Alice McGovern

Jugular vagal ganglia neurons and airway nociception: A target for treating chronic cough

Aung Aung Kywe Moe, Alice E McGovern, Stuart B Mazzone

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The airways receive a dense supply of sensory nerve fibers that are responsive to damaging or potentially injurious stimuli. These..

A Role of the Nervous System in Modulating Respiratory Viral Infections

AE Mcgovern, N Verzele, B Chua, C Law, M Ritchie, A Moe, K Chew, SB Mazzone, K Short

Conference Proceedings  |  2021  |  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The impact of influenza pulmonary infection and inflammation on vagal bronchopulmonary sensory neurons

Nathalie AJ Verzele, Brendon Y Chua, Charity W Law, Albert Zhang, Matthew E Ritchie, Oliver Wightman, Isaac N Edwards, Katina D Hulme, Conor J Bloxham, Helle Bielefeldt-Ohmann, Matthew W Trewella, Aung Aung Kywe Moe, Keng Yih Chew, Stuart B Mazzone, Kirsty R Short, Alice E McGovern

Journal article  |  2021  |  FASEB JOURNAL

Influenza A virus (IAV) is rapidly detected in the airways by the immune system, with resident parenchymal cells and leukocytes or..

Mini Review: Central Organization of Airway Afferent Nerve Circuits

Robert Behrens, Alice E McGovern, Michael J Farrell, Aung Aung Kywe Moe, Stuart B Mazzone

Journal article  |  2021  |  NEUROSCIENCE LETTERS

Airway afferents monitor the local chemical and physical micro-environments in the airway wall and lungs and send this information..

Descending Modulation of Laryngeal Vagal Sensory Processing in the Brainstem Orchestrated by the Submedius Thalamic Nucleus

Stuart B Mazzone, Tara G Bautista, Anthony JM Verberne, Matthew W Trewella, Michael J Farrell, Alice E McGovern

Journal article  |  2020  |  JOURNAL OF NEUROSCIENCE

The nodose and jugular vagal ganglia supply sensory innervation to the airways and lungs. Jugular vagal airway sensory neurons wir..

Peripheral and central mechanisms of cough hypersensitivity

Nabita Singh, Alexandria K Driessen, Alice E McGovern, Aung Aung Kywe Moe, Michael J Farrell, Stuart B Mazzone

Journal article  |  2020  |  JOURNAL OF THORACIC DISEASE

Chronic cough is a difficult to treat symptom of many respiratory and some non-respiratory diseases, indicating that varied pathol..

A role for neurokinin 1 receptor expressing neurons in the paratrigeminal nucleus in bradykinin-evoked cough in guinea-pigs

Alexandria K Driessen, Alice E McGovern, Robert Behrens, Aung Aung Kywe Moe, Michael J Farrell, Stuart B Mazzone

Journal article  |  2020  |  JOURNAL OF PHYSIOLOGY-LONDON

KEY POINTS: Airway projecting sensory neurons arising from the jugular vagal ganglia terminate centrally in the brainstem paratrig..

Local D2-to D1-neuron transmodulation updates goal-directed learning in the striatum

Miriam Matamales, Alice E McGovern, Jia Dai Mi, Stuart B Mazzone, Bernard W Balleine, Jesus Bertran-Gonzalez

Journal article  |  2020  |  SCIENCE

Extinction learning allows animals to withhold voluntary actions that are no longer related to reward and so provides a major sour..

Transcriptional Profiling of Individual Airway Projecting Vagal Sensory Neurons

Stuart B Mazzone, Luyi Tian, Aung Aung Kywe Moe, Matthew W Trewella, Matthew E Ritchie, Alice E McGovern

Journal article  |  2019  |  MOLECULAR NEUROBIOLOGY

Bronchopulmonary sensory neurons are derived from the vagal sensory ganglia and are essential for monitoring the physical and chem..

D1 and D2 systems converge in the striatum to update goal-directed learning

Miriam Matamales, Alice McGovern, Jia Dai Mi, Stuart Mazzone, Bernard Balleine, Jesus Bertran-Gonzalez

Journal article  |  2019

Extinction learning allows animals to withhold voluntary actions that are no longer related to reward and so provides a major sour..