Irene Gallego Romero

Harnessing pluripotent stem cells as models to decipher human evolution

Michael Dannemann, Irene Gallego Romero

Journal article  |  2021  |  FEBS JOURNAL

The study of human evolution, long constrained by a lack of experimental model systems, has been transformed by the emergence of t..

Transcriptomic profiles of Plasmodium falciparum and Plasmodium vivax-infected individuals in Indonesia

Katalina Bobowik, Din Syafruddin, Chelzie Crenna Darusallam, Herawati Sudoyo, Christine Wells, Irene Gallego Romero

Journal article  |  2021

Malaria is one of the leading causes of illness and death globally. The vast majority of transcriptomic studies of the impact of m..

Genetic architecture of gene regulation in Indonesian populations identifies QTLs associated with local ancestry and archaic introgression

Heini Natri, Georgi Hudjashov, Guy Jacobs, Pradiptajati Kusuma, Lauri Saag, Chelzie Crenna Darusallam, Mait Metspalu, Herawati Sudoyo, Murray Cox, Irene Gallego Romero, Nicholas Banovich

Journal article  |  2020

Lack of diversity in human genomics limits our understanding of the genetic underpinnings of complex traits, hinders precision med..

Denisovan introgression has shaped the immune system of present-day Papuans

Davide Vespasiani, Guy Jacobs, Nicolas Brucato, Murray Cox, Irene Gallego Romero

Journal article  |  2020

Modern humans have substantially admixed with multiple archaic hominins. New Guineans, in particular, owe up to 5% of their genome..

Genome-wide DNA methylation and gene expression patterns reflect genetic ancestry and environmental differences across the Indonesian archipelago.

Heini M Natri, Katalina S Bobowik, Pradiptajati Kusuma, Chelzie Crenna Darusallam, Guy S Jacobs, Georgi Hudjashov, J Stephen Lansing, Herawati Sudoyo, Nicholas E Banovich, Murray P Cox, Irene Gallego Romero

Journal article  |  2020  |  PLoS Genetics

Indonesia is the world's fourth most populous country, host to striking levels of human diversity, regional patterns of admixture,..

Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal

Kevin X Lau, Elizabeth A Mason, Joshua Kie, David P De Souza, Joachim Kloehn, Dedreia Tull, Malcolm J McConville, Andrew Keniry, Tamara Beck, Marnie E Blewitt, Matthew E Ritchie, Shalin H Naik, Daniela Zalcenstein, Othmar Korn, Shian Su, Irene Gallego Romero, Catrina Spruce, Christopher L Baker, Tracy C McGarr, Christine A Wells, et al.

Journal article  |  2020  |  Nature Communications

Archetypal human pluripotent stem cells (hPSC) are widely considered to be equivalent in developmental status to mouse epiblast st..

Ancestry-Specific Analyses Reveal Differential Demographic Histories and Opposite Selective Pressures in Modern South Asian Populations

Burak Yelmen, Mayukh Mondal, Davide Marnetto, Ajai K Pathak, Francesco Montinaro, Irene Gallego Romero, Toomas Kivisild, Mait Metspalu, Luca Pagani

Journal article  |  2019  |  MOLECULAR BIOLOGY AND EVOLUTION

Genetic variation in contemporary South Asian populations follows a northwest to southeast decreasing cline of shared West Eurasia..

Genome-wide DNA methylation and gene expression patterns reflect genetic ancestry and environmental differences across the Indonesian archipelago

Heini Natri, Katalina Bobowik, Pradiptajati Kusuma, Chelzie Crenna Darusallam, Guy Jacobs, Georgi Hudjashov, Stephen Lansing, Herawati Sudoyo, Nicholas Banovich, Murray Cox, Irene Gallego Romero

Journal article  |  2019

Indonesia is the world’s fourth most populous country, host to striking levels of human diversity, regional patterns of admixture,..

Widespread conservation of chromatin accessibility patterns and transcription factor binding in human and chimpanzee induced pluripotent stem cells

Irene Gallego Romero, Shyam Gopalakrishnan, Yoav Gilad

Journal article  |  2018

Changes in gene regulation have been shown to contribute to phenotypic differences between closely related species, most notably i..

Impact of regulatory variation across human iPSCs and differentiated cells

Nicholas E Banovich, Yang I Li, Anil Raj, Michelle C Ward, Peyton Greenside, Diego Calderon, Po Yuan Tung, Jonathan E Burnett, Marsha Myrthil, Samantha M Thomas, Courtney K Burrows, Irene Gallego Romero, Bryan J Pavlovic, Anshul Kundaje, Jonathan K Pritchard, Yoav Gilad

Journal article  |  2018  |  GENOME RESEARCH

Induced pluripotent stem cells (iPSCs) are an essential tool for studying cellular differentiation and cell types that are otherwi..