Lynette Beattie

A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver T-RM Cell-Mediated Immunity against Malaria in Mice

Ana Maria Valencia-Hernandez, Wei Yi Ng, Nazanin Ghazanfari, Sonia Ghilas, Maria N de Menezes, Lauren E Holz, Cheng Huang, Kieran English, Myo Naung, Peck Szee Tan, Kirsteen M Tullett, Thiago M Steiner, Matthias H Enders, Lynette Beattie, Yu Cheng Chua, Claerwen M Jones, Anton Cozijnsen, Vanessa Mollard, Yeping Cai, David G Bowen, et al.

Journal article  |  2020  |  Cell Host & Microbe

Liver-resident memory CD8+ T (TRM) cells remain in and constantly patrol the liver to elicit rapid immunity upon antigen encounter..

Glycolipid-peptide vaccination induces liver-resident memory CD8( ) T cells that protect against rodent malaria

Lauren E Holz, Yu Cheng Chua, Maria N de Menezes, Regan J Anderson, Sarah L Draper, Benjamin J Compton, Susanna TS Chan, Juby Mathew, Jasmine Li, Lukasz Kedzierski, Zhongfang Wang, Lynette Beattie, Matthias H Enders, Sonia Ghilas, Rose May, Thiago M Steiner, Joshua Lange, Daniel Fernandez-Ruiz, Ana Maria Valencia-Hernandez, Taryn L Osmond, et al.

Journal article  |  2020  |  Science Immunology

Liver resident-memory CD8+ T cells (TRM cells) can kill liver-stage Plasmodium-infected cells and prevent malaria, but simple vacc..

Raster adaptive optics for video rate aberration correction and large FOV multiphoton imaging

Yongxiao Li, Yean J Lim, Qiongkai Xu, Lynette Beattie, Elizabeth E Gardiner, Katharina Gaus, William R Heath, Woei Ming Lee

Journal article  |  2020  |  Biomedical Optics Express

Macrophage Transactivation for chemokine Production identified as a negative regulator of granulomatous inflammation Using agent-Based Modeling

Daniel Moyo, Lynette Beattie, Paul S Andrews, John WJ Moore, Jon Timmis, Amy Sawtell, Stefan Hoehme, Adam T Sampson, Paul M Kaye

Journal article  |  2018  |  Frontiers in Immunology

Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection

Susanna S Ng, Fernando Souza-Fonseca-Guimaraes, Fabian de Labastida Rivera, Fiona H Amante, Rajiv Kumar, Yulong Gao, Meru Sheel, Lynette Beattie, Marcela Montes de Oca, Camille Guillerey, Chelsea L Edwards, Rebecca J Faleiro, Teija Frame, Patrick T Bunn, Eric Vivier, Dale I Godfrey, Daniel G Pellicci, J Alejandro Lopez, Katherine T Andrews, Nicholas D Huntington, et al.

Journal article  |  2018  |  Clinical & Translational Immunology

A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment

Frederic Sierro, Maximilien Evrard, Simone Rizzetto, Michelle Melino, Andrew J Mitchell, Manuela Florido, Lynette Beattie, Shaun B Walters, Szun Szun Tay, Bo Lu, Lauren E Holz, Ben Roediger, Yik Chun Wong, Alessandra Warren, William Ritchie, Claire McGuffog, Wolfgang Weninger, David G Le Couteur, Florent Ginhoux, Warwick J Britton, et al.

Journal article  |  2017  |  Immunity

In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice

Raymond Reif, Ahmed Ghallab, Lynette Beattie, Georgia Guenther, Lars Kuepfer, Paul M Kaye, Jan G Hengstler

Journal article  |  2017  |  Archives of Toxicology

We describe a two-photon microscopy-based method to evaluate the in vivo systemic transport of compounds. This method comprises im..

IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection

Ismail Sebina, Kylie R James, Megan SF Soon, Lily G Fogg, Shannon E Best, Fabian de Labastida Rivera, Marcela Montes de Oca, Fiona H Amante, Bryce S Thomas, Lynette Beattie, Fernando Souza-Fonseca-Guimaraes, Mark J Smyth, Paul J Hertzog, Geoffrey R Hill, Andreas Hutloff, Christian R Engwerda, Ashraful Haque

Journal article  |  2016  |  PLOS Pathogens

Parasite-specific antibodies protect against blood-stage Plasmodium infection. However, in malaria-endemic regions, it takes many ..

Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection

Marcela Montes de Oca, Rajiv Kumar, Fabian de Labastida Rivera, Fiona H Amante, Meru Sheel, Rebecca J Faleiro, Patrick T Bunn, Shannon E Best, Lynette Beattie, Susanna S Ng, Chelsea L Edwards, Glen M Boyle, Ric N Price, Nicholas M Anstey, Jessica R Loughland, Julie Burel, Denise L Doolan, Ashraful Haque, James S McCarthy, Christian R Engwerda

Journal article  |  2016  |  Cell Reports

The development of immunoregulatory networks is important to prevent disease. However, these same networks allow pathogens to pers..

Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions

Lynette Beattie, Amy Sawtell, Jason Mann, Teija CM Frame, Bianca Teal, Fabian de Labastida Rivera, Najmeeyah Brown, Katherine Walwyn-Brown, John WJ Moore, Sandy MacDonald, Eng-Kiat Lim, Jane E Dalton, Christian R Engwerda, Kelli P MacDonald, Paul M Kaye

Journal article  |  2016  |  Journal of Hepatology

BACKGROUND & AIMS: Kupffer cells (KCs), the resident tissue macrophages of the liver, play a crucial role in the clearance of path..

CD4( ) Recent Thymic Emigrants Are Recruited into Granulomas during Leishmania donovani Infection but Have Limited Capacity for Cytokine Production

John WJ Moore, Lynette Beattie, Mohamed Osman, Benjamin MJ Owens, Najmeeyah Brown, Jane E Dalton, Asher Maroof, Paul M Kaye

Journal article  |  2016  |  PLOS ONE

Lessons from other diseases: granulomatous inflammation in leishmaniasis

Paul M Kaye, Lynette Beattie

Journal article  |  2016  |  Seminars in Immunopathology

The Leishmania granuloma shares some, though not all, properties with that formed following mycobacterial infection. As a simplifi..

Spatiotemporal Characterization of the Cellular and Molecular Contributors to Liver Fibrosis in a Murine Hepatotoxic-Injury Model

Michelle Melino, Victoria L Gadd, Kylie A Alexander, Lynette Beattie, Katie E Lineburg, Michelle Martinez, Bianca Teal, Laetitia Le Texier, Katharine M Irvine, Gregory C Miller, Glen M Boyle, Geoffrey R Hill, Andrew D Clouston, Elizabeth E Powel, Kelli PA MacDonald

Journal article  |  2016  |  The American Journal of Pathology

The interplay between the inflammatory infiltrate and tissue resident cell populations invokes fibrogenesis. However, the temporal..

Combined Immune Therapy for the Treatment of Visceral Leishmaniasis

Rebecca J Faleiro, Rajiv Kumar, Patrick T Bunn, Neetu Singh, Shashi Bhushan Chauhan, Meru Sheel, Fiona H Amante, Marcela Montes de Oca, Chelsea L Edwards, Susanna S Ng, Shannon E Best, Ashraful Haque, Lynette Beattie, Louise M Hafner, David Sacks, Susanne Nylen, Shyam Sundar, Christian R Engwerda

Journal article  |  2016  |  PLOS Neglected Tropical Diseases

Chronic disease caused by infections, cancer or autoimmunity can result in profound immune suppression. Immunoregulatory networks ..

Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology

Marcela Montes de Oca, Rajiv Kumar, Fabian de labastida Rivera, Fiona H Amante, Meru Sheel, Rebecca J Faleiro, Patrick T Bunn, Shannon E Best, Lynette Beattie, Susanna S Ng, Chelsea L Edwards, Werner Muller, Erika Cretney, Stephen L Nutt, Mark J Smyth, Ashraful Haque, Geoffrey R Hill, Shyam Sundar, Axel Kallies, Christian R Engwerda

Journal article  |  2016  |  PLOS Pathogens

IL-17A-Producing gamma delta T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver

Meru Sheel, Lynette Beattie, Teija CM Frame, Fabian de Labastida Rivera, Rebecca J Faleiro, Patrick T Bunn, Marcela Montes de Oca, Chelsea L Edwards, Susanna S Ng, Rajiv Kumar, Fiona H Amante, Shannon E Best, Shaun R McColl, Antiopi Varelias, Rachel D Kuns, Kelli PA MacDonald, Mark J Smyth, Ashraful Haque, Geoff R Hill, Christian R Engwerda

Journal article  |  2015  |  The Journal of Immunology

Intracellular infections, such as those caused by the protozoan parasite Leishmania donovani, a causative agent of visceral leishm..

Bile canalicular dynamics in hepatocyte sandwich cultures

Raymond Reif, Johan Karlsson, Georgia Guenther, Lynette Beattie, David Wrangborg, Seddik Hammad, Brigitte Begher-Tibbe, Amruta Vartak, Simone Melega, Paul M Kaye, Jan G Hengstler, Mats Jirstrand

Journal article  |  2015  |  Archives of Toxicology

Many substances are hepatotoxic due to their ability to cause intrahepatic cholestasis. Therefore, there is a high demand for in v..

The Neurotrophic Receptor Ntrk2 Directs Lymphoid Tissue Neovascularization during Leishmania donovani Infection

Jane E Dalton, Amy C Glover, Laura Hoodless, Eng-Kiat Lim, Lynette Beattie, Alun Kirby, Paul M Kaye

Journal article  |  2015  |  PLOS Pathogens

The neurotrophic tyrosine kinase receptor type 2 (Ntrk2, also known as TrkB) and its ligands brain derived neurotrophic factor (Bd..

A Petri Net Model of Granulomatous Inflammation: Implications for IL-10 Mediated Control of Leishmania donovani Infection

Luca Albergante, Jon Timmis, Lynette Beattie, Paul M Kaye

Journal article  |  2013  |  PLoS Computational Biology

Experimental visceral leishmaniasis, caused by infection of mice with the protozoan parasite Leishmania donovani, is characterized..

A Transcriptomic Network Identified in Uninfected Macrophages Responding to Inflammation Controls Intracellular Pathogen Survival

Lynette Beattie, Micely d'El-Rei Hermida, John WJ Moore, Asher Maroof, Najmeeyah Brown, Dimitris Lagos, Paul M Kaye

Journal article  |  2013  |  Cell Host & Microbe

Intracellular pathogens modulate host cell function to promote their survival. However, in vitro infection studies do not account ..

Functional complexity of the Leishmania granuloma and the potential of in silico modeling

John WJ Moore, Daniel Moyo, Lynette Beattie, Paul S Andrews, Jon Timmis, Paul M Kaye

Journal article  |  2013  |  Frontiers in Immunology

IL-10-Producing Th1 Cells and Disease Progression Are Regulated by Distinct CD11c( ) Cell Populations during Visceral Leishmaniasis

Benjamin MJ Owens, Lynette Beattie, John WJ Moore, Najmeeyah Brown, Jason L Mann, Jane E Dalton, Asher Maroof, Paul M Kaye

Journal article  |  2012  |  PLoS Pathogens

IL-10 is a critical regulatory cytokine involved in the pathogenesis of visceral leishmaniasis caused by Leishmania donovani and c..

B Cell: T Cell Interactions Occur within Hepatic Granulomas during Experimental Visceral Leishmaniasis

John WJ Moore, Lynette Beattie, Jane E Dalton, Benjamin MJ Owens, Asher Maroof, Mark C Coles, Paul M Kaye

Journal article  |  2012  |  PLoS ONE

Hepatic resistance to Leishmania donovani infection in mice is associated with the development of granulomas, in which a variety o..

Leishmania-host interactions: what has imaging taught us?

Lynette Beattie, Paul M Kaye

Journal article  |  2011  |  Cellular Microbiology

Leishmania parasites are well adapted to initiate infection, resist the onslaught of innate immunity and achieve a state of long-l..

Compartment-Specific Remodeling of Splenic Micro-Architecture during Experimental Visceral Leishmaniasis

Pinar Yurdakul, Jane Dalton, Lynette Beattie, Nlajmeeyah Brown, Sibel Erguven, Asher Maroof, Paul M Kaye

Journal article  |  2011  |  The American Journal of Pathology

Progressive splenomegaly is a hallmark of visceral leishmaniasis in humans, canids, and rodents. In experimental murine visceral l..

Interferon Regulatory Factor 7 Contributes to the Control of Leishmania donovani in the Mouse Liver

Lynette Beattie, Rebecca Phillips, Najmeeyah Brown, Benjamin MJ Owens, Neal Chauhan, Jane E Dalton, Paul M Kaye

Journal article  |  2011  |  Infection and Immunity

Optimal hepatic resistance to Leishmania donovani in mice requires the coordinated effort of a variety of leukocyte populations th..

Inhibition of receptor tyrosine kinases restores immunocompetence and improves immune-dependent chemotherapy against experimental leishmaniasis in mice

Jane E Dalton, Asher Maroof, Benjamin MJ Owens, Priyanka Narang, Katherine Johnson, Najmeeyah Brown, Lovisa Rosenquist, Lynette Beattie, Mark Coles, Paul M Kaye

Journal article  |  2010  |  Journal of Clinical Investigation

Receptor tyrosine kinases are involved in multiple cellular processes, and drugs that inhibit their action are used in the clinic ..

Dynamic Imaging of Experimental Leishmania donovani-Induced Hepatic Granulomas Detects Kupffer Cell-Restricted Antigen Presentation to Antigen-Specific CD8( ) T Cells

Lynette Beattie, Adam Peltan, Asher Maroof, Alun Kirby, Najmeeyah Brown, Mark Coles, Deborah F Smith, Paul M Kaye

Journal article  |  2010  |  PLoS Pathogens

Kupffer cells (KCs) represent the major phagocytic population within the liver and provide an intracellular niche for the survival..

Innate Killing of Leishmania donovani by Macrophages of the Splenic Marginal Zone Requires IRF-7

Rebecca Phillips, Mattias Svensson, Naveed Aziz, Asher Maroof, Najmeeyah Brown, Lynette Beattie, Nathalie Signoret, Paul M Kaye

Journal article  |  2010  |  PLoS Pathogens

Highly phagocytic macrophages line the marginal zone (MZ) of the spleen and the lymph node subcapsular sinus. Although these macro..

Leishmania donovani-induced expression of signal regulatory protein alpha on Kupffer cells enhances hepatic invariant NKT-cell activation

Lynette Beattie, Mattias Svensson, Alison Bune, Najmeeyah Brown, Asher Maroof, Soombul Zubairi, Katharine R Smith, Paul M Kaye

Journal article  |  2010  |  European Journal of Immunology

Signal regulatory protein alpha (SIRPalpha) and its cognate ligand CD47 have been documented to have a broad range of cellular fun..

A Petri Net Model of Granulomatous Inflammation

Luca Albergante, Jon Timmis, Paul Andrews, Lynette Beattie, Paul M Kaye

Conference Proceedings  |  2010  |  Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

Dendritic Cells Matured by Inflammation Induce CD86-Dependent Priming of Naive CD8( ) T Cells in the Absence of Their Cognate Peptide Antigen

Asher Maroof, Lynette Beattie, Alun Kirby, Mark Coles, Paul M Kaye

Journal article  |  2009  |  The Journal of Immunology

Dendritic cells (DC) licensed by the interaction between pathogen products and pattern recognition receptors can activate naive T ..

SIGNR1-Negative Red Pulp Macrophages Protect against Acute Streptococcal Sepsis after Leishmania donovani-Induced Loss of Marginal Zone Macrophages

Alun C Kirby, Lynette Beattie, Asher Maroof, Nico van Rooijen, Paul M Kaye

Journal article  |  2009  |  The American Journal of Pathology

Marginal zone macrophages in the murine spleen play an important role in the capture of blood-borne pathogens and are viewed as an..

Posttranscriptional regulation of Il10 gene expression allows natural killer cells to express immunoregulatory function

Asher Maroof, Lynette Beattie, Soombul Zubairi, Mattias Svensson, Simona Stager, Paul M Kaye

Journal article  |  2008  |  Immunity

Natural killer (NK) cells play a well-recognized role in early pathogen containment and in shaping acquired cell-mediated immunity..

Transgenic Leishmania and the immune response to infection

L Beattie, KJ Evans, PM Kaye, DF Smith

Journal article  |  2008  |  Parasite Immunology

Genetic manipulation of single-celled organisms such as the Leishmania parasite enables in depth analysis of the consequences of g..

Plasmodium strain determines dendritic cell function essential for survival from malaria

Michelle N Wykes, Xue Q Liu, Lynette Beattie, Danielle I Stanisic, Katryn J Stacey, Mark J Smyth, Ranjeny Thomas, Michael F Good

Journal article  |  2007  |  PLoS Pathogens

The severity of malaria can range from asymptomatic to lethal infections involving severe anaemia and cerebral disease. However, t..

CD8( ) T lymphocyte-mediated loss of marginal metallophilic macrophages following infection with Plasmodium chabaudi chabaudi AS

Beattie Lynette, Christian R Engwerda, Michelle Wykes, Michael F Good

Journal article  |  2006  |  The Journal of Immunology

The splenic architecture is essential for the quick resolution of a primary infection with Plasmodium. A critical component of thi..

Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria

KT Andrews, DP Fairlie, PK Madala, J Ray, DM Wyatt, PM Hilton, LA Melville, L Beattie, DL Gardiner, RC Reid, MJ Stoermer, T Skinner-Adams, C Berry, JS McCarthy

Journal article  |  2006  |  Antimicrobial Agents and Chemotherapy

Parasite resistance to antimalarial drugs is a serious threat to human health, and novel agents that act on enzymes essential for ..

The importance of the spleen in malaria

CR Engwerda, L Beattie, FH Amante

Journal article  |  2005  |  Trends in Parasitology

There are several malaria vaccine candidates at various stages of development. Many of these target blood stages of Plasmodium fal..

Dendritic cells and follicular dendritic cells express a novel ligand for CD38 which influences their maturation and antibody responses

MN Wykes, L Beattie, GG Macpherson, DN Hart

Journal article  |  2004  |  Immunology

CD38 is a cell surface molecule with ADP-ribosyl cyclase activity, which is predominantly expressed on lymphoid and myeloid cells...