Stephen Wong

Phase Ib/II Trial of BRAF and EGFR inhibition in BRAFV600E metastatic colorectal cancer and other cancers: EVICT (Erlotinib and Vemurafenib In Combination Trial).

Lavinia Tan, Ben Tran, Jeanne Tie, Ben Markman, Sumi Ananda, Niall C Tebbutt, Michael Michael, Emma Link, Stephen Q Wong, Sushma Chandrashekar, Jerick Guinto, David Ritchie, Rachel Koldej, Benjamin J Solomon, Grant A McArthur, Rodney J Hicks, Peter Gibbs, Sarah-Jane Dawson, Jayesh Desai

Journal article  |  2023  |  Clin Cancer Res

PURPOSE: BRAF V600E mutant metastatic colorectal cancer represents a significant clinical problem, with combination approaches bei..

Clinical validation and implementation of droplet digital PCR for the detection of BRAF mutations from cell-free DNA

Rainer Arnolda, Kerry Howlett, Timmy Chan, Jeanette Raleigh, Athena Hatzimihalis, Anthony Bell, Andrew Fellowes, Shahneen Sandhu, Grant A Mcarthur, Stephen B Fox, Sarah-jane Dawson, Chelsee Hewitt, Kate Jones, Stephen Q Wong

Journal article  |  2022  |  PATHOLOGY

Droplet digital PCR (ddPCR) has been demonstrated in many research studies to be a sensitive method in the analysis of circulating..

Potential Clinical Utility of a Targeted Circulating Tumor DNA Assay in Esophageal Adenocarcinoma

Carlos S Cabalag, Michael Yates, Mariana Benitez Corrales, Paul Yeh, Stephen Q Wong, Bonnie Z Zhang, Kenji M Fujihara, Lynn Chong, Michael W Hii, Sarah-Jane Dawson, Wayne A Phillips, Cuong P Duong, Nicholas J Clemons

Journal article  |  2022  |  ANNALS OF SURGERY

OBJECTIVE: To explore the clinical utility of circulating tumor DNA (ctDNA) in esophageal adenocarcinoma (EAC) by developing a cos..

DETECTION phase II/III trial: Circulating tumor DNA-guided therapy for stage IIB/C melanoma after surgical resection.

Rebecca Lee, Dominic G Rothwell, Richard Jackson, Nigel Smith, Stephen Q Wong, Noel Kelso, George Burghel, Chelsee Hewitt, Harry Clarke, Jackie Mitchell, Kate Jones, Andrew Muinonen-Martin, Samra Turajlic, Philippa Gail Corrie, Richard Marais, Mark R Middleton, Sarah-Jane Dawson, Shahneen Sandhu, Caroline Dive, Paul Lorigan

Conference Proceedings  |  2022  |  JOURNAL OF CLINICAL ONCOLOGY

DETECTION phase II/III trial: Circulating tumor DNA–guided therapy for stage IIB/C melanoma after surgical resection.

Rebecca Lee, Dominic G Rothwell, Richard Jackson, Nigel Smith, Stephen Q Wong, Noel Kelso, George Burghel, Chelsee Hewitt, Harry Clarke, Jackie Mitchell, Kate Jones, Andrew Muinonen-Martin, Samra Turajlic, Philippa Gail Corrie, Richard Marais, Mark R Middleton, Sarah-Jane Dawson, Shahneen Sandhu, Caroline Dive, Paul Lorigan

Conference Proceedings  |  2022  |  Journal of Clinical Oncology

TPS9603 Background: Circulating tumor DNA (ctDNA; the tumor derived fraction of circulating free DNA in the blood) is a well reco..

Custom workflows to improve joint variant calling from multiple related tumour samples: FreeBayesSomatic and Strelka2Pass

S Hollizeck, SQ Wong, B Solomon, D Chandrananda, S-J Dawson

Journal article  |  2021  |  BIOINFORMATICS

SUMMARY: This work describes two novel workflows for variant calling that extend the widely used algorithms of Strelka2 and FreeBa..

Abstract 539: Utility of circulating tumor DNA in esophageal cancer: A potential prognostic biomarker in tumor staging, monitoring of treatment response and detection of recurrent disease

Carlos Suhady Cabalag, Michael Yates, Mariana B Corrales, Paul Yeh, Stephen Q Wong, Bonnie Zhang, Kenji M Fujihara, Lynn Chong, Michael Hii, Sarah-Jane Dawson, Wayne A Phillips, Cuong P Duong, Nicholas J Clemons

Conference Proceedings  |  2021  |  Cancer Research

Abstract Background: Circulating tumor DNA (ctDNA) has clinical utility in monitoring treatment response and in the..

Utility of circulating tumor DNA in esophageal cancer: A potential prognostic biomarker in tumor staging, monitoring of treatment response and detection of recurrent disease.

Carlos Suhady Cabalag, Michael Yates, Mariana B Corrales, Paul Yeh, Stephen Q Wong, Bonnie Zhang, Kenji M Fujihara, Lynn Chong, Michael Hii, Sarah-Jane Dawson, Wayne A Phillips, Cuong P Duong, Nicholas J Clemons

Conference Proceedings  |  2021  |  CANCER RESEARCH

Detection of cell-free microbial DNA using a contaminant-controlled analysis framework

Enrique Zozaya-Valdes, Stephen Q Wong, Jeanette Raleigh, Athena Hatzimihalis, Sarah Ftouni, Anthony T Papenfuss, Shahneen Sandhu, Mark A Dawson, Sarah-Jane Dawson

Journal article  |  2021  |  GENOME BIOLOGY

BACKGROUND: The human microbiome plays an important role in cancer. Accumulating evidence indicates that commensal microbiome-deri..

Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling

Ismael A Vergara, Christopher P Mintoff, Shahneen Sandhu, Lachlan McIntosh, Richard J Young, Stephen Q Wong, Andrew Colebatch, Daniel L Cameron, Julia Lai Kwon, Rory Wolfe, Angela Peng, Jason Ellul, Xuelin Dou, Clare Fedele, Samantha Boyle, Gisela Mir Arnau, Jeanette Raleigh, Athena Hatzimihalis, Pacman Szeto, Jennifer Mooi, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Although melanoma is initiated by acquisition of point mutations and limited focal copy number alterations in melanocytes-of-origi..