Irene Gallego Romero

Leveraging massively parallel reporter assays for evolutionary questions

Irene Gallego Romero, Amanda J Lea

Journal article  |  2023  |  GENOME BIOLOGY

A long-standing goal of evolutionary biology is to decode how gene regulation contributes to organismal diversity. Doing so is cha..

Denisovan introgression has shaped the immune system of present-day Papuans

Davide M Vespasiani, Guy S Jacobs, Laura E Cook, Nicolas Brucato, Matthew Leavesley, Christopher Kinipi, Francois-Xavier Ricaut, Murray P Cox, Irene Gallego Romero

Journal article  |  2022  |  PLOS GENETICS

Modern humans have admixed with multiple archaic hominins. Papuans, in particular, owe up to 5% of their genome to Denisovans, a s..

GENOME-WIDE INSIGHTS INTO HUMAN POPULATION STRUCTURE

Irene Gallego Romero

Journal article  |  2022  |  NATURE REVIEWS GENETICS

Genetic architecture of gene regulation in Indonesian populations identifies QTLs associated with global and local ancestries

Heini M Natri, Georgi Hudjashov, Guy Jacobs, Pradiptajati Kusuma, Lauri Saag, Chelzie Crenna Darusallam, Mait Metspalu, Herawati Sudoyo, Murray P Cox, Irene Gallego Romero, Nicholas E Banovich

Journal article  |  2022  |  AMERICAN JOURNAL OF HUMAN GENETICS

Lack of diversity in human genomics limits our understanding of the genetic underpinnings of complex traits, hinders precision med..

Genetic Diversity in Chimpanzee Transcriptomics Does Not Represent Wild Populations

Navya Shukla, Bobbie Shaban, Irene Gallego Romero

Journal article  |  2021  |  GENOME BIOLOGY AND EVOLUTION

Chimpanzees (Pan troglodytes) are a genetically diverse species, consisting of four highly distinct subspecies. As humans' closest..

Papua New Guinean Genomes Reveal the Complex Settlement of North Sahul.

Nicolas Brucato, Mathilde André, Roxanne Tsang, Lauri Saag, Jason Kariwiga, Kylie Sesuki, Teppsy Beni, William Pomat, John Muke, Vincent Meyer, Anne Boland, Jean-François Deleuze, Herawati Sudoyo, Mayukh Mondal, Luca Pagani, Irene Gallego Romero, Mait Metspalu, Murray P Cox, Matthew Leavesley, François-Xavier Ricaut

Journal article  |  2021  |  Mol Biol Evol

The settlement of Sahul, the lost continent of Oceania, remains one of the most ancient and debated human migrations. Modern New G..

Harnessing pluripotent stem cells as models to decipher human evolution

Michael Dannemann, Irene Gallego Romero

Journal article  |  2021  |  FEBS JOURNAL

The study of human evolution, long constrained by a lack of experimental model systems, has been transformed by the emergence of t..

Genome-wide DNA methylation and gene expression patterns reflect genetic ancestry and environmental differences across the Indonesian archipelago.

Heini M Natri, Katalina S Bobowik, Pradiptajati Kusuma, Chelzie Crenna Darusallam, Guy S Jacobs, Georgi Hudjashov, J Stephen Lansing, Herawati Sudoyo, Nicholas E Banovich, Murray P Cox, Irene Gallego Romero

Journal article  |  2020  |  PLoS Genetics

Indonesia is the world's fourth most populous country, host to striking levels of human diversity, regional patterns of admixture,..

Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal

Kevin X Lau, Elizabeth A Mason, Joshua Kie, David P De Souza, Joachim Kloehn, Dedreia Tull, Malcolm J McConville, Andrew Keniry, Tamara Beck, Marnie E Blewitt, Matthew E Ritchie, Shalin H Naik, Daniela Zalcenstein, Othmar Korn, Shian Su, Irene Gallego Romero, Catrina Spruce, Christopher L Baker, Tracy C McGarr, Christine A Wells, et al.

Journal article  |  2020  |  Nature Communications

Archetypal human pluripotent stem cells (hPSC) are widely considered to be equivalent in developmental status to mouse epiblast st..

Population-genetic and functional investigation of high altitude adaptation in the Himalayan populations

Elena Arciero, Marc Haber, Thirsa Kraaijenbrink, undefined Asan, Michal Szpak, Pille Hallast, Nikolaos Panousis, Yuan Chen, Shane Mccarthy, Irene Gallego Romero, Huanming Yang, Mark Jobling, George Van Driem, Peter De Knijff, Qasim Ayub, Yali Xue, Chris Tyler-Smith

Conference Proceedings  |  2020  |  AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY