Alice McGovern

Loss of NEDD4 causes complete XY gonadal sex reversal in mice

Simon P Windley, Chloe Mayere, Alice E McGovern, Natasha L Harvey, Serge Nef, Quenten Schwarz, Sharad Kumar, Dagmar Wilhelm

Journal article  |  2022  |  CELL DEATH & DISEASE

Gonadogenesis is the process wherein two morphologically distinct organs, the testis and the ovary, arise from a common precursor...

Editorial: Neural and Mechanical Mechanisms in Pulmonary Defense: What Does the Future Hold?

Nicolle J Domnik, John T Fisher, M Diane Lougheed, Stuart B Mazzone, Alice E McGovern

Journal article  |  2022  |  Front Physiol

Modulation of Vagal Sensory Neurons via High Mobility Group Box-1 and Receptor for Advanced Glycation End Products: Implications for Respiratory Viral Infections

Stuart B Mazzone, Seung-Kwon Yang, Jennifer A Keller, Juste Simanauskaite, Jaisy Arikkatt, Matthew J Fogarty, Aung Aung Kywe Moe, Chen Chen, Matthew W Trewella, Luyi Tian, Matthew E Ritchie, Brendan Y Chua, Simon Phipps, Kirsty R Short, Alice E McGovern

Journal article  |  2021  |  FRONTIERS IN PHYSIOLOGY

Vagal sensory neurons contribute to the symptoms and pathogenesis of inflammatory pulmonary diseases through processes that involv..

A Role of the Nervous System in Modulating Respiratory Viral Infections

AE Mcgovern, N Verzele, B Chua, C Law, M Ritchie, A Moe, K Chew, SB Mazzone, K Short

Conference Proceedings  |  2021  |  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Jugular vagal ganglia neurons and airway nociception: A target for treating chronic cough

Aung Aung Kywe Moe, Alice E McGovern, Stuart B Mazzone

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The airways receive a dense supply of sensory nerve fibers that are responsive to damaging or potentially injurious stimuli. These..

The impact of influenza pulmonary infection and inflammation on vagal bronchopulmonary sensory neurons

Nathalie AJ Verzele, Brendon Y Chua, Charity W Law, Albert Zhang, Matthew E Ritchie, Oliver Wightman, Isaac N Edwards, Katina D Hulme, Conor J Bloxham, Helle Bielefeldt-Ohmann, Matthew W Trewella, Aung Aung Kywe Moe, Keng Yih Chew, Stuart B Mazzone, Kirsty R Short, Alice E McGovern

Journal article  |  2021  |  FASEB JOURNAL

Influenza A virus (IAV) is rapidly detected in the airways by the immune system, with resident parenchymal cells and leukocytes or..

Mini Review: Central Organization of Airway Afferent Nerve Circuits

Robert Behrens, Alice E McGovern, Michael J Farrell, Aung Aung Kywe Moe, Stuart B Mazzone

Journal article  |  2021  |  NEUROSCIENCE LETTERS

Airway afferents monitor the local chemical and physical micro-environments in the airway wall and lungs and send this information..

Descending Modulation of Laryngeal Vagal Sensory Processing in the Brainstem Orchestrated by the Submedius Thalamic Nucleus

Stuart B Mazzone, Tara G Bautista, Anthony JM Verberne, Matthew W Trewella, Michael J Farrell, Alice E McGovern

Journal article  |  2020  |  JOURNAL OF NEUROSCIENCE

The nodose and jugular vagal ganglia supply sensory innervation to the airways and lungs. Jugular vagal airway sensory neurons wir..

Peripheral and central mechanisms of cough hypersensitivity

Nabita Singh, Alexandria K Driessen, Alice E McGovern, Aung Aung Kywe Moe, Michael J Farrell, Stuart B Mazzone

Journal article  |  2020  |  JOURNAL OF THORACIC DISEASE

Chronic cough is a difficult to treat symptom of many respiratory and some non-respiratory diseases, indicating that varied pathol..

A role for neurokinin 1 receptor expressing neurons in the paratrigeminal nucleus in bradykinin-evoked cough in guinea-pigs

Alexandria K Driessen, Alice E McGovern, Robert Behrens, Aung Aung Kywe Moe, Michael J Farrell, Stuart B Mazzone

Journal article  |  2020  |  JOURNAL OF PHYSIOLOGY-LONDON

KEY POINTS: Airway projecting sensory neurons arising from the jugular vagal ganglia terminate centrally in the brainstem paratrig..