neil J Glassford, Isabela Y Tsuji, Glenn M Eastwood, Adam M Deane, Elif I Ekinci, Rinaldo Bellomo, Johan Martensson

Journal article  |  2016  |  Critical Care Medicine

Liberal Glycemic Control in Critically III Patients With Type 2 Diabetes: An Exploratory Study

Palash Kar, Mark P Plummer, Rinaldo Bellomo, Alicia J Jenkins, Andrzej S Januszewski, Marianne J Chapman, Karen L Jones, Michael Horowitz, Adam M Deane

Journal article  |  2016  |  Critical Care Medicine

Critical Illness Is Associated With Impaired Gallbladder Emptying as Assessed by 3D Ultrasound.

Mark P Plummer, Palash Kar, Caroline E Cousins, Trygve Hausken, Kylie Lange, Marianne J Chapman, Karen L Jones, Michael Horowitz, Adam M Deane

Journal article  |  2016  |  Critical Care Medicine

OBJECTIVE: To quantify gallbladder dysfunction during critical illness. DESIGN: Prospective observational comparison study of nutr..

Energy-Dense Formulae May Slow Gastric Emptying in the Critically Ill.

Palash Kar, Mark P Plummer, Marianne J Chapman, Caroline E Cousins, Kylie Lange, Michael Horowitz, Karen L Jones, Adam M Deane

Journal article  |  2016  |  Journal of Parenteral and Enteral Nutrition

BACKGROUND: Enteral feed intolerance occurs frequently in critically ill patients and can be associated with adverse outcomes. "En..

Individualizing endpoints in randomized clinical trials to better inform individual patient care: the TARGET proposal

Theodore J Iwashyna, Adam M Deane

Journal article  |  2016  |  Critical Care

DPP-4 Inhibition and the Known Unknown.

Michael Horowitz, Tongzhi Wu, Adam M Deane, Karen L Jones, Christopher K Rayner

Journal article  |  2016  |  Diabetes

The effect of camicinal (GSK962040), a motilin agonist, on gastric emptying and glucose absorption in feed-intolerant critically ill patients: a randomized, blinded, placebo-controlled, clinical trial.

Marianne J Chapman, Adam M Deane, Stephanie L O'Connor, Nam Q Nguyen, Robert JL Fraser, Duncan B Richards, Kimberley E Hacquoil, Lakshmi S Vasist Johnson, Matthew E Barton, George E Dukes

Journal article  |  2016  |  Critical Care

BACKGROUND: The promotility agents currently available to treat gastroparesis and feed intolerance in the critically ill are limit..

A prospective observational study of the effect of critical illness on ultrastructural and microscopic morphology of duodenal mucosa.

Victor Y Liew, Marianne J Chapman, Nam Q Nguyen, Caroline E Cousins, Mark P Plummer, Lee-Anne S Chapple, Yasmine Ali Abdelhamid, Nicholas D Manton, Adam Swalling, Peter Sutton-Smith, Alastair D Burt, Adam M Deane

Journal article  |  2016  |  Critical Care and Resuscitation

OBJECTIVE: Disturbed intestinal barrier function due to 'leaky' tight junctions may cause secondary sepsis via paracellular transl..

Dysglycemia and Glucose Control During Sepsis.

Mark P Plummer, Adam M Deane

Journal article  |  2016  |  Clinics in Chest Medicine

Sepsis predisposes to disordered metabolism and dysglycemia; the latter is a broad term that includes hyperglycemia, hypoglycemia,..

Stress ulcer prophylaxis in critical illness: a Canadian survey.

Melissa Shears, Waleed Alhazzani, John C Marshall, John Muscedere, Richard Hall, Shane W English, Peter M Dodek, François Lauzier, Salmaan Kanji, Mark Duffett, Jeffrey Barletta, Mohammed Alshahrani, Yaseen Arabi, Adam Deane, Deborah J Cook

Journal article  |  2016  |  Canadian Journal of Anesthesia/Journal canadien d'anesthésie

PURPOSE: Stress ulcer prophylaxis (SUP) using histamine-2-receptor antagonists has been a standard of care in intensive care units..

The insulinotropic effect of pulsatile compared with continuous intravenous delivery of GLP-1.

Mark P Plummer, Palash Kar, Caroline E Cousins, Kylie Lange, Marianne J Chapman, Michael A Nauck, Michael Horowitz, Juris J Meier, Adam M Deane

Journal article  |  2016  |  Diabetologia

AIMS/HYPOTHESIS: In healthy individuals, both insulin and glucagon-like peptide 1 (GLP-1) are secreted in a pulsatile fashion. Ins..

The effect of augmenting early nutritional energy delivery on quality of life and employment status one year after ICU admission

DB Reid, LS Chapple, SN O'Connor, R Bellomo, H Buhr, MJ Chapman, AR Davies, GM Eastwood, S Ferrie, K Lange, J McIntyre, DM Needham, SL Peake, S Rai, EJ Ridley, H Rodgers, AM Deane

Journal article  |  2016  |  Anaesthesia and Intensive Care

Event-rate and delta inflation when evaluating mortality as a primary outcome from randomized controlled trials of nutritional interventions during critical illness: a systematic review.

Matthew J Summers, Lee-anne S Chapple, Stephen A McClave, Adam M Deane

Journal article  |  2016  |  The American Journal of Clinical Nutrition

BACKGROUND: There is a lack of high-quality evidence that proves that nutritional interventions during critical illness reduce mor..

Nutrition support practices in critically ill head-injured patients: a global perspective.

Lee-Anne S Chapple, Marianne J Chapman, Kylie Lange, Adam M Deane, Daren K Heyland

Journal article  |  2016  |  Critical Care

BACKGROUND: Critical illness following head injury is associated with a hypermetabolic state but there are insufficient epidemiolo..

Peri-operative nutrition.

Y Ali Abdelhamid, MJ Chapman, AM Deane

Journal article  |  2016  |  Anaesthesia

Patients are frequently malnourished or are at risk of malnutrition before surgery. Peri-operative nutritional support can improve..

Stress Induced Hyperglycemia and the Subsequent Risk of Type 2 Diabetes in Survivors of Critical Illness.

Mark P Plummer, Mark E Finnis, Liza K Phillips, Palash Kar, Shailesh Bihari, Vishwanath Biradar, Stewart Moodie, Michael Horowitz, Jonathan E Shaw, Adam M Deane

Journal article  |  2016  |  PLOS ONE

OBJECTIVE: Stress induced hyperglycemia occurs in critically ill patients who have normal glucose tolerance following resolution o..

Enhanced Protein-Energy Provision via the Enteral Route Feeding (PEPuP) protocol in critically ill surgical patients: a multicentre prospective evaluation.

B Declercq, AM Deane, M Wang, MJ Chapman, DK Heyland

Journal article  |  2016  |  Anaesthesia and Intensive Care

Suboptimal levels of feeding in critically ill patients are associated with poor clinical outcomes. The Enhanced Protein-Energy Pr..

Survivors of intensive care with type 2 diabetes and the effect of shared care follow-up clinics: study protocol for the SWEET-AS randomised controlled feasibility study.

Yasmine Ali Abdelhamid, Liza Phillips, Michael Horowitz, Adam Deane

Journal article  |  2016  |  Pilot and Feasibility Studies

BACKGROUND: Many patients who survive the intensive care unit (ICU) experience long-term complications such as peripheral neuropat..

Enterohormones and the response to critical illness

MP Plummer, AR Blaser, AM Deane

Book Chapter  |  2016

Supplemental parenteral nutrition in critically ill patients: a study protocol for a phase II randomised controlled trial

Emma J Ridley, Andrew R Davies, Rachael Parke, Michael Bailey, Colin McArthur, Lyn Gillanders, David J Cooper, Shay McGuinness

Journal article  |  2015  |  Trials

Attenuated platelet aggregation in patients with septic shock is independent from the activity state of myosin light chain phosphorylation or a reduction in Rho kinase-dependent inhibition of myosin light chain phosphatase.

Benjamin Aj Reddi, Samantha M Iannella, Stephanie N O'Connor, Adam M Deane, Scott R Willoughby, David P Wilson

Journal article  |  2015  |  Intensive Care Medicine Experimental

BACKGROUND: Impaired coagulation contributes to the morbidity and mortality associated with septic shock. Whether abnormal platele..

Personalised glucose therapy: glucose targets in critically ill patients with pre-existing poorly controlled type 2 diabetes.

P Kar, MP Plummer, R Bellomo, AJ Jenkins, AS Januszewski, K Lange, MJ Chapman, M Horowitz, AM Deane

Journal article  |  2015  |  Intensive Care Medicine Experimental

The incidence of ocular candidiasis and evaluation of routine opthalmic examination in critically ill patients with candidaemia.

S Gluck, WG Headdon, Dws Tang, IB Bastian, MJ Goggin, AM Deane

Journal article  |  2015  |  Anaesthesia and Intensive Care

Despite a paucity of data regarding both the incidence of ocular candidiasis and the utility of ophthalmic examination in critical..

Effect of Critical Illness on Triglyceride Absorption.

Yasmine Ali Abdelhamid, Caroline E Cousins, Jennifer A Sim, Max S Bellon, Nam Q Nguyen, Michael Horowitz, Marianne J Chapman, Adam M Deane

Journal article  |  2015  |  Journal of Parenteral and Enteral Nutrition

BACKGROUND: Adequate nutrition support for critically ill patients optimizes outcome, and enteral feeding is the preferred route o..

Comparison of different definitions of feeding intolerance: A retrospective observational study.

Annika Reintam Blaser, Liis Starkopf, Adam M Deane, Martijn Poeze, Joel Starkopf

Journal article  |  2015  |  Clinical Nutrition

BACKGROUND & AIMS: While feeding intolerance (FI) is clinically important in the critically ill it is inconsistently defined. By e..

Preclinical research in critical care - the Australasian perspective

Shailesh Bihari, Matthew Maiden, Adam Deane, Ralph Fuchs, John Fraser, Andrew D Bersten, Rinaldo Bellomo

Journal article  |  2015  |  Critical Care and Resuscitation

Measurement of gastric emptying in the critically ill.

Palash Kar, Karen L Jones, Michael Horowitz, Marianne J Chapman, Adam M Deane

Journal article  |  2015  |  Clinical Nutrition

BACKGROUND & AIMS: Enteral nutrition is important in critically ill patients and is usually administered via a nasogastric tube. A..

Effects of exogenous glucagon-like peptide-1 on blood pressure, heart rate, gastric emptying, mesenteric blood flow and glycaemic responses to oral glucose in older individuals with normal glucose tolerance or type 2 diabetes.

Laurence G Trahair, Michael Horowitz, Julie E Stevens, Christine Feinle-Bisset, Scott Standfield, Diana Piscitelli, Christopher K Rayner, Adam M Deane, Karen L Jones

Journal article  |  2015  |  Diabetologia

AIMS/HYPOTHESIS: A postprandial fall in BP occurs frequently in older individuals and in patients with type 2 diabetes. The magnit..

Trials on stress ulcer prophylaxis: finding the balance between benefit and harm. Response to Krag et al.

Adam M Deane, Gordon H Guyatt

Journal article  |  2015  |  Intensive Care Medicine

Management of critically ill patients with type 2 diabetes: The need for personalised therapy.

Palash Kar, Karen L Jones, Michael Horowitz, Adam M Deane

Journal article  |  2015  |  World Journal of Diabetes

Critical illness in patients with pre-existing diabetes frequently causes deterioration in glycaemic control. Despite the prevalen..

Hyperglycemia potentiates the slowing of gastric emptying induced by exogenous GLP-1.

Mark P Plummer, Karen L Jones, Caroline E Cousins, Laurence G Trahair, Juris J Meier, Marianne J Chapman, Michael Horowitz, Adam M Deane

Journal article  |  2015  |  Diabetes Care

OBJECTIVE: Acute hyperglycemia markedly slows gastric emptying. Exogenous GLP-1 also slows gastric emptying, leading to diminished..

Prevalence, risk factors, clinical consequences, and treatment of enteral feed intolerance during critical illness.

Usha Gungabissoon, Kimberley Hacquoil, Chanchal Bains, Michael Irizarry, George Dukes, Russell Williamson, Adam M Deane, Daren K Heyland

Journal article  |  2015  |  Journal of Parenteral and Enteral Nutrition

BACKGROUND: We aimed to determine the incidence of enteral feed intolerance and factors associated with intolerance and to assess ..

International observational study of nutritional support in mechanically ventilated patients following burn injury.

Adam Czapran, William Headdon, Adam M Deane, Kylie Lange, Marianne J Chapman, Daren K Heyland

Journal article  |  2015  |  Burns

INTRODUCTION: It has been proposed that nutritional therapy in critically ill patients after major burn reduces mortality. However..

Primum non nocere and challenging conventional treatment.

Adam M Deane, Gordon H Guyatt

Journal article  |  2015  |  Intensive Care Medicine

Incretins: player or stayer?

Adam M Deane, Michael Horowitz

Journal article  |  2015  |  Journal of Intensive Care Medicine

Diarrhoea in the critically ill.

Annika Reintam Blaser, Adam M Deane, Sonja Fruhwald

Journal article  |  2015  |  Current Opinion in Critical Care

PURPOSE OF REVIEW: To summarize existing evidence on definition, epidemiology, mechanisms, risk factors, consequences, outcome and..

Gastrointestinal dysfunction relating to the provision of nutrition in the critically ill.

Marianne J Chapman, Adam M Deane

Journal article  |  2015  |  Current Opinion in Clinical Nutrition and Metabolic Care

PURPOSE OF REVIEW: During critical illness, enteral nutrition remains central to clinical care and an understanding of gut dysfunc..

Accelerated intestinal glucose absorption in morbidly obese humans: relationship to glucose transporters, incretin hormones, and glycemia.

Nam Q Nguyen, Tamara L Debreceni, Jenna E Bambrick, Bridgette Chia, Judith Wishart, Adam M Deane, Chris K Rayner, Michael Horowitz, Richard L Young

Journal article  |  2015  |  The Journal of Clinical Endocrinology & Metabolism

CONTEXT: Intestinal glucose absorption is mediated by sodium-dependent glucose transporter 1 (SGLT-1) and glucose transporter 2 (G..

Gastric emptying and glycaemia in health and diabetes mellitus.

Liza K Phillips, Adam M Deane, Karen L Jones, Chris K Rayner, Michael Horowitz

Journal article  |  2015  |  Nature Reviews Endocrinology

The rate of gastric emptying is a critical determinant of postprandial glycaemia and, accordingly, is fundamental to maintaining b..

Effects of glucose-dependent insulinotropic polypeptide on gastric emptying, glycaemia and insulinaemia during critical illness: a prospective, double blind, randomised, crossover study.

Palash Kar, Caroline E Cousins, Christopher E Annink, Karen L Jones, Marianne J Chapman, Juris J Meier, Michael A Nauck, Michael Horowitz, Adam M Deane

Journal article  |  2015  |  Critical Care

INTRODUCTION: Insulin is used to treat hyperglycaemia in critically ill patients but can cause hypoglycaemia, which is associated ..

The relationship between fasting plasma citrulline concentration and small intestinal function in the critically ill.

Alexis Poole, Adam Deane, Matthew Summers, Janice Fletcher, Marianne Chapman

Journal article  |  2015  |  Critical Care

INTRODUCTION: In this study, we aimed to evaluate whether fasting plasma citrulline concentration predicts subsequent glucose abso..

Full predicted energy from nutrition and the effect on mortality and infectious complications in critically ill adults: a protocol for a systematic review and meta-analysis of parallel randomised controlled trials

Emma J Ridley, Andrew R Davies, Carol Hodgson, Adam Deane, Michael Bailey, D James Cooper

Journal article  |  2015  |  Systematic Reviews

Toward a sustainable intensive care training program.

Yasmine Ali Abdelhamid, Mary G White, Adam M Deane

Journal article  |  2014  |  Critical Care and Resuscitation

Understanding incretins.

Adam M Deane, Palle B Jeppesen

Journal article  |  2014  |  Intensive Care Medicine

Upregulation of intestinal glucose transporters after Roux-en-Y gastric bypass to prevent carbohydrate malabsorption.

Nam Q Nguyen, Tamara L Debreceni, Jenna E Bambrick, Bridgette Chia, Adam M Deane, Gary Wittert, Chris K Rayner, Michael Horowitz, Richard L Young

Journal article  |  2014  |  Obesity

OBJECTIVE: To determine the effect of Roux-en-Y gastric bypass (RYGB) on the expression of intestinal sweet taste receptors (STRs)..

Definition, prevalence, and outcome of feeding intolerance in intensive care: a systematic review and meta-analysis.

A Reintam Blaser, J Starkopf, Ü Kirsimägi, AM Deane

Journal article  |  2014  |  Acta Anaesthesiologica Scandinavica

Clinicians and researchers frequently use the phrase 'feeding intolerance' (FI) as a descriptive term in enterally fed critically ..

Use of a concentrated enteral nutrition solution to increase calorie delivery to critically ill patients: a randomized, double-blind, clinical trial

Sandra L Peake, Andrew R Davies, Adam M Deane, Kylie Lange, John L Moran, Stephanie N O'Connor, Emma J Ridley, Patricia J Williams, Marianne J Chapman

Journal article  |  2014  |  The American Journal of Clinical Nutrition

Dysglycaemia in the critically ill and the interaction of chronic and acute glycaemia with mortality

Mark P Plummer, Rinaldo Bellomo, Caroline E Cousins, Christopher E Annink, Krishnaswamy Sundararajan, Benjamin AJ Reddi, John P Raj, Marianne J Chapman, Michael Horowitz, Adam M Deane

Journal article  |  2014  |  Intensive Care Medicine

Impact of delirium and suture-less securement on accidental vascular catheter removal in the ICU.

K Sundararajan, S Wills, B Chacko, G Kanabar, S O'Connor, AM Deane

Journal article  |  2014  |  Anaesthesia and Intensive Care

The objectives were to describe the incidence of accidental vascular catheter removal (AVCR) in an Australian Intensive Care Unit ..

Glucagon-like peptide 1 attenuates the acceleration of gastric emptying induced by hypoglycemia in healthy subjects.

Mark P Plummer, Karen L Jones, Chris E Annink, Caroline E Cousins, Juris J Meier, Marianne J Chapman, Michael Horowitz, Adam M Deane

Journal article  |  2014  |  Diabetes Care

OBJECTIVE: Exogenous GLP-1 slows gastric emptying in health and diabetes leading to diminished glycemic excursions. Gastric emptyi..

Intensivists under threat: who's in charge here?

Adam M Deane

Journal article  |  2014  |  Critical Care and Resuscitation

The model currently used in public hospitals in Australia and New Zealand - of closed, mixed medical-surgical ICUs, led by consult..

Stress ulceration: prevalence, pathology and association with adverse outcomes.

Mark P Plummer, Annika Reintam Blaser, Adam M Deane

Journal article  |  2014  |  Critical Care

Incretins and the intensivist: what are they and what does an intensivist need to know about them?

Mark P Plummer, Marianne J Chapman, Michael Horowitz, Adam M Deane

Journal article  |  2014  |  Critical Care

Hyperglycaemia occurs frequently in the critically ill, even in those patients without a history of diabetes. The mechanisms under..

Comment. Is incretin-based therapy ready for the care of hospitalized patients with type 2 diabetes?

Adam M Deane, Michael Horowitz

Journal article  |  2014  |  Diabetes Care

Endogenous amylin and glucagon-like peptide-1 concentrations are not associated with gastric emptying in critical illness.

MJ Summers, AE DI Bartolomeo, AV Zaknic, MJ Chapman, NQ Nguyen, B Zacharakis, CK Rayner, M Horowitz, AM Deane

Journal article  |  2014  |  Acta Anaesthesiologica Scandinavica

BACKGROUND: In health, the hormones amylin and glucagon-like peptide-1 (GLP-1) slow gastric emptying (GE) and modulate glycaemia. ..

Comparative effects of prolonged and intermittent stimulation of the glucagon-like peptide 1 receptor on gastric emptying and glycemia.

Mahesh M Umapathysivam, Michael Y Lee, Karen L Jones, Christopher E Annink, Caroline E Cousins, Laurence G Trahair, Chris K Rayner, Marianne J Chapman, Michael A Nauck, Michael Horowitz, Adam M Deane

Journal article  |  2014  |  Diabetes

Acute administration of glucagon-like peptide 1 (GLP-1) and its agonists slows gastric emptying, which represents the major mechan..

The effects of critical illness on intestinal glucose sensing, transporters, and absorption.

Adam M Deane, Chris K Rayner, Alex Keeshan, Nada Cvijanovic, Zelia Marino, Nam Q Nguyen, Bridgette Chia, Matthew J Summers, Jennifer A Sim, Theresia van Beek, Marianne J Chapman, Michael Horowitz, Richard L Young

Journal article  |  2014  |  Critical Care Medicine

OBJECTIVES: Providing effective enteral nutrition is important during critical illness. In health, glucose is absorbed from the sm..

The effect of exogenous glucose-dependent insulinotropic polypeptide in combination with glucagon-like peptide-1 on glycemia in the critically ill.

Michael Y Lee, Jonathan D Fraser, Marianne J Chapman, Krishnaswamy Sundararajan, Mahesh M Umapathysivam, Matthew J Summers, Antony V Zaknic, Christopher K Rayner, Juris J Meier, Michael Horowitz, Adam M Deane

Journal article  |  2013  |  Diabetes Care

OBJECTIVE: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) have additive insulinotropic eff..

Modulation of individual components of gastric motor response to duodenal glucose.

Adam M Deane, Laura K Besanko, Carly M Burgstad, Marianne J Chapman, Michael Horowitz, Robert JL Fraser

Journal article  |  2013  |  World Journal of Gastroenterology

AIM: To evaluate individual components of the antro-pyloro-duodenal (APD) motor response to graded small intestinal glucose infusi..

Dysglycaemia in the critically ill - significance and management.

AM Deane, M Horowitz

Journal article  |  2013  |  Diabetes, Obesity and Metabolism

Hyperglycaemia frequently occurs in the critically ill, in patients with diabetes, as well as those who were previously glucose-to..

The gut-brain axis in the critically ill: is glucagon-like peptide-1 protective in neurocritical care?

Mark P Plummer, Juris J Meier, Adam M Deane

Journal article  |  2013  |  Critical Care

Enteral nutrient is a potent glucagon-like peptide-1 (GLP-1) secretagogue. In vitro and animal studies indicate that GLP-1 has imm..

Gastric emptying measurement of liquid nutrients using the (13)C-octanoate breath test in critically ill patients: a comparison with scintigraphy.

Nam Q Nguyen, Laura K Bryant, Carly M Burgstad, Marianne Chapman, Adam Deane, Max Bellon, Kylie Lange, Dylan Bartholomeuz, Michael Horowitz, Richard H Holloway, Robert J Fraser

Journal article  |  2013  |  Intensive Care Medicine

PURPOSE: Scintigraphy is considered the most accurate technique for the measurement of gastric emptying (GE) but, for patients in ..

Comparisons between intragastric and small intestinal delivery of enteral nutrition in the critically ill: a systematic review and meta-analysis.

Adam M Deane, Rupinder Dhaliwal, Andrew G Day, Emma J Ridley, Andrew R Davies, Daren K Heyland

Journal article  |  2013  |  Critical Care

INTRODUCTION: The largest cohort of critically ill patients evaluating intragastric and small intestinal delivery of nutrients was..

Sucrose malabsorption and impaired mucosal integrity in enterally fed critically ill patients: a prospective cohort observational study.

Carly M Burgstad, Laura K Besanko, Adam M Deane, Nam Q Nguyen, Khaschayar Saadat-Gilani, Geoff Davidson, Esther Burt, Anthony Thomas, Richard H Holloway, Marianne J Chapman, Robert JL Fraser

Journal article  |  2013  |  Critical Care Medicine

OBJECTIVE: Inadequate nutrition is common in critical illness due in part to gastric stasis. However, recent data suggest that alt..

Should hospitals have intensivist consultants in-house 24 hours a 01? - No.

Adam M Deane, Mary G White

Journal article  |  2013  |  The Medical Journal of Australia

Gastrointestinal dysmotility: evidence and clinical management

Marianne J Chapman, Nam Q Nguyen, Adam M Deane

Journal article  |  2013  |  Current Opinion in Clinical Nutrition and Metabolic Care

Mesenteric blood flow, glucose absorption and blood pressure responses to small intestinal glucose in critically ill patients older than 65 years

Jennifer A Sim, M Horowitz, MJ Summers, LG Trahair, RS Goud, AV Zaknic, T Hausken, JD Fraser, MJ Chapman, KL Jones, AM Deane

Journal article  |  2013  |  Intensive Care Medicine

Comparative effects on glucose absorption of intragastric and post-pyloric nutrient delivery in the critically ill.

Anna E Di Bartolomeo, Marianne J Chapman, Antony V Zaknic, Matthew J Summers, Karen L Jones, Nam Q Nguyen, Christopher K Rayner, Michael Horowitz, Adam M Deane

Journal article  |  2012  |  Critical Care

INTRODUCTION: Studies in the critically ill that evaluate intragastric and post-pyloric delivery of nutrient have yielded conflict..

Randomized double-blind crossover study to determine the effects of erythromycin on small intestinal nutrient absorption and transit in the critically ill

Adam M Deane, Gerald L Wong, Michael Horowitz, Antony V Zaknic, Matthew J Summers, Anna E Di Bartolomeo, Jennifer A Sim, Anne F Maddox, Max S Bellon, Christopher K Rayner, Marianne J Chapman, Robert JL Fraser

Journal article  |  2012  |  The American Journal of Clinical Nutrition

Gastrointestinal Dysmotility: Clinical Consequences and Management of the Critically Ill Patient

Marianne J Chapman, Nam Q Nguyen, Adam M Deane

Journal article  |  2011  |  Gastroenterology Clinics of North America

Glucose absorption and small intestinal transit in critical illness

Adam M Deane, Matthew J Summers, Antony V Zaknic, Marianne J Chapman, Anna E Di Bartolomeo, Max Bellon, Anne Maddox, Antoinette Russo, Michael Horowitz, Robert JL Fraser

Journal article  |  2011  |  Critical Care Medicine

Dysregulation of Intestinal Glucose Transporter and Sweet Taste Receptor Expression in Critical Illness

Richard L Young, Adam M Deane, Bridgette Chia, Michael Horowitz, L Ashley Blackshaw, Chris Rayner

Conference Proceedings  |  2011  |  GASTROENTEROLOGY

Exogenous glucagon-like peptide-1 attenuates the glycaemic response to postpyloric nutrient infusion in critically ill patients with type-2 diabetes

Adam M Deane, Matthew J Summers, Antony V Zaknic, Marianne J Chapman, Robert JL Fraser, Anna E Di Bartolomeo, Judith M Wishart, Michael Horowitz

Journal article  |  2011  |  Critical Care

Intrasubject variability of gastric emptying in the critically ill using a stable isotope breath test

Adam M Deane, Antony V Zaknic, Matthew Summers, Marianne J Chapman, Kylie Lange, Mark A Ritz, Geoff Davidson, Michael Horowitz, Robert JL Fraser

Journal article  |  2010  |  Clinical Nutrition

Effects of exogenous glucagon-like peptide-1 on gastric emptying and glucose absorption in the critically ill: Relationship to glycemia

Adam M Deane, Marianne J Chapman, Robert JL Fraser, Matthew J Summers, Antony V Zaknic, James P Storey, Karen L Jones, Christopher K Rayner, Michael Horowitz

Journal article  |  2010  |  Critical Care Medicine

Endogenous glucagon-like peptide-1 slows gastric emptying in healthy subjects, attenuating postprandial glycemia

AM Deane, NQ Nguyen, JE Stevens, RJL Fraser, RH Holloway, LK Besanko, C Burgstad, KL Jones, MJ Chapman, CK Rayner, M Horowitz

Journal article  |  2010  |  The Journal of Clinical Endocrinology & Metabolism

Bench-to-bedside review: the gut as an endocrine organ in the critically ill.

Adam Deane, Marianne J Chapman, Robert JL Fraser, Michael Horowitz

Journal article  |  2010  |  Critical Care

In health, hormones secreted from the gastrointestinal tract have an important role in regulating gastrointestinal motility, gluco..

The therapeutic potential of a venomous lizard: the use of glucagon-like peptide-1 analogues in the critically ill

Adam M Deane, Marianne J Chapman, Michael Horowitz

Journal article  |  2010  |  Critical Care

Evaluation of a bedside technique for postpyloric placement of feeding catheters

Adam M Deane, Robert J Fraser, Robert J Young, Benita Foreman, Stephanie N O'Conner, Marianne J Chapman

Journal article  |  2009  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

Prokinetic drugs for feed intolerance in critical illness: current and potential therapies

Adam M Deane, Robert J Fraser, Marianne J Chapman

Journal article  |  2009  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

The effect of exogenous glucagon-like peptide-1 on the glycaemic response to small intestinal nutrient in the critically ill: a randomised double-blind placebo-controlled cross over study

Adam M Deane, Marianne J Chapman, Robert JL Fraser, Carly M Burgstad, Laura K Besanko, Michael Horowitz

Journal article  |  2009  |  Critical Care

A clinical audit of the efficacy of tegaserod as a prokinetic agent in the intensive care unit.

Adam Deane, Robert Young, Marianne Chapman, Robert Fraser

Journal article  |  2008  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

Predicted body weight during mechanical ventilation: using arm demispan to aid clinical assessment.

Adam M Deane, David A Reid, Antony E Tobin

Journal article  |  2008  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

INTRODUCTION: Recent research suggests an association between the development of acute lung injury (ALI) and mechanical ventilatio..

Comment on: The use of erythromycin as a gastrointestinal prokinetic agent in adult critical care: benefits versus risks.

Adam Deane, Robert Young

Journal article  |  2008  |  Journal of Antimicrobial Chemotherapy

Predicted body weight during mechanical ventilation: Using arm demispan to aid clinical assessment

AM Deane, DA Reid, AE Tobin

Journal article  |  2008  |  Critical Care and Resuscitation

Mechanisms underlying feed intolerance in the critically ill: implications for treatment.

Adam Deane, Marianne J Chapman, Robert J Fraser, Laura K Bryant, Carly Burgstad, Nam Q Nguyen

Journal article  |  2007  |  World Journal of Gastroenterology

Malnutrition is associated with poor outcomes in critically ill patients. Although nutritional support is yet to be proven to impr..