Stephen Wong

Combining liquid biopsies and PET-CT for early cancer detection

Stephen Q Wong, Sarah-Jane Dawson

Journal article  |  2020  |  Nature Medicine

Longitudinal monitoring of ctDNA in patients with melanoma and brain metastases treated with immune checkpoint inhibitors.

Jenny H Lee, Alexander M Menzies, Matteo S Carlino, Ashleigh C McEvoy, Shahneen Sandhu, Alison M Weppler, Russell J Diefenbach, Sarah-Jane Dawson, Richard F Kefford, Michael J Millward, Zeyad Al-Ogaili, Thien Tra, Elin S Gray, Stephen Q Wong, Richard A Scolyer, Georgina V Long, Helen Rizos

Journal article  |  2020  |  Clinical Cancer Research

PURPOSE: Brain involvement occurs in majority of patients with metastatic melanoma. The potential of circulating tumor DNA (ctDNA)..

Genome-wide plasma DNA methylation features of metastatic prostate cancer

Anjui Wu, Paolo Cremaschi, Daniel Wetterskog, Vincenza Conteduca, Gian Marco Franceschini, Dimitrios Kleftogiannis, Anuradha Jayaram, Shahneen Sandhu, Stephen Q Wong, Matteo Benelli, Samanta Salvi, Giorgia Gurioli, Andrew Feber, Mariana Buongermino Pereira, Anna Maria Wingate, Enrique Gonzalez-Billalebeitia, Ugo De Giorgi, Francesca Demichelis, Stefano Lise, Gerhardt Attard

Journal article  |  2020  |  Journal of Clinical Investigation

Tumor DNA circulates in the plasma of cancer patients admixed with DNA from noncancerous cells. The genomic landscape of plasma DN..

RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies

Benjamin J Solomon, Lavinia Tan, Jessica J Lin, Stephen Q Wong, Sebastian Hollizeck, Kevin Ebata, Brian B Tuch, Satoshi Yoda, Justin F Gainor, Lecia V Sequist, Geoffrey R Oxnard, Oliver Gautschi, Alexander Drilon, Vivek Subbiah, Christine Khoo, Edward Y Zhu, Michele Nguyen, Dahlia Henry, Kevin R Condroski, Gabrielle R Kolakowski, et al.

Journal article  |  2020  |  Journal of Thoracic Oncology

INTRODUCTION: Novel rearranged in transfection (RET)-specific tyrosine kinase inhibitors (TKIs) such as selpercatinib (LOXO-292) h..

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

Marian L Burr, Christina E Sparbier, Kah Lok Chan, Yih-Chih Chan, Ariena Kersbergen, Enid YN Lam, Elizabeth Azidis-Yates, Dane Vassiliadis, Charles C Bell, Omer Gilan, Susan Jackson, Lavinia Tan, Stephen Q Wong, Sebastian Hollizeck, Ewa M Michalak, Hannah Siddle, Michael T McCabe, Rab K Prinjha, Glen R Guerra, Benjamin J Solomon, et al.

Journal article  |  2019  |  Cancer Cell

Prospective testing of circulating tumour DNA in metastatic breast cancer facilitates clinical trial enrollment and precision oncology

AZ Bujak, C-F Weng, M-J Silva, M Yeung, L Lo, S Ftouni, C Litchfield, A Ko, K Kuykhoven, C van Geelen, S Chandrashekar, MA Dawson, S Loi, SQ Wong, S-J Dawson

Conference Proceedings  |  2019  |  ANNALS OF ONCOLOGY

Identification of single nucleotide variants using position-specific error estimation in deep sequencing data

Dimitrios Kleftogiannis, Marco Punta, Anuradha Jayaram, Shahneen Sandhu, Stephen Q Wong, Delila Gasi Tandefelt, Vincenza Conteduca, Daniel Wetterskog, Gerhardt Attard, Stefano Lise

Journal article  |  2019  |  BMC Medical Genomics

Low-coverage whole genome sequencing of FFPE-derived-DNA and extracellular vesicle-associated DNA in patients with metastatic cancer.

Hai Nguyen Bella, Nick Wong, Timothy Semple, Olivia Ruhen, Stephen Q Wong, Connull Leslie, Bob Mirzai, Michael Millward, Katie Meehan, Annette May Ling Lim

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

Genomic Analysis of Circulating Tumor DNA Using a Melanoma-Specific UltraSEEK Oncogene Panel

Elin S Gray, Tom Witkowski, Michelle Pereira, Leslie Calapre, Karl Herron, Darryl Irwin, Brett Chapman, Muhammad A Khattak, Jeanette Raleigh, Athena Hatzimihalis, Jonathan Cebon, Shahneen Sandhu, Grant A McArthur, Michael Millward, Melanie Ziman, Alexander Dobrovic, Stephen Q Wong

Journal article  |  2019  |  The Journal of Molecular Diagnostics

Prediction and monitoring of relapse in stage III melanoma using circulating tumor DNA

L Tan, S Sandhu, RJ Lee, J Li, J Callahan, S Ftouni, N Dhomen, P Middlehurst, A Wallace, J Raleigh, A Hatzimihalis, MA Henderson, M Shackleton, A Haydon, V Mar, DE Gyorki, D Oudit, MA Dawson, RJ Hicks, P Lorigan, et al.

Journal article  |  2019  |  Annals of Oncology

BACKGROUND: The advent of effective adjuvant therapies for patients with resected melanoma has highlighted the need to stratify pa..

Genomic stratification and liquid biopsy in a rare adrenocortical carcinoma (ACC) case, with dual lung metastases

Mark J McCabe, Mark Pinese, Chia-Ling Chan, Nisa Sheriff, Tanya J Thompson, John Grady, Marie Wong, Marie-Emilie A Gauthier, Clare Puttick, Velimir Gayevskiy, Elektra Hajdu, Stephen Q Wong, Wade Barrett, Peter Earls, Robyn Lukeis, Yuen Y Cheng, Ruby CY Lin, David M Thomas, D Neil Watkins, Marcel E Dinger, et al.

Journal article  |  2019  |  Molecular Case Studies

Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

Rishu Agarwal, Yih-Chih Chan, Constantine S Tam, Tane Hunter, Dane Vassiliadis, Charis E Teh, Rachel Thijssen, Paul Yeh, Stephen Q Wong, Sarah Ftouni, Enid YN Lam, Mary Ann Anderson, Christiane Pott, Omer Gilan, Charles C Bell, Kathy Knezevic, Piers Blombery, Kathleen Rayeroux, Adrian Zordan, Jason Li, et al.

Journal article  |  2019  |  Nature Medicine

Overview of Fusion Detection Strategies Using Next-Generation Sequencing.

Jan Schröder, Amit Kumar, Stephen Q Wong

Book Chapter  |  2019  |  Methods in Molecular Biology

Structural gene fusion rearrangements leading to aberrant signaling are frequently detected in many cancer types. Gene fusions hav..

Optimizing Amplification of the GC-Rich TERT Promoter Region Using 7-Deaza-dGTP for Droplet Digital PCR Quantification of TERT Promoter Mutations

Andrew J Colebatch, Tom Witkowski, Paul M Waring, Grant A McArthur, Stephen Q Wong, Alexander Dobrovic

Journal article  |  2018  |  Clinical Chemistry

TERT structural rearrangements in metastatic pheochromocytomas

Trisha Dwight, Aidan Flynn, Kaushalya Amarasinghe, Diana E Benn, Richard Lupat, Jason Li, Daniel L Cameron, Annette Hogg, Shiva Balachander, Ida LM Candiloro, Stephen Q Wong, Bruce G Robinson, Anthony T Papenfuss, Anthony J Gill, Alexander Dobrovic, Rodney J Hicks, Roderick J Clifton-Bligh, Richard W Tothill

Journal article  |  2018  |  Endocrine-Related Cancer

Multiplexed transcriptome analysis to detect ALK, ROS1 and RET rearrangements in lung cancer

Toni-Maree Rogers, Gisela Mir Arnau, Georgina L Ryland, Stephen Huang, Maruja E Lira, Yvette Emmanuel, Omar D Perez, Darryl Irwin, Andrew P Fellowes, Stephen Q Wong, Stephen B Fox

Journal article  |  2017  |  Scientific Reports

Circulating Tumor DNA Analysis and Functional Imaging Provide Complementary Approaches for Comprehensive Disease Monitoring in Metastatic Melanoma

Stephen Q Wong, Jeanette M Raleigh, Jason Callahan, Ismael A Vergara, Sarah Ftouni, Athena Hatzimihalis, Andrew J Colebatch, Jason Li, Timothy Semple, Kenneth Doig, Christopher Mintoff, Devbarna Sinha, Paul Yeh, Maria Joao Silva, Kathryn Alsop, Heather Thorne, David D Bowtell, David E Gyorki, Gisela Mir Arnau, Carleen Cullinane, et al.

Journal article  |  2017  |  JCO Precision Oncology

Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies

Andrew J Colebatch, Leon Di Stefano, Stephen Q Wong, Ross D Hannan, Paul M Waring, Alexander Dobrovic, Grant A McArthur, Anthony T Papenfuss

Journal article  |  2016  |  ONCOTARGET

KRAS mutation testing in colorectal cancer: the model for molecular pathology testing in the future

Stephen Q Wong, Rodney Scott, Stephen B Fox

Journal article  |  2016  |  Colorectal Cancer

Exemplary multiplex bisulfite amplicon data used to demonstrate the utility of Methpat

Nicholas C Wong, Bernard J Pope, Ida Candiloro, Darren Korbie, Matt Trau, Stephen Q Wong, Thomas Mikeska, Bryce JW van Denderen, Erik W Thompson, Stefanie Eggers, Stephen R Doyle, Alexander Dobrovic

Journal article  |  2015  |  GigaScience

The role of BRAF mutations in primary melanoma growth rate and survival

VJ Mar, W Liu, B Devitt, SQ Wong, A Dobrovic, GA McArthur, R Wolfe, JW Kelly

Journal article  |  2015  |  British Journal of Dermatology

Appraisal of the technologies and review of the genomic landscape of ductal carcinoma in situ of the breast

Jia-Min B Pang, Kylie L Gorringe, Stephen Q Wong, Alexander Dobrovic, Ian G Campbell, Stephen B Fox

Journal article  |  2015  |  Breast Cancer Research

Genomic Classification of Serous Ovarian Cancer with Adjacent Borderline Differentiates RAS Pathway and TP53-Mutant Tumors and Identifies NRAS as an Oncogenic Driver

Catherine Emmanuel, Yoke-Eng Chiew, Joshy George, Dariush Etemadmoghadam, Michael S Anglesio, Raghwa Sharma, Peter Russell, Catherine Kennedy, Sian Fereday, Jillian Hung, Laura Galletta, Russell Hogg, Gerard V Wain, Alison Brand, Rosemary Balleine, Laura MacConaill, Emanuele Palescandolo, Sally M Hunter, Ian Campbell, Alexander Dobrovic, et al.

Journal article  |  2014  |  Clinical Cancer Research

Mutational profiling of familial male breast cancers reveals similarities with luminal A female breast cancer with rare TP53 mutations

S Deb, SQ Wong, J Li, H Do, J Weiss, D Byrne, A Chakrabarti, T Bosma, A Fellowes, A Dobrovic, SB Fox

Journal article  |  2014  |  Br J Cancer

Erdheim-Chester Disease Harboring the BRAF V600E Mutation

Piers Blombery, Stephen Q Wong, Stephen Lade, H Miles Prince

Journal article  |  2012  |  Journal of Clinical Oncology

Glucocorticoids Stimulate Hepatic and Renal Catecholamine Inactivation by Direct Rapid Induction of the Dopamine Sulfotransferase Sult1d1

Stephen Wong, Kheng Tan, Kirstyn T Carey, Atsushi Fukushima, Tony Tiganis, Timothy J Cole

Journal article  |  2010  |  Endocrinology

A direct effect of aldosterone on endothelin-1 gene expression in vivo

Stephen Wong, Francine E Brennan, Morag J Young, Peter J Fuller, Timothy J Cole

Journal article  |  2007  |  Endocrinology