Paul Gleeson

Arf5-mediated regulation of mTORC1 at the plasma membrane.

Christian Makhoul, Fiona J Houghton, Elizabeth Hinde, Paul A Gleeson

Journal article  |  2023  |  Mol Biol Cell

The mechanistic target of rapamycin (mTOR) kinase regulates a major signaling pathway in eukaryotic cells. In addition to regulati..

Interorganellar Communication – Overview

Paul A Gleeson

Book Chapter  |  2023

Quantification of Golgi Entry and Exit Kinetics of Protein Cargoes.

Jingqi Wang, Ellie Hyun-Jung Cho, Paul A Gleeson, Lou Fourriere

Book Chapter  |  2023  |  Methods in Molecular Biology

The Golgi apparatus is a pivotal secretory organelle in membrane trafficking, a hub responsible for posttranslational modification..

A special issue of IUBMB Life celebrating the 50th anniversary of FAOBMB (1972-2022)

Akira Kikuchi, Zengyi Chang, Paul A Gleeson

Journal article  |  2022  |  IUBMB LIFE

Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1 Tregs.

Janine Becker-Gotot, Mirjam Meissner, Vadim Kotov, Blanca Jurado-Mestre, Andrea Maione, Andreas Pannek, Thilo Albert, Chrystel Flores, Frank A Schildberg, Paul A Gleeson, Birgit M Reipert, Johannes Oldenburg, Christian Kurts

Journal article  |  2022  |  J Clin Invest

A major complication of hemophilia A therapy is the development of alloantibodies (inhibitors) that neutralize intravenously admin..

Interacting partners of Golgi-localized small G protein Arl5b identified by a combination of in vivo proximity labelling and GFP-Trap pull down

Fiona J Houghton, Christian Makhoul, Ellie Hyun-Jung Cho, Nicholas A Williamson, Paul A Gleeson

Journal article  |  2022  |  FEBS LETTERS

The small G protein Arl5b is localised on the trans-Golgi network (TGN) and regulates endosomes-to-TGN transport. Here, we combine..

Segregation of the membrane cargoes, BACE1 and amyloid precursor protein (APP) throughout the Golgi apparatus

Lou Fourriere, Ellie Hyun-Jung Cho, Paul A Gleeson

Journal article  |  2022  |  TRAFFIC

The intracellular trafficking of β-site amyloid precursor protein (APP) cleaving enzyme (BACE1) and APP regulates amyloid-β produc..

Dynamics of intracellular neonatal Fc receptor-ligand interactions in primary macrophages using biophysical fluorescence techniques

Andreas Pannek, Fiona J Houghton, Anne M Verhagen, Steven K Dower, Elizabeth Hinde, Paul A Gleeson

Journal article  |  2022  |  MOLECULAR BIOLOGY OF THE CELL

The neonatal Fc receptor (FcRn) is responsible for the recycling of endocytosed albumin and IgG, and contributes to their long pla..

Amyloid beta production along the neuronal secretory pathway: Dangerous liaisons in the Golgi?

Lou Fourriere, Paul A Gleeson

Journal article  |  2021  |  TRAFFIC

β-amyloid peptides (Aβ) are generated in intracellular compartments of neurons and secreted to form cytotoxic fibrils and plaques...

A role for Rab30 in retrograde trafficking and maintenance of endosome-TGN organization

Khalisah L Zulkefli, Ismail S Mahmoud, Nicholas A Williamson, Prajakta Kulkarni Gosavi, Fiona J Houghton, Paul A Gleeson

Journal article  |  2021  |  EXPERIMENTAL CELL RESEARCH

Rab30 is a poorly characterized small GTPase. Here we show that Rab30 is localised primarily to the TGN and recycling endosomes in..