Lucy Li

Microbe-Metabolite Associations Linked to the Rebounding Murine Gut Microbiome Postcolonization with Vancomycin-Resistant Enterococcus faecium

Andre Mu, Glen P Carter, Lucy Li, Nicole S Isles, Alison F Vrbanac, James T Morton, Alan K Jarmusch, David P De Souza, Vinod K Narayana, Komal Kanojia, Brunda Nijagal, Malcolm J McConville, Rob Knight, Benjamin P Howden, Timothy P Stinear

Journal article  |  2020  |  mSystems

Vancomycin-resistant Enterococcus faecium (VREfm) is an emerging antibiotic-resistant pathogen. Strain-level investigations are be..

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

Mark F van Delft, Stephane Chappaz, Yelena Khakham, T Bui Chinh, Marlyse A Debrincat, Kym N Lowes, Jason M Brouwer, Christoph Grohmann, Phillip P Sharp, Laura F Dagley, Lucy Li, Kate McArthur, Meng-Xiao Luo, Hui San Chin, W Douglas Fairlie, Erinna F Lee, David Segal, Stephane Duflocq, Romina Lessene, Sabrina Bernard, et al.

Journal article  |  2019  |  Nature Chemical Biology

Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contr..

Unstable chromosome rearrangements in Staphylococcus aureus cause phenotype switching associated with persistent infections

Romain Guerillot, Xenia Kostoulias, Liam Donovan, Lucy Li, Glen P Carter, Abderrahman Hachani, Koen Vandelannoote, Stefano Giulieri, Ian R Monk, Mayu Kunimoto, Lora Starrs, Gaetan Burgio, Torsten Seemann, Anton Y Peleg, Timothy P Stinear, Benjamin P Howden

Journal article  |  2019  |  Proceedings of the National Academy of Sciences of USA

Comprehensive antibiotic-linked mutation assessment by resistance mutation sequencing (RM-seq)

Romain Guerillot, Lucy Li, Sarah Baines, Brian Howden, Mark B Schultz, Torsten Seemann, Ian Monk, Sacha J Pidot, Wei Gao, Stefano Giulieri, Anders Goncalves da Silva, Anthony D'Agata, Takehiro Tomita, Anton Y Peleg, Timothy P Stinear, Benjamin P Howden

Journal article  |  2018  |  GENOME MEDICINE

1,2,4-Oxadiazole antimicrobials act synergistically with daptomycin and display rapid kill kinetics against MDR Enterococcus faecium

Glen P Carter, Jitendra R Harjani, Lucy Li, Noel P Pitcher, Yi Nong, Thomas V Riley, Deborah A Williamson, Timothy P Stinear, Jonathan B Baell, Benjamin P Howden

Journal article  |  2018  |  Journal of Antimicrobial Chemotherapy

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

Kate McArthur, Lachlan W Whitehead, John M Heddleston, Lucy Li, Benjamin S Padman, Viola Oorschot, Niall D Geoghegan, Stephane Chappaz, Sophia Davidson, Hui San Chin, Rachael M Lane, Marija Dramicanin, Tahnee L Saunders, Canny Sugiana, Romina Lessene, Laura D Osellame, Teng-Leong Chew, Grant Dewson, Michael Lazarou, Georg Ramm, et al.

Journal article  |  2018  |  Science

Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections

Glen P Carter, Anjana Chakravorty, Anh Pham Nguyen Tu, Steven Mileto, Fernanda Schreiber, Lucy Li, Pauline Howarth, Simon Clare, Bliss Cunningham, Susan P Sambol, Adam Cheknis, Iris Figueroa, Stuart Johnson, Dale Gerding, Julian I Rood, Gordon Dougan, Trevor D Lawley, Dena Lyras

Journal article  |  2015  |  mBio

Expression of the large clostridial toxins is controlled by conserved regulatory mechanisms

Glen P Carter, Sarah Larcombe, Lucy Li, Darshani Jayawardena, Milena M Awad, J Glenn Songer, Dena Lyras

Journal article  |  2014  |  International Journal of Medical Microbiology