Kathleen Pishas

Chromatin profiling reveals relocalization of lysine-specific demethylase 1 by an oncogenic fusion protein.

Emily R Theisen, Julia Selich-Anderson, Kyle R Miller, Jason M Tanner, Cenny Taslim, Kathleen I Pishas, Sunil Sharma, Stephen L Lessnick

Journal article  |  2021  |  Epigenetics

Paediatric cancers commonly harbour quiet mutational landscapes and are instead characterized by single driver events such as the ..

The development of drug resistance through reversion mutation in BRCA genes in ovarian cancer

Elizabeth L Christie, Alison E Freimund, Sian Fereday, Kathryn Alsop, Therese Hoang, Kathleen Pishas, George Au-Yeung, Michael Friedlander, David D Bowtell

Book Chapter  |  2021

Spatial characterization of drug resistance in ovarian cancer.

Kathleen I Pishas, Elizabeth L Christie, Jessica A Beach, Kathryn Alsop, Alison Freimund, Nidhi Vashistha, Niyati Jhaveri, Emerald Doolittle, Wei Wei, Bingqing Zhang, Xiao-Jun Ma, David DL Bowtell

Conference Proceedings  |  2020  |  Poster Presentations - Proffered Abstracts

Mutant p53 upregulates alpha-1 antitrypsin expression and promotes invasion in lung cancer

R Shakya, GA Tarulli, L Sheng, NA Lokman, C Ricciardelli, KI Pishas, CI Selinger, MRJ Kohonen-Corish, WA Cooper, AG Turner, PM Neilsen, DF Callen

Journal article  |  2017  |  Oncogene

Missense mutations in the TP53 tumor-suppressor gene inactivate its antitumorigenic properties and endow the incipient cells with ..

Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Kathleen I Pishas, Susan J Neuhaus, Mark T Clayer, Andreas W Schreiber, David M Lawrence, Michelle Perugini, Robert J Whitfield, Gelareh Farshid, Jim Manavis, Steve Chryssidis, Bronwen J Mayo, Rebecca C Haycox, Kristen Ho, Michael P Brown, Richard J D'Andrea, Andreas Evdokiou, David M Thomas, Jayesh Desai, David F Callen, Paul M Neilsen

Journal article  |  2014  |  Cancer Research

Nutlin-3a is a small-molecule antagonist of p53/MDM2 that is being explored as a treatment for sarcoma. In this study, we examined..

Targeting the p53 Pathway in Ewing Sarcoma.

Paul M Neilsen, Kathleen I Pishas, David F Callen, David M Thomas

Journal article  |  2011  |  Sarcoma

The p53 tumour suppressor plays a pivotal role in the prevention of oncogenic transformation. Cancers frequently evade the potent ..