Bianca Bernardo

Translational Potential of Non-coding RNAs for Cardiovascular Disease

Jenny YY Ooi, Bianca C Bernardo

Journal article  |  2020  |  Advances in experimental medicine and biology

Heart failure is the end result of a variety of cardiovascular disease states. Heart failure remains a challenge to treat, and the..

Noncoding RNAs regulating cardiac muscle mass

Glenn D Wadley, Severine Lamon, Sarah E Alexander, Julie R McMullen, Bianca C Bernardo

Journal article  |  2019  |  Journal of Applied Physiology

Non-coding RNAs, including miRNAs, lncRNAs and circRNAs play roles in the development and homeostasis of nearly every tissue of th..

Adeno-Associated Virus Gene Therapy: Translational Progress and Future Prospects in the Treatment of Heart Failure

Sebastian Bass-Stringer, Bianca C Bernardo, Clive N May, Colleen J Thomas, Kate L Weeks, Julie R McMullen

Journal article  |  2018  |  Heart, Lung and Circulation

Generation of MicroRNA-34 Sponges and Tough Decoys for the Heart: Developments and Challenges

Bianca C Bernardo, Paul Gregorevic, Rebecca H Ritchie, Julie R McMullen

Journal article  |  2018  |  Frontiers in Pharmacology

Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets

Yow Keat Tham, Bianca C Bernardo, Kevin Huynh, Jenny YY Ooi, Xiao Ming Gao, Helen Kiriazis, Corey Giles, Peter J Meikle, Julie R McMullen

Journal article  |  2018  |  Cell Reports

Gene delivery of medium chain acyl-coenzyme A dehydrogenase induces physiological cardiac hypertrophy and protects against pathological remodelling

Bianca C Bernardo, Kate L Weeks, Thawin Pongsukwechkul, Xiaoming Gao, Helen Kiriazis, Nelly Cemerlang, Esther JH Boey, Yow Keat Tham, Chad J Johnson, Hongwei Qian, Xiao-Jun Du, Paul Gregorevic, Julie R McMullen

Journal article  |  2018  |  Clinical Science

UNDERSTANDING KEY MECHANISMS OF EXERCISE-INDUCED CARDIAC PROTECTION TO MITIGATE DISEASE: CURRENT KNOWLEDGE AND EMERGING CONCEPTS

Bianca C Bernardo, Jenny YY Ooi, Kate L Weeks, Natalie L Patterson, Julie R McMullen

Journal article  |  2018  |  Physiological Reviews

Identification of miR-34 regulatory networks in settings of disease and antimiR-therapy: Implications for treating cardiac pathology and other diseases.

Jenny YY Ooi, Bianca C Bernardo, Saloni Singla, Natalie L Patterson, Ruby CY Lin, Julie R McMullen

Journal article  |  2017  |  RNA Biology

Expression of the miR-34 family (miR-34a, -34b, -34c) is elevated in settings of heart disease, and inhibition with antimiR-34a/an..

β-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55α-PP2A-Mediated Dephosphorylation.

Kate L Weeks, Antonella Ranieri, Agnieszka Karaś, Bianca C Bernardo, Alexandra S Ashcroft, Chris Molenaar, Julie R McMullen, Metin Avkiran

Journal article  |  2017  |  Journal of the American Heart Association

BACKGROUND: Class IIa histone deacetylase (HDAC) isoforms such as HDAC5 are critical signal-responsive repressors of maladaptive c..

The IGF1-PI3K-Akt Signaling Pathway in Mediating Exercise-Induced Cardiac Hypertrophy and Protection.

Kate L Weeks, Bianca C Bernardo, Jenny YY Ooi, Natalie L Patterson, Julie R McMullen

Book Chapter  |  2017  |  Advances in Experimental Medicine and Biology

Regular physical activity or exercise training can lead to heart enlargement known as cardiac hypertrophy. Cardiac hypertrophy is ..

Therapeutic silencing of miR-652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy

Bianca C Bernardo, Sally S Nguyen, Catherine E Winbanks, Xiao-Ming Gao, Esther JH Boey, Yow Keat Tham, Helen Kiriazis, Jenny YY Ooi, Enzo R Porrello, Sindhu Igoor, Colleen J Thomas, Paul Gregorevic, Ruby CY Lin, Xiao-Jun Du, Julie R McMullen

Journal article  |  2014  |  The FASEB Journal

Silencing of miR-34a Attenuates Cardiac Dysfunction in a Setting of Moderate, but Not Severe, Hypertrophic Cardiomyopathy

Bianca C Bernardo, Xiao-Ming Gao, Yow Keat Tham, Helen Kiriazis, Catherine E Winbanks, Jenny YY Ooi, Esther JH Boey, Susanna Obad, Sakari Kauppinen, Paul Gregorevic, Xiao-Jun Du, Ruby CY Lin, Julie R McMullen

Journal article  |  2014  |  PLOS ONE

Cartilage Intermediate Layer Protein 2 (CILP-2) Is Expressed in Articular and Meniscal Cartilage and Down-regulated in Experimental Osteoarthritis

Bianca C Bernardo, Daniele Belluoccio, Lynn Rowley, Christopher B Little, Uwe Hansen, John F Bateman

Journal article  |  2011  |  Journal of Biological Chemistry