Paul A Gleeson

Amyloid beta production along the neuronal secretory pathway: Dangerous liaisons in the Golgi?

Lou Fourriere, Paul A Gleeson

Journal article  |  2021  |  TRAFFIC

β-amyloid peptides (Aβ) are generated in intracellular compartments of neurons and secreted to form cytotoxic fibrils and plaques...

A role for Rab30 in retrograde trafficking and maintenance of endosome-TGN organization

Khalisah L Zulkefli, Ismail S Mahmoud, Nicholas A Williamson, Prajakta Kulkarni Gosavi, Fiona J Houghton, Paul A Gleeson

Journal article  |  2021  |  EXPERIMENTAL CELL RESEARCH

Rab30 is a poorly characterized small GTPase. Here we show that Rab30 is localised primarily to the TGN and recycling endosomes in..

Sorting nexin 5 mediates virus-induced autophagy and immunity

Xiaonan Dong, Yuting Yang, Zhongju Zou, Yuting Zhao, Bo Ci, Lin Zhong, Madhura Bhave, Liwei Wang, Yi-Chun Kuo, Xiao Zang, Rui Zhong, Elizabeth R Aguilera, R Blake Richardson, Boris Simonetti, John W Schoggins, Julie K Pfeiffer, Li Yu, Xuewu Zhang, Yang Xie, Sandra L Schmid, et al.

Journal article  |  2021  |  NATURE

Autophagy, a process of degradation that occurs via the lysosomal pathway, has an essential role in multiple aspects of immunity, ..

Regulation of mTORC1 activity by the Golgi apparatus.

Christian Makhoul, Paul A Gleeson

Journal article  |  2021  |  Fac Rev

Mechanistic (or mammalian) target of rapamycin complex 1 (mTORC1) is a major signalling kinase in cells that regulates proliferati..

Local Secretory Trafficking Pathways in Neurons and the Role of Dendritic Golgi Outposts in Different Cell Models

Jingqi Wang, Lou Fourriere, Paul A Gleeson

Journal article  |  2020  |  FRONTIERS IN MOLECULAR NEUROSCIENCE

A fundamental characteristic of neurons is the relationship between the architecture of the polarized neuron and synaptic transmis..

Macropinocytosis in Different Cell Types: Similarities and Differences

Xiao Peng Lin, Justine D Mintern, Paul A Gleeson

Journal article  |  2020  |  MEMBRANES

Macropinocytosis is a unique pathway of endocytosis characterised by the nonspecific internalisation of large amounts of extracell..

FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages

Wei Hong Toh, Jade Louber, Ismail S Mahmoud, Jenny Chia, Greg T Bass, Steve K Dower, Anne M Verhagen, Paul A Gleeson

Journal article  |  2020  |  JOURNAL OF CELL SCIENCE

The neonatal Fc receptor (FcRn) rescues albumin and IgG from degradation following endocytosis and thereby extends the half-life o..

Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-beta production

Jing Zhi A Tan, Lou Fourriere, Jingqi Wang, Franck Perez, Gaelle Boncompain, Paul A Gleeson

Journal article  |  2020  |  MOLECULAR BIOLOGY OF THE CELL

Processing of amyloid precursor protein (APP) by the β-secretase BACE1 is the initial step of the amyloidogenic pathway to generat..

The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease

Alessandra Webers, Michael T Heneka, Paul A Gleeson

Journal article  |  2019  |  IMMUNOLOGY AND CELL BIOLOGY

Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) accumulation, tau pathology and neuroinflammation. Recently, there ..

Form and function of the Golgi apparatus: scaffolds, cytoskeleton and signalling

Prajakta Kulkarni-Gosavi, Christian Makhoul, Paul A Gleeson

Journal article  |  2019  |  FEBS LETTERS

In addition to the classical functions of the Golgi in membrane transport and glycosylation, the Golgi apparatus of mammalian cell..