Paul Gleeson is a molecular cell biologist with long term research interests in the mechanisms of intracellular membrane transport and the basis of organ-specific autoimmune diseases. His research is currently primarily focused on intracellular trafficking pathways and the sorting of membrane cargo in a range of primary cells.
Membrane trafficking underpins many cell processes, including secretion, receptor signalling, endocytosis, antigen presentation, and neural networking. Many diseases arise from defects in membrane trafficking, including Alzheimer’s disease. Our aim is to understand the molecular basis of membrane and protein sorting in the secretory and endocytic pathways in a variety of physiological processes using cultured cells and differentiated primary cells, and to exploit this knowledge for the design of new therapeutics.
Paul established an independent laboratory in the Department of Immunology at Monash University in 1986 and in 2001 moved to the Department of Biochemistry and Molecular Biology at the University of Melbourne where he was Head of the Department for 10 years from 2006-2016. He has been a visiting scientist at the EMBL, Heidelberg and the Curie Institute, Paris. He is currently Chair of the Fellowships Committee for Federation of Asian and Oceanic Biochemists and Molecular Biologists (FAOBMB). He has received ongoing funding from both NHMRC and the ARC for the past 30 years and has published >175 articles/reviews.
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Paul A Gleeson's highlights
FEATURED Journal article
Dysregulation of intracellular trafficking and endosomal sorting in Alzheimer's disease: controversies and unanswered questions
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Projects
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Project Types
33
Research Grant
4
Internal Research Grant
2
Research Contracts
Scholarly Works
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Credentials
Positions
Professorial Fellow
Biochemistry And Molecular Biology
Education
Doctor of Philosophy
University of Melbourne