Alice McGovern

A role for neurokinin 1 receptor expressing neurons in the paratrigeminal nucleus in bradykinin-evoked cough in guinea-pigs

Alexandria K Driessen, Alice E McGovern, Robert Behrens, Aung Aung Kywe Moe, Michael J Farrell, Stuart B Mazzone

Journal article  |  2020  |  The Journal of Physiology

KEY POINTS: Airway projecting sensory neurons arising from the jugular vagal ganglia terminate centrally in the brainstem paratrig..

Local D2-to D1-neuron transmodulation updates goal-directed learning in the striatum

Miriam Matamales, Alice E McGovern, Jia Dai Mi, Stuart B Mazzone, Bernard W Balleine, Jesus Bertran-Gonzalez

Journal article  |  2020  |  Science

Extinction learning allows animals to withhold voluntary actions that are no longer related to reward and so provides a major sour..

Transcriptional Profiling of Individual Airway Projecting Vagal Sensory Neurons

Stuart B Mazzone, Luyi Tian, Aung Aung Kywe Moe, Matthew W Trewella, Matthew E Ritchie, Alice E McGovern

Journal article  |  2019  |  Molecular Neurobiology

Bronchopulmonary sensory neurons are derived from the vagal sensory ganglia and are essential for monitoring the physical and chem..

D1 and D2 systems converge in the striatum to update goal-directed learning

Miriam Matamales, Alice McGovern, Jia Dai Mi, Stuart Mazzone, Bernard Balleine, Jesus Bertran-Gonzalez

Journal article  |  2019

Abstract Extinction learning allows animals to withhold voluntary actions that are no longer related to reward and so provides a m..

Reflex regulation of breathing by the paratrigeminal nucleus via multiple bulbar circuits

Alexandria K Driessen, Michael J Farrell, Mathias Dutschmann, Davor Stanic, Alice E McGovern, Stuart B Mazzone

Journal article  |  2018  |  Brain Structure and Function

Translational review: Neuroimmune mechanisms in cough and emerging therapeutic targets

Alice E McGovern, Kirsty R Short, Aung Aung Kywe Moe, Stuart B Mazzone

Journal article  |  2018  |  Journal of Allergy and Clinical Immunology

Cholinergic basal forebrain neurons regulate fear extinction consolidation through p75 neurotrophin receptor signaling

Zoran Boskovic, Michael R Milne, Lei Qian, Hamish D Clifton, Alice E McGovern, Marion T Turnbull, Stuart B Mazzone, Elizabeth J Coulson

Journal article  |  2018  |  Translational Psychiatry

Hippocampal modulation of cardiorespiratory function

Itopa E Ajayi, Alice E McGovern, Alexandria K Driessen, Nicole F Kerr, Paul C Mills, Stuart B Mazzone

Journal article  |  2018  |  Respiratory Physiology & Neurobiology

Central mechanisms of airway sensation and cough hypersensitivity

Alexandria K Driessen, Alice E McGovern, Monica Narula, Seung-Kwon Yang, Jennifer A Keller, Michael J Farrell, Stuart B Mazzone

Journal article  |  2017  |  Pulmonary Pharmacology & Therapeutics

A neuroanatomical framework for the central modulation of respiratory sensory processing and cough by the periaqueductal grey

Alice E McGovern, Itopa E Ajayi, Michael J Farrell, Stuart B Mazzone

Journal article  |  2017  |  Journal of Thoracic Disease

Translating Cough Mechanisms Into Better Cough Suppressants

Jennifer A Keller, Alice E McGovern, Stuart B Mazzone

Journal article  |  2017  |  Chest

Multiple neural circuits mediating airway sensations: Recent advances in the neurobiology of the urge-to-cough

Alexandria K Driessen, Michael J Farrell, Stuart B Mazzone, Alice E McGovern

Journal article  |  2016  |  Respiratory Physiology & Neurobiology

The Role of the Paratrigeminal Nucleus in Vagal Afferent Evoked Respiratory Reflexes: A Neuroanatomical and Functional Study in Guinea Pigs

Alexandria K Driessen, Michael J Farrell, Stuart B Mazzone, Alice E McGovern

Journal article  |  2015  |  FRONTIERS IN PHYSIOLOGY

Evidence for multiple sensory circuits in the brain arising from the respiratory system: an anterograde viral tract tracing study in rodents

Alice E McGovern, Nicholas Davis-Poynter, Seung-Kwon Yang, David G Simmons, Michael J Farrell, Stuart B Mazzone

Journal article  |  2015  |  Brain Structure and Function

Endogenous central suppressive mechanisms regulating cough as potential targets for novel antitussive therapies

Stuart B Mazzone, Alice E McGovern, Michael J Farrell

Journal article  |  2015  |  Current Opinion in Pharmacology

Distinct Brainstem and Forebrain Circuits Receiving Tracheal Sensory Neuron Inputs Revealed Using a Novel Conditional Anterograde Transsynaptic Viral Tracing System

Alice E McGovern, Alexandria K Driessen, David G Simmons, Joseph Powell, Nicholas Davis-Poynter, Michael J Farrell, Stuart B Mazzone

Journal article  |  2015  |  JOURNAL OF NEUROSCIENCE

Distinct Organization of Upper Airway Nodose and Jugular Vagal Circuits in the Brain: Evidence from Conditional Anterograde Transneuronal Tracing and Physiology

Alice McGovern, Ally Driessen, David Simmons, Michael Farrell, Nicholas Davis-Poynter, Stuart Mazzone

Conference Proceedings  |  2015  |  FASEB JOURNAL

Guinea pig models of asthma.

Alice E McGovern, Stuart B Mazzone

Journal article  |  2014  |  Current Protocols in Pharmacology

Described in this unit are methods for establishing guinea pig models of asthma. Sufficient detail is provided to enable investiga..

Afferent neural pathways mediating cough in animals and humans

Monica Narula, Alice E McGovern, Seung-Kwon Yang, Michael J Farrell, Stuart B Mazzone

Journal article  |  2014  |  Journal of Thoracic Disease

The effect of hyperpolarization-activated cyclic nucleotide-gated ion channel inhibitors on the vagal control of guinea pig airway smooth muscle tone

Alice E McGovern, Jed Robusto, Joanna Rakoczy, David G Simmons, Simon Phipps, Stuart B Mazzone

Journal article  |  2014  |  British Journal of Pharmacology

Neural regulation of inflammation in the airways and lungs

Alice E McGovern, Stuart B Mazzone

Journal article  |  2014  |  Autonomic Neuroscience

Sensorimotor circuitry involved in the higher brain control of coughing

Stuart B Mazzone, Alice E McGovern, Seung-Kwon Yang, Ariel Woo, Simon Phipps, Ayaka Ando, Jennifer Leech, Michael J Farrell

Journal article  |  2013  |  Cough

There is an overwhelming body of evidence to support the existence of higher brain circuitries involved in the sensory detection o..

Anterograde neuronal circuit tracing using a genetically modified herpes simplex virus expressing EGFP

Alice E McGovern, Nicholas Davis-Poynter, Joanna Rakoczy, Simon Phipps, David G Simmons, Stuart B Mazzone

Journal article  |  2012  |  Journal of Neuroscience Methods

TRANSNEURONAL TRACING OF AIRWAYS-RELATED SENSORY CIRCUITRY USING HERPES SIMPLEX VIRUS 1, STRAIN H129

AE McGovern, N Davis-Poynter, MJ Farrell, SB Mazzone

Journal article  |  2012  |  Neuroscience

Central nervous system control of cough: pharmacological implications

Stuart B Mazzone, Alice E McGovern, Leonie J Cole, Michael J Farrell

Journal article  |  2011  |  Current Opinion in Pharmacology

Characterization of the vagal motor neurons projecting to the Guinea pig airways and esophagus

Alice E McGovern, Stuart B Mazzone

Journal article  |  2010  |  Frontiers in Neurology

Distinct parasympathetic postganglionic neurons mediate contractions and relaxations of the guinea pig airways. We set out to char..

Innervation of tracheal parasympathetic ganglia by esophageal cholinergic neurons: evidence from anatomic and functional studies in guinea pigs

Stuart B Mazzone, Alice E McGovern

Journal article  |  2010  |  American Journal of Physiology-Lung Cellular and Molecular Physiology

Mapping supramedullary pathways involved in cough using functional brain imaging: Comparison with pain

Stuart B Mazzone, Alice E McGovern, Kendrick Koo, Michael J Farrell

Journal article  |  2009  |  Pulmonary Pharmacology and Therapeutics

Immunohistochemical characterization of nodose cough receptor neurons projecting to the trachea of guinea pigs

Stuart B Mazzone, Alice E McGovern

Journal article  |  2008  |  Cough

BACKGROUND: Cough in guinea pigs is mediated in part by capsaicin-insensitive low threshold mechanoreceptors (cough receptors). Fu..

Sensory neural targets for the treatment of cough

Stuart B Mazzone, Alice E McGovern

Journal article  |  2007  |  Clinical and Experimental Pharmacology and Physiology

Representation of capsaicin-evoked urge-to-cough in the human brain using functional magnetic resonance imaging

Stuart B Mazzone, Lisa McLennan, Alice E McGovern, Gary F Egan, Michael J Farrell

Journal article  |  2007  |  American Journal of Respiratory and Critical Care Medicine

Na -K -2Cl(-) cotransporters and Cl- channels regulate citric acid cough in guinea pigs

Stuart B Mazzone, Alice E McGovern

Journal article  |  2006  |  Journal of Applied Physiology