Lou Fourriere-Chea

Quantification of Golgi Entry and Exit Kinetics of Protein Cargoes.

Jingqi Wang, Ellie Hyun-Jung Cho, Paul A Gleeson, Lou Fourriere

Book Chapter  |  2023  |  Methods in Molecular Biology

The Golgi apparatus is a pivotal secretory organelle in membrane trafficking, a hub responsible for posttranslational modification..

Segregation of the membrane cargoes, BACE1 and amyloid precursor protein (APP) throughout the Golgi apparatus

Lou Fourriere, Ellie Hyun-Jung Cho, Paul A Gleeson

Journal article  |  2022  |  TRAFFIC

The intracellular trafficking of β-site amyloid precursor protein (APP) cleaving enzyme (BACE1) and APP regulates amyloid-β produc..

Amyloid beta production along the neuronal secretory pathway: Dangerous liaisons in the Golgi?

Lou Fourriere, Paul A Gleeson

Journal article  |  2021  |  TRAFFIC

β-amyloid peptides (Aβ) are generated in intracellular compartments of neurons and secreted to form cytotoxic fibrils and plaques...

Retention Using Selective Hooks-Synchronized Secretion to Measure Local Exocytosis

Gaelle Boncompain, Lou Fourriere, Nelly Gareil, Franck Perez

Book Chapter  |  2021  |  Methods in Molecular Biology

Proteins destined to be exposed to the extracellular space enter the secretory pathway at the level of the endoplasmic reticulum. ..

Local Secretory Trafficking Pathways in Neurons and the Role of Dendritic Golgi Outposts in Different Cell Models

Jingqi Wang, Lou Fourriere, Paul A Gleeson

Journal article  |  2020  |  FRONTIERS IN MOLECULAR NEUROSCIENCE

A fundamental characteristic of neurons is the relationship between the architecture of the polarized neuron and synaptic transmis..

The role of microtubules in secretory protein transport

Lou Fourriere, Ana Joaquina Jimenez, Franck Perez, Gaelle Boncompain

Journal article  |  2020  |  JOURNAL OF CELL SCIENCE

Microtubules are part of the dynamic cytoskeleton network and composed of tubulin dimers. They are the main tracks used in cells t..

Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-beta production

Jing Zhi A Tan, Lou Fourriere, Jingqi Wang, Franck Perez, Gaelle Boncompain, Paul A Gleeson

Journal article  |  2020  |  MOLECULAR BIOLOGY OF THE CELL

Processing of amyloid precursor protein (APP) by the β-secretase BACE1 is the initial step of the amyloidogenic pathway to generat..

RAB6 and microtubules restrict protein secretion to focal adhesions

Lou Fourriere, Amal Kasri, Nelly Gareil, Sabine Bardin, Hugo Bousquet, David Pereira, Franck Perez, Bruno Goud, Gaelle Boncompain, Stephanie Miserey-Lenkei

Journal article  |  2019  |  JOURNAL OF CELL BIOLOGY

To ensure their homeostasis and sustain differentiated functions, cells continuously transport diverse cargos to various cell comp..

Yeast cells reveal the misfolding and the cellular mislocalization of the human BRCA1 protein

Pierre Thouvenot, Lou Fourriere, Elodie Dardillac, Barbara Ben Yamin, Aurianne Lescure, Vincent Lejour, Xavier Heiligenstein, Jean-Baptiste Boule, Maryse Romao, Graca Raposo-Benedetti, Bernard S Lopez, Alain Nicolas, Gael A Millot

Journal article  |  2016  |  JOURNAL OF CELL SCIENCE

Understanding the effect of an ever-growing number of human variants detected by genome sequencing is a medical challenge. The yea..

Microtubule-independent secretion requires functional maturation of Golgi elements

Lou Fourriere, Severine Divoux, Mila Roceri, Franck Perez, Gaelle Boncompain

Journal article  |  2016  |  JOURNAL OF CELL SCIENCE

The Golgi complex is responsible for processing and sorting of secretory cargos. Microtubules are known to accelerate the transpor..