Audrey Chan

STAT3 Hyperactivation Due to SOCS3 Deletion in Murine Osteocytes Accentuates Responses to Exercise- and Load-Induced Bone Formation

Narelle E McGregor, Emma C Walker, Audrey SM Chan, Ingrid J Poulton, Ellie H-J Cho, Sara H Windahl, Natalie A Sims

Journal article  |  2021  |  JOURNAL OF BONE AND MINERAL RESEARCH

Cortical bone develops and changes in response to mechanical load, which is sensed by bone-embedded osteocytes. The bone formation..

Investigating the Potential for Sulforaphane to Attenuate Gastrointestinal Dysfunction in mdx Dystrophic Mice

Kristy Swiderski, Suzannah J Read, Audrey S Chan, Jin D Chung, Jennifer Trieu, Timur Naim, Rene Koopman, Gordon S Lynch

Journal article  |  2021  |  NUTRIENTS

Gastrointestinal (GI) dysfunction is an important, yet understudied condition associated with Duchenne muscular dystrophy (DMD), w..

Comprehensive characterization of single-cell full-length isoforms in human and mouse with long-read sequencing

Luyi Tian, Jafar S Jabbari, Rachel Thijssen, Quentin Gouil, Shanika L Amarasinghe, Oliver Voogd, Hasaru Kariyawasam, Mei RM Du, Jakob Schuster, Changqing Wang, Shian Su, Xueyi Dong, Charity W Law, Alexis Lucattini, Yair David Joseph Prawer, Coralina Collar-Fernandez, Jin D Chung, Timur Naim, Audrey Chan, Chi Hai Ly, et al.

Journal article  |  2021  |  GENOME BIOLOGY

A modified Chromium 10x droplet-based protocol that subsamples cells for both short-read and long-read (nanopore) sequencing toget..

Dystrophin deficiency disrupts muscle clock expression and mitochondrial quality control in mdx mice

Justin P Hardee, Marissa K Caldow, Audrey SM Chan, Stuart K Plenderleith, Jennifer Trieu, Rene Koopman, Gordon S Lynch

Journal article  |  2021  |  AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Impaired oxidative capacity and mitochondrial function contribute to the dystrophic pathology in muscles of patients with Duchenne..

Bone Geometry Is Altered by Follistatin-Induced Muscle Growth in Young Adult Male Mice

Audrey SM Chan, Narelle E McGregor, Ingrid J Poulton, Justin P Hardee, Ellie H-J Cho, T John Martin, Paul Gregorevic, Natalie A Sims, Gordon S Lynch

Journal article  |  2021  |  JBMR PLUS

The development of the musculoskeletal system and its maintenance depends on the reciprocal relationship between muscle and bone. ..

Measuring Bone Volume at Multiple Densities by Micro-computed Tomography

Emma C Walker, Narelle E McGregor, Audrey SM Chan, Natalie A Sims

Journal article  |  2021  |  BIO-PROTOCOL

Bone strength is controlled by both bone mass, and the organization and quality of the bone material. The current standard method ..

Brief exposure to full length parathyroid hormone-related protein (PTHrP) causes persistent generation of cyclic AMP through an endocytosis-dependent mechanism

Patricia WM Ho, Audrey S Chan, Nathan J Pavlos, Natalie A Sims, T John Martin

Journal article  |  2019  |  BIOCHEMICAL PHARMACOLOGY

Parathyroid hormone (PTH)-related protein (PTHrP) (gene name Pthlh) was discovered as the factor responsible for the humoral hyper..

Parathyroid Hormone-Related Protein Negatively Regulates Tumor Cell Dormancy Genes in a PTHR1/Cyclic AMP-Independent Manner

Rachelle W Johnson, Yao Sun, Patricia WM Ho, Audrey SM Chan, Jasmine A Johnson, Nathan J Pavlos, Natalie A Sims, T John Martin

Journal article  |  2018  |  FRONTIERS IN ENDOCRINOLOGY

Parathyroid hormone-related protein (PTHrP) expression in breast cancer is enriched in bone metastases compared to primary tumors...

A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex

Thomas Clairfeuille, Caroline Mas, Audrey SM Chan, Zhe Yang, Maria Tello-Lafoz, Mintu Chandra, Jocelyn Widagdo, Markus C Kerr, Blessy Paul, Isabel Merida, Rohan D Teasdale, Nathan J Pavlos, Victor Anggono, Brett M Collins

Journal article  |  2016  |  NATURE STRUCTURAL & MOLECULAR BIOLOGY

Recycling of internalized receptors from endosomal compartments is essential for the receptors' cell-surface homeostasis. Sorting ..

Mutations of Vasopressin Receptor 2 Including Novel L312S Have Differential Effects on Trafficking

Anatoly Tiulpakov, Carl W White, Rekhati S Abhayawardana, Heng B See, Audrey S Chan, Ruth M Seeber, Julian I Heng, Ivan Dedov, Nathan J Pavlos, Kevin DG Pfleger

Journal article  |  2016  |  MOLECULAR ENDOCRINOLOGY

Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a genetic disease first described in 2 unrelated male infants with s..