Timothy Jackson

Mutual enlightenment: A toolbox of concepts and methods for integrating evolutionary and clinical toxinology via snake venomics and the contextual stance.

Juan J Calvete, Bruno Lomonte, Anthony J Saviola, Fabián Bonilla, Mahmood Sasa, David J Williams, Eivind AB Undheim, Kartik Sunagar, Timothy NW Jackson

Journal article  |  2021  |  Toxicon X

Snakebite envenoming is a neglected tropical disease that may claim over 100,000 human lives annually worldwide. Snakebite occurs ..

How the Toxin got its Toxicity

Timothy NW Jackson, Ivan Koludarov

Journal article  |  2020  |  FRONTIERS IN PHARMACOLOGY

Venom systems are functional and ecological traits, typically used by one organism to subdue or deter another. A predominant subse..

Causes and Consequences of Snake Venom Variation

Nicholas R Casewell, Timothy NW Jackson, Andreas H Laustsen, Kartik Sunagar

Journal article  |  2020  |  TRENDS IN PHARMACOLOGICAL SCIENCES

Snake venoms are mixtures of toxins that vary extensively between and within snake species. This variability has serious consequen..

Functional venomics of the Big-4 snakes of Pakistan

Syeda U Hashmi, Areej Alvi, Iqra Munir, Mehvish Perveen, Amaila Fazal, Timothy NW Jackson, Syed A Ali

Journal article  |  2020  |  TOXICON

In South Asia, the "Big-4" venomous snakes Naja naja, Bungarus caeruleus, Daboia russelii, and Echis carinatus are so-called becau..

Snake Venom in Context: Neglected Clades and Concepts

Timothy NW Jackson, Hadrian Jouanne, Nicolas Vidal

Journal article  |  2019  |  FRONTIERS IN ECOLOGY AND EVOLUTION

Despite the fact that venom is an intrinsically ecological trait, the ecological perspective has been widely neglected in toxinolo..

Coagulotoxic effects by brown snake (Pseudonaja) and taipan (Oxyuranus) venoms, and the efficacy of a new antivenom

Christina N Zdenek, Chris Hay, Kevin Arbuckle, Timothy NW Jackson, Mettine HA Bos, Bianca op den Brouw, Jordan Debono, Luke Allen, Nathan Dunstan, Terry Morley, Maria Herrera, Jose M Gutierrez, David J Williams, Bryan G Fry

Journal article  |  2019  |  TOXICOLOGY IN VITRO

Snakebite is a neglected tropical disease that disproportionately affects the poor. Antivenom is the only specific and effective t..

Rattling the border wall: Pathophysiological implications of functional and proteomic venom variation between Mexican and US subspecies of the desert rattlesnake Crotalus scutulatus

James Dobson, Daryl C Yang, Bianca op den Brouw, Chip Cochran, Huynh Tam, Sanjaya Kurrupu, Elda E Sanchez, Daniel J Massey, Kate Baumann, Timothy NW Jackson, Amanda Nouwens, Peter Josh, Edgar Neri-Castro, Alejandro Alagon, Wayne C Hodgson, Bryan G Fry

Journal article  |  2018  |  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

While some US populations of the Mohave rattlesnake (Crotalus scutulatus scutulatus) are infamous for being potently neurotoxic, t..

Proteomic and functional variation within black snake venoms (Elapidae: Pseudechis)

Jonathan Goldenberg, Vittoria Cipriani, Timothy NW Jackson, Kevin Arbuckle, Jordan Debono, Daniel Dashevsky, Nadya Panagides, Maria P Ikonomopoulou, Ivan Koludarov, Bin Li, Renan Castro Santana, Amanda Nouwens, Alun Jones, Chris Hay, Nathan Dunstan, Luke Allen, Brian Bush, John J Miles, Lilin Ge, Hang Fai Kwok, et al.

Journal article  |  2018  |  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Pseudechis (black snakes) is an Australasian elapid snake genus that inhabits much of mainland Australia, with two representatives..

Catch a tiger snake by its tail: Differential toxicity, co-factor dependence and antivenom efficacy in a procoagulant clade of Australian venomous snakes

Callum Lister, Kevin Arbuckle, Timothy NW Jackson, Jordan Debono, Christina N Zdenek, Daniel Dashevsky, Nathan Dunstan, Luke Allen, Chris Hay, Brian Bush, Amber Gillett, Bryan G Fry

Journal article  |  2017  |  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

A paradigm of venom research is adaptive evolution of toxins as part of a predator-prey chemical arms race. This study examined di..

Enter the Dragon: The Dynamic and Multifunctional Evolution of Anguimorpha Lizard Venoms

Ivan Koludarov, Timothy NW Jackson, Bianca op den Brouw, James Dobson, Daniel Dashevsky, Kevin Arbuckle, Christofer J Clemente, Edward J Stockdale, Chip Cochran, Jordan Debono, Carson Stephens, Nadya Panagides, Bin Li, Mary-Louise Roy Manchadi, Aude Violette, Rudy Fourmy, Iwan Hendrikx, Amanda Nouwens, Judith Clements, Paolo Martelli, et al.

Journal article  |  2017  |  TOXINS

While snake venoms have been the subject of intense study, comparatively little work has been done on lizard venoms. In this study..