Irene Gallego Romero

Denisovan introgression has shaped the immune system of present-day Papuans

Davide Maria Vespasiani, Guy Jacobs, Nicolas Brucato, Murray Cox, Irene Gallego Romero

Journal article  |  2020

Modern humans have substantially admixed with multiple archaic hominins. New Guineans, in particular, owe up to 5% of their genome..

Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal

Kevin X Lau, Elizabeth A Mason, Joshua Kie, David P De Souza, Joachim Kloehn, Dedreia Tull, Malcolm J McConville, Andrew Keniry, Tamara Beck, Marnie E Blewitt, Matthew E Ritchie, Shalin H Naik, Daniela Zalcenstein, Othmar Korn, Shian Su, Irene Gallego Romero, Catrina Spruce, Christopher L Baker, Tracy C McGarr, Christine A Wells, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

Archetypal human pluripotent stem cells (hPSC) are widely considered to be equivalent in developmental status to mouse epiblast st..

Genome-wide DNA methylation and gene expression patterns reflect genetic ancestry and environmental differences across the Indonesian archipelago.

Heini M Natri, Katalina S Bobowik, Pradiptajati Kusuma, Chelzie Crenna Darusallam, Guy S Jacobs, Georgi Hudjashov, J Stephen Lansing, Herawati Sudoyo, Nicholas E Banovich, Murray P Cox, Irene Gallego Romero

Journal article  |  2020  |  PLOS Genetics

Indonesia is the world's fourth most populous country, host to striking levels of human diversity, regional patterns of admixture,..

Ancestry-Specific Analyses Reveal Differential Demographic Histories and Opposite Selective Pressures in Modern South Asian Populations

Burak Yelmen, Mayukh Mondal, Davide Marnetto, Ajai K Pathak, Francesco Montinaro, Irene Gallego Romero, Toomas Kivisild, Mait Metspalu, Luca Pagani

Journal article  |  2019  |  Molecular Biology and Evolution

Genetic variation in contemporary South Asian populations follows a northwest to southeast decreasing cline of shared West Eurasia..

Genome-wide DNA methylation and gene expression patterns reflect genetic ancestry and environmental differences across the Indonesian archipelago

Heini Natri, Katalina Bobowik, Pradiptajati Kusuma, Chelzie Crenna Darusallam, Guy Jacobs, Georgi Hudjashov, Stephen Lansing, Herawati Sudoyo, Nicholas Banovich, Murray Cox, Irene Gallego Romero

Journal article  |  2019

Abstract Indonesia is the world’s fourth most populous country, host to striking levels of human diversity, regional patterns of a..

Widespread conservation of chromatin accessibility patterns and transcription factor binding in human and chimpanzee induced pluripotent stem cells

Irene Gallego Romero, Shyam Gopalakrishnan, Yoav Gilad

Journal article  |  2018

Abstract Changes in gene regulation have been shown to contribute to phenotypic differences between closely related species, most ..

Impact of regulatory variation across human iPSCs and differentiated cells

Nicholas E Banovich, Yang I Li, Anil Raj, Michelle C Ward, Peyton Greenside, Diego Calderon, Po Yuan Tung, Jonathan E Burnett, Marsha Myrthil, Samantha M Thomas, Courtney K Burrows, Irene Gallego Romero, Bryan J Pavlovic, Anshul Kundaje, Jonathan K Pritchard, Yoav Gilad

Journal article  |  2018  |  Genome Research

Induced pluripotent stem cells (iPSCs) are an essential tool for studying cellular differentiation and cell types that are otherwi..

Impact of regulatory variation across human iPSCs and differentiated cells

Nicholas Banovich, Yang Li, Anil Raj, Michelle Ward, Peyton Greenside, Diego Calderon, Po Yuan Tung, Jonathan Burnett, Marsha Myrthil, Samantha Thomas, Courtney Burrows, Irene Gallego Romero, Bryan Pavlovic, Anshul Kundaje, Jonathan Pritchard, Yoav Gilad

Journal article  |  2016

Abstract Induced pluripotent stem cells (iPSCs) are an essential tool for studying cellular differentiation and cell types that ar..

The Simons Genome Diversity Project: 300 genomes from 142 diverse populations

Swapan Mallick, Heng Li, Mark Lipson, Iain Mathieson, Melissa Gymrek, Fernando Racimo, Mengyao Zhao, Niru Chennagiri, Susanne Nordenfelt, Arti Tandon, Pontus Skoglund, Iosif Lazaridis, Sriram Sankararaman, Qiaomei Fu, Nadin Rohland, Gabriel Renaud, Yaniv Erlich, Thomas Willems, Carla Gallo, Jeffrey P Spence, et al.

Journal article  |  2016  |  Nature

Genetic Variation, Not Cell Type of Origin, Underlies the Majority of Identifiable Regulatory Differences in iPSCs

Courtney K Burrows, Nicholas E Banovich, Bryan J Pavlovic, Kristen Patterson, Irene Gallego Romero, Jonathan K Pritchard, Yoav Gilad

Journal article  |  2016  |  PLOS Genetics

Global diversity, population stratification, and selection of human copy-number variation

Peter H Sudmant, Swapan Mallick, Bradley J Nelson, Fereydoun Hormozdiari, Niklas Krumm, John Huddleston, Bradley P Coe, Carl Baker, Susanne Nordenfelt, Michael Bamshad, Lynn B Jorde, Olga L Posukh, Hovhannes Sahakyan, W Scott Watkins, Levon Yepiskoposyan, M Syafiq Abdullah, Claudio M Bravi, Cristian Capelli, Tor Hervig, Joseph TS Wee, et al.

Journal article  |  2015  |  Science

A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics

Irene Gallego Romero, Bryan J Pavlovic, Irene Hernando-Herraez, Xiang Zhou, Michelle C Ward, Nicholas E Banovich, Courtney L Kagan, Jonathan E Burnett, Constance H Huang, Amy Mitrano, Claudia I Chavarria, Inbar Friedrich Ben-Nun, Yingchun Li, Karen Sabatini, Trevor R Leonardo, Mana Parast, Tomas Marques-Bonet, Louise C Laurent, Jeanne F Loring, Yoav Gilad

Journal article  |  2015  |  eLife

A panel of induced pluripotent stem cells from chimpanzees: A resource for comparative functional genomics

IG Romero, BJ Pavlovic, I Hernando-Herraez, X Zhou, MC Ward, NE Banovich, CL Kagan, JE Burnett, CH Huang, A Mitrano, CI Chavarria, IF Ben-Nun, Y Li, K Sabatini, TR Leonardo, M Parast, T Marques-Bonet, LC Laurent, JF Loring, Y Gilad

Journal article  |  2015  |  eLife

Increased Risk of Genetic and Epigenetic Instability in Human Embryonic Stem Cells Associated with Specific Culture Conditions

Ibon Garitaonandia, Hadar Amir, Francesca Sesillo Boscolo, Gerald K Wambua, Heather L Schultheisz, Karen Sabatini, Robert Morey, Shannon Waltz, Yu-Chieh Wang, Ha Tran, Trevor R Leonardo, Kristopher Nazor, Ileana Slavin, Candace Lynch, Yingchun Li, Ronald Coleman, Irene Gallego Romero, Gulsah Altun, David Reynolds, Stephen Dalton, et al.

Journal article  |  2015  |  PLOS ONE

Ancient human genomes suggest three ancestral populations for present-day Europeans

Iosif Lazaridis, Nick Patterson, Alissa Mittnik, Gabriel Renaud, Swapan Mallick, Karola Kirsanow, Peter H Sudmant, Joshua G Schraiber, Sergi Castellano, Mark Lipson, Bonnie Berger, Christos Economou, Ruth Bollongino, Qiaomei Fu, Kirsten I Bos, Susanne Nordenfelt, Heng Li, Cesare de Filippo, Kay Pruefer, Susanna Sawyer, et al.

Journal article  |  2014  |  Nature

RNA-seq: impact of RNA degradation on transcript quantification

Irene Gallego Romero, Athma A Pai, Jenny Tung, Yoav Gilad

Journal article  |  2014  |  BMC Biology

Genome-Wide Analysis of Cold Adaptation in Indigenous Siberian Populations

Alexia Cardona, Luca Pagani, Tiago Antao, Daniel J Lawson, Christina A Eichstaedt, Bryndis Yngvadottir, Than Than Shwe Ma, Joseph Wee, Irene Gallego Romero, Srilakshmi Raj, Mait Metspalu, Richard Villems, Eske Willerslev, Chris Tyler-Smith, Boris A Malyarchuk, Miroslava V Derenko, Toomas Kivisild

Journal article  |  2014  |  PLoS ONE

The Light Skin Allele of SLC24A5 in South Asians and Europeans Shares Identity by Descent

Chandana Basu Mallick, Florin Mircea Iliescu, Mart Mols, Sarah Hill, Rakesh Tamang, Gyaneshwer Chaubey, Rie Goto, Simon YW Ho, Irene Gallego Romero, Federica Crivellaro, Georgi Hudjashov, Niraj Rai, Mait Metspalu, CG Nicholas Mascie-Taylor, Ramasamy Pitchappan, Lalji Singh, Marta Mirazon-Lahr, Kumarasamy Thangaraj, Richard Villems, Toomas Kivisild

Journal article  |  2013  |  PLoS Genetics

A general linear model-based approach for inferring selection to climate

Srilakshmi M Raj, Luca Pagani, Irene Gallego Romero, Toomas Kivisild, William Amos

Journal article  |  2013  |  BMC Genetics

Variation at Diabetes- and Obesity-Associated Loci May Mirror Neutral Patterns of Human Population Diversity and Diabetes Prevalence in India

Srilakshmi M Raj, Pradeep Halebeedu, Jayarama S Kadandale, Marta Mirazon Lahr, Irene Gallego Romero, Jamuna R Yadhav, Mircea Iliescu, Niraj Rai, Federica Crivellaro, Gyaneshwer Chaubey, Richard Villems, Kumarasamy Thangaraj, Kalappagowda Muniyappa, H Sharat Chandra, Toomas Kivisild

Journal article  |  2013  |  Annals of Human Genetics

Evolution of the pygmy phenotype: evidence of positive selection fro genome-wide scans in African, Asian, and Melanesian pygmies

Journal article  |  2013  |  Human biology

Evolution of the Pygmy Phenotype: Evidence of Positive Selection from Genome-wide Scans in African, Asian, and Melanesian Pygmies

Andrea Bamberg Migliano, Irene Gallego Romero, Mait Metspalu, Matthew Leavesley, Luca Pagani, Tiago Antao, Da-Wei Huang, Brad T Sherman, Katharine Siddle, Clarissa Scholes, Georgi Hudjashov, Elton Kaitokai, Avis Babalu, Maggie Belatti, Alex Cagan, Bryony Hopkinshaw, Colin Shaw, Mari Nelis, Ene Metspalu, Reedik Maegi, et al.

Journal article  |  2013  |  Human Biology

Ethiopian Genetic Diversity Reveals Linguistic Stratification and Complex Influences on the Ethiopian Gene Pool

Luca Pagani, Toomas Kivisild, Ayele Tarekegn, Rosemary Ekong, Chris Plaster, Irene Gallego Romero, Qasim Ayub, S Qasim Mehdi, Mark G Thomas, Donata Luiselli, Endashaw Bekele, Neil Bradman, David J Balding, Chris Tyler-Smith

Journal article  |  2012  |  The American Journal of Human Genetics

Comparative studies of gene expression and the evolution of gene regulation

Irene Gallego Romero, Ilya Ruvinsky, Yoav Gilad

Journal article  |  2012  |  Nature Reviews Genetics

Exploration of signals of positive selection derived from genotype-based human genome scans using re-sequencing data

Min Hu, Qasim Ayub, Jose Afonso Guerra-Assuncao, Quan Long, Zemin Ning, Ni Huang, Irene Gallego Romero, Lira Mamanova, Pelin Akan, Xin Liu, Alison J Coffey, Daniel J Turner, Harold Swerdlow, John Burton, Michael A Quail, Donald F Conrad, Anton J Enright, Chris Tyler-Smith, Yali Xue

Journal article  |  2012  |  Human Genetics

A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes

Daniel G MacArthur, Suganthi Balasubramanian, Adam Frankish, Ni Huang, James Morris, Klaudia Walter, Luke Jostins, Lukas Habegger, Joseph K Pickrell, Stephen B Montgomery, Cornelis A Albers, Zhengdong D Zhang, Donald F Conrad, Gerton Lunter, Hancheng Zheng, Qasim Ayub, Mark A DePristo, Eric Banks, Min Hu, Robert E Handsaker, et al.

Journal article  |  2012  |  Science

Shared and Unique Components of Human Population Structure and Genome-Wide Signals of Positive Selection in South Asia (vol 90, pg 731, 2011)

Mait Metspalu, Irene Gallego Romero, Bayazit Yunusbayev, Gyaneshwer Chaubey, Chandana Basu Mallick, Georgi Hudjashov, Mari Nelis, Reedik Maegi, Ene Metspalu, Maido Remm, Ramasamy Pitchappan, Lalji Singh, Kumarasamy Thangaraj, Richard Villems, Toomas Kivisild

Journal article  |  2012  |  The American Journal of Human Genetics

Herders of Indian and European Cattle Share Their Predominant Allele for Lactase Persistence

Irene Gallego Romero, Chandana Basu Mallick, Anke Liebert, Federica Crivellaro, Gyaneshwer Chaubey, Yuval Itan, Mait Metspalu, Muthukrishnan Eaaswarkhanth, Ramasamy Pitchappan, Richard Villems, David Reich, Lalji Singh, Kumarasamy Thangaraj, Mark G Thomas, Dallas M Swallow, Marta Mirazon Lahr, Toomas Kivisild

Journal article  |  2012  |  Molecular Biology and Evolution

Shared and Unique Components of Human Population Structure and Genome-Wide Signals of Positive Selection in South Asia

Mait Metspalu, Irene Gallego Romero, Bayazit Yunusbayev, Gyaneshwer Chaubey, Chandana Basu Mallick, Georgi Hudjashov, Mari Nelis, Reedik Maegi, Ene Metspalu, Maido Remm, Ramasamy Pitchappan, Lalji Singh, Kumarasamy Thangaraj, Richard Villems, Toomas Kivisild

Journal article  |  2011  |  The American Journal of Human Genetics

South Asia harbors one of the highest levels genetic diversity in Eurasia, which could be interpreted as a result of its long-term..

An Aboriginal Australian Genome Reveals Separate Human Dispersals into Asia

Morten Rasmussen, Xiaosen Guo, Yong Wang, Kirk E Lohmueller, Simon Rasmussen, Anders Albrechtsen, Line Skotte, Stinus Lindgreen, Mait Metspalu, Thibaut Jombart, Toomas Kivisild, Weiwei Zhai, Anders Eriksson, Andrea Manica, Ludovic Orlando, Francisco M De La Vega, Silvana Tridico, Ene Metspalu, Kasper Nielsen, Maria C Avila-Arcos, et al.

Journal article  |  2011  |  Science

Population Genetic Structure in Indian Austroasiatic Speakers: The Role of Landscape Barriers and Sex-Specific Admixture

Gyaneshwer Chaubey, Mait Metspalu, Ying Choi, Reedik Maegi, Irene Gallego Romero, Pedro Soares, Mannis van Oven, Doron M Behar, Siiri Rootsi, Georgi Hudjashov, Chandana Basu Mallick, Monika Karmin, Mari Nelis, Jueri Parik, Alla Goverdhana Reddy, Ene Metspalu, George van Driem, Yali Xue, Chris Tyler-Smith, Kumarasamy Thangaraj, et al.

Journal article  |  2011  |  Molecular Biology and Evolution

Traces of sub-Saharan and Middle Eastern lineages in Indian Muslim populations

Muthukrishnan Eaaswarkhanth, Ikramul Haque, Zeinab Ravesh, Irene Gallego Romero, Poorlin Ramakodi Meganathan, Bhawna Dubey, Faizan Ahmed Khan, Gyaneshwer Chaubey, Toomas Kivisild, Chris Tyler-Smith, Lalji Singh, Kumarasamy Thangaraj

Journal article  |  2010  |  European Journal of Human Genetics

How accurate is the current picture of human genetic variation?

IG Romero, A Manica, J Goudet, LL Handley, F Balloux

Journal article  |  2009  |  Heredity

CFTR mutations and reproductive outcomes in a population isolate

Irene Gallego Romero, Carole Ober

Journal article  |  2008  |  Human Genetics