Stefan Bjelosevic

Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML

Jessica M Salmon, Izabela Todorovski, Kym L Stanley, Claudia Bruedigam, Conor J Kearney, Luciano G Martelotto, Fernando Rossello, Timothy Semple, Gisela Mir Arnau, Magnus Zethoven, Michael Bots, Stefan Bjelosevic, Leonie A Cluse, Peter J Fraser, Veronique Litalien, Eva Vidacs, Kate McArthur, Antony Y Matthews, Elise Gressier, Nicole A de Weerd, et al.

Journal article  |  2022  |  CANCER DISCOVERY

UNLABELLED: Pharmacologic inhibition of epigenetic enzymes can have therapeutic benefit against hematologic malignancies. In addit..

The Combination of Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Delays KMT2A-Rearranged Leukemia Progression

Lin Xiao, Mawar Karsa, Emma Ronca, Angelika Bongers, Angelika Kosciolek, Ali El-Ayoubi, Jezrael L Revalde, Janith A Seneviratne, Belamy B Cheung, Laurence C Cheung, Rishi S Kotecha, Andrea Newbold, Stefan Bjelosevic, Greg M Arndt, Richard B Lock, Ricky W Johnstone, Andrei V Gudkov, Katerina V Gurova, Michelle Haber, Murray D Norris, et al.

Journal article  |  2022  |  FRONTIERS IN ONCOLOGY

Rearrangements of the Mixed Lineage Leukemia (MLL/KMT2A) gene are present in approximately 10% of acute leukemias and characterist..

SFPQ-ABL1 and BCR-ABL1 use different signaling networks to drive B-cell acute lymphoblastic leukemia

Lauren M Brown, Soroor Hediyeh-Zadeh, Teresa Sadras, Hannah Huckstep, Jarrod J Sandow, Ray C Bartolo, Hansen J Kosasih, Nadia M Davidson, Breon Schmidt, Stefan Bjelosevic, Ricky Johnstone, Andrew Webb, Seong L Khaw, Alicia Oshlack, Melissa J Davis, Paul G Ekert

Journal article  |  2022  |  BLOOD ADVANCES

Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) is a high-risk subtype of B-cell ALL characterized by a gene expres..

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

Stephin J Vervoort, Sarah A Welsh, Jennifer R Devlin, Elisa Barbieri, Deborah A Knight, Sarah Offley, Stefan Bjelosevic, Matteo Costacurta, Izabela Todorovski, Conor J Kearney, Jarrod J Sandow, Zheng Fan, Benjamin Blyth, Victoria McLeod, Joseph HA Vissers, Karolina Pavic, Ben P Martin, Gareth Gregory, Elena Demosthenous, Magnus Zethoven, et al.

Journal article  |  2021  |  CELL

Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent kinases (CDKs) at discrete checkpoints dur..

Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD-Driven Acute Myeloid Leukemia

Stefan Bjelosevic, Emily Gruber, Andrea Newbold, Carolyn Shembrey, Jennifer R Devlin, Simon J Hogg, Lev Kats, Izabela Todorovski, Zheng Fan, Thomas C Abrehart, Giovanna Pomilio, Andrew Wei, Gareth P Gregory, Stephin J Vervoort, Kristin K Brown, Ricky W Johnstone

Journal article  |  2021  |  CANCER DISCOVERY

Internal tandem duplication of the FMS-like tyrosine kinase 3 gene (FLT3-ITD) occurs in 30% of all acute myeloid leukemias (AML). ..

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

Simon J Hogg, Olga Motorna, Leonie A Cluse, Timothy M Johanson, Hannah D Coughlan, Ramya Raviram, Robert M Myers, Matteo Costacurta, Izabela Todorovski, Lizzy Pijpers, Stefan Bjelosevic, Tobias Williams, Shannon N Huskins, Conor J Kearney, Jennifer R Devlin, Zheng Fan, Jafar S Jabbari, Ben P Martin, Mohamed Fareh, Madison J Kelly, et al.

Journal article  |  2021  |  MOLECULAR CELL

To separate causal effects of histone acetylation on chromatin accessibility and transcriptional output, we used integrated epigen..

MLL-TFE3: a novel and aggressive KMT2A fusion identified in infant leukemia

Hansen J Kosasih, Nadia M Davidson, Stefan Bjelosevic, Emma Morrish, Margs S Brennan, Alicia Oshlack, Ricky W Johnstone, Gabriela Brumatti, Seong L Khaw, Paul G Ekert

Journal article  |  2020  |  BLOOD ADVANCES

A novel KMT2A-rearrangement, MLL-TFE3, was identified in an infant leukemia patient. MLL-TFE3 expression produces aggressive leuke..

Mathematical modelling indicates that lower activity of the haemostatic system in neonates is primarily due to lower prothrombin concentration

Ivo Siekmann, Stefan Bjelosevic, Kerry Landman, Paul Monagle, Vera Ignjatovic, Edmund J Crampin

Journal article  |  2019  |  SCIENTIFIC REPORTS

Haemostasis is governed by a highly complex system of interacting proteins. Due to the central role of thrombin, thrombin generati..

Different Classes of ABL1 Fusions Activate Different Downstream Signalling Nodes

Lauren M Brown, Hannah Huckstep, Jarrod Sandow, Ray C Bartolo, Nadia Davidson, Breon Schmidt, Stefan Bjelosevic, Ricky W Johnstone, Alicia Oshlack, Melissa Davis, Paul G Ekert

Conference Proceedings  |  2018  |  BLOOD

Abstract Background: Philadelphia-like acute lymphoblastic leukaemia (Ph-like ALL) is a high-risk subtype of ALL dr..

Blood biomarkers in paediatric mild traumatic brain injury: a systematic review

Micaela Lugones, Georgia Parkin, Stefan Bjelosevic, Michael Takagi, Cathriona Clarke, Vicki Anderson, Vera Ignjatovic

Journal article  |  2018  |  NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

OBJECTIVE: To summarize all current studies focusing on blood biomarkers in paediatric mild traumatic brain injury (mTBI) and to o..