Lynette Beattie

Development of Plasmodium-specific liver-resident memory CD8( ) T cells after heat-killed sporozoite immunization in mice

Sonia Ghilas, Matthias H Enders, Rose May, Lauren E Holz, Daniel Fernandez-Ruiz, Anton Cozijnsen, Vanessa Mollard, Ian A Cockburn, Geoffrey McFadden, William R Heath, Lynette Beattie

Conference Proceedings  |  2021  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Malaria remains a major cause of mortality in the world and an efficient vaccine is the best chance of reducing the disease burden..

Harnessing liver-resident memory T cells for protection against malaria

Daniel Fernandez-Ruiz, Maria N de Menezes, Lauren E Holz, Sonia Ghilas, William R Heath, Lynette Beattie

Journal article  |  2021  |  EXPERT REVIEW OF VACCINES

INTRODUCTION: Tissue-resident memory T cells (TRM cells) are powerful mediators of protracted adaptive immunity to infection in pe..

Plasmodium berghei Hsp90 contains a natural immunogenic I-Ab-restricted antigen common to rodent and human Plasmodium species

Matthias H Enders, Ganchimeg Bayarsaikhan, Sonia Ghilas, Yu Cheng Chua, Rose May, Maria N de Menezes, Zhengyu Ge, Peck Szee Tan, Anton Cozijnsen, Vanessa Mollard, Katsuyuki Yui, Geoffrey I McFadden, Mireille H Lahoud, Irina Caminschi, Anthony W Purcell, Ralf B Schittenhelm, Lynette Beattie, William R Heath, Daniel Fernandez-Ruiz

Journal article  |  2021  |  Current Research in Immunology

Display of Native Antigen on cDC1 That Have Spatial Access to Both T and B Cells Underlies Efficient Humoral Vaccination.

Yu Kato, Thiago M Steiner, Hae-Young Park, Rohan O Hitchcock, Ali Zaid, Jyh Liang Hor, Sapna Devi, Gayle M Davey, David Vremec, Kirsteen M Tullett, Peck S Tan, Fatma Ahmet, Scott N Mueller, Sylvie Alonso, David M Tarlinton, Hidde L Ploegh, Tsuneyasu Kaisho, Lynette Beattie, Jonathan H Manton, Daniel Fernandez-Ruiz, et al.

Journal article  |  2020  |  Journal of Immunology

Follicular dendritic cells and macrophages have been strongly implicated in presentation of native Ag to B cells. This property ha..

A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver T-RM Cell-Mediated Immunity against Malaria in Mice

Ana Maria Valencia-Hernandez, Wei Yi Ng, Nazanin Ghazanfari, Sonia Ghilas, Maria N de Menezes, Lauren E Holz, Cheng Huang, Kieran English, Myo Naung, Peck Szee Tan, Kirsteen M Tullett, Thiago M Steiner, Matthias H Enders, Lynette Beattie, Yu Cheng Chua, Claerwen M Jones, Anton Cozijnsen, Vanessa Mollard, Yeping Cai, David G Bowen, et al.

Journal article  |  2020  |  CELL HOST & MICROBE

Liver-resident memory CD8+ T (TRM) cells remain in and constantly patrol the liver to elicit rapid immunity upon antigen encounter..

Glycolipid-peptide vaccination induces liver-resident memory CD8( ) T cells that protect against rodent malaria

Lauren E Holz, Yu Cheng Chua, Maria N de Menezes, Regan J Anderson, Sarah L Draper, Benjamin J Compton, Susanna TS Chan, Juby Mathew, Jasmine Li, Lukasz Kedzierski, Zhongfang Wang, Lynette Beattie, Matthias H Enders, Sonia Ghilas, Rose May, Thiago M Steiner, Joshua Lange, Daniel Fernandez-Ruiz, Ana Maria Valencia-Hernandez, Taryn L Osmond, et al.

Journal article  |  2020  |  SCIENCE IMMUNOLOGY

Liver resident-memory CD8+ T cells (TRM cells) can kill liver-stage Plasmodium-infected cells and prevent malaria, but simple vacc..

Raster adaptive optics for video rate aberration correction and large FOV multiphoton imaging

Yongxiao Li, Yean J Lim, Qiongkai Xu, Lynette Beattie, Elizabeth E Gardiner, Katharina Gaus, William R Heath, Woei Ming Lee

Journal article  |  2020  |  BIOMEDICAL OPTICS EXPRESS

Removal of complex aberrations at millisecond time scales over millimeters in distance in multiphoton laser scanning microscopy li..

Raster Adaptive Optics for Video Rate Laser Scanning Microscopy with Large Field of View Correction

Yongxiao Li, Yean J Lim, Qiongkai Xu, Lynette Beattie, Elizabeth E Gardiner, Katharina Gaus, William R Heath, Woei Ming Lee

Conference Proceedings  |  2020  |  2020 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO)

We propose a raster scanning adaptive optics method that uses digital image segmentation and a low-resolution deformable mirror wi..

Raster adaptive optics for video rate laser scanning microscopy with large field of view correction

Y Li, YJ Lim, Q Xu, L Beattie, EE Gardiner, K Gaus, WR Heath, WM Lee

Conference Proceedings  |  2020  |  Optics InfoBase Conference Papers

We propose a raster scanning adaptive optics method that uses digital image segmentation and a low-resolution deformable mirror wi..

Macrophage Transactivation for chemokine Production identified as a negative regulator of granulomatous inflammation Using agent-Based Modeling

Daniel Moyo, Lynette Beattie, Paul S Andrews, John WJ Moore, Jon Timmis, Amy Sawtell, Stefan Hoehme, Adam T Sampson, Paul M Kaye

Journal article  |  2018  |  FRONTIERS IN IMMUNOLOGY

Cellular activation in trans by interferons, cytokines, and chemokines is a commonly recognized mechanism to amplify immune effect..