Lynette completed her PhD on the immunology of malaria infection at the Queensland Institute of Medical Research. She then moved to the United Kingdom where her research focussed on Leishmaniasis and the mechanisms of control of infection in the liver, with a particular focus on the biology of liver macrophages.
In 2015, Lynette relocated to QIMR-Berghofer in Brisbane and then in 2017 to the Doherty Institute in Melbourne where she now runs an independent team within the laboratory of Professor William Heath. Lynette's research currently focusses on the immune response to the liver stage of Plasmodium infection.
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The Role Of Il-17 In Regulating Liver Macrophage Permissiveness For Leishmania Infection
Glycolipid-peptide vaccination induces liver-resident memory CD8( ) T cells that protect a..
Raster adaptive optics for video rate aberration correction and large FOV multiphoton imag..
Macrophage Transactivation for chemokine Production identified as a negative regulator of ..
Displaying the most recent project by Lynette Beattie.
Displaying the 40 most recent scholarly works by Lynette Beattie.
A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver T-RM Cell-Mediated Immunity against Malaria in Mice
Ana Maria Valencia-Hernandez, Wei Yi Ng, Nazanin Ghazanfari, Sonia Ghilas, Maria N de Menezes, Lauren E Holz, Cheng Huang, Kieran English, Myo Naung, Peck Szee Tan, Kirsteen M Tullett, Thiago M Steiner, Matthias H Enders, Lynette Beattie, Yu Cheng Chua, Claerwen M Jones, Anton Cozijnsen, Vanessa Mollard, Yeping Cai, David G Bowen, et al.
Journal article | 2020 | Cell Host & Microbe
Liver-resident memory CD8+ T (TRM) cells remain in and constantly patrol the liver to elicit rapid immunity upon antigen encounter..
Glycolipid-peptide vaccination induces liver-resident memory CD8( ) T cells that protect against rodent malaria
Lauren E Holz, Yu Cheng Chua, Maria N de Menezes, Regan J Anderson, Sarah L Draper, Benjamin J Compton, Susanna TS Chan, Juby Mathew, Jasmine Li, Lukasz Kedzierski, Zhongfang Wang, Lynette Beattie, Matthias H Enders, Sonia Ghilas, Rose May, Thiago M Steiner, Joshua Lange, Daniel Fernandez-Ruiz, Ana Maria Valencia-Hernandez, Taryn L Osmond, et al.
Journal article | 2020 | Science Immunology
Liver resident-memory CD8+ T cells (TRM cells) can kill liver-stage Plasmodium-infected cells and prevent malaria, but simple vacc..
Macrophage Transactivation for chemokine Production identified as a negative regulator of granulomatous inflammation Using agent-Based Modeling
Daniel Moyo, Lynette Beattie, Paul S Andrews, John WJ Moore, Jon Timmis, Amy Sawtell, Stefan Hoehme, Adam T Sampson, Paul M Kaye
Journal article | 2018 | Frontiers in Immunology
Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection
Susanna S Ng, Fernando Souza-Fonseca-Guimaraes, Fabian de Labastida Rivera, Fiona H Amante, Rajiv Kumar, Yulong Gao, Meru Sheel, Lynette Beattie, Marcela Montes de Oca, Camille Guillerey, Chelsea L Edwards, Rebecca J Faleiro, Teija Frame, Patrick T Bunn, Eric Vivier, Dale I Godfrey, Daniel G Pellicci, J Alejandro Lopez, Katherine T Andrews, Nicholas D Huntington, et al.
Journal article | 2018 | Clinical & Translational Immunology
A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment
Frederic Sierro, Maximilien Evrard, Simone Rizzetto, Michelle Melino, Andrew J Mitchell, Manuela Florido, Lynette Beattie, Shaun B Walters, Szun Szun Tay, Bo Lu, Lauren E Holz, Ben Roediger, Yik Chun Wong, Alessandra Warren, William Ritchie, Claire McGuffog, Wolfgang Weninger, David G Le Couteur, Florent Ginhoux, Warwick J Britton, et al.
Journal article | 2017 | Immunity
In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice
Raymond Reif, Ahmed Ghallab, Lynette Beattie, Georgia Guenther, Lars Kuepfer, Paul M Kaye, Jan G Hengstler
Journal article | 2017 | Archives of Toxicology
We describe a two-photon microscopy-based method to evaluate the in vivo systemic transport of compounds. This method comprises im..
IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection
Ismail Sebina, Kylie R James, Megan SF Soon, Lily G Fogg, Shannon E Best, Fabian de Labastida Rivera, Marcela Montes de Oca, Fiona H Amante, Bryce S Thomas, Lynette Beattie, Fernando Souza-Fonseca-Guimaraes, Mark J Smyth, Paul J Hertzog, Geoffrey R Hill, Andreas Hutloff, Christian R Engwerda, Ashraful Haque
Journal article | 2016 | PLOS Pathogens
Parasite-specific antibodies protect against blood-stage Plasmodium infection. However, in malaria-endemic regions, it takes many ..
Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection
Marcela Montes de Oca, Rajiv Kumar, Fabian de Labastida Rivera, Fiona H Amante, Meru Sheel, Rebecca J Faleiro, Patrick T Bunn, Shannon E Best, Lynette Beattie, Susanna S Ng, Chelsea L Edwards, Glen M Boyle, Ric N Price, Nicholas M Anstey, Jessica R Loughland, Julie Burel, Denise L Doolan, Ashraful Haque, James S McCarthy, Christian R Engwerda
Journal article | 2016 | Cell Reports
The development of immunoregulatory networks is important to prevent disease. However, these same networks allow pathogens to pers..
Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions
Lynette Beattie, Amy Sawtell, Jason Mann, Teija CM Frame, Bianca Teal, Fabian de Labastida Rivera, Najmeeyah Brown, Katherine Walwyn-Brown, John WJ Moore, Sandy MacDonald, Eng-Kiat Lim, Jane E Dalton, Christian R Engwerda, Kelli P MacDonald, Paul M Kaye
Journal article | 2016 | Journal of Hepatology
BACKGROUND & AIMS: Kupffer cells (KCs), the resident tissue macrophages of the liver, play a crucial role in the clearance of path..
CD4( ) Recent Thymic Emigrants Are Recruited into Granulomas during Leishmania donovani Infection but Have Limited Capacity for Cytokine Production
John WJ Moore, Lynette Beattie, Mohamed Osman, Benjamin MJ Owens, Najmeeyah Brown, Jane E Dalton, Asher Maroof, Paul M Kaye
Journal article | 2016 | PLOS ONE
Spatiotemporal Characterization of the Cellular and Molecular Contributors to Liver Fibrosis in a Murine Hepatotoxic-Injury Model
Michelle Melino, Victoria L Gadd, Kylie A Alexander, Lynette Beattie, Katie E Lineburg, Michelle Martinez, Bianca Teal, Laetitia Le Texier, Katharine M Irvine, Gregory C Miller, Glen M Boyle, Geoffrey R Hill, Andrew D Clouston, Elizabeth E Powel, Kelli PA MacDonald
Journal article | 2016 | The American Journal of Pathology
The interplay between the inflammatory infiltrate and tissue resident cell populations invokes fibrogenesis. However, the temporal..
Combined Immune Therapy for the Treatment of Visceral Leishmaniasis
Rebecca J Faleiro, Rajiv Kumar, Patrick T Bunn, Neetu Singh, Shashi Bhushan Chauhan, Meru Sheel, Fiona H Amante, Marcela Montes de Oca, Chelsea L Edwards, Susanna S Ng, Shannon E Best, Ashraful Haque, Lynette Beattie, Louise M Hafner, David Sacks, Susanne Nylen, Shyam Sundar, Christian R Engwerda
Journal article | 2016 | PLOS Neglected Tropical Diseases
Chronic disease caused by infections, cancer or autoimmunity can result in profound immune suppression. Immunoregulatory networks ..
Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology
Marcela Montes de Oca, Rajiv Kumar, Fabian de labastida Rivera, Fiona H Amante, Meru Sheel, Rebecca J Faleiro, Patrick T Bunn, Shannon E Best, Lynette Beattie, Susanna S Ng, Chelsea L Edwards, Werner Muller, Erika Cretney, Stephen L Nutt, Mark J Smyth, Ashraful Haque, Geoffrey R Hill, Shyam Sundar, Axel Kallies, Christian R Engwerda
Journal article | 2016 | PLOS Pathogens
IL-17A-Producing gamma delta T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver
Meru Sheel, Lynette Beattie, Teija CM Frame, Fabian de Labastida Rivera, Rebecca J Faleiro, Patrick T Bunn, Marcela Montes de Oca, Chelsea L Edwards, Susanna S Ng, Rajiv Kumar, Fiona H Amante, Shannon E Best, Shaun R McColl, Antiopi Varelias, Rachel D Kuns, Kelli PA MacDonald, Mark J Smyth, Ashraful Haque, Geoff R Hill, Christian R Engwerda
Journal article | 2015 | The Journal of Immunology
Intracellular infections, such as those caused by the protozoan parasite Leishmania donovani, a causative agent of visceral leishm..
Bile canalicular dynamics in hepatocyte sandwich cultures
Raymond Reif, Johan Karlsson, Georgia Guenther, Lynette Beattie, David Wrangborg, Seddik Hammad, Brigitte Begher-Tibbe, Amruta Vartak, Simone Melega, Paul M Kaye, Jan G Hengstler, Mats Jirstrand
Journal article | 2015 | Archives of Toxicology
Many substances are hepatotoxic due to their ability to cause intrahepatic cholestasis. Therefore, there is a high demand for in v..
The Neurotrophic Receptor Ntrk2 Directs Lymphoid Tissue Neovascularization during Leishmania donovani Infection
Jane E Dalton, Amy C Glover, Laura Hoodless, Eng-Kiat Lim, Lynette Beattie, Alun Kirby, Paul M Kaye
Journal article | 2015 | PLOS Pathogens
The neurotrophic tyrosine kinase receptor type 2 (Ntrk2, also known as TrkB) and its ligands brain derived neurotrophic factor (Bd..
A Petri Net Model of Granulomatous Inflammation: Implications for IL-10 Mediated Control of Leishmania donovani Infection
Luca Albergante, Jon Timmis, Lynette Beattie, Paul M Kaye
Journal article | 2013 | PLoS Computational Biology
Experimental visceral leishmaniasis, caused by infection of mice with the protozoan parasite Leishmania donovani, is characterized..
A Transcriptomic Network Identified in Uninfected Macrophages Responding to Inflammation Controls Intracellular Pathogen Survival
Lynette Beattie, Micely d'El-Rei Hermida, John WJ Moore, Asher Maroof, Najmeeyah Brown, Dimitris Lagos, Paul M Kaye
Journal article | 2013 | Cell Host & Microbe
Intracellular pathogens modulate host cell function to promote their survival. However, in vitro infection studies do not account ..
IL-10-Producing Th1 Cells and Disease Progression Are Regulated by Distinct CD11c( ) Cell Populations during Visceral Leishmaniasis
Benjamin MJ Owens, Lynette Beattie, John WJ Moore, Najmeeyah Brown, Jason L Mann, Jane E Dalton, Asher Maroof, Paul M Kaye
Journal article | 2012 | PLoS Pathogens
IL-10 is a critical regulatory cytokine involved in the pathogenesis of visceral leishmaniasis caused by Leishmania donovani and c..
B Cell: T Cell Interactions Occur within Hepatic Granulomas during Experimental Visceral Leishmaniasis
John WJ Moore, Lynette Beattie, Jane E Dalton, Benjamin MJ Owens, Asher Maroof, Mark C Coles, Paul M Kaye
Journal article | 2012 | PLoS ONE
Hepatic resistance to Leishmania donovani infection in mice is associated with the development of granulomas, in which a variety o..
Compartment-Specific Remodeling of Splenic Micro-Architecture during Experimental Visceral Leishmaniasis
Pinar Yurdakul, Jane Dalton, Lynette Beattie, Nlajmeeyah Brown, Sibel Erguven, Asher Maroof, Paul M Kaye
Journal article | 2011 | The American Journal of Pathology
Progressive splenomegaly is a hallmark of visceral leishmaniasis in humans, canids, and rodents. In experimental murine visceral l..
Interferon Regulatory Factor 7 Contributes to the Control of Leishmania donovani in the Mouse Liver
Lynette Beattie, Rebecca Phillips, Najmeeyah Brown, Benjamin MJ Owens, Neal Chauhan, Jane E Dalton, Paul M Kaye
Journal article | 2011 | Infection and Immunity
Optimal hepatic resistance to Leishmania donovani in mice requires the coordinated effort of a variety of leukocyte populations th..
Inhibition of receptor tyrosine kinases restores immunocompetence and improves immune-dependent chemotherapy against experimental leishmaniasis in mice
Jane E Dalton, Asher Maroof, Benjamin MJ Owens, Priyanka Narang, Katherine Johnson, Najmeeyah Brown, Lovisa Rosenquist, Lynette Beattie, Mark Coles, Paul M Kaye
Journal article | 2010 | Journal of Clinical Investigation
Receptor tyrosine kinases are involved in multiple cellular processes, and drugs that inhibit their action are used in the clinic ..
Dynamic Imaging of Experimental Leishmania donovani-Induced Hepatic Granulomas Detects Kupffer Cell-Restricted Antigen Presentation to Antigen-Specific CD8( ) T Cells
Lynette Beattie, Adam Peltan, Asher Maroof, Alun Kirby, Najmeeyah Brown, Mark Coles, Deborah F Smith, Paul M Kaye
Journal article | 2010 | PLoS Pathogens
Kupffer cells (KCs) represent the major phagocytic population within the liver and provide an intracellular niche for the survival..
Innate Killing of Leishmania donovani by Macrophages of the Splenic Marginal Zone Requires IRF-7
Rebecca Phillips, Mattias Svensson, Naveed Aziz, Asher Maroof, Najmeeyah Brown, Lynette Beattie, Nathalie Signoret, Paul M Kaye
Journal article | 2010 | PLoS Pathogens
Highly phagocytic macrophages line the marginal zone (MZ) of the spleen and the lymph node subcapsular sinus. Although these macro..
Leishmania donovani-induced expression of signal regulatory protein alpha on Kupffer cells enhances hepatic invariant NKT-cell activation
Lynette Beattie, Mattias Svensson, Alison Bune, Najmeeyah Brown, Asher Maroof, Soombul Zubairi, Katharine R Smith, Paul M Kaye
Journal article | 2010 | European Journal of Immunology
Signal regulatory protein alpha (SIRPalpha) and its cognate ligand CD47 have been documented to have a broad range of cellular fun..
Dendritic Cells Matured by Inflammation Induce CD86-Dependent Priming of Naive CD8( ) T Cells in the Absence of Their Cognate Peptide Antigen
Asher Maroof, Lynette Beattie, Alun Kirby, Mark Coles, Paul M Kaye
Journal article | 2009 | The Journal of Immunology
Dendritic cells (DC) licensed by the interaction between pathogen products and pattern recognition receptors can activate naive T ..
SIGNR1-Negative Red Pulp Macrophages Protect against Acute Streptococcal Sepsis after Leishmania donovani-Induced Loss of Marginal Zone Macrophages
Alun C Kirby, Lynette Beattie, Asher Maroof, Nico van Rooijen, Paul M Kaye
Journal article | 2009 | The American Journal of Pathology
Marginal zone macrophages in the murine spleen play an important role in the capture of blood-borne pathogens and are viewed as an..
Posttranscriptional regulation of Il10 gene expression allows natural killer cells to express immunoregulatory function
Asher Maroof, Lynette Beattie, Soombul Zubairi, Mattias Svensson, Simona Stager, Paul M Kaye
Journal article | 2008 | Immunity
Natural killer (NK) cells play a well-recognized role in early pathogen containment and in shaping acquired cell-mediated immunity..
Plasmodium strain determines dendritic cell function essential for survival from malaria
Michelle N Wykes, Xue Q Liu, Lynette Beattie, Danielle I Stanisic, Katryn J Stacey, Mark J Smyth, Ranjeny Thomas, Michael F Good
Journal article | 2007 | PLoS Pathogens
The severity of malaria can range from asymptomatic to lethal infections involving severe anaemia and cerebral disease. However, t..
CD8( ) T lymphocyte-mediated loss of marginal metallophilic macrophages following infection with Plasmodium chabaudi chabaudi AS
Beattie Lynette, Christian R Engwerda, Michelle Wykes, Michael F Good
Journal article | 2006 | The Journal of Immunology
The splenic architecture is essential for the quick resolution of a primary infection with Plasmodium. A critical component of thi..
Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria
KT Andrews, DP Fairlie, PK Madala, J Ray, DM Wyatt, PM Hilton, LA Melville, L Beattie, DL Gardiner, RC Reid, MJ Stoermer, T Skinner-Adams, C Berry, JS McCarthy
Journal article | 2006 | Antimicrobial Agents and Chemotherapy
Parasite resistance to antimalarial drugs is a serious threat to human health, and novel agents that act on enzymes essential for ..
Dendritic cells and follicular dendritic cells express a novel ligand for CD38 which influences their maturation and antibody responses
MN Wykes, L Beattie, GG Macpherson, DN Hart
Journal article | 2004 | Immunology
CD38 is a cell surface molecule with ADP-ribosyl cyclase activity, which is predominantly expressed on lymphoid and myeloid cells...
Microbiology And Immunology
Doctor of Philosophy
Queensland University of Technology
Bachelor of Applied Science
Queensland University of Technology