Bianca Bernardo

Estrogen receptor alpha deficiency in cardiomyocytes reprograms the heart-derived extracellular vesicle proteome and induces obesity in female mice

Yow Keat Tham, Bianca C Bernardo, Bethany Claridge, Gunes S Yildiz, Liesel Min-Linn Woon, Simon Bond, Haoyun Fang, Jenny YY Ooi, Aya Matsumoto, Jieting Luo, Celeste MK Tai, Claudia A Harmawan, Helen Kiriazis, Daniel G Donner, Natalie A Mellett, E Dale Abel, Sohaib A Khan, David P De Souza, Sheik Nadeem Elahee Doomun, Kevin Liu, et al.

Journal article  |  2023  |  Nature Cardiovascular Research

Estrogen receptor a deficiency in cardiac myocytes reprograms heart-derived extracellular vesicle proteome and induces obesity in female mice

Yow Keat Tham, Bianca Bernardo, Bethany Claridge, Liesel Woon, Gunes Yildiz, Jenny Ooi, Aya Matsumoto, Jieting Luo, Celeste Tai, Claudia Harmawan, Helen Kiriazis, Daniel Donner, Natalie Mellett, Dale Abel, Sohaib Khan, Peter Meikle, Kate Weeks, David Greening, Julie McMullen

Journal article  |  2022  |  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

In Vivo Inhibition of miR-34a Modestly Limits Cardiac Enlargement and Fibrosis in a Mouse Model with Established Type 1 Diabetes-Induced Cardiomyopathy, but Does Not Improve Diastolic Function

Bianca C Bernardo, Gunes S Yildiz, Helen Kiriazis, Claudia A Harmawan, Celeste MK Tai, Rebecca H Ritchie, Julie R McMullen

Journal article  |  2022  |  CELLS

MicroRNA 34a (miR-34a) is elevated in the heart in a setting of cardiac stress or pathology, and we previously reported that inhib..

FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K

Kate L Weeks, Yow Keat Tham, Suzan G Yildiz, Yonali Alexander, Daniel G Donner, Helen Kiriazis, Claudia A Harmawan, Amy Hsu, Bianca C Bernardo, Aya Matsumoto, Ronald A DePinho, E Dale Abel, Elizabeth A Woodcock, Julie R McMullen

Journal article  |  2021  |  AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The insulin-like growth factor 1 receptor (IGF1R) and phosphoinositide 3-kinase p110α (PI3K) are critical regulators of exercise-i..

Old Drug, New Trick: Tilorone, a Broad-Spectrum Antiviral Drug as a Potential Anti-Fibrotic Therapeutic for the Diseased Heart

Duncan Horlock, David M Kaye, Catherine E Winbanks, Xiao-Ming Gao, Helen Kiriazis, Daniel G Donner, Paul Gregorevic, Julie R McMullen, Bianca C Bernardo

Journal article  |  2021  |  PHARMACEUTICALS

Cardiac fibrosis is associated with most forms of cardiovascular disease. No reliable therapies targeting cardiac fibrosis are ava..

Oestrogen Receptor α in the Heart is Critical for Protection Against Systemic Obesity in Female Mice

Y Tham, B Bernardo, L Woon, S Yildiz, C Tai, N Mellett, P Chen, P Meikle, E Abel, S Khan, K Weeks, J McMullen

Journal article  |  2021  |  Heart, Lung and Circulation

Generation and Characterisation of Novel PI3K-Based Gene Therapies for the Treatment of Heart Failure

S Bass-Stringer, D Donner, H Kiriazis, A Brown, P Gregorevic, C May, B Bernardo, C Thomas, K Weeks, J McMullen

Journal article  |  2021  |  Heart, Lung and Circulation

Translational Potential of Non-coding RNAs for Cardiovascular Disease

Jenny YY Ooi, Bianca C Bernardo

Journal article  |  2020  |  NON-CODING RNAS IN CARDIOVASCULAR DISEASES

Heart failure is the end result of a variety of cardiovascular disease states. Heart failure remains a challenge to treat, and the..

Noncoding RNAs regulating cardiac muscle mass

Glenn D Wadley, Severine Lamon, Sarah E Alexander, Julie R McMullen, Bianca C Bernardo

Journal article  |  2019  |  JOURNAL OF APPLIED PHYSIOLOGY

Noncoding RNAs, including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) play roles in the develo..

Investigating the Safety of Enhanced Cardiac Phosphoinositide 3-Kinase [PI3K (p110alpha)] as a Prospective Therapeutic Gene

S Bass-Stringer, L Bottrel, C Harmawan, S Yildiz, D Donner, H Kiriazis, K Weeks, C Thomas, B Bernardo, J McMullen

Journal article  |  2019  |  Heart, Lung and Circulation