Stephen Wong

Circulating tumour DNA in metastatic breast cancer to guide clinical trial enrolment and precision oncology: A cohort study

Andjelija Zivanovic Bujak, Chen-Fang Weng, Maria Joao Silva, Miriam Yeung, Louisa Lo, Sarah Ftouni, Cassandra Litchfield, Yi-An Ko, Keilly Kuykhoven, Courtney Van Geelen, Sushma Chandrashekar, Mark A Dawson, Sherene Loi, Stephen Q Wong, Sarah-Jane Dawson

Journal article  |  2020  |  PLoS Medicine

BACKGROUND: Metastatic breast cancer (mBC) is a heterogenous disease with increasing availability of targeted therapies as well as..

Spliced Peptides and Cytokine-Driven Changes in the Immunopeptidome of Melanoma

Pouya Faridi, Katherine Woods, Simone Ostrouska, Cyril Deceneux, Ritchlynn Aranha, Divya Duscharla, Stephen Q Wong, Weisan Chen, Sri H Ramarathinam, Terry CC Lim Kam Sian, Nathan P Croft, Chen Li, Rochelle Ayala, Jonathan S Cebon, Anthony W Purcell, Ralf B Schittenhelm, Andreas Behren

Journal article  |  2020  |  Cancer Immunology Research

Antigen recognition by CD8+ T cells is governed by the pool of peptide antigens presented on the cell surface in the context of HL..

Longitudinal Monitoring of ctDNA in Patients with Melanoma and Brain Metastases Treated with Immune Checkpoint Inhibitors.

Jenny H Lee, Alexander M Menzies, Matteo S Carlino, Ashleigh C McEvoy, Shahneen Sandhu, Alison M Weppler, Russell J Diefenbach, Sarah-Jane Dawson, Richard F Kefford, Michael J Millward, Zeyad Al-Ogaili, Thien Tra, Elin S Gray, Stephen Q Wong, Richard A Scolyer, Georgina V Long, Helen Rizos

Journal article  |  2020  |  Clinical Cancer Research

PURPOSE: Brain involvement occurs in the majority of patients with metastatic melanoma. The potential of circulating tumor DNA (ct..

Combining liquid biopsies and PET-CT for early cancer detection

Stephen Q Wong, Sarah-Jane Dawson

Journal article  |  2020  |  Nature Medicine

Genome-wide plasma DNA methylation features of metastatic prostate cancer

Anjui Wu, Paolo Cremaschi, Daniel Wetterskog, Vincenza Conteduca, Gian Marco Franceschini, Dimitrios Kleftogiannis, Anuradha Jayaram, Shahneen Sandhu, Stephen Q Wong, Matteo Benelli, Samanta Salvi, Giorgia Gurioli, Andrew Feber, Mariana Buongermino Pereira, Anna Maria Wingate, Enrique Gonzalez-Billalebeitia, Ugo De Giorgi, Francesca Demichelis, Stefano Lise, Gerhardt Attard

Journal article  |  2020  |  Journal of Clinical Investigation

Tumor DNA circulates in the plasma of cancer patients admixed with DNA from noncancerous cells. The genomic landscape of plasma DN..

RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies

Benjamin J Solomon, Lavinia Tan, Jessica J Lin, Stephen Q Wong, Sebastian Hollizeck, Kevin Ebata, Brian B Tuch, Satoshi Yoda, Justin F Gainor, Lecia V Sequist, Geoffrey R Oxnard, Oliver Gautschi, Alexander Drilon, Vivek Subbiah, Christine Khoo, Edward Y Zhu, Michele Nguyen, Dahlia Henry, Kevin R Condroski, Gabrielle R Kolakowski, et al.

Journal article  |  2020  |  Journal of Thoracic Oncology

INTRODUCTION: Novel rearranged in transfection (RET)-specific tyrosine kinase inhibitors (TKIs) such as selpercatinib (LOXO-292) h..

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

Marian L Burr, Christina E Sparbier, Kah Lok Chan, Yih-Chih Chan, Ariena Kersbergen, Enid YN Lam, Elizabeth Azidis-Yates, Dane Vassiliadis, Charles C Bell, Omer Gilan, Susan Jackson, Lavinia Tan, Stephen Q Wong, Sebastian Hollizeck, Ewa M Michalak, Hannah Siddle, Michael T McCabe, Rab K Prinjha, Glen R Guerra, Benjamin J Solomon, et al.

Journal article  |  2019  |  Cancer Cell

Prospective testing of circulating tumour DNA in metastatic breast cancer facilitates clinical trial enrollment and precision oncology

AZ Bujak, C-F Weng, M-J Silva, M Yeung, L Lo, S Ftouni, C Litchfield, A Ko, K Kuykhoven, C van Geelen, S Chandrashekar, MA Dawson, S Loi, SQ Wong, S-J Dawson

Conference Proceedings  |  2019  |  ANNALS OF ONCOLOGY

Identification of single nucleotide variants using position-specific error estimation in deep sequencing data

Dimitrios Kleftogiannis, Marco Punta, Anuradha Jayaram, Shahneen Sandhu, Stephen Q Wong, Delila Gasi Tandefelt, Vincenza Conteduca, Daniel Wetterskog, Gerhardt Attard, Stefano Lise

Journal article  |  2019  |  BMC Medical Genomics

Low-coverage whole genome sequencing of FFPE-derived-DNA and extracellular vesicle-associated DNA in patients with metastatic cancer.

Hai Nguyen Bella, Nick Wong, Timothy Semple, Olivia Ruhen, Stephen Q Wong, Connull Leslie, Bob Mirzai, Michael Millward, Katie Meehan, Annette May Ling Lim

Conference Proceedings  |  2019  |  Journal of Clinical Oncology