Marcela De Lima Moreira

The role of mucosal-associated invariant T cells in visceral leishmaniasis

Marcela de Lima Moreira, Luana Oliveira Borges-Fernandes, Marcelo Antonio Pascoal-Xavier, Agata Lopes Ribeiro, Victoria Hellena Silva Pereira, Troi Pediongco, Marcio Sobreira da Silva Araujo, Andrea Teixeira-Carvalho, Andrea Lucchesi de Carvalho, Maria Vitoria Assumpcao Mourao, Flavia Alves Campos, Marineide Borges, Mariangela Carneiro, Zhenjun Chen, Eleanor Saunders, Malcolm McConville, Moriya Tsuji, James McCluskey, Olindo Assis Martins-Filho, Sidonia Barbara Guiomar Eckle, et al.

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections...

Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection

Zhe Zhao, Huimeng Wang, Mai Shi, Tianyuan Zhu, Troi Pediongco, Xin Yi Lim, Bronwyn S Meehan, Adam G Nelson, David P Fairlie, Jeffrey YW Mak, Sidonia BG Eckle, Marcela de Lima Moreira, Carolin Tumpach, Michael Bramhall, Cameron G Williams, Hyun Jae Lee, Ashraful Haque, Maximilien Evrard, Jamie Rossjohn, James McCluskey, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Mucosal-associated Invariant T (MAIT) cells are recognized for their antibacterial functions. The protective capacity of MAIT cell..

Transcriptome dynamics of CD4( ) T cells during malaria maps gradual transit from effector to memory

Megan SF Soon, Hyun Jae Lee, Jessica A Engel, Jasmin Straube, Bryce S Thomas, Clara PS Pernold, Lachlan S Clarke, Pawat Laohamonthonkul, Rohit N Haldar, Cameron G Williams, Lianne IM Lansink, Marcela L Moreira, Michael Bramhall, Lambros T Koufariotis, Scott Wood, Xi Chen, Kylie R James, Tapio Lonnberg, Steven W Lane, Gabrielle T Belz, et al.

Journal article  |  2020  |  NATURE IMMUNOLOGY

The dynamics of CD4+ T cell memory development remain to be examined at genome scale. In malaria-endemic regions, antimalarial che..

Hypersensitivities following allergen antigen recognition by unconventional T cells

Marcela de Lima Moreira, Michael NT Souter, Zhenjun Chen, Liyen Loh, James McCluskey, Daniel G Pellicci, Sidonia BG Eckle

Journal article  |  2020  |  ALLERGY

Conventional T cells recognise protein-derived antigens in the context of major histocompatibility complex (MHC) class Ia and clas..

Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCR alpha beta Clonotypes with Potent Antimicrobial Responses

Liyen Loh, Nicholas A Gherardin, Sneha Sant, Ludivine Grzelak, Jeremy Chase Crawford, Nicola L Bird, Hui-Fern Koay, Carolien E van de Sandt, Marcela L Moreira, Martha Lappas, E Kaitlynn Allen, Jane Crowe, Thomas Loudovaris, Katie L Flanagan, Kylie M Quinn, Jamie Rossjohn, Paul G Thomas, Sidonia BG Eckle, James McCluskey, Dale I Godfrey, et al.

Journal article  |  2020  |  JOURNAL OF IMMUNOLOGY

Mucosal-associated invariant T (MAIT) cells are important for immune responses against microbial infections. Although known to und..

Cell-derived microvesicles in infective endocarditis: Role in diagnosis and potential for risk stratification at hospital admission

Milton Henriques Guimaraes Junior, Teresa Cristina Abreu Ferrari, Andrea Teixeira-Carvalho, Marcela de Lima Moreira, Lorena Jinia de Souza Santos, Matheus Fernandes Costa-Silva, Rodrigo Matos Pinto Coelho, Pedro Henrique Oliveira Murta Pinto, Tijmen Hermen Ris, Jonathas Teixeira Salles, Livia Silva Araujo Passos, Maria Carmo Pereira Nunes

Journal article  |  2019  |  JOURNAL OF INFECTION

OBJECTIVES: To characterize the plasmatic profile of cell-derived microvesicles (MVs) at diagnosis and during the treatment of pat..

Phenotypic and functional features of innate and adaptive immunity as putative biomarkers for clinical status and leprosy reactions

Jairo Campos de Carvalho, Marcelo Grossi Araujo, Jordana Grazziela Alves Coelho-dos-Reis, Vanessa Peruhype-Magalhaes, Claudio Caetano Alvares, Marcela de Lima Moreira, Andrea Teixeira-Carvalho, Olindo Assis Martins-Filho, Marcio Sobreira Silva Araujo

Journal article  |  2018  |  MICROBIAL PATHOGENESIS

The aim of this study was to identify phenotypic and functional biomarkers associated with distinct clinical status of leprosy or ..

Leishmanicidal Effects of Piperlongumine (Piplartine) and Its Putative Metabolites

Fernanda de Lima Moreira, Thalita Bachelli Riul, Marcela de Lima Moreira, Alan Cesar Pilon, Marcelo Dias-Baruffi, Marcio SS Araujo, Norberto Peporine Lopes, Anderson RM de Oliveira

Journal article  |  2018  |  PLANTA MEDICA

Piperlongumine is an amide alkaloid found in Piperaceae species that shows a broad spectrum of biological properties, including an..

MAIT-cells: A tailor-made mate in the ancient battle against infectious diseases?

Marcela de Lima Moreira, Moriya Tsuji, Alexandra Jane Corbett, Marcio Sobreira Silva Araujo, Andrea Teixeira-Carvalho, Olindo Assis Martins-Filho, Vanessa Peruhype-Magalhaes, Jordana Grazziela Coelho-dos-Reis

Journal article  |  2017  |  IMMUNOLOGY LETTERS

It has been almost two decades since the discovery of mucosal-associated invariant T (MAIT)-cells. Several advances in the field h..

Vaccination against canine leishmaniosis increases the phagocytic activity, nitric oxide production and expression of cell activation/migration molecules in neutrophils and monocytes

Marcela L Moreira, Christiane Costa-Pereira, Marina Luiza Rodrigues Alves, Bruno H Marteleto, Vitor M Ribeiro, Vanessa Peruhype-Magalhaes, Rodolfo C Giunchetti, Olindo A Martins-Filho, Marcio SS Araujo

Journal article  |  2016  |  VETERINARY PARASITOLOGY

Visceral leishmaniasis (VL) is transmitted by phlebotomine sandfly vectors and domestic dogs serve as a reservoir. The elimination..