Luc Furic

Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate.

Viacheslav Kriachkov, Angelique R Ormsby, Eric P Kusnadi, Hamish EG McWilliam, Justine D Mintern, Shanika L Amarasinghe, Matthew E Ritchie, Luc Furic, Danny M Hatters

Journal article  |  2023  |  J Biol Chem

Hexanucleotide expansion mutations in C9ORF72 are a frequent cause of amyotrophic lateral sclerosis. We previously reported that l..

Abstract 2155: PMR-116, a novel inhibitor of ribosome biogenesis with antitumor activity in preclinical models of prostate cancer

Alisee Huglo, Richard Rebello, Mitchell Lawrence, Gail Risbridger, Denis Drygin, Mustapha Haddach, Katherine Hannan, Ross Hannan, Luc Furic

Conference Proceedings  |  2022  |  Cancer Research

Abstract Advanced prostate cancer is characterised by mutations and amplifications of genes involved in regulating ..

Look youse guys and gals, dat just ain't right.

Daniel J Klionsky

Journal article  |  2021  |  Autophagy

When I invite authors to submit a punctum to Autophagy, my e-mail includes the following: "Note for international authors: I would..

Look youse guys and gals, dat just ain't right

Daniel J Klionsky

Journal article  |  2021  |  AUTOPHAGY

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received inc..

CX-5461 Sensitizes DNA Damage Repair-proficient Castrate-resistant Prostate Cancer to PARP Inhibition

Mitchell G Lawrence, Laura H Porter, Nicholas Choo, David Pook, Jeremy P Grummet, Carmel J Pezaro, Shahneen Sandhu, Susanne Ramm, Jennii Luu, Andrew Bakshi, David L Goode, Elaine Sanij, Richard B Pearson, Ross D Hannan, Kaylene J Simpson, Renea A Taylor, Gail P Risbridger, Luc Furic

Journal article  |  2021  |  MOLECULAR CANCER THERAPEUTICS

Monotherapy with PARP inhibitors is effective for the subset of castrate-resistant prostate cancer (CRPC) with defects in homologo..

Regulation of gene expression via translational buffering

Eric P Kusnadi, Clelia Timpone, Ivan Topisirovic, Ola Larsson, Luc Furic

Journal article  |  2021  |  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Translation of an mRNA represents a critical step during the expression of protein-coding genes. As mechanisms governing post-tran..

The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology

Gail P Risbridger, Ashlee K Clark, Laura H Porter, Roxanne Toivanen, Andrew Bakshi, Natalie L Lister, David Pook, Carmel J Pezaro, Shahneen Sandhu, Shivakumar Keerthikumar, Rosalia Quezada Urban, Melissa Papargiris, Jenna Kraska, Heather B Madsen, Hong Wang, Michelle G Richards, Birunthi Niranjan, Samantha O'Dea, Linda Teng, William Wheelahan, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Preclinical testing is a crucial step in evaluating cancer therapeutics. We aimed to establish a significant resource of patient-d..

Regulation of mRNA Translation by Hormone Receptors in Breast and Prostate Cancer

Jianling Xie, Eric P Kusnadi, Luc Furic, Luke A Selth

Journal article  |  2021  |  CANCERS

Breast and prostate cancer are the second and third leading causes of death amongst all cancer types, respectively. Pathogenesis o..

Mast Cell-Derived SAMD14 Is a Novel Regulator of the Human Prostate Tumor Microenvironment

Linda KH Teng, Brooke A Pereira, Shivakumar Keerthikumar, Cheng Huang, Birunthi Niranjan, Sophie N Lee, Michelle Richards, Ralf B Schittenhelm, Luc Furic, David L Goode, Mitchell G Lawrence, Renea A Taylor, Stuart J Ellem, Gail P Risbridger, Natalie L Lister

Journal article  |  2021  |  CANCERS

Mast cells (MCs) are important cellular components of the tumor microenvironment and are significantly associated with poor patien..

Inhibition of the Lysophosphatidylinositol Transporter ABCC1 Reduces Prostate Cancer Cell Growth and Sensitizes to Chemotherapy

Aikaterini Emmanouilidi, Ilaria Casari, Begum Gokcen Akkaya, Tania Maffucci, Luc Furic, Federica Guffanti, Massimo Broggini, Xi Chen, Yulia Y Maxuitenko, Adam B Keeton, Gary A Piazza, Kenneth J Linton, Marco Falasca

Journal article  |  2020  |  CANCERS

Expression of ATP-binding cassette (ABC) transporters has long been implicated in cancer chemotherapy resistance. Increased expres..